Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation

Autores
Moncada, D.; Ballarini, F.; Martinez, M.C.; Frey, J.U.; Viola, H.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca 2+/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace.
Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Martinez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fuente
Proc. Natl. Acad. Sci. U. S. A. 2011;108(31):12931-12936
Materia
CA1
Dentate gyrus
Synaptic tagging
beta adrenergic receptor
calcium calmodulin dependent protein kinase II
dopamine 1 receptor
dopamine 5 receptor
n methyl dextro aspartic acid receptor
neurotransmitter
animal experiment
article
controlled study
dopaminergic system
dopaminergic transmission
long term memory
male
memory consolidation
molecule
nonhuman
noradrenergic system
priority journal
protein synthesis
rat
short term memory
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
2-Amino-5-phosphonovalerate
Adrenergic beta-Antagonists
Animals
Avoidance Learning
Benzazepines
CA1 Region, Hippocampal
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Dobutamine
Enzyme Inhibitors
Excitatory Amino Acid Antagonists
Exploratory Behavior
Male
Memory, Long-Term
Memory, Short-Term
Neuronal Plasticity
Propranolol
Rats
Rats, Wistar
Receptors, Adrenergic, beta
Receptors, Dopamine D1
Receptors, Dopamine D5
Receptors, N-Methyl-D-Aspartate
Rattus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
paperaa:paper_00278424_v108_n31_p12931_Moncada

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oai_identifier_str paperaa:paper_00278424_v108_n31_p12931_Moncada
network_acronym_str BDUBAFCEN
repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formationMoncada, D.Ballarini, F.Martinez, M.C.Frey, J.U.Viola, H.CA1Dentate gyrusSynaptic taggingbeta adrenergic receptorcalcium calmodulin dependent protein kinase IIdopamine 1 receptordopamine 5 receptorn methyl dextro aspartic acid receptorneurotransmitteranimal experimentarticlecontrolled studydopaminergic systemdopaminergic transmissionlong term memorymalememory consolidationmoleculenonhumannoradrenergic systempriority journalprotein synthesisratshort term memory1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine2-Amino-5-phosphonovalerateAdrenergic beta-AntagonistsAnimalsAvoidance LearningBenzazepinesCA1 Region, HippocampalCalcium-Calmodulin-Dependent Protein Kinase Type 2DobutamineEnzyme InhibitorsExcitatory Amino Acid AntagonistsExploratory BehaviorMaleMemory, Long-TermMemory, Short-TermNeuronal PlasticityPropranololRatsRats, WistarReceptors, Adrenergic, betaReceptors, Dopamine D1Receptors, Dopamine D5Receptors, N-Methyl-D-AspartateRattusLong-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca 2+/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace.Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Martinez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_00278424_v108_n31_p12931_MoncadaProc. Natl. Acad. Sci. U. S. A. 2011;108(31):12931-12936reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:43:02Zpaperaa:paper_00278424_v108_n31_p12931_MoncadaInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:43:04.201Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
title Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
spellingShingle Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
Moncada, D.
CA1
Dentate gyrus
Synaptic tagging
beta adrenergic receptor
calcium calmodulin dependent protein kinase II
dopamine 1 receptor
dopamine 5 receptor
n methyl dextro aspartic acid receptor
neurotransmitter
animal experiment
article
controlled study
dopaminergic system
dopaminergic transmission
long term memory
male
memory consolidation
molecule
nonhuman
noradrenergic system
priority journal
protein synthesis
rat
short term memory
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
2-Amino-5-phosphonovalerate
Adrenergic beta-Antagonists
Animals
Avoidance Learning
Benzazepines
CA1 Region, Hippocampal
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Dobutamine
Enzyme Inhibitors
Excitatory Amino Acid Antagonists
Exploratory Behavior
Male
Memory, Long-Term
Memory, Short-Term
Neuronal Plasticity
Propranolol
Rats
Rats, Wistar
Receptors, Adrenergic, beta
Receptors, Dopamine D1
Receptors, Dopamine D5
Receptors, N-Methyl-D-Aspartate
Rattus
title_short Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
title_full Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
title_fullStr Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
title_full_unstemmed Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
title_sort Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
dc.creator.none.fl_str_mv Moncada, D.
Ballarini, F.
Martinez, M.C.
Frey, J.U.
Viola, H.
author Moncada, D.
author_facet Moncada, D.
Ballarini, F.
Martinez, M.C.
Frey, J.U.
Viola, H.
author_role author
author2 Ballarini, F.
Martinez, M.C.
Frey, J.U.
Viola, H.
author2_role author
author
author
author
dc.subject.none.fl_str_mv CA1
Dentate gyrus
Synaptic tagging
beta adrenergic receptor
calcium calmodulin dependent protein kinase II
dopamine 1 receptor
dopamine 5 receptor
n methyl dextro aspartic acid receptor
neurotransmitter
animal experiment
article
controlled study
dopaminergic system
dopaminergic transmission
long term memory
male
memory consolidation
molecule
nonhuman
noradrenergic system
priority journal
protein synthesis
rat
short term memory
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
2-Amino-5-phosphonovalerate
Adrenergic beta-Antagonists
Animals
Avoidance Learning
Benzazepines
CA1 Region, Hippocampal
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Dobutamine
Enzyme Inhibitors
Excitatory Amino Acid Antagonists
Exploratory Behavior
Male
Memory, Long-Term
Memory, Short-Term
Neuronal Plasticity
Propranolol
Rats
Rats, Wistar
Receptors, Adrenergic, beta
Receptors, Dopamine D1
Receptors, Dopamine D5
Receptors, N-Methyl-D-Aspartate
Rattus
topic CA1
Dentate gyrus
Synaptic tagging
beta adrenergic receptor
calcium calmodulin dependent protein kinase II
dopamine 1 receptor
dopamine 5 receptor
n methyl dextro aspartic acid receptor
neurotransmitter
animal experiment
article
controlled study
dopaminergic system
dopaminergic transmission
long term memory
male
memory consolidation
molecule
nonhuman
noradrenergic system
priority journal
protein synthesis
rat
short term memory
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
2-Amino-5-phosphonovalerate
Adrenergic beta-Antagonists
Animals
Avoidance Learning
Benzazepines
CA1 Region, Hippocampal
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Dobutamine
Enzyme Inhibitors
Excitatory Amino Acid Antagonists
Exploratory Behavior
Male
Memory, Long-Term
Memory, Short-Term
Neuronal Plasticity
Propranolol
Rats
Rats, Wistar
Receptors, Adrenergic, beta
Receptors, Dopamine D1
Receptors, Dopamine D5
Receptors, N-Methyl-D-Aspartate
Rattus
dc.description.none.fl_txt_mv Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca 2+/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace.
Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Martinez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca 2+/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12110/paper_00278424_v108_n31_p12931_Moncada
url http://hdl.handle.net/20.500.12110/paper_00278424_v108_n31_p12931_Moncada
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Proc. Natl. Acad. Sci. U. S. A. 2011;108(31):12931-12936
reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
repository.mail.fl_str_mv ana@bl.fcen.uba.ar
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