Risk of chlorine dioxide as emerging contaminant during SARS-CoV-2 pandemic: enzyme, cardiac, and behavior effects on amphibian tadpoles

Autores
Peltzer, Paola; Cuzziol Boccioni, Ana Paula; Attademo, Andres Maximiliano; Martinuzzi, Candela Soledad; Colussi, Carlina Leila; Lajmanovich, Rafael Carlos
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective The use of chlorine dioxide (ClO2) increased in the last year to prevent SARS-CoV-2 infection due to its use as disinfectant and therapeutic human treatments against viral infections. The absence of toxicological studies and sanitary regulation of this contaminant represents a serious threat to human and environmental health worldwide. The aim of this study was to evaluate the acute toxicity and sublethal efects of ClO2 on tadpoles of Trachycephalus typhonius, which is a common bioindicator species of contamination from aquatic ecosystems. Materials and methods Median lethal concentration (LC50), the lowest-observed efect concentration (LOEC), and the noobserved efect concentration (NOEC) were performed. Acetylcholinesterase (AChE) and glutathione-S-transferase (GST) activities, swimming behavior parameters, and cardiac rhythm were estimated on tadpoles of concentrations≤LOEC exposed at 24 and 96 h. ANOVA and Dunnett’s post-hoc comparisons were performed to defne treatments signifcance (p≤0.05). Results The LC50 of ClO2 was 4.17 mg L−1 (confdence limits: 3.73–4.66). In addition, NOEC and LOEC values were 1.56 and 3.12 mg L−1 ClO2, respectively, at 48 h. AChE and GST activities, swimming parameters, and heart rates increased in sublethal exposure of ClO2 (0.78–1.56 mg L−1) at 24 h. However, both enzyme activities and swimming parameters decreased, whereas heart rates increased at 96 h. Conclusion Overall, this study determined that sublethal concentrations of ClO2 produced alterations on antioxidant systems, neurotoxicity refected on swimming performances, and variations in cardiac rhythm on treated tadpoles. Thus, our fndings highlighted the need for urgent monitoring of this chemical in the aquatic ecosystems.
Fil: Peltzer, Paola. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Cuzziol Boccioni, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Attademo, Andres Maximiliano. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinuzzi, Candela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Colussi, Carlina Leila. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Lajmanovich, Rafael Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Materia
ANURANS
CHLORINE DISINFECTANT
COVID-19
SUBLETHAL TOXICITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/149369
Acceder
id CONICETDig_010f3c407222ecc123b52c7d363ad4c8
oai_identifier_str oai:ri.conicet.gov.ar:11336/149369
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Risk of chlorine dioxide as emerging contaminant during SARS-CoV-2 pandemic: enzyme, cardiac, and behavior effects on amphibian tadpolesPeltzer, PaolaCuzziol Boccioni, Ana PaulaAttademo, Andres MaximilianoMartinuzzi, Candela SoledadColussi, Carlina LeilaLajmanovich, Rafael CarlosANURANSCHLORINE DISINFECTANTCOVID-19SUBLETHAL TOXICITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Objective The use of chlorine dioxide (ClO2) increased in the last year to prevent SARS-CoV-2 infection due to its use as disinfectant and therapeutic human treatments against viral infections. The absence of toxicological studies and sanitary regulation of this contaminant represents a serious threat to human and environmental health worldwide. The aim of this study was to evaluate the acute toxicity and sublethal efects of ClO2 on tadpoles of Trachycephalus typhonius, which is a common bioindicator species of contamination from aquatic ecosystems. Materials and methods Median lethal concentration (LC50), the lowest-observed efect concentration (LOEC), and the noobserved efect concentration (NOEC) were performed. Acetylcholinesterase (AChE) and glutathione-S-transferase (GST) activities, swimming behavior parameters, and cardiac rhythm were estimated on tadpoles of concentrations≤LOEC exposed at 24 and 96 h. ANOVA and Dunnett’s post-hoc comparisons were performed to defne treatments signifcance (p≤0.05). Results The LC50 of ClO2 was 4.17 mg L−1 (confdence limits: 3.73–4.66). In addition, NOEC and LOEC values were 1.56 and 3.12 mg L−1 ClO2, respectively, at 48 h. AChE and GST activities, swimming parameters, and heart rates increased in sublethal exposure of ClO2 (0.78–1.56 mg L−1) at 24 h. However, both enzyme activities and swimming parameters decreased, whereas heart rates increased at 96 h. Conclusion Overall, this study determined that sublethal concentrations of ClO2 produced alterations on antioxidant systems, neurotoxicity refected on swimming performances, and variations in cardiac rhythm on treated tadpoles. Thus, our fndings highlighted the need for urgent monitoring of this chemical in the aquatic ecosystems.Fil: Peltzer, Paola. