Induction of long-term memory by exposure to novelty requires protein synthesis: Evidence for a behavioral tagging

• Autores: Moncada, D.; Viola, H.
• Año de publicación: 2007
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: J. Neurosci. 2007;27(28):7476-7481
• Materia: Behavioral tag; Hippocampus; Inhibitory avoidance; Long-term memory; Rats; Spatial novelty; 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate; anisomycin; dopamine 1 receptor; dopamine 5 receptor; animal experiment; article; behavior; controlled study; environment; exploratory behavior; hippocampus; long term memory; male; nonhuman; plasticity; priority journal; protein stability; protein synthesis; rat; training; Animals; Avoidance Learning; Exploratory Behavior; Hippocampus; Male; Memory; Nerve Tissue Proteins; Neuronal Plasticity; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D5; Time Factors
• Institución: Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales

A behavioral analog of the synaptic tagging and capture process, a key property of synaptic plasticity, has been predicted recently. Here, we demonstrate that weak inhibitory avoidance training, which induces short- but not long-term memory (LTM), can be consolidated into LTM by an exploration to a novel, but not a familiar, environment occurring close in time to the training session. This memorypromoting effect caused by novelty depends on activation of dopamine D1/D5 receptors and requires newly synthesized proteins in the dorsal hippocampus. Thus, our results indicate the existence of a behavioral tagging process in which the exploration to a novel environment provides the plasticity-related proteins to stabilize the inhibitory avoidance memory trace. Copyright © 2007 Society for Neuroscience.
Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.