The Relationship Between Serotonin-2A Receptor and Cognitive Functions in Nondemented Parkinson's Disease Patients with Visual Hallucinations

Autores
Cho, Sang Soo; Strafella, Antonio P.; Duff Canning, Sarah; Zurowski, Mateusz; Vijverman, Anne Catherine; Bruno, Veronica Andrea; Aquino, Camila C.; Criaud, Marion; Rusjan, Pablo M.; Houle, Sylvain; Fox, Susan H.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: There is growing evidence that the serotonergic system, in particular serotonin 2A receptors, is involved in neuropsychiatric symptoms in Parkinson's disease (PD), including cognitive processing and visual hallucinations. However, the relationship between serotonin 2A receptor availability, visual hallucinations, and cognitive profile is unknown. The objective of this study was to investigate the level of serotonin 2A receptor availability in brain regions affected by visual hallucinations and to test the association with cognitive/behavioral changes in patients who have PD with visual hallucinations. Methods: Nondemented patients who had PD with (n = 11) and without (n = 8) visual hallucinations and age‐matched controls (n = 10) were recruited. All participants completed neuropsychological testing, which consisted of visuoperceptual, executive, memory, language, and frontal‐behavioral function. Positron emission tomography scans using [18F]setoperone, a serotonin 2A antagonist radioligand, were acquired in patients with PD, and a parametric binding potential map of [18F]setoperone was calculated with the simplified reference tissue model using the cerebellum as a reference. Results: Patients who had PD with visual hallucinations exhibited significantly lower scores on measures of executive and visuoperceptual functions compared with age‐matched controls. These changes were paralleled by decreased [18F]setoperone binding in the right insula, bilateral dorsolateral prefrontal cortex, right orbitofrontal cortex, right middle temporal gyrus, and right fusiform gyrus. The psychometric correlation analysis revealed significant relationships among tests associated with visuoperceptual function, memory and learning, and serotonin 2A binding in different prefrontal and ventral visual stream regions. There was also reduced serotonin 2A receptor binding in patients who had PD with depression. Conclusions: These findings support a complex interaction between serotonin 2A receptor function and cognitive processing in patients who have PD with visual hallucinations.
Fil: Cho, Sang Soo. University of Toronto; Canadá
Fil: Strafella, Antonio P.. University of Toronto; Canadá
Fil: Duff Canning, Sarah. University of Toronto; Canadá
Fil: Zurowski, Mateusz. University of Toronto; Canadá
Fil: Vijverman, Anne Catherine. Onze‐Lieve‐Vrouw Hospital; Bélgica
Fil: Bruno, Veronica Andrea. University of Toronto; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aquino, Camila C.. University of Toronto; Canadá
Fil: Criaud, Marion. University of Toronto; Canadá
Fil: Rusjan, Pablo M.. University of Toronto; Canadá
Fil: Houle, Sylvain. University of Toronto; Canadá
Fil: Fox, Susan H.. University of Toronto; Canadá
Materia
Alucinaciones
Deterioro Cognitivo
Parkinson
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/41170
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/41170
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Relationship Between Serotonin-2A Receptor and Cognitive Functions in Nondemented Parkinson's Disease Patients with Visual HallucinationsCho, Sang SooStrafella, Antonio P.Duff Canning, SarahZurowski, MateuszVijverman, Anne CatherineBruno, Veronica AndreaAquino, Camila C.Criaud, MarionRusjan, Pablo M.Houle, SylvainFox, Susan H.AlucinacionesDeterioro CognitivoParkinsonhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Background: There is growing evidence that the serotonergic system, in particular serotonin 2A receptors, is involved in neuropsychiatric symptoms in Parkinson's disease (PD), including cognitive processing and visual hallucinations. However, the relationship between serotonin 2A receptor availability, visual hallucinations, and cognitive profile is unknown. The objective of this study was to investigate the level of serotonin 2A receptor availability in brain regions affected by visual hallucinations and to test the association with cognitive/behavioral changes in patients who have PD with visual hallucinations. Methods: Nondemented patients who had PD with (n = 11) and without (n = 8) visual hallucinations and age‐matched controls (n = 10) were recruited. All participants completed