Biological effects of argentine asbestos: mineralogical and morphological characterisation
- Autores
- Lescano, Leticia; Gandini, Norberto A.; Marfil, Silvina Andrea; Maiza, Pedro
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Asbestiform minerals, namely serpentine (chrysotile) and amphiboles (tremolite–actinolite) as well as others of fibrous habit (sepiolite) from Argentine deposits were characterised to assess their biological hazard. Materials currently used as asbestos substitutes were also assessed (glass fibre and ceramic fibre). Studies with laboratory animals were conducted. Sixty mice (30 females and 30 males), 8 weeks old, were used following the good practices in the care and handling of laboratory animals. They were split into six groups of ten mice each (5 females and 5 males), designated as control, tremolite, glass fibre, chrysotile, sepiolite and ceramic fibre, and were exposed by inhalation to these previously ground materials. The animals were examined throughout the experiments to see how they responded to the inhaled substances to establish the effects of inhalation at the time of exposure and once they had been killed. The respiratory tract (trachea, bronchi and lungs) of the animals exposed to the different materials was examined in tissue sections. Differences in the amount of connective tissue in the lungs and the presence of alveolar macrophages were observed in the animals exposed to tremolite, chrysotile and sepiolite, as compared to the control group. It was concluded that, of all the materials used, amphiboles caused greater damage and an incipient development of carcinogenesis. The other ones, especially chrysotile, produced connective tissue thickening.
- Materia
-
Geología
Asbestos
Carcinogénesis
Asbestosis
Amphibole
Chrysotile - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
- OAI Identificador
- oai:digital.cic.gba.gob.ar:11746/11144
Ver los metadatos del registro completo
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Biological effects of argentine asbestos: mineralogical and morphological characterisationLescano, LeticiaGandini, Norberto A.Marfil, Silvina AndreaMaiza, PedroGeologíaAsbestosCarcinogénesisAsbestosisAmphiboleChrysotileAsbestiform minerals, namely serpentine (chrysotile) and amphiboles (tremolite–actinolite) as well as others of fibrous habit (sepiolite) from Argentine deposits were characterised to assess their biological hazard. Materials currently used as asbestos substitutes were also assessed (glass fibre and ceramic fibre). Studies with laboratory animals were conducted. Sixty mice (30 females and 30 males), 8 weeks old, were used following the good practices in the care and handling of laboratory animals. They were split into six groups of ten mice each (5 females and 5 males), designated as control, tremolite, glass fibre, chrysotile, sepiolite and ceramic fibre, and were exposed by inhalation to these previously ground materials. The animals were examined throughout the experiments to see how they responded to the inhaled substances to establish the effects of inhalation at the time of exposure and once they had been killed. The respiratory tract (trachea, bronchi and lungs) of the animals exposed to the different materials was examined in tissue sections. Differences in the amount of connective tissue in the lungs and the presence of alveolar macrophages were observed in the animals exposed to tremolite, chrysotile and sepiolite, as compared to the control group. It was concluded that, of all the materials used, amphiboles caused greater damage and an incipient development of carcinogenesis. The other ones, especially chrysotile, produced connective tissue thickening.2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://digital.cic.gba.gob.ar/handle/11746/11144enginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s12665-014-3638-2info:eu-repo/semantics/altIdentifier/issn/1866-6299info:eu-repo/semantics/altIdentifier/issn/1866-6280info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/reponame:CIC Digital (CICBA)instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Airesinstacron:CICBA2025-09-29T13:40:05Zoai:digital.cic.gba.gob.ar:11746/11144Institucionalhttp://digital.cic.gba.gob.arOrganismo científico-tecnológicoNo correspondehttp://digital.cic.gba.gob.ar/oai/snrdmarisa.degiusti@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:94412025-09-29 13:40:06.152CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Airesfalse |
dc.title.none.fl_str_mv |
Biological effects of argentine asbestos: mineralogical and morphological characterisation |
title |
Biological effects of argentine asbestos: mineralogical and morphological characterisation |
spellingShingle |
Biological effects of argentine asbestos: mineralogical and morphological characterisation Lescano, Leticia Geología Asbestos Carcinogénesis Asbestosis Amphibole Chrysotile |
title_short |
Biological effects of argentine asbestos: mineralogical and morphological characterisation |
