Structural and functional properties of hydration and confined water in membrane interfaces
- Autores
- Disalvo, E.A.; Lairion, F.; Martini, F.; Tymczyszyn, E.; Frías, M.; Almaleck, H.; Gordillo, G.J.
- Año de publicación
- 2008
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The scope of the present review focuses on the interfacial properties of cell membranes that may establish a link between the membrane and the cytosolic components. We present evidences that the current view of the membrane as a barrier of permeability that contains an aqueous solution of macromolecules may be replaced by one in which the membrane plays a structural and functional role. Although this idea has been previously suggested, the present is the first systematic work that puts into relevance the relation water-membrane in terms of thermodynamic and structural properties of the interphases that cannot be ignored in the understanding of cell function. To pursue this aim, we introduce a new definition of interphase, in which the water is organized in different levels on the surface with different binding energies. Altogether determines the surface free energy necessary for the structural response to changes in the surrounding media. The physical chemical properties of this region are interpreted in terms of hydration water and confined water, which explain the interaction with proteins and could affect the modulation of enzyme activity. Information provided by several methodologies indicates that the organization of the hydration states is not restricted to the membrane plane albeit to a region extending into the cytoplasm, in which polar head groups play a relevant role. In addition, dynamic properties studied by cyclic voltammetry allow one to deduce the energetics of the conformational changes of the lipid head group in relation to the head-head interactions due to the presence of carbonyls and phosphates at the interphase. These groups are, apparently, surrounded by more than one layer of water molecules: a tightly bound shell, that mostly contributes to the dipole potential, and a second one that may be displaced by proteins and osmotic stress. Hydration water around carbonyl and phosphate groups may change by the presence of polyhydroxylated compounds or by changing the chemical groups esterified to the phosphates, mainly choline, ethanolamine or glycerol. Thus, surface membrane properties, such as the dipole potential and the surface pressure, are modulated by the water at the interphase region by changing the structure of the membrane components. An understanding of the properties of the structural water located at the hydration sites and the functional water confined around the polar head groups modulated by the hydrocarbon chains is helpful to interpret and analyze the consequences of water loss at the membranes of dehydrated cells. In this regard, a correlation between the effects of water activity on cell growth and the lipid composition is discussed in terms of the recovery of the cell volume and their viability. Critical analyses of the properties of water at the interface of lipid membranes merging from these results and others from the literature suggest that the interface links the membrane with the aqueous soluble proteins in a functional unit in which the cell may be considered as a complex structure stabilized by water rather than a water solution of macromolecules surrounded by a semi permeable barrier. © 2008 Elsevier B.V. All rights reserved.
Fil:Gordillo, G.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. - Fuente
- Biochim. Biophys. Acta Biomembr. 2008;1778(12):2655-2670
- Materia
-
Carbonyl and phosphate groups
Confined water
Dipole potential
H-bonding compounds
Interphase region
Lipid membranes
Protein/membrane interaction
Surface potential
Surface pressure
Water of hydration
carbonyl derivative
choline
ethanolamine
glycerol
hydrocarbon
phosphate
water
chemical structure
dipole
electric field
hydration
interphase
lipid membrane
membrane binding
priority journal
protein interaction
review
surface charge
surface property
Biophysical Phenomena
Cell Membrane
Hydrogen Bonding
Lipid Bilayers
Membrane Lipids
Membranes
Models, Biological
Structure-Activity Relationship
Surface Properties
Water - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/2.5/ar
- Repositorio
- Institución
- Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
- OAI Identificador
- paperaa:paper_00052736_v1778_n12_p2655_Disalvo
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Structural and functional properties of hydration and confined water in membrane interfacesDisalvo, E.A.Lairion, F.Martini, F.Tymczyszyn, E.Frías, M.Almaleck, H.Gordillo, G.J.Carbonyl and phosphate groupsConfined waterDipole potentialH-bonding compoundsInterphase regionLipid membranesProtein/membrane interactionSurface potentialSurface pressureWater of hydrationcarbonyl derivativecholineethanolamineglycerolhydrocarbonphosphatewaterchemical structuredipoleelectric fieldhydrationinterphaselipid membranemembrane bindingpriority journalprotein interactionreviewsurface chargesurface propertyBiophysical PhenomenaCell MembraneHydrogen BondingLipid BilayersMembrane LipidsMembranesModels, BiologicalStructure-Activity RelationshipSurface PropertiesWaterThe scope of the present review focuses on the interfacial properties of cell membranes that may establish a link between the membrane and the cytosolic components. We present evidences that the current view of the membrane as a barrier of permeability that contains an aqueous solution of macromolecules may be replaced by one in which the membrane plays a structural and functional role. Although this idea has been previously suggested, the present is the first systematic work that puts into relevance the relation water-membrane in terms of thermodynamic and structural properties of the interphases that cannot be ignored in the understanding of cell function. To pursue this aim, we introduce a new definition of interphase, in which the water is organized in different levels on the surface with different binding energies. Altogether determines the surface free energy necessary for the structural response to changes in the surrounding media. The physical chemical properties of this region are interpreted in terms of hydration water and confined water, which explain the interaction with proteins and could affect the modulation of enzyme activity. Information provided by several methodologies indicates that the organization of the hydration states