neuropsychological testing, which consisted of visuoperceptual, executive, memory, language, and frontal‐behavioral function. Positron emission tomography scans using [18F]setoperone, a serotonin 2A antagonist radioligand, were acquired in patients with PD, and a parametric binding potential map of [18F]setoperone was calculated with the simplified reference tissue model using the cerebellum as a reference. Results: Patients who had PD with visual hallucinations exhibited significantly lower scores on measures of executive and visuoperceptual functions compared with age‐matched controls. These changes were paralleled by decreased [18F]setoperone binding in the right insula, bilateral dorsolateral prefrontal cortex, right orbitofrontal cortex, right middle temporal gyrus, and right fusiform gyrus. The psychometric correlation analysis revealed significant relationships among tests associated with visuoperceptual function, memory and learning, and serotonin 2A binding in different prefrontal and ventral visual stream regions. There was also reduced serotonin 2A receptor binding in patients who had PD with depression. Conclusions: These findings support a complex interaction between serotonin 2A receptor function and cognitive processing in patients who have PD with visual hallucinations.Fil: Cho, Sang Soo. University of Toronto; CanadáFil: Strafella, Antonio P.. University of Toronto; CanadáFil: Duff Canning, Sarah. University of Toronto; CanadáFil: Zurowski, Mateusz. University of Toronto; CanadáFil: Vijverman, Anne Catherine. Onze‐Lieve‐Vrouw Hospital; BélgicaFil: Bruno, Veronica Andrea. University of Toronto; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aquino, Camila C.. University of Toronto; CanadáFil: Criaud, Marion. University of Toronto; CanadáFil: Rusjan, Pablo M.. University of Toronto; CanadáFil: Houle, Sylvain. University of Toronto; CanadáFil: Fox, Susan H.. University of Toronto; CanadáWiley2017-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41170Cho, Sang Soo; Strafella, Antonio P.; Duff Canning, Sarah; Zurowski, Mateusz; Vijverman, Anne Catherine; et al.; The Relationship Between Serotonin-2A Receptor and Cognitive Functions in Nondemented Parkinson's Disease Patients with Visual Hallucinations; Wiley; Movement Disorders Clinical Practice; 4; 5; 9-2017; 698-7092330-1619CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/mdc3.12466info:eu-repo/semantics/altIdentifier/doi/10.1002/mdc3.12466info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:04Zoai:ri.conicet.gov.ar:11336/41170instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:04.769CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Relationship Between Serotonin-2A Receptor and Cognitive Functions in Nondemented Parkinson's Disease Patients with Visual Hallucinations
title The Relationship Between Serotonin-2A Receptor and Cognitive Functions in Nondemented Parkinson's Disease Patients with Visual Hallucinations
spellingShingle The Relationship Between Serotonin-2A Receptor and Cognitive Functions in Nondemented Parkinson's Disease Patients with Visual Hallucinations
Cho, Sang Soo
Alucinaciones
Deterioro Cognitivo
Parkinson
title_short The Relationship Between Serotonin-2A Receptor and Cognitive Functions in Nondemented Parkinson's Disease Patients with Visual Hallucinations
title_full The Relationship Between Serotonin-2A Receptor and Cognitive Functions in Nondemented Parkinson's Disease Patients with Visual Hallucinations
title_fullStr The Relationship Between Serotonin-2A Receptor and Cognitive Functions in Nondemented Parkinson's Disease Patients with Visual Hallucinations
title_full_unstemmed The Relationship Between Serotonin-2A Receptor and Cognitive Functions in Nondemented Parkinson's Disease Patients with Visual Hallucinations
title_sort The Relationship Between Serotonin-2A Receptor and Cognitive Functions in Nondemented Parkinson's Disease Patients with Visual Hallucinations
dc.creator.none.fl_str_mv Cho, Sang Soo
Strafella, Antonio P.
Duff Canning, Sarah
Zurowski, Mateusz
Vijverman, Anne Catherine
Bruno, Veronica Andrea
Aquino, Camila C.
Criaud, Marion
Rusjan, Pablo M.
Houle, Sylvain
Fox, Susan H.
author Cho, Sang Soo
author_facet Cho, Sang Soo
Strafella, Antonio P.
Duff Canning, Sarah
Zurowski, Mateusz
Vijverman, Anne Catherine
Bruno, Veronica Andrea
Aquino, Camila C.
Criaud, Marion
Rusjan, Pablo M.
Houle, Sylvain
Fox, Susan H.
author_role author
author2 Strafella, Antonio P.
Duff Canning, Sarah
Zurowski, Mateusz
Vijverman, Anne Catherine
Bruno, Veronica Andrea
Aquino, Camila C.
Criaud, Marion
Rusjan, Pablo M.
