The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery

Autores
Natalini, Paola Marisel; Razuc, Mariela Fernanda; Sørli, Jorid Birkelund; Bucala, Veronica; Ramírez Rigo, María Veronica
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Albendazole is a first line drug for the treatment of several parasitic diseases in humans. Some parasites target the lungs, however lung delivery of albendazole has so far not been reported. We have developed albendazole-based powders suitable for pulmonary delivery, and studied the impact of surfactant on the formulation properties. High-pressure homogenization followed by spray drying was used to produce inhalable particles of albendazole containing the bile salts sodium taurocholate and sodium glycocholate. The process resulted in porous microparticles, that exhibited good spray drying yield (>50%), low moisture contents (<1%) and aerodynamic D90 < 5 μm. The particles showed adequate aerosolization performance either for normal conditions (respiratory fraction > 71%) or conditions that simulate decreased respiratory capacity (respiratory fraction > 49%). The powders did not disturb lung surfactant function. The comparison between both formulations has revealed that the properties of the surfactants affect mainly the particle size of the suspensions and the porosity of the powders. The higher porosity of the albendazole-sodium taurocholate powder led to an enhanced aerodynamic performance of the formulation compared to albendazole-sodium glycocholate. The developed albendazole powders may pave a way for local lung treatment of parasitic diseases.
Fil: Natalini, Paola Marisel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. University of Southern Denmark; Dinamarca
Fil: Razuc, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Sørli, Jorid Birkelund. The National Research Centre for the Working Environment; Dinamarca
Fil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
Fil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Materia
DRY POWDER INHALER
HIGH-PRESSURE HOMOGENIZATION
NANOAGGREGATES
SODIUM GLYCOCHOLATE
SODIUM TAUROCHOLATE
SPRAY DRYING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/120433
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/120433
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The influence of surfactant on the properties of albendazole-bile salts particles designed for lung deliveryNatalini, Paola MariselRazuc, Mariela FernandaSørli, Jorid BirkelundBucala, VeronicaRamírez Rigo, María VeronicaDRY POWDER INHALERHIGH-PRESSURE HOMOGENIZATIONNANOAGGREGATESSODIUM GLYCOCHOLATESODIUM TAUROCHOLATESPRAY DRYINGhttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2Albendazole is a first line drug for the treatment of several parasitic diseases in humans. Some parasites target the lungs, however lung delivery of albendazole has so far not been reported. We have developed albendazole-based powders suitable for pulmonary delivery, and studied the impact of surfactant on the formulation properties. High-pressure homogenization followed by spray drying was used to produce inhalable particles of albendazole containing the bile salts sodium taurocholate and sodium glycocholate. The process resulted in porous microparticles, that exhibited good spray drying yield (>50%), low moisture contents (<1%) and aerodynamic D90 < 5 μm. The particles showed adequate aerosolization performance either for normal conditions (respiratory fraction > 71%) or conditions that simulate decreased respiratory capacity (respiratory fraction > 49%). The powders did not disturb lung surfactant function. The comparison between both formulations has revealed that the properties of the surfactants affect mainly the particle size of the suspensions and the porosity of the powders. The higher porosity of the albendazole-sodium taurocholate powder led to an enhanced aerodynamic performance of the formulation compared to albendazole-sodium glycocholate. The developed albendazole powders may pave a way for local lung treatment of parasitic diseases.Fil: Natalini, Paola Marisel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. University of Southern Denmark; DinamarcaFil: Razuc, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Sørli, Jorid Birkelund. The National Research Centre for the Working Environment; DinamarcaFil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; ArgentinaFil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaEditions Sante2019-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/120433Natalini, Paola Marisel; Razuc, Mariela Fernanda; Sørli, Jorid Birkelund; Bucala, Veronica; Ramírez Rigo, María Veronica; The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery; Editions Sante; Journal of Drug Delivery Science and Technology; 53; 10-2019; 1-91773-2247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1773224719304824info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2019.101162info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:28:48Zoai:ri.conicet.gov.ar:11336/120433instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:28:48.338CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery
title The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery
spellingShingle The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery
Natalini, Paola Marisel
DRY POWDER INHALER
HIGH-PRESSURE HOMOGENIZATION
NANOAGGREGATES
SODIUM GLYCOCHOLATE
