Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
- Autores
- Moncada, D.; Ballarini, F.; Martinez, M.C.; Frey, J.U.; Viola, H.
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca 2+/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace.
Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Martinez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. - Fuente
- Proc. Natl. Acad. Sci. U. S. A. 2011;108(31):12931-12936
- Materia
-
CA1
Dentate gyrus
Synaptic tagging
beta adrenergic receptor
calcium calmodulin dependent protein kinase II
dopamine 1 receptor
dopamine 5 receptor
n methyl dextro aspartic acid receptor
neurotransmitter
animal experiment
article
controlled study
dopaminergic system
dopaminergic transmission
long term memory
male
memory consolidation
molecule
nonhuman
noradrenergic system
priority journal
protein synthesis
rat
short term memory
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
2-Amino-5-phosphonovalerate
Adrenergic beta-Antagonists
Animals
Avoidance Learning
Benzazepines
CA1 Region, Hippocampal
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Dobutamine
Enzyme Inhibitors
Excitatory Amino Acid Antagonists
Exploratory Behavior
Male
Memory, Long-Term
Memory, Short-Term
Neuronal Plasticity
Propranolol
Rats
Rats, Wistar
Receptors, Adrenergic, beta
Receptors, Dopamine D1
Receptors, Dopamine D5
Receptors, N-Methyl-D-Aspartate
Rattus - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/2.5/ar
- Repositorio
- Institución
- Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
- OAI Identificador
- paperaa:paper_00278424_v108_n31_p12931_Moncada
Ver los metadatos del registro completo
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Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formationMoncada, D.Ballarini, F.Martinez, M.C.Frey, J.U.Viola, H.CA1Dentate gyrusSynaptic taggingbeta adrenergic receptorcalcium calmodulin dependent protein kinase IIdopamine 1 receptordopamine 5 receptorn methyl dextro aspartic acid receptorneurotransmitteranimal experimentarticlecontrolled studydopaminergic systemdopaminergic transmissionlong term memorymalememory consolidationmoleculenonhumannoradrenergic systempriority journalprotein synthesisratshort term memory1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine2-Amino-5-phosphonovalerateAdrenergic beta-AntagonistsAnimalsAvoidance LearningBenzazepinesCA1 Region, HippocampalCalcium-Calmodulin-Dependent Protein Kinase Type 2DobutamineEnzyme InhibitorsExcitatory Amino Acid AntagonistsExploratory BehaviorMaleMemory, Long-TermMemory, Short-TermNeuronal PlasticityPropranololRatsRats, WistarReceptors, Adrenergic, betaReceptors, Dopamine D1Receptors, Dopamine D5Receptors, N-Methyl-D-AspartateRattusLong-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca 2+/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace.Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Martinez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_00278424_v108_n31_p12931_MoncadaProc. Natl. Acad. Sci. U. S. A. 2011;108(31):12931-12936reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:43:02Zpaperaa:paper_00278424_v108_n31_p12931_MoncadaInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:43:04.201Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse |
dc.title.none.fl_str_mv |
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation |
title |
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation |
spellingShingle |
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation Moncada, D. CA1 Dentate gyrus Synaptic tagging beta adrenergic receptor calcium calmodulin dependent protein kinase II dopamine 1 receptor dopamine 5 receptor n methyl dextro aspartic acid receptor neurotransmitter animal experiment article controlled study dopaminergic system dopaminergic transmission long term memory male memory consolidation molecule nonhuman noradrenergic system priority journal protein synthesis rat short term memory 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 2-Amino-5-phosphonovalerate Adrenergic beta-Antagonists Animals Avoidance Learning Benzazepines CA1 Region, Hippocampal Calcium-Calmodulin-Dependent Protein Kinase Type 2 Dobutamine Enzyme Inhibitors Excitatory Amino Acid Antagonists Exploratory Behavior Male Memory, Long-Term Memory, Short-Term Neuronal Plasticity Propranolol Rats Rats, Wistar Receptors, Adrenergic, beta Receptors, Dopamine D1 Receptors, Dopamine D5 Receptors, N-Methyl-D-Aspartate Rattus |
title_short |
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation |
title_full |
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation |
title_fullStr |
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation |
title_full_unstemmed |
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation |
title_sort |
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation |
dc.creator.none.fl_str_mv |
Moncada, D. Ballarini, F. Martinez, M.C. Frey, J.U. Viola, H. |
author |
Moncada, D. |
author_facet |
Moncada, D. Ballarini, F. Martinez, M.C. Frey, J.U. Viola, H. |
author_role |
author |
author2 |
Ballarini, F. Martinez, M.C. Frey, J.U. Viola, H. |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
CA1 Dentate gyrus Synaptic tagging beta adrenergic receptor calcium calmodulin dependent protein kinase II dopamine 1 receptor dopamine 5 receptor n methyl dextro aspartic acid receptor neurotransmitter animal experiment article controlled study dopaminergic system dopaminergic transmission long term memory male memory consolidation molecule nonhuman noradrenergic system priority journal protein synthesis rat short term memory 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 2-Amino-5-phosphonovalerate Adrenergic beta-Antagonists Animals Avoidance Learning Benzazepines CA1 Region, Hippocampal Calcium-Calmodulin-Dependent Protein Kinase Type 2 Dobutamine Enzyme Inhibitors Excitatory Amino Acid Antagonists Exploratory Behavior Male Memory, Long-Term Memory, Short-Term Neuronal Plasticity Propranolol Rats Rats, Wistar Receptors, Adrenergic, beta Receptors, Dopamine D1 Receptors, Dopamine D5 Receptors, N-Methyl-D-Aspartate Rattus |
topic |
CA1 Dentate gyrus Synaptic tagging beta adrenergic receptor calcium calmodulin dependent protein kinase II dopamine 1 receptor dopamine 5 receptor n methyl dextro aspartic acid receptor neurotransmitter animal experiment article controlled study dopaminergic system dopaminergic transmission long term memory male memory consolidation molecule nonhuman noradrenergic system priority journal protein synthesis rat short term memory 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 2-Amino-5-phosphonovalerate Adrenergic beta-Antagonists Animals Avoidance Learning Benzazepines CA1 Region, Hippocampal Calcium-Calmodulin-Dependent Protein Kinase Type 2 Dobutamine Enzyme Inhibitors Excitatory Amino Acid Antagonists Exploratory Behavior Male Memory, Long-Term Memory, Short-Term Neuronal Plasticity Propranolol Rats Rats, Wistar Receptors, Adrenergic, beta Receptors, Dopamine D1 Receptors, Dopamine D5 Receptors, N-Methyl-D-Aspartate Rattus |
dc.description.none.fl_txt_mv |
Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca 2+/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace. Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Martinez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. |
description |
Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca 2+/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12110/paper_00278424_v108_n31_p12931_Moncada |
url |
http://hdl.handle.net/20.500.12110/paper_00278424_v108_n31_p12931_Moncada |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/2.5/ar |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Proc. Natl. Acad. Sci. U. S. A. 2011;108(31):12931-12936 reponame:Biblioteca Digital (UBA-FCEN) instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales instacron:UBA-FCEN |
reponame_str |
Biblioteca Digital (UBA-FCEN) |
collection |
Biblioteca Digital (UBA-FCEN) |
instname_str |
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
instacron_str |
UBA-FCEN |
institution |
UBA-FCEN |
repository.name.fl_str_mv |
Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
repository.mail.fl_str_mv |
ana@bl.fcen.uba.ar |
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1844618738056298496 |
score |
13.070432 |