Effectiveness of two common antivenoms for North, Central, and South American Micrurus envenomations

Autores
de Roodt, Adolfo R.; Paniagua-Solís, Jorge F.; Dolab, Jorge A.; Estévez-Ramírez, Judith; Ramos-Cerrillo, Blanca; Litwin, Silvana; Dokmetjian, Christian; Alagón, Alejandro
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Micrurus snakes (coral snakes) may produce severe envenomation that can lead to death by peripheral respiratory paralysis. Only few laboratories produce specific antivenoms, and despite the cross-reactivity found in some Micrurus species venoms, the treatment is not always effective. To test two therapeutic antivenoms against the venom of four species of Micrurus from Southern America, North of South America, Central America, and North America, the determination of the lethal potency of the venoms, the study of some biochemical and immunochemical characteristics, and the determination of the neutralizing activity of both antivenoms were studied. North American and South American antivenoms neutralized well venoms from Micrurus species of the corresponding hemisphere but displayed lower effectiveness against venoms of species from different hemispheres. It was concluded that the neutralization of Micrurus venoms by regional antivenoms could be useful to treat the envenomation by some Micrurus snakes but is necessary to evaluate carefully the antivenoms to be used with the venoms from the snakes of the region. Also, considering the difficulties for coral snake antivenom production, the development of a polyvalent antivenom is useful to treat the envenomation by coral snakes from different regions is necessary.
Fil: de Roodt, Adolfo R. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos. Área de Investigación y Desarrollo. Serpentario; Argentina.
Fil: Paniagua-Solís, Jorge F. Laboratorios Silanes S.A. de C.V. Dirección de Investigación y Desarrollo; México.
Fil: Dolab, Jorge A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos. Departamento de Vacunas y Sueros; Argentina.
Fil: Estevez-Ramirez, Judith. Instituto Bioclón. Laboratorio Investigación y Desarrollo; México.
Fil: Ramos-Cerrillo, Blanca. Universidad Autónoma de México (UNAM). Departamento de Medicina Molecular y Bioprocesos; México.
Fil: Litwin, Silvana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos. Área de Investigación y Desarrollo. Serpentario; Argentina.
Fil: Dokmetjian, J. C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos. Área de Investigación y Desarrollo. Serpentario; Argentina.
Fil: Alagón, Alejandro. Universidad Autónoma de México (UNAM). Departamento de Medicina Molecular y Bioprocesos; México.
Fuente
Journal of Toxicology Clinical Toxicology, 2004, 42(2), 171-178.
Materia
Elapidae
Venenos Elapidicos
Venenos de Serpiente
Terapéutica
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/421
Acceder
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oai_identifier_str oai:sgc.anlis.gob.ar:123456789/421
network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Effectiveness of two common antivenoms for North, Central, and South American Micrurus envenomationsde Roodt, Adolfo R.Paniagua-Solís, Jorge F.Dolab, Jorge A.Estévez-Ramírez, JudithRamos-Cerrillo, BlancaLitwin, SilvanaDokmetjian, ChristianAlagón, AlejandroElapidaeVenenos ElapidicosVenenos de SerpienteTerapéuticaMicrurus snakes (coral snakes) may produce severe envenomation that can lead to death by peripheral respiratory paralysis. Only few laboratories produce specific antivenoms, and despite the cross-reactivity found in some Micrurus species venoms, the treatment is not always effective. To test two therapeutic antivenoms against the venom of four species of Micrurus from Southern America, North of South America, Central America, and North America, the determination of the lethal potency of the venoms, the study of some biochemical and immunochemical characteristics, and the determination of the neutralizing activity of both antivenoms were studied. North American and South American antivenoms neutralized well venoms from Micrurus species of the corresponding hemisphere but displayed lower effectiveness against venoms of species from different hemispheres. It was concluded that the neutralization of Micrurus venoms by regional antivenoms could be useful to treat the envenomation by some Micrurus snakes but is necessary to evaluate carefully the antivenoms to be used with the venoms from the snakes of the region. Also, considering the difficulties for coral snake antivenom production, the development of a polyvalent antivenom is useful to treat the envenomation by coral snakes from different regions is necessary.Fil: de Roodt, Adolfo R. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos. Área de Investigación y Desarrollo. Serpentario; Argentina.Fil: Paniagua-Solís, Jorge F. Laboratorios Silanes S.A. de C.V. Dirección de Investigación y Desarrollo; México.Fil: Dolab, Jorge A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos. Departamento de Vacunas y Sueros; Argentina.Fil: Estevez-Ramirez, Judith. Instituto Bioclón. Laboratorio Investigación y Desarrollo; México.Fil: Ramos-Cerrillo, Blanca. Universidad Autónoma de México (UNAM). Departamento de Medicina Molecular y Bioprocesos; México.Fil: Litwin, Silvana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos. Área de Investigación y Desarrollo. Serpentario; Argentina.Fil: Dokmetjian, J. C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos. Área de Investigación y Desarrollo. Serpentario; Argentina.Fil: Alagón, Alejandro. Universidad Autónoma de México (UNAM). Departamento de Medicina Molecular y Bioprocesos; México.2004info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1556-9519http://sgc.anlis.gob.ar/handle/123456789/421http://informahealthcare.com/journal/ctx/Journal of Toxicology Clinical Toxicology, 2004, 42(2), 171-178.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISenginfo:eu-repo/semantics/openAccess2025-09-04T11:15:51Zoai:sgc.anlis.gob.ar:123456789/421Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-04 11:15:51.476Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Effectiveness of two common antivenoms for North, Central, and South American Micrurus envenomations
title Effectiveness of two common antivenoms for North, Central, and South American Micrurus envenomations
spellingShingle Effectiveness of two common antivenoms for North, Central, and South American Micrurus envenomations
de Roodt, Adolfo R.
