A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production
- Autores
- Siebert, S.; Spinnler, K.; Matzkin, Maria Eugenia; Kunz, L.; Calandra, Ricardo Saul; Frungieri, Monica Beatriz; Mayerhofer, A.
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Previously, we found that human steroid-producing ovarian granulosa cells express all major types of Ca2+-activated potassium channels (KCa), including BKCa, IK and SKs (Traut et al., RB&E, 2009), and that modulation of the activity of these channels resulted in alteration of steroid production. In the male gonad Leydig cells produce androgens, but whether these cells are endowed with KCas is not known. We addressed these points and focussed on BKCa, which is Ca2+-activated and the underlying channel for a prominent current. It can be manipulated, e.g. by a specific blocker, the red scorpion toxin iberiotoxin (IbTx), which binds to the outer face with high affinity and selectively inhibits the current by decreasing both the probability of opening and the open time of the channel.
Fil: Siebert, S.. Ludwig Maximilians Universitat; Alemania
Fil: Spinnler, K.. Ludwig Maximilians Universitat; Alemania
Fil: Matzkin, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Kunz, L.. Ludwig Maximilians Universitat; Alemania
Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Mayerhofer, A.. Ludwig Maximilians Universitat; Alemania
22. Jahrestagung der Deutschen Gesellschaft für Andrologie
Hamburgo
Alemania
Deutsche Gesellschaft für Andrologie
Conventus Congressmanagement und Marketing GmbH - Materia
-
TESTOSTERONE
TESTES
ION CHANNEL - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/200035
Ver los metadatos del registro completo
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A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone productionSiebert, S.Spinnler, K.Matzkin, Maria EugeniaKunz, L.Calandra, Ricardo SaulFrungieri, Monica BeatrizMayerhofer, A.TESTOSTERONETESTESION CHANNELhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Previously, we found that human steroid-producing ovarian granulosa cells express all major types of Ca2+-activated potassium channels (KCa), including BKCa, IK and SKs (Traut et al., RB&E, 2009), and that modulation of the activity of these channels resulted in alteration of steroid production. In the male gonad Leydig cells produce androgens, but whether these cells are endowed with KCas is not known. We addressed these points and focussed on BKCa, which is Ca2+-activated and the underlying channel for a prominent current. It can be manipulated, e.g. by a specific blocker, the red scorpion toxin iberiotoxin (IbTx), which binds to the outer face with high affinity and selectively inhibits the current by decreasing both the probability of opening and the open time of the channel.Fil: Siebert, S.. Ludwig Maximilians Universitat; AlemaniaFil: Spinnler, K.. Ludwig Maximilians Universitat; AlemaniaFil: Matzkin, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Kunz, L.. Ludwig Maximilians Universitat; AlemaniaFil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Mayerhofer, A.. Ludwig Maximilians Universitat; Alemania22. Jahrestagung der Deutschen Gesellschaft für AndrologieHamburgoAlemaniaDeutsche Gesellschaft für AndrologieConventus Congressmanagement und Marketing GmbHVerlag für Medizin und Wirtschaft2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/200035A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production; 22. Jahrestagung der Deutschen Gesellschaft für Andrologie; Hamburgo; Alemania; 2010; 445-4451810-2107CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.kup.at/journals/inhalt/1391.htmlInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:21Zoai:ri.conicet.gov.ar:11336/200035instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:21.758CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production |
title |
A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production |
spellingShingle |
A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production Siebert, S. TESTOSTERONE TESTES ION CHANNEL |
title_short |
A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production |
title_full |
A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production |
title_fullStr |
A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production |
title_full_unstemmed |
A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production |
title_sort |
A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production |
dc.creator.none.fl_str_mv |
Siebert, S. Spinnler, K. Matzkin, Maria Eugenia Kunz, L. Calandra, Ricardo Saul Frungieri, Monica Beatriz Mayerhofer, A. |
author |
Siebert, S. |
author_facet |
Siebert, S. Spinnler, K. Matzkin, Maria Eugenia Kunz, L. Calandra, Ricardo Saul Frungieri, Monica Beatriz Mayerhofer, A. |
author_role |
author |
author2 |
Spinnler, K. Matzkin, Maria Eugenia Kunz, L. Calandra, Ricardo Saul Frungieri, Monica Beatriz Mayerhofer, A. |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
TESTOSTERONE TESTES ION CHANNEL |
topic |
TESTOSTERONE TESTES ION CHANNEL |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Previously, we found that human steroid-producing ovarian granulosa cells express all major types of Ca2+-activated potassium channels (KCa), including BKCa, IK and SKs (Traut et al., RB&E, 2009), and that modulation of the activity of these channels resulted in alteration of steroid production. In the male gonad Leydig cells produce androgens, but whether these cells are endowed with KCas is not known. We addressed these points and focussed on BKCa, which is Ca2+-activated and the underlying channel for a prominent current. It can be manipulated, e.g. by a specific blocker, the red scorpion toxin iberiotoxin (IbTx), which binds to the outer face with high affinity and selectively inhibits the current by decreasing both the probability of opening and the open time of the channel. Fil: Siebert, S.. Ludwig Maximilians Universitat; Alemania Fil: Spinnler, K.. Ludwig Maximilians Universitat; Alemania Fil: Matzkin, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Kunz, L.. Ludwig Maximilians Universitat; Alemania Fil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Mayerhofer, A.. Ludwig Maximilians Universitat; Alemania 22. Jahrestagung der Deutschen Gesellschaft für Andrologie Hamburgo Alemania Deutsche Gesellschaft für Andrologie Conventus Congressmanagement und Marketing GmbH |
description |
Previously, we found that human steroid-producing ovarian granulosa cells express all major types of Ca2+-activated potassium channels (KCa), including BKCa, IK and SKs (Traut et al., RB&E, 2009), and that modulation of the activity of these channels resulted in alteration of steroid production. In the male gonad Leydig cells produce androgens, but whether these cells are endowed with KCas is not known. We addressed these points and focussed on BKCa, which is Ca2+-activated and the underlying channel for a prominent current. It can be manipulated, e.g. by a specific blocker, the red scorpion toxin iberiotoxin (IbTx), which binds to the outer face with high affinity and selectively inhibits the current by decreasing both the probability of opening and the open time of the channel. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Congreso Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/200035 A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production; 22. Jahrestagung der Deutschen Gesellschaft für Andrologie; Hamburgo; Alemania; 2010; 445-445 1810-2107 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/200035 |
identifier_str_mv |
A Ca2+-activated potassium channel (BKCa) in Leydig cells is involved in testosterone production; 22. Jahrestagung der Deutschen Gesellschaft für Andrologie; Hamburgo; Alemania; 2010; 445-445 1810-2107 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.kup.at/journals/inhalt/1391.html |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.coverage.none.fl_str_mv |
Internacional |
dc.publisher.none.fl_str_mv |
Verlag für Medizin und Wirtschaft |
publisher.none.fl_str_mv |
Verlag für Medizin und Wirtschaft |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268919420682240 |
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13.13397 |