Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells

Autores
Mendieta, Julieta Renée; Fimognari, Carmela; Daleo, Gustavo Raúl; Hrelia, Patrizia; Guevara, María G.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión enviada
Descripción
StAPs are potato aspartic proteases with cytotoxic activity against plant pathogens and spermatozoa.StAPs cytotoxic activity is selective, since these proteins do not exert toxic effect on plant cells and erythrocytes. In this work, we investigated the capacity ofStAPs to exert cytotoxicity on human leukaemia cells. Obtained results show thatStAPs induce apoptosis on Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no significative effect on the T lymphocytes viability was observed at allStAPs incubation times and concentrations tested. These results suggest thatStAPs can be conceptually promising leads for cancer therapy.
Materia
Biología Celular, Microbiología
Aspartic proteases
Antimicrobial plant proteins
Apoptosis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-nd/4.0/
Repositorio
CIC Digital (CICBA)
Institución
Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
OAI Identificador
oai:digital.cic.gba.gob.ar:11746/5364
Acceder
id CICBA_cadb1138699bf91f8258a95978a4ffc6
oai_identifier_str oai:digital.cic.gba.gob.ar:11746/5364
network_acronym_str CICBA
repository_id_str 9441
network_name_str CIC Digital (CICBA)
spelling Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cellsMendieta, Julieta RenéeFimognari, CarmelaDaleo, Gustavo RaúlHrelia, PatriziaGuevara, María G.Biología Celular, MicrobiologíaAspartic proteasesAntimicrobial plant proteinsApoptosis<em>St</em>APs are potato aspartic proteases with cytotoxic activity against plant pathogens and spermatozoa.<em>St</em>APs cytotoxic activity is selective, since these proteins do not exert toxic effect on plant cells and erythrocytes. In this work, we investigated the capacity of<em>St</em>APs to exert cytotoxicity on human leukaemia cells. Obtained results show that<em>St</em>APs induce apoptosis on Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no significative effect on the T lymphocytes viability was observed at all<em>St</em>APs incubation times and concentrations tested. These results suggest that<em>St</em>APs can be conceptually promising leads for cancer therapy.2010-10-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://digital.cic.gba.gob.ar/handle/11746/5364enginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/reponame:CIC Digital (CICBA)instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Airesinstacron:CICBA2025-10-16T09:26:55Zoai:digital.cic.gba.gob.ar:11746/5364Institucionalhttp://digital.cic.gba.gob.arOrganismo científico-tecnológicoNo correspondehttp://digital.cic.gba.gob.ar/oai/snrdmarisa.degiusti@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:94412025-10-16 09:26:55.734CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Airesfalse
dc.title.none.fl_str_mv Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells
title Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells
spellingShingle Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells
Mendieta, Julieta Renée
Biología Celular, Microbiología
Aspartic proteases
Antimicrobial plant proteins
Apoptosis
title_short Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells
title_full Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells
title_fullStr Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells
title_full_unstemmed Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells
title_sort Cytotoxic effect of potato aspartic proteases (StAPs) on Jurkat T cells
dc.creator.none.fl_str_mv Mendieta, Julieta Renée
Fimognari, Carmela
Daleo, Gustavo Raúl
Hrelia, Patrizia
Guevara, María G.
author Mendieta, Julieta Renée
author_facet Mendieta, Julieta Renée
Fimognari, Carmela
Daleo, Gustavo Raúl
Hrelia, Patrizia
Guevara, María G.
author_role author
author2 Fimognari, Carmela
Daleo, Gustavo Raúl
Hrelia, Patrizia
Guevara, María G.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biología Celular, Microbiología
Aspartic proteases
Antimicrobial plant proteins
Apoptosis
topic Biología Celular, Microbiología
Aspartic proteases
Antimicrobial plant proteins
Apoptosis
dc.description.none.fl_txt_mv <em>St</em>APs are potato aspartic proteases with cytotoxic activity against plant pathogens and spermatozoa.<em>St</em>APs cytotoxic activity is selective, since these proteins do not exert toxic effect on plant cells and erythrocytes. In this work, we investigated the capacity of<em>St</em>APs to exert cytotoxicity on human leukaemia cells. Obtained results show that<em>St</em>APs induce apoptosis on Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no significative effect on the T lymphocytes viability was observed at all<em>St</em>APs incubation times and concentrations tested. These results suggest that<em>St</em>APs can be conceptually promising leads for cancer therapy.
description <em>St</em>APs are potato aspartic proteases with cytotoxic activity against plant pathogens and spermatozoa.<em>St</em>APs cytotoxic activity is selective, since these proteins do not exert toxic effect on plant cells and erythrocytes. In this work, we investigated the capacity of<em>St</em>APs to exert cytotoxicity on human leukaemia cells. Obtained results show that<em>St</em>APs induce apoptosis on Jurkat T cells after a short time of incubation in a dose-dependent manner. However, no significative effect on the T lymphocytes viability was observed at all<em>St</em>APs incubation times and concentrations tested. These results suggest that<em>St</em>APs can be conceptually promising leads for cancer therapy.
publishDate 2010
dc.date.none.fl_str_mv 2010-10-13
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://digital.cic.gba.gob.ar/handle/11746/5364
url https://digital.cic.gba.gob.ar/handle/11746/5364
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:CIC Digital (CICBA)
instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
instacron:CICBA
reponame_str CIC Digital (CICBA)
collection CIC Digital (CICBA)
instname_str Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
instacron_str CICBA
institution CICBA
repository.name.fl_str_mv CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
repository.mail.fl_str_mv marisa.degiusti@sedici.unlp.edu.ar
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score 12.712165

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