Control of alternative pre-mRNA splicing by RNA pol II elongation: Faster is not always better

Autores
Nogués, G.; Kadener, S.; Cramer, P.; De la Mata, M.; Fededa, J.P.; Blaustein, M.; Srebrow, A.; Kornblihtt, A.R.
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The realization that the mammalian proteomic complexity is achieved with a limited number of genes demands a better understanding of alternative splicing regulation. Promoter control of alternative splicing was originally described by our group in studies performed on the fibronectin gene. Recently, other labs extended our findings to the cystic fibrosis, CD44 and CGRP genes strongly supporting a coupling between transcription and pre-mRNA splicing. A possible mechanism that would fit in these results is that the promoter itself is responsible for recruiting splicing factors, such as SR proteins, to the site of transcription, possibly through transcription factors that bind the promoter or the transcriptional enhancers. An alternative model, discussed more extensively in this review, involves modulation of RNA pol II (pol II) elongation rate. The model is supported by findings that cis- and trans-acting factors that modulate pol II elongation on a particular template also provoke changes in the alternative splicing balance of the encoded mRNAs.
Fil:Nogués, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Kadener, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Cramer, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:De la Mata, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Fededa, J.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Blaustein, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Srebrow, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fuente
IUBMB Life 2003;55(4-5):235-241
Materia
Alternative splicing
Elongation
mRNA processing
RNA polymerase II
Transcription
calcitonin gene related peptide
fibronectin
Hermes antigen
messenger RNA
protein
proteome
transcription factor
alternative RNA splicing
animal cell
controlled study
cystic fibrosis
DNA template
gene control
gene function
genetic code
genetic transcription
mammalian genetics
nonhuman
promoter region
protein RNA binding
proteomics
regulatory mechanism
review
Alternative Splicing
Animals
Models, Genetic
RNA Polymerase II
RNA Precursors
RNA, Messenger
RNA-Binding Proteins
Transcription, Genetic
Animalia
Mammalia
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
paperaa:paper_15216543_v55_n4-5_p235_Nogues
Acceder
id BDUBAFCEN_57bdb533e594e8b484ffe78a760b67a2
oai_identifier_str paperaa:paper_15216543_v55_n4-5_p235_Nogues
network_acronym_str BDUBAFCEN
repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Control of alternative pre-mRNA splicing by RNA pol II elongation: Faster is not always betterNogués, G.Kadener, S.Cramer, P.De la Mata, M.Fededa, J.P.Blaustein, M.Srebrow, A.Kornblihtt, A.R.Alternative splicingElongationmRNA processingRNA polymerase IITranscriptioncalcitonin gene related peptidefibronectinHermes antigenmessenger RNAproteinproteometranscription factoralternative RNA splicinganimal cellcontrolled studycystic fibrosisDNA templategene controlgene functiongenetic codegenetic transcriptionmammalian geneticsnonhumanpromoter regionprotein RNA bindingproteomicsregulatory mechanismreviewAlternative SplicingAnimalsModels, GeneticRNA Polymerase IIRNA PrecursorsRNA, MessengerRNA-Binding ProteinsTranscription, GeneticAnimaliaMammaliaThe realization that the mammalian proteomic complexity is achieved with a limited number of genes demands a better understanding of alternative splicing regulation. Promoter control of alternative splicing was originally described by our group in studies performed on the fibronectin gene. Recently, other labs extended our findings to the cystic fibrosis, CD44 and CGRP genes strongly supporting a coupling between transcription and pre-mRNA splicing. A possible mechanism that would fit in these results is that the promoter itself is responsible for recruiting splicing factors, such as SR proteins, to the site of transcription, possibly through transcription factors that bind the promoter or the transcriptional enhancers. An alternative model, discussed more extensively in this review, involves modulation of RNA pol II (pol II) elongation rate. The model is supported by findings that cis- and trans-acting factors that modulate pol II elongation on a particular template also provoke changes in the alternative splicing balance of the encoded mRNAs.Fil:Nogués, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Kadener, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Cramer, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:De la Mata, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Fededa, J.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Blaustein, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Srebrow, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2003info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_15216543_v55_n4-5_p235_NoguesIUBMB Life 2003;55(4-5):235-241reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-11-06T09:39:32Zpaperaa:paper_15216543_v55_n4-5_p235_NoguesInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-11-06 09:39:34.929Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Control of alternative pre-mRNA splicing by RNA pol II elongation: Faster is not always better
title Control of alternative pre-mRNA splicing by RNA pol II elongation: Faster is not always better
spellingShingle Control of alternative pre-mRNA splicing by RNA pol II elongation: Faster is not always better
Nogués, G.