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaFil: Cuzziol Boccioni, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaFil: Attademo, Andres Maximiliano. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Martinuzzi, Candela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaFil: Colussi, Carlina Leila. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaFil: Lajmanovich, Rafael Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaElsevier2021-11-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/149369Peltzer, Paola; Cuzziol Boccioni, Ana Paula; Attademo, Andres Maximiliano; Martinuzzi, Candela Soledad; Colussi, Carlina Leila; et al.; Risk of chlorine dioxide as emerging contaminant during SARS-CoV-2 pandemic: enzyme, cardiac, and behavior effects on amphibian tadpoles; Elsevier; Toxicology and Environmental Health Sciences; 2021; 3-11-2021; 1-112005-97522233-7784CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/10.1007/s13530-021-00116-3info:eu-repo/semantics/altIdentifier/doi/10.1007/s13530-021-00116-3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T09:10:16Zoai:ri.conicet.gov.ar:11336/149369instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 09:10:17.279CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Risk of chlorine dioxide as emerging contaminant during SARS-CoV-2 pandemic: enzyme, cardiac, and behavior effects on amphibian tadpoles
title Risk of chlorine dioxide as emerging contaminant during SARS-CoV-2 pandemic: enzyme, cardiac, and behavior effects on amphibian tadpoles
spellingShingle Risk of chlorine dioxide as emerging contaminant during SARS-CoV-2 pandemic: enzyme, cardiac, and behavior effects on amphibian tadpoles
Peltzer, Paola
ANURANS
CHLORINE DISINFECTANT
COVID-19
SUBLETHAL TOXICITY
title_short Risk of chlorine dioxide as emerging contaminant during SARS-CoV-2 pandemic: enzyme, cardiac, and behavior effects on amphibian tadpoles
title_full Risk of chlorine dioxide as emerging contaminant during SARS-CoV-2 pandemic: enzyme, cardiac, and behavior effects on amphibian tadpoles
title_fullStr Risk of chlorine dioxide as emerging contaminant during SARS-CoV-2 pandemic: enzyme, cardiac, and behavior effects on amphibian tadpoles
title_full_unstemmed Risk of chlorine dioxide as emerging contaminant during SARS-CoV-2 pandemic: enzyme, cardiac, and behavior effects on amphibian tadpoles
title_sort Risk of chlorine dioxide as emerging contaminant during SARS-CoV-2 pandemic: enzyme, cardiac, and behavior effects on amphibian tadpoles
dc.creator.none.fl_str_mv Peltzer, Paola
Cuzziol Boccioni, Ana Paula
Attademo, Andres Maximiliano
Martinuzzi, Candela Soledad
Colussi, Carlina Leila
Lajmanovich, Rafael Carlos
author Peltzer, Paola
author_facet Peltzer, Paola
Cuzziol Boccioni, Ana Paula
Attademo, Andres Maximiliano
Martinuzzi, Candela Soledad
Colussi, Carlina Leila
Lajmanovich, Rafael Carlos
author_role author
author2 Cuzziol Boccioni, Ana Paula
Attademo, Andres Maximiliano
Martinuzzi, Candela Soledad
Colussi, Carlina Leila
Lajmanovich, Rafael Carlos
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANURANS
CHLORINE DISINFECTANT
COVID-19
SUBLETHAL TOXICITY
topic ANURANS
CHLORINE DISINFECTANT
COVID-19
SUBLETHAL TOXICITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Objective The use of chlorine dioxide (ClO2) increased in the last year to prevent SARS-CoV-2 infection due to its use as disinfectant and therapeutic human treatments against viral infections. The absence of toxicological studies and sanitary regulation of this contaminant represents a serious threat to human and environmental health worldwide. The aim of this study was to evaluate the acute toxicity and sublethal efects of ClO2 on tadpoles of Trachycephalus typhonius, which is a common bioindicator species of contamination from aquatic ecosystems. Materials and methods Median lethal concentration (LC50), the lowest-observed efect concentration (LOEC), and the noobserved efect concentration (NOEC) were performed. Acetylcholinesterase (AChE) and glutathione-S-transferase (GST) activities, swimming behavior parameters, and cardiac rhythm were estimated on tadpoles of concentrations≤LOEC exposed at 24 and 96 h. ANOVA and Dunnett’s post-hoc comparisons were performed to defne treatments signifcance (p≤0.05). Results The LC50 of ClO2 was 4.17 mg L−1 (confdence limits: 3.73–4.66). In addition, NOEC and LOEC values were 1.56 and 3.12 mg L−1 ClO2, respectively, at 48 h. AChE and GST activities, swimming parameters, and heart rates increased in sublethal exposure of ClO2 (0.78–1.56 mg L−1) at 24 h. However, both enzyme activities and swimming parameters decreased, whereas heart rates increased at 96 h. Conclusion Overall, this study determined that sublethal concentrations of ClO2 produced alterations on antioxidant systems, neurotoxicity refected on swimming performances, and variations in cardiac rhythm on treated tadpoles. Thus, our fndings highlighted the need for urgent monitoring of this chemical in the aquatic ecosystems.
