Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes

Autores
Monsalvo, Ana Clara; Batalle, Juan P.; Lopez, M. Florencia; Krause, Jens C.; Klemenc, Jennifer; Zea, Johanna; Maskin, Bernardo; Bugna, Jimena; Rubinstein, Carlos; Aguilar, Leandro; Dalurzo, Liliana; Libster, Romina; Savy, Vilma L.; Baumeister, Elsa; Aguilar, Liliana; Cabral, Graciela; Font, Julia; Solari, Liliana; Weller, Kevin P.; Johnson, Joyce; Echavarria, Marcela; Edwards, Kathryn M.; Chappell, James D.; Crowe, James E.; Williams, John V.; Melendi, Guillermina A.; Polack, Fernando P.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Monsalvo, Ana Clara. Fundacion INFANT, Buenos Aires; Argentina.
Fil: Batalle, Juan P. Fundacion INFANT, Buenos Aires; Argentina.
Fil: Lopez, M Florencia. Fundacion INFANT, Buenos Aires; Argentina.
Fil: Krause, Jens C. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Klemenc, Jennifer. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Hernandez, Johanna Zea. . Fundacion INFANT, Buenos Aires; Argentina.
Fil: Maskin, Bernardo. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.
Fil: Bugna, Jimena. Fundacion INFANT, Buenos Aires; Argentina.
Fil: Rubinstein, Carlos. Hospital Dr Federico Abete, Malvinas Argentinas, Buenos Aires; Argentina.
Fil: Aguilar, Leandro. Hospital Dr Federico Abete, Malvinas Argentinas, Buenos Aires; Argentina.
Fil: Dalurzo, Liliana. Hospital Italiano, Buenos Aires; Argentina.
Fil: Libster, Romina. Fundacion INFANT, Buenos Aires; Argentina.
Fil: Savy, Vilma. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Baumeister, Elsa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Aguilar, Liliana. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.
Fil: Cabral, Graciela. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.
Fil: Font, Julia. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.
Fil: Solari, Liliana. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.
Fil: Weller, Kevin P. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Johnson, Joyce. Department of Pathology, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Echavarria, Marcela. Department of Microbiology, CEMIC, Buenos Aires; Argentina.
Fil: Edwards, Kathryn M. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Chappell, James D. Department of Pathology, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Crowe, James E. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Williams, John V. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Melendi, Guillermina A. Fundacion INFANT, Buenos Aires; Argentina.
Fil: Polack, Fernando P. Fundacion INFANT, Buenos Aires; Argentina.
Pandemic influenza viruses often cause severe disease in middle-aged adults without preexisting comorbidities. The mechanism of illness associated with severe disease in this age group is not well understood. Here we find preexisting serum antibodies that cross-react with, but do not protect against, 2009 H1N1 influenza virus in middle-aged adults. Nonprotective antibody is associated with immune complex-mediated disease after infection. We detected high titers of serum antibody of low avidity for H1-2009 antigen, and low-avidity pulmonary immune complexes against the same protein, in severely ill individuals. Moreover, C4d deposition--a marker of complement activation mediated by immune complexes--was present in lung sections of fatal cases. Archived lung sections from middle-aged adults with confirmed fatal influenza 1957 H2N2 infection revealed a similar mechanism of illness. These observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics.
Fuente
Nature medicine 2011; 17(2): 195-199.
