A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production

Autores
Siebert, S.; Spinnler, K.; Matzkin, Maria Eugenia; Kunz, L.; Calandra, Ricardo Saul; Frungieri, Monica Beatriz; Mayerhofer, A.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Previously, we found that human steroid-producing ovarian granulosa cells express all major types of Ca2+-activated potassium channels (KCa), including BKCa, IK and SKs (Traut et al., RB&E, 2009), and that modulation of the activity of these channels resulted in alteration of steroid production. In the male gonad Leydig cells produce androgens, but whether these cells are endowed with KCas is not known. We addressed these points and focussed on BKCa, which is Ca2+-activated and the underlying channel for a prominent current. It can be manipulated, e.g. by a specific blocker, the red scorpion toxin iberiotoxin (IbTx), which binds to the outer face with high affinity and selectively inhibits the current by decreasing both the probability of opening and the open time of the channel.
Fil: Siebert, S.. Ludwig Maximilians Universitat; Alemania
Fil: Spinnler, K.. Ludwig Maximilians Universitat; Alemania
Fil: Matzkin, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Kunz, L.. Ludwig Maximilians Universitat; Alemania
Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Mayerhofer, A.. Ludwig Maximilians Universitat; Alemania
22. Jahrestagung der Deutschen Gesellschaft für Andrologie
Hamburgo
Alemania
Deutsche Gesellschaft für Andrologie
Conventus Congressmanagement und Marketing GmbH
Materia
TESTOSTERONE
TESTES
ION CHANNEL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/200035
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/200035
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone productionSiebert, S.Spinnler, K.Matzkin, Maria EugeniaKunz, L.Calandra, Ricardo SaulFrungieri, Monica BeatrizMayerhofer, A.TESTOSTERONETESTESION CHANNELhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Previously, we found that human steroid-producing ovarian granulosa cells express all major types of Ca2+-activated potassium channels (KCa), including BKCa, IK and SKs (Traut et al., RB&E, 2009), and that modulation of the activity of these channels resulted in alteration of steroid production. In the male gonad Leydig cells produce androgens, but whether these cells are endowed with KCas is not known. We addressed these points and focussed on BKCa, which is Ca2+-activated and the underlying channel for a prominent current. It can be manipulated, e.g. by a specific blocker, the red scorpion toxin iberiotoxin (IbTx), which binds to the outer face with high affinity and selectively inhibits the current by decreasing both the probability of opening and the open time of the channel.Fil: Siebert, S.. Ludwig Maximilians Universitat; AlemaniaFil: Spinnler, K.. Ludwig Maximilians Universitat; AlemaniaFil: Matzkin, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Kunz, L.. Ludwig Maximilians Universitat; AlemaniaFil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Mayerhofer, A.. Ludwig Maximilians Universitat; Alemania22. Jahrestagung der Deutschen Gesellschaft für AndrologieHamburgoAlemaniaDeutsche Gesellschaft für AndrologieConventus Congressmanagement und Marketing GmbHVerlag für Medizin und Wirtschaft2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/200035A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production; 22. Jahrestagung der Deutschen Gesellschaft für Andrologie; Hamburgo; Alemania; 2010; 445-4451810-2107CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.kup.at/journals/inhalt/1391.htmlInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:29Zoai:ri.conicet.gov.ar:11336/200035instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:29.459CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production
title A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production
spellingShingle A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production
Siebert, S.
TESTOSTERONE
TESTES
ION CHANNEL
title_short A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production
title_full A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production
title_fullStr A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production
title_full_unstemmed A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production
title_sort A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production
dc.creator.none.fl_str_mv Siebert, S.
Spinnler, K.
Matzkin, Maria Eugenia
Kunz, L.
Calandra, Ricardo Saul
Frungieri, Monica Beatriz
Mayerhofer, A.
author Siebert, S.
author_facet Siebert, S.
Spinnler, K.
Matzkin, Maria Eugenia
Kunz, L.
Calandra, Ricardo Saul
Frungieri, Monica Beatriz
Mayerhofer, A.
author_role author
author2 Spinnler, K.
Matzkin, Maria Eugenia
Kunz, L.
Calandra, Ricardo Saul
Frungieri, Monica Beatriz
Mayerhofer, A.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv TESTOSTERONE
TESTES
ION CHANNEL
topic TESTOSTERONE
TESTES
ION CHANNEL
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Previously, we found that human steroid-producing ovarian granulosa cells express all major types of Ca2+-activated potassium channels (KCa), including BKCa, IK and SKs (Traut et al., RB&E, 2009), and that modulation of the activity of these channels resulted in alteration of steroid production. In the male gonad Leydig cells produce androgens, but whether these cells are endowed with KCas is not known. We addressed these points and focussed on BKCa, which is Ca2+-activated and the underlying channel for a prominent current. It can be manipulated, e.g. by a specific blocker, the red scorpion toxin iberiotoxin (IbTx), which binds to the outer face with high affinity and selectively inhibits the current by decreasing both the probability of opening and the open time of the channel.
Fil: Siebert, S.. Ludwig Maximilians Universitat; Alemania
Fil: Spinnler, K.. Ludwig Maximilians Universitat; Alemania
Fil: Matzkin, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Kunz, L.. Ludwig Maximilians Universitat; Alemania
Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Mayerhofer, A.. Ludwig Maximilians Universitat; Alemania
22. Jahrestagung der Deutschen Gesellschaft für Andrologie
Hamburgo
Alemania
Deutsche Gesellschaft für Andrologie
Conventus Congressmanagement und Marketing GmbH
description Previously, we found that human steroid-producing ovarian granulosa cells express all major types of Ca2+-activated potassium channels (KCa), including BKCa, IK and SKs (Traut et al., RB&E, 2009), and that modulation of the activity of these channels resulted in alteration of steroid production. In the male gonad Leydig cells produce androgens, but whether these cells are endowed with KCas is not known. We addressed these points and focussed on BKCa, which is Ca2+-activated and the underlying channel for a prominent current. It can be manipulated, e.g. by a specific blocker, the red scorpion toxin iberiotoxin (IbTx), which binds to the outer face with high affinity and selectively inhibits the current by decreasing both the probability of opening and the open time of the channel.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/200035
A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production; 22. Jahrestagung der Deutschen Gesellschaft für Andrologie; Hamburgo; Alemania; 2010; 445-445
1810-2107
CONICET Digital
CONICET
url http://hdl.handle.net/11336/200035
identifier_str_mv A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production; 22. Jahrestagung der Deutschen Gesellschaft für Andrologie; Hamburgo; Alemania; 2010; 445-445
1810-2107
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.kup.at/journals/inhalt/1391.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Verlag für Medizin und Wirtschaft
publisher.none.fl_str_mv Verlag für Medizin und Wirtschaft
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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