title_full |
Biological effects of argentine asbestos: mineralogical and morphological characterisation |
title_fullStr |
Biological effects of argentine asbestos: mineralogical and morphological characterisation |
title_full_unstemmed |
Biological effects of argentine asbestos: mineralogical and morphological characterisation |
title_sort |
Biological effects of argentine asbestos: mineralogical and morphological characterisation |
dc.creator.none.fl_str_mv |
Lescano, Leticia Gandini, Norberto A. Marfil, Silvina Andrea Maiza, Pedro |
author |
Lescano, Leticia |
author_facet |
Lescano, Leticia Gandini, Norberto A. Marfil, Silvina Andrea Maiza, Pedro |
author_role |
author |
author2 |
Gandini, Norberto A. Marfil, Silvina Andrea Maiza, Pedro |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Geología Asbestos Carcinogénesis Asbestosis Amphibole Chrysotile |
topic |
Geología Asbestos Carcinogénesis Asbestosis Amphibole Chrysotile |
dc.description.none.fl_txt_mv |
Asbestiform minerals, namely serpentine (chrysotile) and amphiboles (tremolite–actinolite) as well as others of fibrous habit (sepiolite) from Argentine deposits were characterised to assess their biological hazard. Materials currently used as asbestos substitutes were also assessed (glass fibre and ceramic fibre). Studies with laboratory animals were conducted. Sixty mice (30 females and 30 males), 8 weeks old, were used following the good practices in the care and handling of laboratory animals. They were split into six groups of ten mice each (5 females and 5 males), designated as control, tremolite, glass fibre, chrysotile, sepiolite and ceramic fibre, and were exposed by inhalation to these previously ground materials. The animals were examined throughout the experiments to see how they responded to the inhaled substances to establish the effects of inhalation at the time of exposure and once they had been killed. The respiratory tract (trachea, bronchi and lungs) of the animals exposed to the different materials was examined in tissue sections. Differences in the amount of connective tissue in the lungs and the presence of alveolar macrophages were observed in the animals exposed to tremolite, chrysotile and sepiolite, as compared to the control group. It was concluded that, of all the materials used, amphiboles caused greater damage and an incipient development of carcinogenesis. The other ones, especially chrysotile, produced connective tissue thickening. |
description |
Asbestiform minerals, namely serpentine (chrysotile) and amphiboles (tremolite–actinolite) as well as others of fibrous habit (sepiolite) from Argentine deposits were characterised to assess their biological hazard. Materials currently used as asbestos substitutes were also assessed (glass fibre and ceramic fibre). Studies with laboratory animals were conducted. Sixty mice (30 females and 30 males), 8 weeks old, were used following the good practices in the care and handling of laboratory animals. They were split into six groups of ten mice each (5 females and 5 males), designated as control, tremolite, glass fibre, chrysotile, sepiolite and ceramic fibre, and were exposed by inhalation to these previously ground materials. The animals were examined throughout the experiments to see how they responded to the inhaled substances to establish the effects of inhalation at the time of exposure and once they had been killed. The respiratory tract (trachea, bronchi and lungs) of the animals exposed to the different materials was examined in tissue sections. Differences in the amount of connective tissue in the lungs and the presence of alveolar macrophages were observed in the animals exposed to tremolite, chrysotile and sepiolite, as compared to the control group. It was concluded that, of all the materials used, amphiboles caused greater damage and an incipient development of carcinogenesis. The other ones, especially chrysotile, produced connective tissue thickening. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://digital.cic.gba.gob.ar/handle/11746/11144 |
url |
https://digital.cic.gba.gob.ar/handle/11746/11144 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1007/s12665-014-3638-2 info:eu-repo/semantics/altIdentifier/issn/1866-6299 info:eu-repo/semantics/altIdentifier/issn/1866-6280 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:CIC Digital (CICBA) instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires instacron:CICBA |
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CIC Digital (CICBA) |
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CIC Digital (CICBA) |
instname_str |
Comisión de Investigaciones Científicas de la Provincia de Buenos Aires |
instacron_str |
CICBA |
institution |
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repository.name.fl_str_mv |
CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Aires |
repository.mail.fl_str_mv |
marisa.degiusti@sedici.unlp.edu.ar |
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