Mood instability and functional recovery in bipolar disorders

Autores
Strejilevich, Sergio; Martino, Diego Javier; Murru, A.; Teitelbaum, J.; Fassi, G.; Marengo, Eliana; Igoa, A.; Colom, F.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
OBJECTIVE: The aim of this study was to identify psychopathological factors associated with long term functional outcome in euthymic bipolar disorder patients and to test new measures of mood instability and symptoms intensity. METHOD: Fifty five patients with more than 12 months of follow-up were included. In addition to traditional clinical variables, the time spent ill was documented using a modified life charting technique based on NIHM life-charting method. New measures, Mood Instability Factor and Mood Intensity Factor, were defined and assessed. Functioning Assessment Short Test (FAST) was used to assess disability. RESULTS: The follow-up period was 3.00±1.51 years. Weeks with subsyndromal depressive symptoms (â=0.133, t=2.556, p=0.014), weeks with mild manic symptoms (â=1.441, t=3.10, p=0.003), and the Mood Instability Factor (â=0.105, t=3.593, p=0.001) contributed to approximately 46% of the FAST total score variance. CONCLUSIONS: New methodologies including subsyndromal symptoms and mood instability parameters might contribute to understand the worse long-term functional outcome that affects a considerable percentage of BD patients even after episode remission. Concerns about therapeutic approaches are discussed.
Fil: Strejilevich, Sergio. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Instituto de Neurología Cognitiva; Argentina
Fil: Martino, Diego Javier. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Murru, A.. Universidad de Barcelona; España
Fil: Teitelbaum, J.. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina
Fil: Fassi, G.. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina
Fil: Marengo, Eliana. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Igoa, A.. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina
Fil: Colom, F.. Universidad de Barcelona; España
Materia
Bipolar Disorders
Clinical Aspects
Methodology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25402
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/25402
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mood instability and functional recovery in bipolar disordersStrejilevich, SergioMartino, Diego JavierMurru, A.Teitelbaum, J.Fassi, G.Marengo, ElianaIgoa, A.Colom, F.Bipolar DisordersClinical AspectsMethodologyhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3OBJECTIVE: The aim of this study was to identify psychopathological factors associated with long term functional outcome in euthymic bipolar disorder patients and to test new measures of mood instability and symptoms intensity. METHOD: Fifty five patients with more than 12 months of follow-up were included. In addition to traditional clinical variables, the time spent ill was documented using a modified life charting technique based on NIHM life-charting method. New measures, Mood Instability Factor and Mood Intensity Factor, were defined and assessed. Functioning Assessment Short Test (FAST) was used to assess disability. RESULTS: The follow-up period was 3.00±1.51 years. Weeks with subsyndromal depressive symptoms (â=0.133, t=2.556, p=0.014), weeks with mild manic symptoms (â=1.441, t=3.10, p=0.003), and the Mood Instability Factor (â=0.105, t=3.593, p=0.001) contributed to approximately 46% of the FAST total score variance. CONCLUSIONS: New methodologies including subsyndromal symptoms and mood instability parameters might contribute to understand the worse long-term functional outcome that affects a considerable percentage of BD patients even after episode remission. Concerns about therapeutic approaches are discussed.Fil: Strejilevich, Sergio. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Instituto de Neurología Cognitiva; ArgentinaFil: Martino, Diego Javier. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Murru, A.. Universidad de Barcelona; EspañaFil: Teitelbaum, J.. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; ArgentinaFil: Fassi, G.. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; ArgentinaFil: Marengo, Eliana. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Igoa, A.. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; ArgentinaFil: Colom, F.. Universidad de Barcelona; EspañaWiley2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25402Strejilevich, Sergio; Martino, Diego Javier; Murru, A.; Teitelbaum, J.; Fassi, G.; et al.; Mood instability and functional recovery in bipolar disorders; Wiley; Acta Psychiatrica Scandinavica; 128; 3; 9-2013; 194-2020001-690XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/acps.12065info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/acps.12065/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:38:20Zoai:ri.conicet.gov.ar:11336/25402instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:38:20.373CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mood instability and functional recovery in bipolar disorders
title Mood instability and functional recovery in bipolar disorders
spellingShingle Mood instability and functional recovery in bipolar disorders
Strejilevich, Sergio
Bipolar Disorders
Clinical Aspects
Methodology
title_short Mood instability and functional recovery in bipolar disorders
title_full Mood instability and functional recovery in bipolar disorders
title_fullStr Mood instability and functional recovery in bipolar disorders
title_full_unstemmed Mood instability and functional recovery in bipolar disorders
title_sort Mood instability and functional recovery in bipolar disorders
dc.creator.none.fl_str_mv Strejilevich, Sergio
Martino, Diego Javier
Murru, A.