SODIUM TAUROCHOLATE
SPRAY DRYING
title_short The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery
title_full The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery
title_fullStr The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery
title_full_unstemmed The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery
title_sort The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery
dc.creator.none.fl_str_mv Natalini, Paola Marisel
Razuc, Mariela Fernanda
Sørli, Jorid Birkelund
Bucala, Veronica
Ramírez Rigo, María Veronica
author Natalini, Paola Marisel
author_facet Natalini, Paola Marisel
Razuc, Mariela Fernanda
Sørli, Jorid Birkelund
Bucala, Veronica
Ramírez Rigo, María Veronica
author_role author
author2 Razuc, Mariela Fernanda
Sørli, Jorid Birkelund
Bucala, Veronica
Ramírez Rigo, María Veronica
author2_role author
author
author
author
dc.subject.none.fl_str_mv DRY POWDER INHALER
HIGH-PRESSURE HOMOGENIZATION
NANOAGGREGATES
SODIUM GLYCOCHOLATE
SODIUM TAUROCHOLATE
SPRAY DRYING
topic DRY POWDER INHALER
HIGH-PRESSURE HOMOGENIZATION
NANOAGGREGATES
SODIUM GLYCOCHOLATE
SODIUM TAUROCHOLATE
SPRAY DRYING
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Albendazole is a first line drug for the treatment of several parasitic diseases in humans. Some parasites target the lungs, however lung delivery of albendazole has so far not been reported. We have developed albendazole-based powders suitable for pulmonary delivery, and studied the impact of surfactant on the formulation properties. High-pressure homogenization followed by spray drying was used to produce inhalable particles of albendazole containing the bile salts sodium taurocholate and sodium glycocholate. The process resulted in porous microparticles, that exhibited good spray drying yield (>50%), low moisture contents (<1%) and aerodynamic D90 < 5 μm. The particles showed adequate aerosolization performance either for normal conditions (respiratory fraction > 71%) or conditions that simulate decreased respiratory capacity (respiratory fraction > 49%). The powders did not disturb lung surfactant function. The comparison between both formulations has revealed that the properties of the surfactants affect mainly the particle size of the suspensions and the porosity of the powders. The higher porosity of the albendazole-sodium taurocholate powder led to an enhanced aerodynamic performance of the formulation compared to albendazole-sodium glycocholate. The developed albendazole powders may pave a way for local lung treatment of parasitic diseases.
Fil: Natalini, Paola Marisel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. University of Southern Denmark; Dinamarca
Fil: Razuc, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Sørli, Jorid Birkelund. The National Research Centre for the Working Environment; Dinamarca
Fil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina
Fil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
description Albendazole is a first line drug for the treatment of several parasitic diseases in humans. Some parasites target the lungs, however lung delivery of albendazole has so far not been reported. We have developed albendazole-based powders suitable for pulmonary delivery, and studied the impact of surfactant on the formulation properties. High-pressure homogenization followed by spray drying was used to produce inhalable particles of albendazole containing the bile salts sodium taurocholate and sodium glycocholate. The process resulted in porous microparticles, that exhibited good spray drying yield (>50%), low moisture contents (<1%) and aerodynamic D90 < 5 μm. The particles showed adequate aerosolization performance either for normal conditions (respiratory fraction > 71%) or conditions that simulate decreased respiratory capacity (respiratory fraction > 49%). The powders did not disturb lung surfactant function. The comparison between both formulations has revealed that the properties of the surfactants affect mainly the particle size of the suspensions and the porosity of the powders. The higher porosity of the albendazole-sodium taurocholate powder led to an enhanced aerodynamic performance of the formulation compared to albendazole-sodium glycocholate. The developed albendazole powders may pave a way for local lung treatment of parasitic diseases.
publishDate 2019
dc.date.none.fl_str_mv 2019-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/120433
Natalini, Paola Marisel; Razuc, Mariela Fernanda; Sørli, Jorid Birkelund; Bucala, Veronica; Ramírez Rigo, María Veronica; The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery; Editions Sante; Journal of Drug Delivery Science and Technology; 53; 10-2019; 1-9
1773-2247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/120433
identifier_str_mv Natalini, Paola Marisel; Razuc, Mariela Fernanda; Sørli, Jorid Birkelund; Bucala, Veronica; Ramírez Rigo, María Veronica; The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery; Editions Sante; Journal of Drug Delivery Science and Technology; 53; 10-2019; 1-9
1773-2247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1773224719304824
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2019.101162
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Editions Sante
publisher.none.fl_str_mv Editions Sante
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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