Coordination between transcription and pre-mRNA processing

Autores
Cramer, P.; Srebrow, A.; Kadener, S.; Werbajh, S.; De La Mata, M.; Melen, G.; Nogués, G.; Kornblihtt, A.R.
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing. © 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
Fil:Cramer, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Srebrow, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Kadener, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:De La Mata, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Melen, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Nogués, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fuente
FEBS Lett. 2001;498(2-3):179-182
Materia
Carboxy-terminal domain
Coupling
mRNA processing
RNA polymerase II
messenger RNA
RNA polymerase II
capping phenomenon
carboxy terminal sequence
cell nucleus
nonhuman
phosphorylation
polyadenylation
priority journal
promoter region
RNA processing
RNA splicing
RNA transcription
short survey
spliceosome
transcription regulation
Humans
Macromolecular Substances
Models, Biological
RNA Polymerase II
RNA Precursors
RNA Processing, Post-Transcriptional
RNA Splicing
Transcription, Genetic
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
paperaa:paper_00145793_v498_n2-3_p179_Cramer
Acceder
id BDUBAFCEN_1507865438da15e17fe074ddc7d615a4
oai_identifier_str paperaa:paper_00145793_v498_n2-3_p179_Cramer
network_acronym_str BDUBAFCEN
repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Coordination between transcription and pre-mRNA processingCramer, P.Srebrow, A.Kadener, S.Werbajh, S.De La Mata, M.Melen, G.Nogués, G.Kornblihtt, A.R.Carboxy-terminal domainCouplingmRNA processingRNA polymerase IImessenger RNARNA polymerase IIcapping phenomenoncarboxy terminal sequencecell nucleusnonhumanphosphorylationpolyadenylationpriority journalpromoter regionRNA processingRNA splicingRNA transcriptionshort surveyspliceosometranscription regulationHumansMacromolecular SubstancesModels, BiologicalRNA Polymerase IIRNA PrecursorsRNA Processing, Post-TranscriptionalRNA SplicingTranscription, GeneticA large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing. © 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.Fil:Cramer, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Srebrow, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Kadener, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:De La Mata, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Melen, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Nogués, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2001info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_00145793_v498_n2-3_p179_CramerFEBS Lett. 2001;498(2-3):179-182reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:43:03Zpaperaa:paper_00145793_v498_n2-3_p179_CramerInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:43:04.698Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Coordination between transcription and pre-mRNA processing
title Coordination between transcription and pre-mRNA processing
spellingShingle Coordination between transcription and pre-mRNA processing
Cramer, P.
Carboxy-terminal domain
Coupling
mRNA processing
RNA polymerase II
messenger RNA
RNA polymerase II
capping phenomenon
carboxy terminal sequence
cell nucleus
nonhuman
phosphorylation
polyadenylation
priority journal
promoter region
RNA processing
RNA splicing
RNA transcription
short survey
spliceosome
transcription regulation
Humans
Macromolecular Substances
Models, Biological
RNA Polymerase II
RNA Precursors
RNA Processing, Post-Transcriptional
RNA Splicing
Transcription, Genetic
title_short Coordination between transcription and pre-mRNA processing
title_full Coordination between transcription and pre-mRNA processing
title_fullStr Coordination between transcription and pre-mRNA processing
title_full_unstemmed Coordination between transcription and pre-mRNA processing
title_sort Coordination between transcription and pre-mRNA processing
dc.creator.none.fl_str_mv Cramer, P.
Srebrow, A.
Kadener, S.
Werbajh, S.
De La Mata, M.
Melen, G.
Nogués, G.
Kornblihtt, A.R.
author Cramer, P.
author_facet Cramer, P.
Srebrow, A.
Kadener, S.
Werbajh, S.
De La Mata, M.
Melen, G.
Nogués, G.
Kornblihtt, A.R.
author_role author
author2 Srebrow, A.
Kadener, S.
Werbajh, S.
De La Mata, M.
Melen, G.
Nogués, G.
Kornblihtt, A.R.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Carboxy-terminal domain
Coupling
mRNA processing
RNA polymerase II
messenger RNA
RNA polymerase II
capping phenomenon
carboxy terminal sequence
cell nucleus
nonhuman
phosphorylation
polyadenylation
priority journal
promoter region
RNA processing
RNA splicing
RNA transcription
short survey
spliceosome
transcription regulation
Humans
Macromolecular Substances
Models, Biological
RNA Polymerase II
RNA Precursors
RNA Processing, Post-Transcriptional
RNA Splicing
Transcription, Genetic
topic Carboxy-terminal domain
Coupling
mRNA processing
RNA polymerase II
messenger RNA
RNA polymerase II
capping phenomenon
carboxy terminal sequence
cell nucleus
nonhuman
phosphorylation
polyadenylation
priority journal
promoter region
RNA processing
RNA splicing
RNA transcription
short survey
spliceosome
transcription regulation
Humans
Macromolecular Substances
Models, Biological
RNA Polymerase II
RNA Precursors
RNA Processing, Post-Transcriptional
RNA Splicing
Transcription, Genetic
dc.description.none.fl_txt_mv A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing. © 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
Fil:Cramer, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Srebrow, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Kadener, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:De La Mata, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Melen, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Nogués, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing. © 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
publishDate 2001
dc.date.none.fl_str_mv 2001
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12110/paper_00145793_v498_n2-3_p179_Cramer
url http://hdl.handle.net/20.500.12110/paper_00145793_v498_n2-3_p179_Cramer
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv FEBS Lett. 2001;498(2-3):179-182
reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
repository.mail.fl_str_mv ana@bl.fcen.uba.ar
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score 13.070432

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