Elapidae
Venenos Elapidicos
Venenos de Serpiente
Terapéutica
title_short Effectiveness of two common antivenoms for North, Central, and South American Micrurus envenomations
title_full Effectiveness of two common antivenoms for North, Central, and South American Micrurus envenomations
title_fullStr Effectiveness of two common antivenoms for North, Central, and South American Micrurus envenomations
title_full_unstemmed Effectiveness of two common antivenoms for North, Central, and South American Micrurus envenomations
title_sort Effectiveness of two common antivenoms for North, Central, and South American Micrurus envenomations
dc.creator.none.fl_str_mv de Roodt, Adolfo R.
Paniagua-Solís, Jorge F.
Dolab, Jorge A.
Estévez-Ramírez, Judith
Ramos-Cerrillo, Blanca
Litwin, Silvana
Dokmetjian, Christian
Alagón, Alejandro
author de Roodt, Adolfo R.
author_facet de Roodt, Adolfo R.
Paniagua-Solís, Jorge F.
Dolab, Jorge A.
Estévez-Ramírez, Judith
Ramos-Cerrillo, Blanca
Litwin, Silvana
Dokmetjian, Christian
Alagón, Alejandro
author_role author
author2 Paniagua-Solís, Jorge F.
Dolab, Jorge A.
Estévez-Ramírez, Judith
Ramos-Cerrillo, Blanca
Litwin, Silvana
Dokmetjian, Christian
Alagón, Alejandro
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Elapidae
Venenos Elapidicos
Venenos de Serpiente
Terapéutica
topic Elapidae
Venenos Elapidicos
Venenos de Serpiente
Terapéutica
dc.description.none.fl_txt_mv Micrurus snakes (coral snakes) may produce severe envenomation that can lead to death by peripheral respiratory paralysis. Only few laboratories produce specific antivenoms, and despite the cross-reactivity found in some Micrurus species venoms, the treatment is not always effective. To test two therapeutic antivenoms against the venom of four species of Micrurus from Southern America, North of South America, Central America, and North America, the determination of the lethal potency of the venoms, the study of some biochemical and immunochemical characteristics, and the determination of the neutralizing activity of both antivenoms were studied. North American and South American antivenoms neutralized well venoms from Micrurus species of the corresponding hemisphere but displayed lower effectiveness against venoms of species from different hemispheres. It was concluded that the neutralization of Micrurus venoms by regional antivenoms could be useful to treat the envenomation by some Micrurus snakes but is necessary to evaluate carefully the antivenoms to be used with the venoms from the snakes of the region. Also, considering the difficulties for coral snake antivenom production, the development of a polyvalent antivenom is useful to treat the envenomation by coral snakes from different regions is necessary.
Fil: de Roodt, Adolfo R. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos. Área de Investigación y Desarrollo. Serpentario; Argentina.
Fil: Paniagua-Solís, Jorge F. Laboratorios Silanes S.A. de C.V. Dirección de Investigación y Desarrollo; México.
Fil: Dolab, Jorge A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos. Departamento de Vacunas y Sueros; Argentina.
Fil: Estevez-Ramirez, Judith. Instituto Bioclón. Laboratorio Investigación y Desarrollo; México.
Fil: Ramos-Cerrillo, Blanca. Universidad Autónoma de México (UNAM). Departamento de Medicina Molecular y Bioprocesos; México.
Fil: Litwin, Silvana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos. Área de Investigación y Desarrollo. Serpentario; Argentina.
Fil: Dokmetjian, J. C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos. Área de Investigación y Desarrollo. Serpentario; Argentina.
Fil: Alagón, Alejandro. Universidad Autónoma de México (UNAM). Departamento de Medicina Molecular y Bioprocesos; México.
description Micrurus snakes (coral snakes) may produce severe envenomation that can lead to death by peripheral respiratory paralysis. Only few laboratories produce specific antivenoms, and despite the cross-reactivity found in some Micrurus species venoms, the treatment is not always effective. To test two therapeutic antivenoms against the venom of four species of Micrurus from Southern America, North of South America, Central America, and North America, the determination of the lethal potency of the venoms, the study of some biochemical and immunochemical characteristics, and the determination of the neutralizing activity of both antivenoms were studied. North American and South American antivenoms neutralized well venoms from Micrurus species of the corresponding hemisphere but displayed lower effectiveness against venoms of species from different hemispheres. It was concluded that the neutralization of Micrurus venoms by regional antivenoms could be useful to treat the envenomation by some Micrurus snakes but is necessary to evaluate carefully the antivenoms to be used with the venoms from the snakes of the region. Also, considering the difficulties for coral snake antivenom production, the development of a polyvalent antivenom is useful to treat the envenomation by coral snakes from different regions is necessary.
publishDate 2004
dc.date.none.fl_str_mv 2004
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1556-9519
http://sgc.anlis.gob.ar/handle/123456789/421
http://informahealthcare.com/journal/ctx/
identifier_str_mv 1556-9519
url http://sgc.anlis.gob.ar/handle/123456789/421
http://informahealthcare.com/journal/ctx/
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Journal of Toxicology Clinical Toxicology, 2004, 42(2), 171-178.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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score 12.623145

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