Structural and functional properties of hydration and confined water in membrane interfaces

Autores
Disalvo, E.A.; Lairion, F.; Martini, F.; Tymczyszyn, E.; Frías, M.; Almaleck, H.; Gordillo, G.J.
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The scope of the present review focuses on the interfacial properties of cell membranes that may establish a link between the membrane and the cytosolic components. We present evidences that the current view of the membrane as a barrier of permeability that contains an aqueous solution of macromolecules may be replaced by one in which the membrane plays a structural and functional role. Although this idea has been previously suggested, the present is the first systematic work that puts into relevance the relation water-membrane in terms of thermodynamic and structural properties of the interphases that cannot be ignored in the understanding of cell function. To pursue this aim, we introduce a new definition of interphase, in which the water is organized in different levels on the surface with different binding energies. Altogether determines the surface free energy necessary for the structural response to changes in the surrounding media. The physical chemical properties of this region are interpreted in terms of hydration water and confined water, which explain the interaction with proteins and could affect the modulation of enzyme activity. Information provided by several methodologies indicates that the organization of the hydration states is not restricted to the membrane plane albeit to a region extending into the cytoplasm, in which polar head groups play a relevant role. In addition, dynamic properties studied by cyclic voltammetry allow one to deduce the energetics of the conformational changes of the lipid head group in relation to the head-head interactions due to the presence of carbonyls and phosphates at the interphase. These groups are, apparently, surrounded by more than one layer of water molecules: a tightly bound shell, that mostly contributes to the dipole potential, and a second one that may be displaced by proteins and osmotic stress. Hydration water around carbonyl and phosphate groups may change by the presence of polyhydroxylated compounds or by changing the chemical groups esterified to the phosphates, mainly choline, ethanolamine or glycerol. Thus, surface membrane properties, such as the dipole potential and the surface pressure, are modulated by the water at the interphase region by changing the structure of the membrane components. An understanding of the properties of the structural water located at the hydration sites and the functional water confined around the polar head groups modulated by the hydrocarbon chains is helpful to interpret and analyze the consequences of water loss at the membranes of dehydrated cells. In this regard, a correlation between the effects of water activity on cell growth and the lipid composition is discussed in terms of the recovery of the cell volume and their viability. Critical analyses of the properties of water at the interface of lipid membranes merging from these results and others from the literature suggest that the interface links the membrane with the aqueous soluble proteins in a functional unit in which the cell may be considered as a complex structure stabilized by water rather than a water solution of macromolecules surrounded by a semi permeable barrier. © 2008 Elsevier B.V. All rights reserved.
Fil:Gordillo, G.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fuente
Biochim. Biophys. Acta Biomembr. 2008;1778(12):2655-2670
Materia
Carbonyl and phosphate groups
Confined water
Dipole potential
H-bonding compounds
Interphase region
Lipid membranes
Protein/membrane interaction
Surface potential
Surface pressure
Water of hydration
carbonyl derivative
choline
ethanolamine
glycerol
hydrocarbon
phosphate
water
chemical structure
dipole
electric field
hydration
interphase
lipid membrane
membrane binding
priority journal
protein interaction
review
surface charge
surface property
Biophysical Phenomena
Cell Membrane
Hydrogen Bonding
Lipid Bilayers
Membrane Lipids
Membranes
Models, Biological
Structure-Activity Relationship
Surface Properties
Water
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
paperaa:paper_00052736_v1778_n12_p2655_Disalvo

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oai_identifier_str paperaa:paper_00052736_v1778_n12_p2655_Disalvo
network_acronym_str BDUBAFCEN
repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Structural and functional properties of hydration and confined water in membrane interfacesDisalvo, E.A.Lairion, F.Martini, F.Tymczyszyn, E.Frías, M.Almaleck, H.Gordillo, G.J.Carbonyl and phosphate groupsConfined waterDipole potentialH-bonding compoundsInterphase regionLipid membranesProtein/membrane interactionSurface potentialSurface pressureWater of hydrationcarbonyl derivativecholineethanolamineglycerolhydrocarbonphosphatewaterchemical structuredipoleelectric fieldhydrationinterphaselipid membranemembrane bindingpriority journalprotein interactionreviewsurface chargesurface propertyBiophysical PhenomenaCell MembraneHydrogen BondingLipid BilayersMembrane LipidsMembranesModels, BiologicalStructure-Activity RelationshipSurface PropertiesWaterThe scope of the present review focuses on the interfacial properties of cell membranes