Biological effects of argentine asbestos: mineralogical and morphological characterisation

Autores
Lescano, Leticia; Gandini, Norberto A.; Marfil, Silvina Andrea; Maiza, Pedro
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Asbestiform minerals, namely serpentine (chrysotile) and amphiboles (tremolite–actinolite) as well as others of fibrous habit (sepiolite) from Argentine deposits were characterised to assess their biological hazard. Materials currently used as asbestos substitutes were also assessed (glass fibre and ceramic fibre). Studies with laboratory animals were conducted. Sixty mice (30 females and 30 males), 8 weeks old, were used following the good practices in the care and handling of laboratory animals. They were split into six groups of ten mice each (5 females and 5 males), designated as control, tremolite, glass fibre, chrysotile, sepiolite and ceramic fibre, and were exposed by inhalation to these previously ground materials. The animals were examined throughout the experiments to see how they responded to the inhaled substances to establish the effects of inhalation at the time of exposure and once they had been killed. The respiratory tract (trachea, bronchi and lungs) of the animals exposed to the different materials was examined in tissue sections. Differences in the amount of connective tissue in the lungs and the presence of alveolar macrophages were observed in the animals exposed to tremolite, chrysotile and sepiolite, as compared to the control group. It was concluded that, of all the materials used, amphiboles caused greater damage and an incipient development of carcinogenesis. The other ones, especially chrysotile, produced connective tissue thickening.
Materia
Geología
Asbestos
Carcinogénesis
Asbestosis
Amphibole
Chrysotile
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
CIC Digital (CICBA)
Institución
Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
OAI Identificador
oai:digital.cic.gba.gob.ar:11746/11144

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network_name_str CIC Digital (CICBA)
spelling Biological effects of argentine asbestos: mineralogical and morphological characterisationLescano, LeticiaGandini, Norberto A.Marfil, Silvina AndreaMaiza, PedroGeologíaAsbestosCarcinogénesisAsbestosisAmphiboleChrysotileAsbestiform minerals, namely serpentine (chrysotile) and amphiboles (tremolite–actinolite) as well as others of fibrous habit (sepiolite) from Argentine deposits were characterised to assess their biological hazard. Materials currently used as asbestos substitutes were also assessed (glass fibre and ceramic fibre). Studies with laboratory animals were conducted. Sixty mice (30 females and 30 males), 8 weeks old, were used following the good practices in the care and handling of laboratory animals. They were split into six groups of ten mice each (5 females and 5 males), designated as control, tremolite, glass fibre, chrysotile, sepiolite and ceramic fibre, and were exposed by inhalation to these previously ground materials. The animals were examined throughout the experiments to see how they responded to the inhaled substances to establish the effects of inhalation at the time of exposure and once they had been killed. The respiratory tract (trachea, bronchi and lungs) of the animals exposed to the different materials was examined in tissue sections. Differences in the amount of connective tissue in the lungs and the presence of alveolar macrophages were observed in the animals exposed to tremolite, chrysotile and sepiolite, as compared to the control group. It was concluded that, of all the materials used, amphiboles caused greater damage and an incipient development of carcinogenesis. The other ones, especially chrysotile, produced connective tissue thickening.2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://digital.cic.gba.gob.ar/handle/11746/11144enginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s12665-014-3638-2info:eu-repo/semantics/altIdentifier/issn/1866-6299info:eu-repo/semantics/altIdentifier/issn/1866-6280info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/reponame:CIC Digital (CICBA)instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Airesinstacron:CICBA2025-09-29T13:40:05Zoai:digital.cic.gba.gob.ar:11746/11144Institucionalhttp://digital.cic.gba.gob.arOrganismo científico-tecnológicoNo correspondehttp://digital.cic.gba.gob.ar/oai/snrdmarisa.degiusti@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:94412025-09-29 13:40:06.152CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Airesfalse
dc.title.none.fl_str_mv Biological effects of argentine asbestos: mineralogical and morphological characterisation
title Biological effects of argentine asbestos: mineralogical and morphological characterisation
spellingShingle Biological effects of argentine asbestos: mineralogical and morphological characterisation
Lescano, Leticia
Geología
Asbestos
Carcinogénesis
Asbestosis
Amphibole
Chrysotile
title_short Biological effects of argentine asbestos: mineralogical and morphological characterisation
title_full Biological effects of argentine asbestos: mineralogical and morphological characterisation
title_fullStr Biological effects of argentine asbestos: mineralogical and morphological characterisation
title_full_unstemmed Biological effects of argentine asbestos: mineralogical and morphological characterisation
title_sort Biological effects of argentine asbestos: mineralogical and morphological characterisation
dc.creator.none.fl_str_mv Lescano, Leticia
Gandini, Norberto A.
