Development and validation of an algorithm for cardiomyocyte beating frequency determination

Autores
Wassermann, D.; Mejail, M.
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The Chagas disease or Tripanosomiasis Americana affects between 16 and 18 million people in endemic areas. This disease affects the beating rate of infected patients' cardiomyocytes. At the Molecular Biology of Chagas Disease Laboratory in Argentina the effect of isolated patient's serum antibodies is studied over rat cardiomyocyte cultures. In this work an image processing application to measure the beating rate of this culture over video sequences is presented. This work is organized as follows. Firstly, a preliminary analysis of the problem is introduced, isolating the main characteristics of the problem. Secondly, a Monte Carlo experiment is designed and used to evaluate the robustness and validity of the algorithm. Finally, an algorithm of order O(T(N log N + N)) for tracking cardiomyocyte membranes is presented, where T is the number of frames and N is the maximum area of the membrane. Its performance is compared against the standard beating rate measure method. © Springer-Verlag Berlin Heidelberg 2005.
Fil:Wassermann, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Mejail, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fuente
Lect. Notes Comput. Sci. 2005;3773 LNCS:420-430
Materia
Algorithms
Biological membranes
Diseases
Image processing
Medical imaging
Patient monitoring
Problem solving
Cardiomyocyte beating frequency
Cardiomyocyte membranes
Monte Carlo experiments
Video sequences
Biomedical engineering
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
paperaa:paper_03029743_v3773LNCS_n_p420_Wassermann
Acceder
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oai_identifier_str paperaa:paper_03029743_v3773LNCS_n_p420_Wassermann
network_acronym_str BDUBAFCEN
repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Development and validation of an algorithm for cardiomyocyte beating frequency determinationWassermann, D.Mejail, M.AlgorithmsBiological membranesDiseasesImage processingMedical imagingPatient monitoringProblem solvingCardiomyocyte beating frequencyCardiomyocyte membranesMonte Carlo experimentsVideo sequencesBiomedical engineeringThe Chagas disease or Tripanosomiasis Americana affects between 16 and 18 million people in endemic areas. This disease affects the beating rate of infected patients' cardiomyocytes. At the Molecular Biology of Chagas Disease Laboratory in Argentina the effect of isolated patient's serum antibodies is studied over rat cardiomyocyte cultures. In this work an image processing application to measure the beating rate of this culture over video sequences is presented. This work is organized as follows. Firstly, a preliminary analysis of the problem is introduced, isolating the main characteristics of the problem. Secondly, a Monte Carlo experiment is designed and used to evaluate the robustness and validity of the algorithm. Finally, an algorithm of order O(T(N log N + N)) for tracking cardiomyocyte membranes is presented, where T is the number of frames and N is the maximum area of the membrane. Its performance is compared against the standard beating rate measure method. © Springer-Verlag Berlin Heidelberg 2005.Fil:Wassermann, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Mejail, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2005info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_03029743_v3773LNCS_n_p420_WassermannLect. Notes Comput. Sci. 2005;3773 LNCS:420-430reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:43:06Zpaperaa:paper_03029743_v3773LNCS_n_p420_WassermannInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:43:07.572Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Development and validation of an algorithm for cardiomyocyte beating frequency determination
title Development and validation of an algorithm for cardiomyocyte beating frequency determination
spellingShingle Development and validation of an algorithm for cardiomyocyte beating frequency determination
Wassermann, D.
Algorithms
Biological membranes
Diseases
Image processing
Medical imaging
Patient monitoring
Problem solving
Cardiomyocyte beating frequency
Cardiomyocyte membranes
Monte Carlo experiments
Video sequences
Biomedical engineering
title_short Development and validation of an algorithm for cardiomyocyte beating frequency determination
title_full Development and validation of an algorithm for cardiomyocyte beating frequency determination
title_fullStr Development and validation of an algorithm for cardiomyocyte beating frequency determination
title_full_unstemmed Development and validation of an algorithm for cardiomyocyte beating frequency determination
title_sort Development and validation of an algorithm for cardiomyocyte beating frequency determination
dc.creator.none.fl_str_mv Wassermann, D.
Mejail, M.
author Wassermann, D.
author_facet Wassermann, D.
Mejail, M.
author_role author
author2 Mejail, M.
author2_role author
dc.subject.none.fl_str_mv Algorithms
Biological membranes
Diseases
Image processing
Medical imaging
Patient monitoring
Problem solving
Cardiomyocyte beating frequency
Cardiomyocyte membranes
Monte Carlo experiments
Video sequences
Biomedical engineering
topic Algorithms
Biological membranes
Diseases
Image processing
Medical imaging
Patient monitoring
Problem solving
Cardiomyocyte beating frequency
Cardiomyocyte membranes
Monte Carlo experiments
Video sequences
Biomedical engineering
dc.description.none.fl_txt_mv The Chagas disease or Tripanosomiasis Americana affects between 16 and 18 million people in endemic areas. This disease affects the beating rate of infected patients' cardiomyocytes. At the Molecular Biology of Chagas Disease Laboratory in Argentina the effect of isolated patient's serum antibodies is studied over rat cardiomyocyte cultures. In this work an image processing application to measure the beating rate of this culture over video sequences is presented. This work is organized as follows. Firstly, a preliminary analysis of the problem is introduced, isolating the main characteristics of the problem. Secondly, a Monte Carlo experiment is designed and used to evaluate the robustness and validity of the algorithm. Finally, an algorithm of order O(T(N log N + N)) for tracking cardiomyocyte membranes is presented, where T is the number of frames and N is the maximum area of the membrane. Its performance is compared against the standard beating rate measure method. © Springer-Verlag Berlin Heidelberg 2005.
Fil:Wassermann, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Mejail, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description The Chagas disease or Tripanosomiasis Americana affects between 16 and 18 million people in endemic areas. This disease affects the beating rate of infected patients' cardiomyocytes. At the Molecular Biology of Chagas Disease Laboratory in Argentina the effect of isolated patient's serum antibodies is studied over rat cardiomyocyte cultures. In this work an image processing application to measure the beating rate of this culture over video sequences is presented. This work is organized as follows. Firstly, a preliminary analysis of the problem is introduced, isolating the main characteristics of the problem. Secondly, a Monte Carlo experiment is designed and used to evaluate the robustness and validity of the algorithm. Finally, an algorithm of order O(T(N log N + N)) for tracking cardiomyocyte membranes is presented, where T is the number of frames and N is the maximum area of the membrane. Its performance is compared against the standard beating rate measure method. © Springer-Verlag Berlin Heidelberg 2005.
publishDate 2005
dc.date.none.fl_str_mv 2005
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12110/paper_03029743_v3773LNCS_n_p420_Wassermann
url http://hdl.handle.net/20.500.12110/paper_03029743_v3773LNCS_n_p420_Wassermann
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Lect. Notes Comput. Sci. 2005;3773 LNCS:420-430
reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
repository.mail.fl_str_mv ana@bl.fcen.uba.ar
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score 13.070432

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