Bone mass recovery of osteopenic vitamin D insufficient rats from strontium ranelate treatment: Does the response depend on vitamin D nutritional status or on source of vitamin D (...

Autores
Gonzales Chaves, Macarena Maria Sol; Marote, Clarisa; Pellegrini, Gretel Gisela; Pighin, Andrés; De Landeta, Maria C.; Lifshitz, Fima; Friedman, Silvia María; Mandalunis, Patricia Mónica; Zeni, Susana Noemi
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It was investigated if Vitamin D (Vit D) status or source (Vitamin D2 vs. Vitamin D3) interferes with bone mass recovery from strontium ranelate (SrRa) treatment of rats with Vit D insufficiency and established osteopenia. Osteopenic and Vit D insufficient rats were divided in groups to complete a 105-day period. First experiment: The rats were fed with diets that only varied in Vit D (100 vs. 0 IU%) and/or SrRa (0 vs. 900 mg/kg/day) content. A SHAM group received Vit D throughout the experience. Second experiment: Rats were divided into groups and received Vit D2 or Vit D3 through diet and SrRa by gavages in a fasting state. Two SHAM groups received Vit D2 or Vit D3 throughout the study. Results: Levels of 25-hydroxyvitamin 25OHD were reduced in groups lacking dietary Vit D (p < 0.001). Independently of Vit D status or source, SrRa did not affect body weight gain or bone alkaline phosphatase levels; osteocalcin and C-terminal telopeptide of type I collagen levels were reduced (p < 0.05) and bone Sr content was increased (p < 0.0001). Although no improvement in biomechanical parameters was observed, total skeletal bone mineral content and proximal tibial bone mineral density were increased (p < 0.05). There was a reduction in the trabecular number and an increase in the trabecular surface and bone volume without reaching SHAM levels. Conclusion: This is the first study that examined SrRa effects in an osteopenic vitamin Dinsufficient experimental model. Under our experimental conditions, SrRa increased bone Sr content independently of Vit D status or source; however, no evidence of an anabolic or antifracture effect was found, and only a slight decrease in some bone resorption parameters was observed. © 2010 World Scientific Publishing Company.
Fil: Gonzales Chaves, Macarena Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Marote, Clarisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Pellegrini, Gretel Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Pighin, Andrés. Universidad Nacional de Luján; Argentina
Fil: De Landeta, Maria C.. Universidad Nacional de Luján; Argentina
Fil: Lifshitz, Fima. Pediatric Sunshine Academics & Samsun Diabetes Research Institute; Estados Unidos
Fil: Friedman, Silvia María. Universidad de Buenos Aires; Argentina
Fil: Mandalunis, Patricia Mónica. Universidad de Buenos Aires; Argentina
Fil: Zeni, Susana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Materia
Osteopenic Rats
Strontium Ranelate
Vitamin D
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67283
Acceder
id CONICETDig_00c13ee97280540cd34ec9d617d0d42d
oai_identifier_str oai:ri.conicet.gov.ar:11336/67283
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Bone mass recovery of osteopenic vitamin D insufficient rats from strontium ranelate treatment: Does the response depend on vitamin D nutritional status or on source of vitamin D (D2 versus D3)?Gonzales Chaves, Macarena Maria SolMarote, ClarisaPellegrini, Gretel GiselaPighin, AndrésDe Landeta, Maria C.Lifshitz, FimaFriedman, Silvia MaríaMandalunis, Patricia MónicaZeni, Susana NoemiOsteopenic RatsStrontium RanelateVitamin Dhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3It was investigated if Vitamin D (Vit D) status or source (Vitamin D2 vs. Vitamin D3) interferes with bone mass recovery from strontium ranelate (SrRa) treatment of rats with Vit D insufficiency and established osteopenia. Osteopenic and Vit D insufficient rats were divided in groups to complete a 105-day period. First experiment: The rats were fed with diets that only varied in Vit D (100 vs. 0 IU%) and/or SrRa (0 vs. 900 mg/kg/day) content. A SHAM group received Vit D throughout the experience. Second experiment: Rats were divided into groups and received Vit D2 or Vit D3 through diet and SrRa by gavages in a fasting state. Two SHAM groups received Vit D2 or Vit D3 throughout the study. Results: Levels of 25-hydroxyvitamin 25OHD were reduced in groups lacking dietary Vit D (p < 0.001). Independently of Vit D status or source, SrRa did not affect body weight gain or bone alkaline phosphatase levels; osteocalcin and C-terminal telopeptide of type I collagen levels were reduced (p < 0.05) and bone Sr content was increased (p < 0.0001). Although no improvement in biomechanical parameters was observed, total skeletal bone mineral content and proximal tibial bone mineral density were increased (p < 0.05). There was a reduction in the trabecular number and an increase in the trabecular surface and bone volume without reaching SHAM levels. Conclusion: This is the first study that examined SrRa effects in an osteopenic vitamin Dinsufficient experimental model. Under our experimental conditions, SrRa increased bone Sr content independently of Vit D status or source; however, no evidence of an anabolic or antifracture effect was found, and only a slight decrease in some bone resorption parameters was observed. © 2010 World Scientific Publishing Company.Fil: Gonzales Chaves, Macarena Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Marote, Clarisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Pellegrini, Gretel Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Pighin, Andrés. Universidad Nacional de Luján; ArgentinaFil: De Landeta, Maria C.. Universidad Nacional de Luján; ArgentinaFil: Lifshitz, Fima. Pediatric Sunshine Academics & Samsun Diabetes Research Institute; Estados UnidosFil: Friedman, Silvia María. Universidad de Buenos Aires; ArgentinaFil: Mandalunis, Patricia Mónica. Universidad de Buenos Aires; ArgentinaFil: Zeni, Susana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaWorld Scientific2010-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67283Gonzales Chaves, Macarena Maria Sol; Marote, Clarisa; Pellegrini, Gretel Gisela; Pighin, Andrés; De Landeta, Maria C.; et al.; Bone mass recovery of osteopenic vitamin D insufficient rats from strontium ranelate treatment: Does the response depend on vitamin D nutritional status or on source of vitamin D (D2 versus D3)?; World Scientific; Journal of Musculoskeletal Research; 13; 3; 9-2010; 95-1080218-9577CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.worldscientific.com/doi/abs/10.1142/S0218957710002582info:eu-repo/semantics/altIdentifier/doi/10.1142/S0218957710002582info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:11:26Zoai:ri.conicet.gov.ar:11336/67283instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:11:27.077CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bone mass recovery of osteopenic vitamin D insufficient rats from strontium ranelate treatment: Does the response depend on vitamin D nutritional status or on source of vitamin D (D2 versus D3)?
title Bone mass recovery of osteopenic vitamin D insufficient rats from strontium ranelate treatment: Does the response depend on vitamin D nutritional status or on source of vitamin D (D2 versus D3)?
spellingShingle Bone mass recovery of osteopenic vitamin D insufficient rats from strontium ranelate treatment: Does the response depend on vitamin D nutritional status or on source of vitamin D (D2 versus D3)?
Gonzales Chaves, Macarena Maria Sol
Osteopenic Rats
Strontium Ranelate
Vitamin D
title_short Bone mass recovery of osteopenic vitamin D insufficient rats from strontium ranelate treatment: Does the response depend on vitamin D nutritional status or on source of vitamin D (D2 versus D3)?
title_full Bone mass recovery of osteopenic vitamin D insufficient rats from strontium ranelate treatment: Does the response depend on vitamin D nutritional status or on source of vitamin D (D2 versus D3)?
title_fullStr Bone mass recovery of osteopenic vitamin D insufficient rats from strontium ranelate treatment: Does the response depend on vitamin D nutritional status or on source of vitamin D (D2 versus D3)?
title_full_unstemmed Bone mass recovery of osteopenic vitamin D insufficient rats from strontium ranelate treatment: Does the response depend on vitamin D nutritional status or on source of vitamin D (D2 versus D3)?
title_sort Bone mass recovery of osteopenic vitamin D insufficient rats from strontium ranelate treatment: Does the response depend on vitamin D nutritional status or on source of vitamin D (D2 versus D3)?
dc.creator.none.fl_str_mv Gonzales Chaves, Macarena Maria Sol
Marote, Clarisa
Pellegrini, Gretel Gisela
Pighin, Andrés
De Landeta, Maria C.
Lifshitz, Fima
Friedman, Silvia María
Mandalunis, Patricia Mónica
Zeni, Susana Noemi
author Gonzales Chaves, Macarena Maria Sol
author_facet Gonzales Chaves, Macarena Maria Sol
Marote, Clarisa
Pellegrini, Gretel Gisela
Pighin, Andrés
De Landeta, Maria C.
Lifshitz, Fima
Friedman, Silvia María
Mandalunis, Patricia Mónica
Zeni, Susana Noemi
author_role author
author2 Marote, Clarisa
Pellegrini, Gretel Gisela
Pighin, Andrés
De Landeta, Maria C.
