Preparation and application in drug storage and delivery of agarose nanoparticles

Autores
Argudo, Pablo G.; Guzmán, Eduardo; Lucia, Alejandro; Rubio, Ramón G.; Ortega, Francisco
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this work, monodisperse agarose gel nanoparticles were prepared using a W/O microemulsion as a template to control the size of the obtained particles. The combination of this template method with a temperature-induced gelling and a solvent exchange methodology has allowed preparing stable aqueous dispersions of monodisperse agarose gel nanoparticles in water. The average size, measured as an apparent hydrodynamic diameter, of the obtained particles was around 150 nm. The ability of the obtained hydrogel particles for the encapsulation and release of a synthetic insecticide (azamethiphos) was tested. The results evidence that the insecticide molecules encapsulated in the fabricated nanoparticles are released following a diffusion-controlled mechanism. These results combined with the biodegradability of the agarose provide the bases for the design of a new vector with application in the control of parasites in water reservoirs.
Fil: Argudo, Pablo G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Guzmán, Eduardo. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina
Fil: Rubio, Ramón G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Ortega, Francisco. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Materia
AGAROSE
NANOPARTICLES
DRUG
STORAGE AND DELIVERY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/92204
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Preparation and application in drug storage and delivery of agarose nanoparticlesArgudo, Pablo G.Guzmán, EduardoLucia, AlejandroRubio, Ramón G.Ortega, FranciscoAGAROSENANOPARTICLESDRUGSTORAGE AND DELIVERYhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In this work, monodisperse agarose gel nanoparticles were prepared using a W/O microemulsion as a template to control the size of the obtained particles. The combination of this template method with a temperature-induced gelling and a solvent exchange methodology has allowed preparing stable aqueous dispersions of monodisperse agarose gel nanoparticles in water. The average size, measured as an apparent hydrodynamic diameter, of the obtained particles was around 150 nm. The ability of the obtained hydrogel particles for the encapsulation and release of a synthetic insecticide (azamethiphos) was tested. The results evidence that the insecticide molecules encapsulated in the fabricated nanoparticles are released following a diffusion-controlled mechanism. These results combined with the biodegradability of the agarose provide the bases for the design of a new vector with application in the control of parasites in water reservoirs.Fil: Argudo, Pablo G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Guzmán, Eduardo. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; ArgentinaFil: Rubio, Ramón G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Ortega, Francisco. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaHindawi Publishing Corporation2018-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/92204Argudo, Pablo G.; Guzmán, Eduardo; Lucia, Alejandro; Rubio, Ramón G.; Ortega, Francisco; Preparation and application in drug storage and delivery of agarose nanoparticles; Hindawi Publishing Corporation; International Journal of Polymer Science; 2018; 12-2018; 1-9; 78235871687-94221687-9430CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ijps/2018/7823587/info:eu-repo/semantics/altIdentifier/doi/10.1155/2018/7823587info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:05Zoai:ri.conicet.gov.ar:11336/92204instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:05.65CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Preparation and application in drug storage and delivery of agarose nanoparticles
title Preparation and application in drug storage and delivery of agarose nanoparticles
spellingShingle Preparation and application in drug storage and delivery of agarose nanoparticles
Argudo, Pablo G.
AGAROSE
NANOPARTICLES
DRUG
STORAGE AND DELIVERY
title_short Preparation and application in drug storage and delivery of agarose nanoparticles
title_full Preparation and application in drug storage and delivery of agarose nanoparticles
title_fullStr Preparation and application in drug storage and delivery of agarose nanoparticles
title_full_unstemmed Preparation and application in drug storage and delivery of agarose nanoparticles
title_sort Preparation and application in drug storage and delivery of agarose nanoparticles
dc.creator.none.fl_str_mv Argudo, Pablo G.
Guzmán, Eduardo
Lucia, Alejandro
Rubio, Ramón G.
Ortega, Francisco
author Argudo, Pablo G.
author_facet Argudo, Pablo G.
Guzmán, Eduardo
Lucia, Alejandro
Rubio, Ramón G.
Ortega, Francisco
author_role author
author2 Guzmán, Eduardo
Lucia, Alejandro
Rubio, Ramón G.
Ortega, Francisco
author2_role author
author
author
author
dc.subject.none.fl_str_mv AGAROSE
NANOPARTICLES
DRUG
STORAGE AND DELIVERY
topic AGAROSE
NANOPARTICLES
DRUG
STORAGE AND DELIVERY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In this work, monodisperse agarose gel nanoparticles were prepared using a W/O microemulsion as a template to control the size of the obtained particles. The combination of this template method with a temperature-induced gelling and a solvent exchange methodology has allowed preparing stable aqueous dispersions of monodisperse agarose gel nanoparticles in water. The average size, measured as an apparent hydrodynamic diameter, of the obtained particles was around 150 nm. The ability of the obtained hydrogel particles for the encapsulation and release of a synthetic insecticide (azamethiphos) was tested. The results evidence that the insecticide molecules encapsulated in the fabricated nanoparticles are released following a diffusion-controlled mechanism. These results combined with the biodegradability of the agarose provide the bases for the design of a new vector with application in the control of parasites in water reservoirs.
Fil: Argudo, Pablo G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Guzmán, Eduardo. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina
Fil: Rubio, Ramón G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Ortega, Francisco. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
description In this work, monodisperse agarose gel nanoparticles were prepared using a W/O microemulsion as a template to control the size of the obtained particles. The combination of this template method with a temperature-induced gelling and a solvent exchange methodology has allowed preparing stable aqueous dispersions of monodisperse agarose gel nanoparticles in water. The average size, measured as an apparent hydrodynamic diameter, of the obtained particles was around 150 nm. The ability of the obtained hydrogel particles for the encapsulation and release of a synthetic insecticide (azamethiphos) was tested. The results evidence that the insecticide molecules encapsulated in the fabricated nanoparticles are released following a diffusion-controlled mechanism. These results combined with the biodegradability of the agarose provide the bases for the design of a new vector with application in the control of parasites in water reservoirs.
publishDate 2018
dc.date.none.fl_str_mv 2018-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/92204
Argudo, Pablo G.; Guzmán, Eduardo; Lucia, Alejandro; Rubio, Ramón G.; Ortega, Francisco; Preparation and application in drug storage and delivery of agarose nanoparticles; Hindawi Publishing Corporation; International Journal of Polymer Science; 2018; 12-2018; 1-9; 7823587
1687-9422
1687-9430
CONICET Digital
CONICET
url http://hdl.handle.net/11336/92204
identifier_str_mv Argudo, Pablo G.; Guzmán, Eduardo; Lucia, Alejandro; Rubio, Ramón G.; Ortega, Francisco; Preparation and application in drug storage and delivery of agarose nanoparticles; Hindawi Publishing Corporation; International Journal of Polymer Science; 2018; 12-2018; 1-9; 7823587
1687-9422
1687-9430
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ijps/2018/7823587/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2018/7823587
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269500673622016
score 12.885934

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