FGFR1 signaling is associated with the magnitude of morphological integration in human head shape

Autores
Hünemeier, Tabita; Gómez Valdés, Jorge; de Azevedo, Soledad; Quinto Sanchez, Mirsha Emmanuel; Passaglia, Luciane; Salzano, Francisco M.; Sánchez Mejorada, Gabriela; Acuña Alonzo, Victor; Martínez Abadías, Neus; Bortolini, Maria Catira; Gonzalez José, Rolando
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: The head can be used as a model to study complex phenotypes controlled simultaneously by morphological integration (MI) due to common factors, and modular patterns caused by local factors affecting the development and functional demands of specific structures. The fibroblast growth factor and receptor system (FGF/ FGFR) participates in cell communication and pattern formation in osseous tissues, among others, and there is compel- ling evidence from mouse model studies suggesting a role of the FGF/FGFR pathway as a covariance-generating signal- ing process in head development. Here we use human data to test if specific genetic variants of another gene of this pathway, the FGFR1 gene, can be associated with differences in the integration of the head. Methods: We explored whether and how three specific variants on FGFR1, previously associated with human cephalic index, influence the pattern and level of head integration of one Native American and one admixed group from Mexico. MI, measured as the intensity of covariation among head traits, was assessed using data from three- dimensional head landmark coordinates taken on 176 individuals. Results: Individuals carrying the derived allele of the rs4647905:G>C polymorphism present significantly greater levels of head MI, especially in facial structures and on the shape space where the modular portion of the covariation is explicitly removed. Conclusions: Since FGFR genes present nonconservative and tissue-specific splicing sites, they may have some effect on protein structure and performance likely involved in developmental processes responsible for the magnitude and pattern of MI in the human head.
Fil: Hünemeier, Tabita. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gómez Valdés, Jorge. Universidad Nacional Autónoma de México. Facultad de Medicina; México
Fil: de Azevedo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Fil: Passaglia, Luciane. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Sánchez Mejorada, Gabriela. Universidad Nacional Autónoma de México. Facultad de Medicina; México
Fil: Acuña Alonzo, Victor. Escuela Nacional de Antropología e Historia; México
Fil: Martínez Abadías, Neus. EMBL-CRG Systems Biology Research Unit, Center for Genomic Regulation (CRG); España
Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gonzalez José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Materia
Fgfr1
Human Head Shape
Morphological Integration
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7647
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/7647
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling FGFR1 signaling is associated with the magnitude of morphological integration in human head shapeHünemeier, TabitaGómez Valdés, Jorgede Azevedo, SoledadQuinto Sanchez, Mirsha EmmanuelPassaglia, LucianeSalzano, Francisco M.Sánchez Mejorada, GabrielaAcuña Alonzo, VictorMartínez Abadías, NeusBortolini, Maria CatiraGonzalez José, RolandoFgfr1Human Head ShapeMorphological Integrationhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Objectives: The head can be used as a model to study complex phenotypes controlled simultaneously by morphological integration (MI) due to common factors, and modular patterns caused by local factors affecting the development and functional demands of specific structures. The fibroblast growth factor and receptor system (FGF/ FGFR) participates in cell communication and pattern formation in osseous tissues, among others, and there is compel- ling evidence from mouse model studies suggesting a role of the FGF/FGFR pathway as a covariance-generating signal- ing process in head development. Here we use human data to test if specific genetic variants of another gene of this pathway, the FGFR1 gene, can be associated with differences in the integration of the head. Methods: We explored whether and how three specific variants on FGFR1, previously associated with human cephalic index, influence the pattern and level of head integration of one Native American and one admixed group from Mexico. MI, measured as the intensity of covariation among head traits, was assessed using data from three- dimensional head landmark coordinates taken on 176 individuals. Results: Individuals carrying the derived allele of the rs4647905:G>C polymorphism present significantly greater levels of head MI, especially in facial structures and on the shape space where the modular portion of the covariation is explicitly removed. Conclusions: Since FGFR genes present nonconservative and tissue-specific splicing sites, they may have some effect on protein structure and performance likely involved in developmental processes responsible for the magnitude and pattern of MI in the human head.Fil: Hünemeier, Tabita. Universidade Federal do Rio Grande do Sul; BrasilFil: Gómez Valdés, Jorge. Universidad Nacional Autónoma de México. Facultad de Medicina; MéxicoFil: de Azevedo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Passaglia, Luciane. Universidade Federal do Rio Grande do Sul; BrasilFil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; BrasilFil: Sánchez Mejorada, Gabriela. Universidad Nacional Autónoma de México. Facultad de Medicina; MéxicoFil: Acuña Alonzo, Victor. Escuela Nacional de Antropología e Historia; MéxicoFil: Martínez Abadías, Neus. EMBL-CRG Systems Biology Research Unit, Center for Genomic Regulation (CRG); EspañaFil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; BrasilFil: Gonzalez José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaWiley2013-12-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7647Hünemeier, Tabita; Gómez Valdés, Jorge; de Azevedo, Soledad; Quinto Sanchez, Mirsha Emmanuel; Passaglia, Luciane; et al.; FGFR1 signaling is associated with the magnitude of morphological integration in human head shape; Wiley; American Journal of Human Biology; 26; 2; 10-12-2013; 164-1751042-0533enginfo:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1002/ajhb.22496info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ajhb.22496/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:06Zoai:ri.conicet.gov.ar:11336/7647instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:06.684CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv FGFR1 signaling is associated with the magnitude of morphological integration in human head shape
title FGFR1 signaling is associated with the magnitude of morphological integration in human head shape
spellingShingle FGFR1 signaling is associated with the magnitude of morphological integration in human head shape
Hünemeier, Tabita
Fgfr1
Human Head Shape
Morphological Integration
title_short FGFR1 signaling is associated with the magnitude of morphological integration in human head shape
title_full FGFR1 signaling is associated with the magnitude of morphological integration in human head shape
title_fullStr FGFR1 signaling is associated with the magnitude of morphological integration in human head shape
title_full_unstemmed FGFR1 signaling is associated with the magnitude of morphological integration in human head shape
title_sort FGFR1 signaling is associated with the magnitude of morphological integration in human head shape
dc.creator.none.fl_str_mv Hünemeier, Tabita
Gómez Valdés, Jorge
de Azevedo, Soledad
Quinto Sanchez, Mirsha Emmanuel
Passaglia, Luciane
Salzano, Francisco M.
