Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease
- Autores
- Sosa-Estani, Sergio; Segura, Elsa L.; Ruiz, Andrés Mariano; Velazquez, Elsa; Porcel, Betina Mabel; Yampotis, Cristina
- Año de publicación
- 1998
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A double-blind, randomized, clinical field trial was designed to test the efficacy and tolerance of a specific drug treatment in children in the indeterminate phase of infection by Trypanosoma cruzi. Children were treated with benznidazole at a dose of 5 mg/kg/day for 60 days or placebo and followed-up for 48 months. The treated children showed a significant decrease in geometric mean titers of antibodies against T. cruzi measured by indirect hemagglutination, indirect immunofluorescence, and ELISA. After a four year follow-up, 62% of the benznidazole- treated children and no placebo-treated child were seronegative for T. cruzi when tested by an ELISA using a T. cruzi flagellar calcium-binding protein (F29). Xenodiagnosis carried out after 48 months of follow-up was positive in 4.7% of the benznidazole-treated children and in 51.2% of the placebo-treated children. These results show the tolerance to and efficacy of benznidazole against T. cruzi in seropositive children six to 12 years of age. We used an early serologic marker of cure after treatment, consisting of a recombinant antigen implemented in a rapid, conventional serologic procedure.
Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina.
Fil: Segura, Elsa Leonor. ANLIS Dr.C.G.Malbrán; Argentina.
Fil: Ruiz, Andres Mariano. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.
Fil: Velazquez, Elsa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.
Fil: Porcel, Betina Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.
Fil: Yampotis, Cristina. Hospital San Roque; Argentina. - Fuente
- The American Journal of Tropical Medicine and Hygiene, 1998, 59(4), 526–529.
- Materia
-
Enfermedad de Chagas
Nitroimidazoles
Tripanocidas
Método Doble Ciego
Niño - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
- Institución
- Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
- OAI Identificador
- oai:sgc.anlis.gob.ar:Publications/123456789/241
Ver los metadatos del registro completo
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Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' diseaseSosa-Estani, SergioSegura, Elsa L.Ruiz, Andrés MarianoVelazquez, ElsaPorcel, Betina MabelYampotis, CristinaEnfermedad de ChagasNitroimidazolesTripanocidasMétodo Doble CiegoNiñoA double-blind, randomized, clinical field trial was designed to test the efficacy and tolerance of a specific drug treatment in children in the indeterminate phase of infection by Trypanosoma cruzi. Children were treated with benznidazole at a dose of 5 mg/kg/day for 60 days or placebo and followed-up for 48 months. The treated children showed a significant decrease in geometric mean titers of antibodies against T. cruzi measured by indirect hemagglutination, indirect immunofluorescence, and ELISA. After a four year follow-up, 62% of the benznidazole- treated children and no placebo-treated child were seronegative for T. cruzi when tested by an ELISA using a T. cruzi flagellar calcium-binding protein (F29). Xenodiagnosis carried out after 48 months of follow-up was positive in 4.7% of the benznidazole-treated children and in 51.2% of the placebo-treated children. These results show the tolerance to and efficacy of benznidazole against T. cruzi in seropositive children six to 12 years of age. We used an early serologic marker of cure after treatment, consisting of a recombinant antigen implemented in a rapid, conventional serologic procedure.Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina.Fil: Segura, Elsa Leonor. ANLIS Dr.C.G.Malbrán; Argentina.Fil: Ruiz, Andres Mariano. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.Fil: Velazquez, Elsa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.Fil: Porcel, Betina Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.Fil: Yampotis, Cristina. Hospital San Roque; Argentina.1998info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1476-1645http://sgc.anlis.gob.ar/handle/123456789/241http://www.ajtmh.org/content/59/4/526.full.pdf+htmlThe American Journal of Tropical Medicine and Hygiene, 1998, 59(4), 526–529.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISenginfo:eu-repo/semantics/openAccess2025-09-29T14:29:54Zoai:sgc.anlis.gob.ar:Publications/123456789/241Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:29:55.178Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false |
dc.title.none.fl_str_mv |
Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease |
title |
Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease |
spellingShingle |
Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease Sosa-Estani, Sergio Enfermedad de Chagas Nitroimidazoles Tripanocidas Método Doble Ciego Niño |