is not restricted to the membrane plane albeit to a region extending into the cytoplasm, in which polar head groups play a relevant role. In addition, dynamic properties studied by cyclic voltammetry allow one to deduce the energetics of the conformational changes of the lipid head group in relation to the head-head interactions due to the presence of carbonyls and phosphates at the interphase. These groups are, apparently, surrounded by more than one layer of water molecules: a tightly bound shell, that mostly contributes to the dipole potential, and a second one that may be displaced by proteins and osmotic stress. Hydration water around carbonyl and phosphate groups may change by the presence of polyhydroxylated compounds or by changing the chemical groups esterified to the phosphates, mainly choline, ethanolamine or glycerol. Thus, surface membrane properties, such as the dipole potential and the surface pressure, are modulated by the water at the interphase region by changing the structure of the membrane components. An understanding of the properties of the structural water located at the hydration sites and the functional water confined around the polar head groups modulated by the hydrocarbon chains is helpful to interpret and analyze the consequences of water loss at the membranes of dehydrated cells. In this regard, a correlation between the effects of water activity on cell growth and the lipid composition is discussed in terms of the recovery of the cell volume and their viability. Critical analyses of the properties of water at the interface of lipid membranes merging from these results and others from the literature suggest that the interface links the membrane with the aqueous soluble proteins in a functional unit in which the cell may be considered as a complex structure stabilized by water rather than a water solution of macromolecules surrounded by a semi permeable barrier. © 2008 Elsevier B.V. All rights reserved.Fil:Gordillo, G.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2008info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_00052736_v1778_n12_p2655_DisalvoBiochim. Biophys. Acta Biomembr. 2008;1778(12):2655-2670reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:43:06Zpaperaa:paper_00052736_v1778_n12_p2655_DisalvoInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:43:07.483Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse |
dc.title.none.fl_str_mv |
Structural and functional properties of hydration and confined water in membrane interfaces |
title |
Structural and functional properties of hydration and confined water in membrane interfaces |
spellingShingle |
Structural and functional properties of hydration and confined water in membrane interfaces Disalvo, E.A. Carbonyl and phosphate groups Confined water Dipole potential H-bonding compounds Interphase region Lipid membranes Protein/membrane interaction Surface potential Surface pressure Water of hydration carbonyl derivative choline ethanolamine glycerol hydrocarbon phosphate water chemical structure dipole electric field hydration interphase lipid membrane membrane binding priority journal protein interaction review surface charge surface property Biophysical Phenomena Cell Membrane Hydrogen Bonding Lipid Bilayers Membrane Lipids Membranes Models, Biological Structure-Activity Relationship Surface Properties Water |
title_short |
Structural and functional properties of hydration and confined water in membrane interfaces |
title_full |
Structural and functional properties of hydration and confined water in membrane interfaces |
title_fullStr |
Structural and functional properties of hydration and confined water in membrane interfaces |
title_full_unstemmed |
Structural and functional properties of hydration and confined water in membrane interfaces |
title_sort |
Structural and functional properties of hydration and confined water in membrane interfaces |
dc.creator.none.fl_str_mv |
Disalvo, E.A. Lairion, F. Martini, F. Tymczyszyn, E. Frías, M. Almaleck, H. Gordillo, G.J. |
author |
Disalvo, E.A. |
author_facet |
Disalvo, E.A. Lairion, F. Martini, F. Tymczyszyn, E. Frías, M. Almaleck, H. Gordillo, G.J. |
author_role |
author |
author2 |
Lairion, F. Martini, F. Tymczyszyn, E. Frías, M. Almaleck, H. Gordillo, G.J. |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Carbonyl and phosphate groups Confined water Dipole potential H-bonding compounds Interphase region Lipid membranes Protein/membrane interaction Surface potential Surface pressure Water of hydration carbonyl derivative choline ethanolamine glycerol hydrocarbon phosphate water chemical structure dipole electric field hydration interphase lipid membrane membrane binding priority journal protein interaction review surface charge surface property Biophysical Phenomena Cell Membrane Hydrogen Bonding Lipid Bilayers Membrane Lipids Membranes Models, Biological Structure-Activity Relationship Surface Properties Water |
topic |
Carbonyl and phosphate groups Confined water Dipole potential H-bonding compounds Interphase region Lipid membranes Protein/membrane interaction Surface potential Surface pressure Water of hydration carbonyl derivative choline ethanolamine glycerol hydrocarbon phosphate water chemical structure dipole electric field hydration interphase lipid membrane membrane binding priority journal protein interaction review surface charge surface property Biophysical Phenomena Cell Membrane Hydrogen Bonding Lipid Bilayers Membrane Lipids Membranes Models, Biological Structure-Activity Relationship Surface Properties Water |
dc.description.none.fl_txt_mv |