Sánchez Mejorada, Gabriela
Acuña Alonzo, Victor
Martínez Abadías, Neus
Bortolini, Maria Catira
Gonzalez José, Rolando
author Hünemeier, Tabita
author_facet Hünemeier, Tabita
Gómez Valdés, Jorge
de Azevedo, Soledad
Quinto Sanchez, Mirsha Emmanuel
Passaglia, Luciane
Salzano, Francisco M.
Sánchez Mejorada, Gabriela
Acuña Alonzo, Victor
Martínez Abadías, Neus
Bortolini, Maria Catira
Gonzalez José, Rolando
author_role author
author2 Gómez Valdés, Jorge
de Azevedo, Soledad
Quinto Sanchez, Mirsha Emmanuel
Passaglia, Luciane
Salzano, Francisco M.
Sánchez Mejorada, Gabriela
Acuña Alonzo, Victor
Martínez Abadías, Neus
Bortolini, Maria Catira
Gonzalez José, Rolando
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Fgfr1
Human Head Shape
Morphological Integration
topic Fgfr1
Human Head Shape
Morphological Integration
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Objectives: The head can be used as a model to study complex phenotypes controlled simultaneously by morphological integration (MI) due to common factors, and modular patterns caused by local factors affecting the development and functional demands of specific structures. The fibroblast growth factor and receptor system (FGF/ FGFR) participates in cell communication and pattern formation in osseous tissues, among others, and there is compel- ling evidence from mouse model studies suggesting a role of the FGF/FGFR pathway as a covariance-generating signal- ing process in head development. Here we use human data to test if specific genetic variants of another gene of this pathway, the FGFR1 gene, can be associated with differences in the integration of the head. Methods: We explored whether and how three specific variants on FGFR1, previously associated with human cephalic index, influence the pattern and level of head integration of one Native American and one admixed group from Mexico. MI, measured as the intensity of covariation among head traits, was assessed using data from three- dimensional head landmark coordinates taken on 176 individuals. Results: Individuals carrying the derived allele of the rs4647905:G>C polymorphism present significantly greater levels of head MI, especially in facial structures and on the shape space where the modular portion of the covariation is explicitly removed. Conclusions: Since FGFR genes present nonconservative and tissue-specific splicing sites, they may have some effect on protein structure and performance likely involved in developmental processes responsible for the magnitude and pattern of MI in the human head.
Fil: Hünemeier, Tabita. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gómez Valdés, Jorge. Universidad Nacional Autónoma de México. Facultad de Medicina; México
Fil: de Azevedo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Fil: Passaglia, Luciane. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Salzano, Francisco M.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Sánchez Mejorada, Gabriela. Universidad Nacional Autónoma de México. Facultad de Medicina; México
Fil: Acuña Alonzo, Victor. Escuela Nacional de Antropología e Historia; México
Fil: Martínez Abadías, Neus. EMBL-CRG Systems Biology Research Unit, Center for Genomic Regulation (CRG); España
Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gonzalez José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
description Objectives: The head can be used as a model to study complex phenotypes controlled simultaneously by morphological integration (MI) due to common factors, and modular patterns caused by local factors affecting the development and functional demands of specific structures. The fibroblast growth factor and receptor system (FGF/ FGFR) participates in cell communication and pattern formation in osseous tissues, among others, and there is compel- ling evidence from mouse model studies suggesting a role of the FGF/FGFR pathway as a covariance-generating signal- ing process in head development. Here we use human data to test if specific genetic variants of another gene of this pathway, the FGFR1 gene, can be associated with differences in the integration of the head. Methods: We explored whether and how three specific variants on FGFR1, previously associated with human cephalic index, influence the pattern and level of head integration of one Native American and one admixed group from Mexico. MI, measured as the intensity of covariation among head traits, was assessed using data from three- dimensional head landmark coordinates taken on 176 individuals. Results: Individuals carrying the derived allele of the rs4647905:G>C polymorphism present significantly greater levels of head MI, especially in facial structures and on the shape space where the modular portion of the covariation is explicitly removed. Conclusions: Since FGFR genes present nonconservative and tissue-specific splicing sites, they may have some effect on protein structure and performance likely involved in developmental processes responsible for the magnitude and pattern of MI in the human head.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7647
Hünemeier, Tabita; Gómez Valdés, Jorge; de Azevedo, Soledad; Quinto Sanchez, Mirsha Emmanuel; Passaglia, Luciane; et al.; FGFR1 signaling is associated with the magnitude of morphological integration in human head shape; Wiley; American Journal of Human Biology; 26; 2; 10-12-2013; 164-175
1042-0533
url http://hdl.handle.net/11336/7647
identifier_str_mv Hünemeier, Tabita; Gómez Valdés, Jorge; de Azevedo, Soledad; Quinto Sanchez, Mirsha Emmanuel; Passaglia, Luciane; et al.; FGFR1 signaling is associated with the magnitude of morphological integration in human head shape; Wiley; American Journal of Human Biology; 26; 2; 10-12-2013; 164-175
1042-0533
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1002/ajhb.22496
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ajhb.22496/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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