Marfil, Silvina Andrea
Maiza, Pedro
author Lescano, Leticia
author_facet Lescano, Leticia
Gandini, Norberto A.
Marfil, Silvina Andrea
Maiza, Pedro
author_role author
author2 Gandini, Norberto A.
Marfil, Silvina Andrea
Maiza, Pedro
author2_role author
author
author
dc.subject.none.fl_str_mv Geología
Asbestos
Carcinogénesis
Asbestosis
Amphibole
Chrysotile
topic Geología
Asbestos
Carcinogénesis
Asbestosis
Amphibole
Chrysotile
dc.description.none.fl_txt_mv Asbestiform minerals, namely serpentine (chrysotile) and amphiboles (tremolite–actinolite) as well as others of fibrous habit (sepiolite) from Argentine deposits were characterised to assess their biological hazard. Materials currently used as asbestos substitutes were also assessed (glass fibre and ceramic fibre). Studies with laboratory animals were conducted. Sixty mice (30 females and 30 males), 8 weeks old, were used following the good practices in the care and handling of laboratory animals. They were split into six groups of ten mice each (5 females and 5 males), designated as control, tremolite, glass fibre, chrysotile, sepiolite and ceramic fibre, and were exposed by inhalation to these previously ground materials. The animals were examined throughout the experiments to see how they responded to the inhaled substances to establish the effects of inhalation at the time of exposure and once they had been killed. The respiratory tract (trachea, bronchi and lungs) of the animals exposed to the different materials was examined in tissue sections. Differences in the amount of connective tissue in the lungs and the presence of alveolar macrophages were observed in the animals exposed to tremolite, chrysotile and sepiolite, as compared to the control group. It was concluded that, of all the materials used, amphiboles caused greater damage and an incipient development of carcinogenesis. The other ones, especially chrysotile, produced connective tissue thickening.
description Asbestiform minerals, namely serpentine (chrysotile) and amphiboles (tremolite–actinolite) as well as others of fibrous habit (sepiolite) from Argentine deposits were characterised to assess their biological hazard. Materials currently used as asbestos substitutes were also assessed (glass fibre and ceramic fibre). Studies with laboratory animals were conducted. Sixty mice (30 females and 30 males), 8 weeks old, were used following the good practices in the care and handling of laboratory animals. They were split into six groups of ten mice each (5 females and 5 males), designated as control, tremolite, glass fibre, chrysotile, sepiolite and ceramic fibre, and were exposed by inhalation to these previously ground materials. The animals were examined throughout the experiments to see how they responded to the inhaled substances to establish the effects of inhalation at the time of exposure and once they had been killed. The respiratory tract (trachea, bronchi and lungs) of the animals exposed to the different materials was examined in tissue sections. Differences in the amount of connective tissue in the lungs and the presence of alveolar macrophages were observed in the animals exposed to tremolite, chrysotile and sepiolite, as compared to the control group. It was concluded that, of all the materials used, amphiboles caused greater damage and an incipient development of carcinogenesis. The other ones, especially chrysotile, produced connective tissue thickening.
publishDate 2015
dc.date.none.fl_str_mv 2015
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info:ar-repo/semantics/articulo
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dc.identifier.none.fl_str_mv https://digital.cic.gba.gob.ar/handle/11746/11144
url https://digital.cic.gba.gob.ar/handle/11746/11144
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s12665-014-3638-2
info:eu-repo/semantics/altIdentifier/issn/1866-6299
info:eu-repo/semantics/altIdentifier/issn/1866-6280
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:CIC Digital (CICBA)
instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
instacron:CICBA
reponame_str CIC Digital (CICBA)
collection CIC Digital (CICBA)
instname_str Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
instacron_str CICBA
institution CICBA
repository.name.fl_str_mv CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
repository.mail.fl_str_mv marisa.degiusti@sedici.unlp.edu.ar
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