Fil: Peltzer, Paola. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Cuzziol Boccioni, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Attademo, Andres Maximiliano. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Martinuzzi, Candela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Colussi, Carlina Leila. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Lajmanovich, Rafael Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
description Objective The use of chlorine dioxide (ClO2) increased in the last year to prevent SARS-CoV-2 infection due to its use as disinfectant and therapeutic human treatments against viral infections. The absence of toxicological studies and sanitary regulation of this contaminant represents a serious threat to human and environmental health worldwide. The aim of this study was to evaluate the acute toxicity and sublethal efects of ClO2 on tadpoles of Trachycephalus typhonius, which is a common bioindicator species of contamination from aquatic ecosystems. Materials and methods Median lethal concentration (LC50), the lowest-observed efect concentration (LOEC), and the noobserved efect concentration (NOEC) were performed. Acetylcholinesterase (AChE) and glutathione-S-transferase (GST) activities, swimming behavior parameters, and cardiac rhythm were estimated on tadpoles of concentrations≤LOEC exposed at 24 and 96 h. ANOVA and Dunnett’s post-hoc comparisons were performed to defne treatments signifcance (p≤0.05). Results The LC50 of ClO2 was 4.17 mg L−1 (confdence limits: 3.73–4.66). In addition, NOEC and LOEC values were 1.56 and 3.12 mg L−1 ClO2, respectively, at 48 h. AChE and GST activities, swimming parameters, and heart rates increased in sublethal exposure of ClO2 (0.78–1.56 mg L−1) at 24 h. However, both enzyme activities and swimming parameters decreased, whereas heart rates increased at 96 h. Conclusion Overall, this study determined that sublethal concentrations of ClO2 produced alterations on antioxidant systems, neurotoxicity refected on swimming performances, and variations in cardiac rhythm on treated tadpoles. Thus, our fndings highlighted the need for urgent monitoring of this chemical in the aquatic ecosystems.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/149369
Peltzer, Paola; Cuzziol Boccioni, Ana Paula; Attademo, Andres Maximiliano; Martinuzzi, Candela Soledad; Colussi, Carlina Leila; et al.; Risk of chlorine dioxide as emerging contaminant during SARS-CoV-2 pandemic: enzyme, cardiac, and behavior effects on amphibian tadpoles; Elsevier; Toxicology and Environmental Health Sciences; 2021; 3-11-2021; 1-11
2005-9752
2233-7784
CONICET Digital
CONICET
url http://hdl.handle.net/11336/149369
identifier_str_mv Peltzer, Paola; Cuzziol Boccioni, Ana Paula; Attademo, Andres Maximiliano; Martinuzzi, Candela Soledad; Colussi, Carlina Leila; et al.; Risk of chlorine dioxide as emerging contaminant during SARS-CoV-2 pandemic: enzyme, cardiac, and behavior effects on amphibian tadpoles; Elsevier; Toxicology and Environmental Health Sciences; 2021; 3-11-2021; 1-11
2005-9752
2233-7784
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/10.1007/s13530-021-00116-3
info:eu-repo/semantics/altIdentifier/doi/10.1007/s13530-021-00116-3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.011256

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