that may establish a link between the membrane and the cytosolic components. We present evidences that the current view of the membrane as a barrier of permeability that contains an aqueous solution of macromolecules may be replaced by one in which the membrane plays a structural and functional role. Although this idea has been previously suggested, the present is the first systematic work that puts into relevance the relation water-membrane in terms of thermodynamic and structural properties of the interphases that cannot be ignored in the understanding of cell function. To pursue this aim, we introduce a new definition of interphase, in which the water is organized in different levels on the surface with different binding energies. Altogether determines the surface free energy necessary for the structural response to changes in the surrounding media. The physical chemical properties of this region are interpreted in terms of hydration water and confined water, which explain the interaction with proteins and could affect the modulation of enzyme activity. Information provided by several methodologies indicates that the organization of the hydration states is not restricted to the membrane plane albeit to a region extending into the cytoplasm, in which polar head groups play a relevant role. In addition, dynamic properties studied by cyclic voltammetry allow one to deduce the energetics of the conformational changes of the lipid head group in relation to the head-head interactions due to the presence of carbonyls and phosphates at the interphase. These groups are, apparently, surrounded by more than one layer of water molecules: a tightly bound shell, that mostly contributes to the dipole potential, and a second one that may be displaced by proteins and osmotic stress. Hydration water around carbonyl and phosphate groups may change by the presence of polyhydroxylated compounds or by changing the chemical groups esterified to the phosphates, mainly choline, ethanolamine or glycerol. Thus, surface membrane properties, such as the dipole potential and the surface pressure, are modulated by the water at the interphase region by changing the structure of the membrane components. An understanding of the properties of the structural water located at the hydration sites and the functional water confined around the polar head groups modulated by the hydrocarbon chains is helpful to interpret and analyze the consequences of water loss at the membranes of dehydrated cells. In this regard, a correlation between the effects of water activity on cell growth and the lipid composition is discussed in terms of the recovery of the cell volume and their viability. Critical analyses of the properties of water at the interface of lipid membranes merging from these results and others from the literature suggest that the interface links the membrane with the aqueous soluble proteins in a functional unit in which the cell may be considered as a complex structure stabilized by water rather than a water solution of macromolecules surrounded by a semi permeable barrier. © 2008 Elsevier B.V. All rights reserved.Fil:Gordillo, G.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2008info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_00052736_v1778_n12_p2655_DisalvoBiochim. Biophys. Acta Biomembr. 2008;1778(12):2655-2670reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-29T13:43:06Zpaperaa:paper_00052736_v1778_n12_p2655_DisalvoInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-29 13:43:07.483Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Structural and functional properties of hydration and confined water in membrane interfaces
title Structural and functional properties of hydration and confined water in membrane interfaces
spellingShingle Structural and functional properties of hydration and confined water in membrane interfaces
Disalvo, E.A.
Carbonyl and phosphate groups
Confined water
Dipole potential
H-bonding compounds
Interphase region
Lipid membranes
Protein/membrane interaction
Surface potential
Surface pressure
Water of hydration
carbonyl derivative
choline
ethanolamine
glycerol
hydrocarbon
phosphate
water
chemical structure
dipole
electric field
hydration
interphase
lipid membrane
membrane binding
priority journal
protein interaction
review
surface charge
surface property
Biophysical Phenomena
Cell Membrane
Hydrogen Bonding
Lipid Bilayers
Membrane Lipids
Membranes
Models, Biological
Structure-Activity Relationship
Surface Properties
Water
title_short Structural and functional properties of hydration and confined water in membrane interfaces
title_full Structural and functional properties of hydration and confined water in membrane interfaces
title_fullStr Structural and functional properties of hydration and confined water in membrane interfaces
title_full_unstemmed Structural and functional properties of hydration and confined water in membrane interfaces
title_sort Structural and functional properties of hydration and confined water in membrane interfaces
dc.creator.none.fl_str_mv Disalvo, E.A.
Lairion, F.
Martini, F.
Tymczyszyn, E.
Frías, M.
Almaleck, H.
Gordillo, G.J.
author Disalvo, E.A.
author_facet Disalvo, E.A.
Lairion, F.
Martini, F.
Tymczyszyn, E.
Frías, M.
Almaleck, H.
Gordillo, G.J.
author_role author
author2 Lairion, F.
Martini, F.
Tymczyszyn, E.
Frías, M.
Almaleck, H.