Lifshitz, Fima
Friedman, Silvia María
Mandalunis, Patricia Mónica
Zeni, Susana Noemi
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Osteopenic Rats
Strontium Ranelate
Vitamin D
topic Osteopenic Rats
Strontium Ranelate
Vitamin D
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv It was investigated if Vitamin D (Vit D) status or source (Vitamin D2 vs. Vitamin D3) interferes with bone mass recovery from strontium ranelate (SrRa) treatment of rats with Vit D insufficiency and established osteopenia. Osteopenic and Vit D insufficient rats were divided in groups to complete a 105-day period. First experiment: The rats were fed with diets that only varied in Vit D (100 vs. 0 IU%) and/or SrRa (0 vs. 900 mg/kg/day) content. A SHAM group received Vit D throughout the experience. Second experiment: Rats were divided into groups and received Vit D2 or Vit D3 through diet and SrRa by gavages in a fasting state. Two SHAM groups received Vit D2 or Vit D3 throughout the study. Results: Levels of 25-hydroxyvitamin 25OHD were reduced in groups lacking dietary Vit D (p < 0.001). Independently of Vit D status or source, SrRa did not affect body weight gain or bone alkaline phosphatase levels; osteocalcin and C-terminal telopeptide of type I collagen levels were reduced (p < 0.05) and bone Sr content was increased (p < 0.0001). Although no improvement in biomechanical parameters was observed, total skeletal bone mineral content and proximal tibial bone mineral density were increased (p < 0.05). There was a reduction in the trabecular number and an increase in the trabecular surface and bone volume without reaching SHAM levels. Conclusion: This is the first study that examined SrRa effects in an osteopenic vitamin Dinsufficient experimental model. Under our experimental conditions, SrRa increased bone Sr content independently of Vit D status or source; however, no evidence of an anabolic or antifracture effect was found, and only a slight decrease in some bone resorption parameters was observed. © 2010 World Scientific Publishing Company.
Fil: Gonzales Chaves, Macarena Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Marote, Clarisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Pellegrini, Gretel Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Pighin, Andrés. Universidad Nacional de Luján; Argentina
Fil: De Landeta, Maria C.. Universidad Nacional de Luján; Argentina
Fil: Lifshitz, Fima. Pediatric Sunshine Academics & Samsun Diabetes Research Institute; Estados Unidos
Fil: Friedman, Silvia María. Universidad de Buenos Aires; Argentina
Fil: Mandalunis, Patricia Mónica. Universidad de Buenos Aires; Argentina
Fil: Zeni, Susana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
description It was investigated if Vitamin D (Vit D) status or source (Vitamin D2 vs. Vitamin D3) interferes with bone mass recovery from strontium ranelate (SrRa) treatment of rats with Vit D insufficiency and established osteopenia. Osteopenic and Vit D insufficient rats were divided in groups to complete a 105-day period. First experiment: The rats were fed with diets that only varied in Vit D (100 vs. 0 IU%) and/or SrRa (0 vs. 900 mg/kg/day) content. A SHAM group received Vit D throughout the experience. Second experiment: Rats were divided into groups and received Vit D2 or Vit D3 through diet and SrRa by gavages in a fasting state. Two SHAM groups received Vit D2 or Vit D3 throughout the study. Results: Levels of 25-hydroxyvitamin 25OHD were reduced in groups lacking dietary Vit D (p < 0.001). Independently of Vit D status or source, SrRa did not affect body weight gain or bone alkaline phosphatase levels; osteocalcin and C-terminal telopeptide of type I collagen levels were reduced (p < 0.05) and bone Sr content was increased (p < 0.0001). Although no improvement in biomechanical parameters was observed, total skeletal bone mineral content and proximal tibial bone mineral density were increased (p < 0.05). There was a reduction in the trabecular number and an increase in the trabecular surface and bone volume without reaching SHAM levels. Conclusion: This is the first study that examined SrRa effects in an osteopenic vitamin Dinsufficient experimental model. Under our experimental conditions, SrRa increased bone Sr content independently of Vit D status or source; however, no evidence of an anabolic or antifracture effect was found, and only a slight decrease in some bone resorption parameters was observed. © 2010 World Scientific Publishing Company.
publishDate 2010
dc.date.none.fl_str_mv 2010-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67283
Gonzales Chaves, Macarena Maria Sol; Marote, Clarisa; Pellegrini, Gretel Gisela; Pighin, Andrés; De Landeta, Maria C.; et al.; Bone mass recovery of osteopenic vitamin D insufficient rats from strontium ranelate treatment: Does the response depend on vitamin D nutritional status or on source of vitamin D (D2 versus D3)?; World Scientific; Journal of Musculoskeletal Research; 13; 3; 9-2010; 95-108
0218-9577
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67283
identifier_str_mv Gonzales Chaves, Macarena Maria Sol; Marote, Clarisa; Pellegrini, Gretel Gisela; Pighin, Andrés; De Landeta, Maria C.; et al.; Bone mass recovery of osteopenic vitamin D insufficient rats from strontium ranelate treatment: Does the response depend on vitamin D nutritional status or on source of vitamin D (D2 versus D3)?; World Scientific; Journal of Musculoskeletal Research; 13; 3; 9-2010; 95-108
0218-9577
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.worldscientific.com/doi/abs/10.1142/S0218957710002582
info:eu-repo/semantics/altIdentifier/doi/10.1142/S0218957710002582
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv World Scientific
publisher.none.fl_str_mv World Scientific
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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