Teitelbaum, J.
Fassi, G.
Marengo, Eliana
Igoa, A.
Colom, F.
author Strejilevich, Sergio
author_facet Strejilevich, Sergio
Martino, Diego Javier
Murru, A.
Teitelbaum, J.
Fassi, G.
Marengo, Eliana
Igoa, A.
Colom, F.
author_role author
author2 Martino, Diego Javier
Murru, A.
Teitelbaum, J.
Fassi, G.
Marengo, Eliana
Igoa, A.
Colom, F.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bipolar Disorders
Clinical Aspects
Methodology
topic Bipolar Disorders
Clinical Aspects
Methodology
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv OBJECTIVE: The aim of this study was to identify psychopathological factors associated with long term functional outcome in euthymic bipolar disorder patients and to test new measures of mood instability and symptoms intensity. METHOD: Fifty five patients with more than 12 months of follow-up were included. In addition to traditional clinical variables, the time spent ill was documented using a modified life charting technique based on NIHM life-charting method. New measures, Mood Instability Factor and Mood Intensity Factor, were defined and assessed. Functioning Assessment Short Test (FAST) was used to assess disability. RESULTS: The follow-up period was 3.00±1.51 years. Weeks with subsyndromal depressive symptoms (â=0.133, t=2.556, p=0.014), weeks with mild manic symptoms (â=1.441, t=3.10, p=0.003), and the Mood Instability Factor (â=0.105, t=3.593, p=0.001) contributed to approximately 46% of the FAST total score variance. CONCLUSIONS: New methodologies including subsyndromal symptoms and mood instability parameters might contribute to understand the worse long-term functional outcome that affects a considerable percentage of BD patients even after episode remission. Concerns about therapeutic approaches are discussed.
Fil: Strejilevich, Sergio. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Instituto de Neurología Cognitiva; Argentina
Fil: Martino, Diego Javier. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Murru, A.. Universidad de Barcelona; España
Fil: Teitelbaum, J.. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina
Fil: Fassi, G.. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina
Fil: Marengo, Eliana. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Igoa, A.. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias. Programa de Trastornos Bipolares; Argentina
Fil: Colom, F.. Universidad de Barcelona; España
description OBJECTIVE: The aim of this study was to identify psychopathological factors associated with long term functional outcome in euthymic bipolar disorder patients and to test new measures of mood instability and symptoms intensity. METHOD: Fifty five patients with more than 12 months of follow-up were included. In addition to traditional clinical variables, the time spent ill was documented using a modified life charting technique based on NIHM life-charting method. New measures, Mood Instability Factor and Mood Intensity Factor, were defined and assessed. Functioning Assessment Short Test (FAST) was used to assess disability. RESULTS: The follow-up period was 3.00±1.51 years. Weeks with subsyndromal depressive symptoms (â=0.133, t=2.556, p=0.014), weeks with mild manic symptoms (â=1.441, t=3.10, p=0.003), and the Mood Instability Factor (â=0.105, t=3.593, p=0.001) contributed to approximately 46% of the FAST total score variance. CONCLUSIONS: New methodologies including subsyndromal symptoms and mood instability parameters might contribute to understand the worse long-term functional outcome that affects a considerable percentage of BD patients even after episode remission. Concerns about therapeutic approaches are discussed.
publishDate 2013
dc.date.none.fl_str_mv 2013-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25402
Strejilevich, Sergio; Martino, Diego Javier; Murru, A.; Teitelbaum, J.; Fassi, G.; et al.; Mood instability and functional recovery in bipolar disorders; Wiley; Acta Psychiatrica Scandinavica; 128; 3; 9-2013; 194-202
0001-690X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25402
identifier_str_mv Strejilevich, Sergio; Martino, Diego Javier; Murru, A.; Teitelbaum, J.; Fassi, G.; et al.; Mood instability and functional recovery in bipolar disorders; Wiley; Acta Psychiatrica Scandinavica; 128; 3; 9-2013; 194-202
0001-690X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/acps.12065
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/acps.12065/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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