Gordillo, G.J.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Carbonyl and phosphate groups
Confined water
Dipole potential
H-bonding compounds
Interphase region
Lipid membranes
Protein/membrane interaction
Surface potential
Surface pressure
Water of hydration
carbonyl derivative
choline
ethanolamine
glycerol
hydrocarbon
phosphate
water
chemical structure
dipole
electric field
hydration
interphase
lipid membrane
membrane binding
priority journal
protein interaction
review
surface charge
surface property
Biophysical Phenomena
Cell Membrane
Hydrogen Bonding
Lipid Bilayers
Membrane Lipids
Membranes
Models, Biological
Structure-Activity Relationship
Surface Properties
Water
topic Carbonyl and phosphate groups
Confined water
Dipole potential
H-bonding compounds
Interphase region
Lipid membranes
Protein/membrane interaction
Surface potential
Surface pressure
Water of hydration
carbonyl derivative
choline
ethanolamine
glycerol
hydrocarbon
phosphate
water
chemical structure
dipole
electric field
hydration
interphase
lipid membrane
membrane binding
priority journal
protein interaction
review
surface charge
surface property
Biophysical Phenomena
Cell Membrane
Hydrogen Bonding
Lipid Bilayers
Membrane Lipids
Membranes
Models, Biological
Structure-Activity Relationship
Surface Properties
Water
dc.description.none.fl_txt_mv The scope of the present review focuses on the interfacial properties of cell membranes that may establish a link between the membrane and the cytosolic components. We present evidences that the current view of the membrane as a barrier of permeability that contains an aqueous solution of macromolecules may be replaced by one in which the membrane plays a structural and functional role. Although this idea has been previously suggested, the present is the first systematic work that puts into relevance the relation water-membrane in terms of thermodynamic and structural properties of the interphases that cannot be ignored in the understanding of cell function. To pursue this aim, we introduce a new definition of interphase, in which the water is organized in different levels on the surface with different binding energies. Altogether determines the surface free energy necessary for the structural response to changes in the surrounding media. The physical chemical properties of this region are interpreted in terms of hydration water and confined water, which explain the interaction with proteins and could affect the modulation of enzyme activity. Information provided by several methodologies indicates that the organization of the hydration states is not restricted to the membrane plane albeit to a region extending into the cytoplasm, in which polar head groups play a relevant role. In addition, dynamic properties studied by cyclic voltammetry allow one to deduce the energetics of the conformational changes of the lipid head group in relation to the head-head interactions due to the presence of carbonyls and phosphates at the interphase. These groups are, apparently, surrounded by more than one layer of water molecules: a tightly bound shell, that mostly contributes to the dipole potential, and a second one that may be displaced by proteins and osmotic stress. Hydration water around carbonyl and phosphate groups may change by the presence of polyhydroxylated compounds or by changing the chemical groups esterified to the phosphates, mainly choline, ethanolamine or glycerol. Thus, surface membrane properties, such as the dipole potential and the surface pressure, are modulated by the water at the interphase region by changing the structure of the membrane components. An understanding of the properties of the structural water located at the hydration sites and the functional water confined around the polar head groups modulated by the hydrocarbon chains is helpful to interpret and analyze the consequences of water loss at the membranes of dehydrated cells. In this regard, a correlation between the effects of water activity on cell growth and the lipid composition is discussed in terms of the recovery of the cell volume and their viability. Critical analyses of the properties of water at the interface of lipid membranes merging from these results and others from the literature suggest that the interface links the membrane with the aqueous soluble proteins in a functional unit in which the cell may be considered as a complex structure stabilized by water rather than a water solution of macromolecules surrounded by a semi permeable barrier. © 2008 Elsevier B.V. All rights reserved.
Fil:Gordillo, G.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description The scope of the present review focuses on the interfacial properties of cell membranes that may establish a link between the membrane and the cytosolic components. We present evidences that the current view of the membrane as a barrier of permeability that contains an aqueous solution of macromolecules may be replaced by one in which the membrane plays a structural and functional role. Although this idea has been previously suggested, the present is the first systematic work that puts into relevance the relation water-membrane in terms of thermodynamic and structural properties of the interphases that cannot be ignored in the understanding of cell function. To pursue this aim, we introduce a new definition of interphase, in which the water is organized in different levels on the surface with different binding energies. Altogether determines the surface free energy necessary for the structural response to changes in the surrounding media. The physical chemical properties of this region are interpreted in terms of hydration water and confined water, which explain the interaction with proteins and could affect the modulation of enzyme activity. Information provided by several methodologies indicates that the organization of the hydration states is not restricted to the membrane plane albeit to a region extending into the cytoplasm, in which polar head groups play a relevant role. In addition, dynamic properties studied by cyclic voltammetry allow one to deduce the energetics of the conformational changes of the lipid head group in relation to the head-head interactions due to the presence of carbonyls and phosphates at the interphase. These groups are, apparently, surrounded by more than one layer of water molecules: a tightly bound shell, that mostly contributes to the dipole potential, and a second one that may be displaced by proteins and osmotic stress. Hydration water around carbonyl and phosphate groups may change by the presence of polyhydroxylated compounds or by changing the chemical groups esterified to the phosphates, mainly choline, ethanolamine or glycerol. Thus, surface membrane properties, such as the dipole potential and the surface pressure, are modulated by the water at the interphase region by changing the structure of the membrane components. An understanding of the properties of the structural water located at the hydration sites and the functional water confined around the polar head groups modulated by the hydrocarbon chains is helpful to interpret and analyze the consequences of water loss at the membranes of dehydrated cells. In this regard, a correlation between the effects of water activity on cell growth and the lipid composition is discussed in terms of the recovery of the cell volume and their viability. Critical analyses of the properties of water at the interface of lipid membranes merging from these results and others from the literature suggest that the interface links the membrane with the aqueous soluble proteins in a functional unit in which the cell may be considered as a complex structure stabilized by water rather than a water solution of macromolecules surrounded by a semi permeable barrier. © 2008 Elsevier B.V. All rights reserved.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12110/paper_00052736_v1778_n12_p2655_Disalvo
url http://hdl.handle.net/20.500.12110/paper_00052736_v1778_n12_p2655_Disalvo
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Biochim. Biophys. Acta Biomembr. 2008;1778(12):2655-2670
reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
repository.mail.fl_str_mv ana@bl.fcen.uba.ar
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