Materia
Subtipo H1N1 del Virus de la Influenza A
Pandemias
Virus de la Influenza A
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/472

id SGCANLIS_c224ac1ed00a19f0ae779f430a1a8d07
oai_identifier_str oai:sgc.anlis.gob.ar:Publications/123456789/472
network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexesMonsalvo, Ana ClaraBatalle, Juan P.Lopez, M. FlorenciaKrause, Jens C.Klemenc, JenniferZea, JohannaMaskin, BernardoBugna, JimenaRubinstein, CarlosAguilar, LeandroDalurzo, LilianaLibster, RominaSavy, Vilma L.Baumeister, ElsaAguilar, LilianaCabral, GracielaFont, JuliaSolari, LilianaWeller, Kevin P.Johnson, JoyceEchavarria, MarcelaEdwards, Kathryn M.Chappell, James D.Crowe, James E.Williams, John V.Melendi, Guillermina A.Polack, Fernando P.Subtipo H1N1 del Virus de la Influenza APandemiasVirus de la Influenza AFil: Monsalvo, Ana Clara. Fundacion INFANT, Buenos Aires; Argentina.Fil: Batalle, Juan P. Fundacion INFANT, Buenos Aires; Argentina.Fil: Lopez, M Florencia. Fundacion INFANT, Buenos Aires; Argentina.Fil: Krause, Jens C. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.Fil: Klemenc, Jennifer. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.Fil: Hernandez, Johanna Zea. . Fundacion INFANT, Buenos Aires; Argentina.Fil: Maskin, Bernardo. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.Fil: Bugna, Jimena. Fundacion INFANT, Buenos Aires; Argentina.Fil: Rubinstein, Carlos. Hospital Dr Federico Abete, Malvinas Argentinas, Buenos Aires; Argentina.Fil: Aguilar, Leandro. Hospital Dr Federico Abete, Malvinas Argentinas, Buenos Aires; Argentina.Fil: Dalurzo, Liliana. Hospital Italiano, Buenos Aires; Argentina.Fil: Libster, Romina. Fundacion INFANT, Buenos Aires; Argentina.Fil: Savy, Vilma. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Baumeister, Elsa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Aguilar, Liliana. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.Fil: Cabral, Graciela. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.Fil: Font, Julia. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.Fil: Solari, Liliana. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.Fil: Weller, Kevin P. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.Fil: Johnson, Joyce. Department of Pathology, Vanderbilt University, Nashville, TN; Estados Unidos.Fil: Echavarria, Marcela. Department of Microbiology, CEMIC, Buenos Aires; Argentina.Fil: Edwards, Kathryn M. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.Fil: Chappell, James D. Department of Pathology, Vanderbilt University, Nashville, TN; Estados Unidos.Fil: Crowe, James E. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.Fil: Williams, John V. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.Fil: Melendi, Guillermina A. Fundacion INFANT, Buenos Aires; Argentina.Fil: Polack, Fernando P. Fundacion INFANT, Buenos Aires; Argentina.Pandemic influenza viruses often cause severe disease in middle-aged adults without preexisting comorbidities. The mechanism of illness associated with severe disease in this age group is not well understood. Here we find preexisting serum antibodies that cross-react with, but do not protect against, 2009 H1N1 influenza virus in middle-aged adults. Nonprotective antibody is associated with immune complex-mediated disease after infection. We detected high titers of serum antibody of low avidity for H1-2009 antigen, and low-avidity pulmonary immune complexes against the same protein, in severely ill individuals. Moreover, C4d deposition--a marker of complement activation mediated by immune complexes--was present in lung sections of fatal cases. Archived lung sections from middle-aged adults with confirmed fatal influenza 1957 H2N2 infection revealed a similar mechanism of illness. These observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics.Nature Research2011-02info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1546-170Xhttp://sgc.anlis.gob.ar/handle/123456789/472Nature medicine 2011; 17(2): 195-199.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISNature Medicineenginfo:eu-repo/semantics/openAccess2025-09-29T14:30:02Zoai:sgc.anlis.gob.ar:Publications/123456789/472Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:02.484Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
title Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
spellingShingle Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
Monsalvo, Ana Clara
Subtipo H1N1 del Virus de la Influenza A
Pandemias
Virus de la Influenza A
title_short Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
title_full Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
title_fullStr Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
title_full_unstemmed Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
title_sort Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
dc.creator.none.fl_str_mv Monsalvo, Ana Clara
Batalle, Juan P.
Lopez, M. Florencia
Krause, Jens C.
Klemenc, Jennifer
Zea, Johanna
Maskin, Bernardo
Bugna, Jimena
Rubinstein, Carlos
Aguilar, Leandro
Dalurzo, Liliana
Libster, Romina
Savy, Vilma L.
Baumeister, Elsa
Aguilar, Liliana
Cabral, Graciela
Font, Julia
Solari, Liliana
Weller, Kevin P.
Johnson, Joyce
Echavarria, Marcela
Edwards, Kathryn M.
Chappell, James D.
Crowe, James E.
Williams, John V.
Melendi, Guillermina A.
Polack, Fernando P.
author Monsalvo, Ana Clara
author_facet Monsalvo, Ana Clara
Batalle, Juan P.
Lopez, M. Florencia
Krause, Jens C.
Klemenc, Jennifer
Zea, Johanna
Maskin, Bernardo
Bugna, Jimena
Rubinstein, Carlos
Aguilar, Leandro
Dalurzo, Liliana
Libster, Romina
Savy, Vilma L.