Alternative splicing
Elongation
mRNA processing
RNA polymerase II
Transcription
calcitonin gene related peptide
fibronectin
Hermes antigen
messenger RNA
protein
proteome
transcription factor
alternative RNA splicing
animal cell
controlled study
cystic fibrosis
DNA template
gene control
gene function
genetic code
genetic transcription
mammalian genetics
nonhuman
promoter region
protein RNA binding
proteomics
regulatory mechanism
review
Alternative Splicing
Animals
Models, Genetic
RNA Polymerase II
RNA Precursors
RNA, Messenger
RNA-Binding Proteins
Transcription, Genetic
Animalia
Mammalia
title_short Control of alternative pre-mRNA splicing by RNA pol II elongation: Faster is not always better
title_full Control of alternative pre-mRNA splicing by RNA pol II elongation: Faster is not always better
title_fullStr Control of alternative pre-mRNA splicing by RNA pol II elongation: Faster is not always better
title_full_unstemmed Control of alternative pre-mRNA splicing by RNA pol II elongation: Faster is not always better
title_sort Control of alternative pre-mRNA splicing by RNA pol II elongation: Faster is not always better
dc.creator.none.fl_str_mv Nogués, G.
Kadener, S.
Cramer, P.
De la Mata, M.
Fededa, J.P.
Blaustein, M.
Srebrow, A.
Kornblihtt, A.R.
author Nogués, G.
author_facet Nogués, G.
Kadener, S.
Cramer, P.
De la Mata, M.
Fededa, J.P.
Blaustein, M.
Srebrow, A.
Kornblihtt, A.R.
author_role author
author2 Kadener, S.
Cramer, P.
De la Mata, M.
Fededa, J.P.
Blaustein, M.
Srebrow, A.
Kornblihtt, A.R.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alternative splicing
Elongation
mRNA processing
RNA polymerase II
Transcription
calcitonin gene related peptide
fibronectin
Hermes antigen
messenger RNA
protein
proteome
transcription factor
alternative RNA splicing
animal cell
controlled study
cystic fibrosis
DNA template
gene control
gene function
genetic code
genetic transcription
mammalian genetics
nonhuman
promoter region
protein RNA binding
proteomics
regulatory mechanism
review
Alternative Splicing
Animals
Models, Genetic
RNA Polymerase II
RNA Precursors
RNA, Messenger
RNA-Binding Proteins
Transcription, Genetic
Animalia
Mammalia
topic Alternative splicing
Elongation
mRNA processing
RNA polymerase II
Transcription
calcitonin gene related peptide
fibronectin
Hermes antigen
messenger RNA
protein
proteome
transcription factor
alternative RNA splicing
animal cell
controlled study
cystic fibrosis
DNA template
gene control
gene function
genetic code
genetic transcription
mammalian genetics
nonhuman
promoter region
protein RNA binding
proteomics
regulatory mechanism
review
Alternative Splicing
Animals
Models, Genetic
RNA Polymerase II
RNA Precursors
RNA, Messenger
RNA-Binding Proteins
Transcription, Genetic
Animalia
Mammalia
dc.description.none.fl_txt_mv The realization that the mammalian proteomic complexity is achieved with a limited number of genes demands a better understanding of alternative splicing regulation. Promoter control of alternative splicing was originally described by our group in studies performed on the fibronectin gene. Recently, other labs extended our findings to the cystic fibrosis, CD44 and CGRP genes strongly supporting a coupling between transcription and pre-mRNA splicing. A possible mechanism that would fit in these results is that the promoter itself is responsible for recruiting splicing factors, such as SR proteins, to the site of transcription, possibly through transcription factors that bind the promoter or the transcriptional enhancers. An alternative model, discussed more extensively in this review, involves modulation of RNA pol II (pol II) elongation rate. The model is supported by findings that cis- and trans-acting factors that modulate pol II elongation on a particular template also provoke changes in the alternative splicing balance of the encoded mRNAs.
Fil:Nogués, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Kadener, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Cramer, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:De la Mata, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Fededa, J.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Blaustein, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Srebrow, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description The realization that the mammalian proteomic complexity is achieved with a limited number of genes demands a better understanding of alternative splicing regulation. Promoter control of alternative splicing was originally described by our group in studies performed on the fibronectin gene. Recently, other labs extended our findings to the cystic fibrosis, CD44 and CGRP genes strongly supporting a coupling between transcription and pre-mRNA splicing. A possible mechanism that would fit in these results is that the promoter itself is responsible for recruiting splicing factors, such as SR proteins, to the site of transcription, possibly through transcription factors that bind the promoter or the transcriptional enhancers. An alternative model, discussed more extensively in this review, involves modulation of RNA pol II (pol II) elongation rate. The model is supported by findings that cis- and trans-acting factors that modulate pol II elongation on a particular template also provoke changes in the alternative splicing balance of the encoded mRNAs.
publishDate 2003
dc.date.none.fl_str_mv 2003
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12110/paper_15216543_v55_n4-5_p235_Nogues
url http://hdl.handle.net/20.500.12110/paper_15216543_v55_n4-5_p235_Nogues
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv IUBMB Life 2003;55(4-5):235-241
reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
repository.mail.fl_str_mv ana@bl.fcen.uba.ar
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score 13.084122

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