title_short |
Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease |
title_full |
Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease |
title_fullStr |
Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease |
title_full_unstemmed |
Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease |
title_sort |
Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease |
dc.creator.none.fl_str_mv |
Sosa-Estani, Sergio Segura, Elsa L. Ruiz, Andrés Mariano Velazquez, Elsa Porcel, Betina Mabel Yampotis, Cristina |
author |
Sosa-Estani, Sergio |
author_facet |
Sosa-Estani, Sergio Segura, Elsa L. Ruiz, Andrés Mariano Velazquez, Elsa Porcel, Betina Mabel Yampotis, Cristina |
author_role |
author |
author2 |
Segura, Elsa L. Ruiz, Andrés Mariano Velazquez, Elsa Porcel, Betina Mabel Yampotis, Cristina |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Enfermedad de Chagas Nitroimidazoles Tripanocidas Método Doble Ciego Niño |
topic |
Enfermedad de Chagas Nitroimidazoles Tripanocidas Método Doble Ciego Niño |
dc.description.none.fl_txt_mv |
A double-blind, randomized, clinical field trial was designed to test the efficacy and tolerance of a specific drug treatment in children in the indeterminate phase of infection by Trypanosoma cruzi. Children were treated with benznidazole at a dose of 5 mg/kg/day for 60 days or placebo and followed-up for 48 months. The treated children showed a significant decrease in geometric mean titers of antibodies against T. cruzi measured by indirect hemagglutination, indirect immunofluorescence, and ELISA. After a four year follow-up, 62% of the benznidazole- treated children and no placebo-treated child were seronegative for T. cruzi when tested by an ELISA using a T. cruzi flagellar calcium-binding protein (F29). Xenodiagnosis carried out after 48 months of follow-up was positive in 4.7% of the benznidazole-treated children and in 51.2% of the placebo-treated children. These results show the tolerance to and efficacy of benznidazole against T. cruzi in seropositive children six to 12 years of age. We used an early serologic marker of cure after treatment, consisting of a recombinant antigen implemented in a rapid, conventional serologic procedure. Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina. Fil: Segura, Elsa Leonor. ANLIS Dr.C.G.Malbrán; Argentina. Fil: Ruiz, Andres Mariano. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina. Fil: Velazquez, Elsa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina. Fil: Porcel, Betina Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina. Fil: Yampotis, Cristina. Hospital San Roque; Argentina. |
description |
A double-blind, randomized, clinical field trial was designed to test the efficacy and tolerance of a specific drug treatment in children in the indeterminate phase of infection by Trypanosoma cruzi. Children were treated with benznidazole at a dose of 5 mg/kg/day for 60 days or placebo and followed-up for 48 months. The treated children showed a significant decrease in geometric mean titers of antibodies against T. cruzi measured by indirect hemagglutination, indirect immunofluorescence, and ELISA. After a four year follow-up, 62% of the benznidazole- treated children and no placebo-treated child were seronegative for T. cruzi when tested by an ELISA using a T. cruzi flagellar calcium-binding protein (F29). Xenodiagnosis carried out after 48 months of follow-up was positive in 4.7% of the benznidazole-treated children and in 51.2% of the placebo-treated children. These results show the tolerance to and efficacy of benznidazole against T. cruzi in seropositive children six to 12 years of age. We used an early serologic marker of cure after treatment, consisting of a recombinant antigen implemented in a rapid, conventional serologic procedure. |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998 |
dc.type.none.fl_str_mv |
info:ar-repo/semantics/articulo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
1476-1645 http://sgc.anlis.gob.ar/handle/123456789/241 http://www.ajtmh.org/content/59/4/526.full.pdf+html |
identifier_str_mv |
1476-1645 |
url |
http://sgc.anlis.gob.ar/handle/123456789/241 http://www.ajtmh.org/content/59/4/526.full.pdf+html |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
The American Journal of Tropical Medicine and Hygiene, 1998, 59(4), 526–529. reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" instacron:ANLIS |
reponame_str |
Sistema de Gestión del Conocimiento ANLIS MALBRÁN |
collection |
Sistema de Gestión del Conocimiento ANLIS MALBRÁN |
instname_str |
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
instacron_str |
ANLIS |
institution |
ANLIS |
repository.name.fl_str_mv |
Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
repository.mail.fl_str_mv |
biblioteca@anlis.gov.ar |
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1844621851244888064 |
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12.559606 |