Houle, Sylvain
Fox, Susan H.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alucinaciones
Deterioro Cognitivo
Parkinson
topic Alucinaciones
Deterioro Cognitivo
Parkinson
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: There is growing evidence that the serotonergic system, in particular serotonin 2A receptors, is involved in neuropsychiatric symptoms in Parkinson's disease (PD), including cognitive processing and visual hallucinations. However, the relationship between serotonin 2A receptor availability, visual hallucinations, and cognitive profile is unknown. The objective of this study was to investigate the level of serotonin 2A receptor availability in brain regions affected by visual hallucinations and to test the association with cognitive/behavioral changes in patients who have PD with visual hallucinations. Methods: Nondemented patients who had PD with (n = 11) and without (n = 8) visual hallucinations and age‐matched controls (n = 10) were recruited. All participants completed neuropsychological testing, which consisted of visuoperceptual, executive, memory, language, and frontal‐behavioral function. Positron emission tomography scans using [18F]setoperone, a serotonin 2A antagonist radioligand, were acquired in patients with PD, and a parametric binding potential map of [18F]setoperone was calculated with the simplified reference tissue model using the cerebellum as a reference. Results: Patients who had PD with visual hallucinations exhibited significantly lower scores on measures of executive and visuoperceptual functions compared with age‐matched controls. These changes were paralleled by decreased [18F]setoperone binding in the right insula, bilateral dorsolateral prefrontal cortex, right orbitofrontal cortex, right middle temporal gyrus, and right fusiform gyrus. The psychometric correlation analysis revealed significant relationships among tests associated with visuoperceptual function, memory and learning, and serotonin 2A binding in different prefrontal and ventral visual stream regions. There was also reduced serotonin 2A receptor binding in patients who had PD with depression. Conclusions: These findings support a complex interaction between serotonin 2A receptor function and cognitive processing in patients who have PD with visual hallucinations.
Fil: Cho, Sang Soo. University of Toronto; Canadá
Fil: Strafella, Antonio P.. University of Toronto; Canadá
Fil: Duff Canning, Sarah. University of Toronto; Canadá
Fil: Zurowski, Mateusz. University of Toronto; Canadá
Fil: Vijverman, Anne Catherine. Onze‐Lieve‐Vrouw Hospital; Bélgica
Fil: Bruno, Veronica Andrea. University of Toronto; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aquino, Camila C.. University of Toronto; Canadá
Fil: Criaud, Marion. University of Toronto; Canadá
Fil: Rusjan, Pablo M.. University of Toronto; Canadá
Fil: Houle, Sylvain. University of Toronto; Canadá
Fil: Fox, Susan H.. University of Toronto; Canadá
description Background: There is growing evidence that the serotonergic system, in particular serotonin 2A receptors, is involved in neuropsychiatric symptoms in Parkinson's disease (PD), including cognitive processing and visual hallucinations. However, the relationship between serotonin 2A receptor availability, visual hallucinations, and cognitive profile is unknown. The objective of this study was to investigate the level of serotonin 2A receptor availability in brain regions affected by visual hallucinations and to test the association with cognitive/behavioral changes in patients who have PD with visual hallucinations. Methods: Nondemented patients who had PD with (n = 11) and without (n = 8) visual hallucinations and age‐matched controls (n = 10) were recruited. All participants completed neuropsychological testing, which consisted of visuoperceptual, executive, memory, language, and frontal‐behavioral function. Positron emission tomography scans using [18F]setoperone, a serotonin 2A antagonist radioligand, were acquired in patients with PD, and a parametric binding potential map of [18F]setoperone was calculated with the simplified reference tissue model using the cerebellum as a reference. Results: Patients who had PD with visual hallucinations exhibited significantly lower scores on measures of executive and visuoperceptual functions compared with age‐matched controls. These changes were paralleled by decreased [18F]setoperone binding in the right insula, bilateral dorsolateral prefrontal cortex, right orbitofrontal cortex, right middle temporal gyrus, and right fusiform gyrus. The psychometric correlation analysis revealed significant relationships among tests associated with visuoperceptual function, memory and learning, and serotonin 2A binding in different prefrontal and ventral visual stream regions. There was also reduced serotonin 2A receptor binding in patients who had PD with depression. Conclusions: These findings support a complex interaction between serotonin 2A receptor function and cognitive processing in patients who have PD with visual hallucinations.
publishDate 2017
dc.date.none.fl_str_mv 2017-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/41170
Cho, Sang Soo; Strafella, Antonio P.; Duff Canning, Sarah; Zurowski, Mateusz; Vijverman, Anne Catherine; et al.; The Relationship Between Serotonin-2A Receptor and Cognitive Functions in Nondemented Parkinson's Disease Patients with Visual Hallucinations; Wiley; Movement Disorders Clinical Practice; 4; 5; 9-2017; 698-709
2330-1619
CONICET Digital
CONICET
url http://hdl.handle.net/11336/41170
identifier_str_mv Cho, Sang Soo; Strafella, Antonio P.; Duff Canning, Sarah; Zurowski, Mateusz; Vijverman, Anne Catherine; et al.; The Relationship Between Serotonin-2A Receptor and Cognitive Functions in Nondemented Parkinson's Disease Patients with Visual Hallucinations; Wiley; Movement Disorders Clinical Practice; 4; 5; 9-2017; 698-709
2330-1619
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/mdc3.12466
info:eu-repo/semantics/altIdentifier/doi/10.1002/mdc3.12466
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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