Baumeister, Elsa
Aguilar, Liliana
Cabral, Graciela
Font, Julia
Solari, Liliana
Weller, Kevin P.
Johnson, Joyce
Echavarria, Marcela
Edwards, Kathryn M.
Chappell, James D.
Crowe, James E.
Williams, John V.
Melendi, Guillermina A.
Polack, Fernando P.
author_role author
author2 Batalle, Juan P.
Lopez, M. Florencia
Krause, Jens C.
Klemenc, Jennifer
Zea, Johanna
Maskin, Bernardo
Bugna, Jimena
Rubinstein, Carlos
Aguilar, Leandro
Dalurzo, Liliana
Libster, Romina
Savy, Vilma L.
Baumeister, Elsa
Aguilar, Liliana
Cabral, Graciela
Font, Julia
Solari, Liliana
Weller, Kevin P.
Johnson, Joyce
Echavarria, Marcela
Edwards, Kathryn M.
Chappell, James D.
Crowe, James E.
Williams, John V.
Melendi, Guillermina A.
Polack, Fernando P.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Subtipo H1N1 del Virus de la Influenza A
Pandemias
Virus de la Influenza A
topic Subtipo H1N1 del Virus de la Influenza A
Pandemias
Virus de la Influenza A
dc.description.none.fl_txt_mv Fil: Monsalvo, Ana Clara. Fundacion INFANT, Buenos Aires; Argentina.
Fil: Batalle, Juan P. Fundacion INFANT, Buenos Aires; Argentina.
Fil: Lopez, M Florencia. Fundacion INFANT, Buenos Aires; Argentina.
Fil: Krause, Jens C. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Klemenc, Jennifer. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Hernandez, Johanna Zea. . Fundacion INFANT, Buenos Aires; Argentina.
Fil: Maskin, Bernardo. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.
Fil: Bugna, Jimena. Fundacion INFANT, Buenos Aires; Argentina.
Fil: Rubinstein, Carlos. Hospital Dr Federico Abete, Malvinas Argentinas, Buenos Aires; Argentina.
Fil: Aguilar, Leandro. Hospital Dr Federico Abete, Malvinas Argentinas, Buenos Aires; Argentina.
Fil: Dalurzo, Liliana. Hospital Italiano, Buenos Aires; Argentina.
Fil: Libster, Romina. Fundacion INFANT, Buenos Aires; Argentina.
Fil: Savy, Vilma. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Baumeister, Elsa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Aguilar, Liliana. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.
Fil: Cabral, Graciela. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.
Fil: Font, Julia. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.
Fil: Solari, Liliana. Hospital Nacional Prof. Alejandro Posadas, Buenos Aires; Argentina.
Fil: Weller, Kevin P. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Johnson, Joyce. Department of Pathology, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Echavarria, Marcela. Department of Microbiology, CEMIC, Buenos Aires; Argentina.
Fil: Edwards, Kathryn M. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Chappell, James D. Department of Pathology, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Crowe, James E. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Williams, John V. Department of Pediatrics, Vanderbilt University, Nashville, TN; Estados Unidos.
Fil: Melendi, Guillermina A. Fundacion INFANT, Buenos Aires; Argentina.
Fil: Polack, Fernando P. Fundacion INFANT, Buenos Aires; Argentina.
Pandemic influenza viruses often cause severe disease in middle-aged adults without preexisting comorbidities. The mechanism of illness associated with severe disease in this age group is not well understood. Here we find preexisting serum antibodies that cross-react with, but do not protect against, 2009 H1N1 influenza virus in middle-aged adults. Nonprotective antibody is associated with immune complex-mediated disease after infection. We detected high titers of serum antibody of low avidity for H1-2009 antigen, and low-avidity pulmonary immune complexes against the same protein, in severely ill individuals. Moreover, C4d deposition--a marker of complement activation mediated by immune complexes--was present in lung sections of fatal cases. Archived lung sections from middle-aged adults with confirmed fatal influenza 1957 H2N2 infection revealed a similar mechanism of illness. These observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics.
description Fil: Monsalvo, Ana Clara. Fundacion INFANT, Buenos Aires; Argentina.
publishDate 2011
dc.date.none.fl_str_mv 2011-02
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1546-170X
http://sgc.anlis.gob.ar/handle/123456789/472
identifier_str_mv 1546-170X
url http://sgc.anlis.gob.ar/handle/123456789/472
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nature Medicine
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv Nature medicine 2011; 17(2): 195-199.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
_version_ 1844621852784197632
score 12.559606