The scope of the present review focuses on the interfacial properties of cell membranes that may establish a link between the membrane and the cytosolic components. We present evidences that the current view of the membrane as a barrier of permeability that contains an aqueous solution of macromolecules may be replaced by one in which the membrane plays a structural and functional role. Although this idea has been previously suggested, the present is the first systematic work that puts into relevance the relation water-membrane in terms of thermodynamic and structural properties of the interphases that cannot be ignored in the understanding of cell function. To pursue this aim, we introduce a new definition of interphase, in which the water is organized in different levels on the surface with different binding energies. Altogether determines the surface free energy necessary for the structural response to changes in the surrounding media. The physical chemical properties of this region are interpreted in terms of hydration water and confined water, which explain the interaction with proteins and could affect the modulation of enzyme activity. Information provided by several methodologies indicates that the organization of the hydration states is not restricted to the membrane plane albeit to a region extending into the cytoplasm, in which polar head groups play a relevant role. In addition, dynamic properties studied by cyclic voltammetry allow one to deduce the energetics of the conformational changes of the lipid head group in relation to the head-head interactions due to the presence of carbonyls and phosphates at the interphase. These groups are, apparently, surrounded by more than one layer of water molecules: a tightly bound shell, that mostly contributes to the dipole potential, and a second one that may be displaced by proteins and osmotic stress. Hydration water around carbonyl and phosphate groups may change by the presence of polyhydroxylated compounds or by changing the chemical groups esterified to the phosphates, mainly choline, ethanolamine or glycerol. Thus, surface membrane properties, such as the dipole potential and the surface pressure, are modulated by the water at the interphase region by changing the structure of the membrane components. An understanding of the properties of the structural water located at the hydration sites and the functional water confined around the polar head groups modulated by the hydrocarbon chains is helpful to interpret and analyze the consequences of water loss at the membranes of dehydrated cells. In this regard, a correlation between the effects of water activity on cell growth and the lipid composition is discussed in terms of the recovery of the cell volume and their viability. Critical analyses of the properties of water at the interface of lipid membranes merging from these results and others from the literature suggest that the interface links the membrane with the aqueous soluble proteins in a functional unit in which the cell may be considered as a complex structure stabilized by water rather than a water solution of macromolecules surrounded by a semi permeable barrier. © 2008 Elsevier B.V. All rights reserved. Fil:Gordillo, G.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. |
description |
The scope of the present review focuses on the interfacial properties of cell membranes that may establish a link between the membrane and the cytosolic components. We present evidences that the current view of the membrane as a barrier of permeability that contains an aqueous solution of macromolecules may be replaced by one in which the membrane plays a structural and functional role. Although this idea has been previously suggested, the present is the first systematic work that puts into relevance the relation water-membrane in terms of thermodynamic and structural properties of the interphases that cannot be ignored in the understanding of cell function. To pursue this aim, we introduce a new definition of interphase, in which the water is organized in different levels on the surface with different binding energies. Altogether determines the surface free energy necessary for the structural response to changes in the surrounding media. The physical chemical properties of this region are interpreted in terms of hydration water and confined water, which explain the interaction with proteins and could affect the modulation of enzyme activity. Information provided by several methodologies indicates that the organization of the hydration states is not restricted to the membrane plane albeit to a region extending into the cytoplasm, in which polar head groups play a relevant role. In addition, dynamic properties studied by cyclic voltammetry allow one to deduce the energetics of the conformational changes of the lipid head group in relation to the head-head interactions due to the presence of carbonyls and phosphates at the interphase. These groups are, apparently, surrounded by more than one layer of water molecules: a tightly bound shell, that mostly contributes to the dipole potential, and a second one that may be displaced by proteins and osmotic stress. Hydration water around carbonyl and phosphate groups may change by the presence of polyhydroxylated compounds or by changing the chemical groups esterified to the phosphates, mainly choline, ethanolamine or glycerol. Thus, surface membrane properties, such as the dipole potential and the surface pressure, are modulated by the water at the interphase region by changing the structure of the membrane components. An understanding of the properties of the structural water located at the hydration sites and the functional water confined around the polar head groups modulated by the hydrocarbon chains is helpful to interpret and analyze the consequences of water loss at the membranes of dehydrated cells. In this regard, a correlation between the effects of water activity on cell growth and the lipid composition is discussed in terms of the recovery of the cell volume and their viability. Critical analyses of the properties of water at the interface of lipid membranes merging from these results and others from the literature suggest that the interface links the membrane with the aqueous soluble proteins in a functional unit in which the cell may be considered as a complex structure stabilized by water rather than a water solution of macromolecules surrounded by a semi permeable barrier. © 2008 Elsevier B.V. All rights reserved. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12110/paper_00052736_v1778_n12_p2655_Disalvo |
url |
http://hdl.handle.net/20.500.12110/paper_00052736_v1778_n12_p2655_Disalvo |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/2.5/ar |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Biochim. Biophys. Acta Biomembr. 2008;1778(12):2655-2670 reponame:Biblioteca Digital (UBA-FCEN) instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales instacron:UBA-FCEN |
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Biblioteca Digital (UBA-FCEN) |
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Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
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UBA-FCEN |
institution |
UBA-FCEN |
repository.name.fl_str_mv |
Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales |
repository.mail.fl_str_mv |
ana@bl.fcen.uba.ar |
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