Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses

Autores
Alvarez, María G; Bertocchi, Graciela Luciana; Cooley, Gretchen; Albareda, María Cecilia; Viotti, Rodolfo; Pérez-Mazliah, Damián E; Lococo, Bruno; Castro Eiro, Melisa D; Laucella, Susana A.; Tarleton, Rick L
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Alvarez, María G. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina.
Fil: Bertocchi, Graciela Luciana. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina.
Fil: Cooley, Gretchen. Center for Tropical and Emerging Global Diseases, Athens, Georgia; Estados Unidos.
Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Viotti, Rodolfo. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina.
Fil: Pérez-Mazliah, Damián E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Lococo, Bruno. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina.
Fil: Castro Eiro, Melisa D. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Tarleton, Rick L. Center for Tropical and Emerging Global Diseases, Athens, Georgia; Estados Unidos.
Chagas disease is the highest impact parasitic disease in Latin America. We have proposed that changes in Trypanosoma cruzi-specific immune responses might serve as surrogate indicators of treatment success. Herein, we addressed in a long-term follow-up study whether cure achieved after treatment can be predicted by changes in non-conventional indexes of anti-parasite serological and T cell activities.
Fuente
PLoS neglected tropical diseases 2016; 10(4):e0004657.
Materia
Enfermedad de Chagas
Trypanosoma cruzi
América Latina
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/1426
Acceder
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network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell ResponsesAlvarez, María GBertocchi, Graciela LucianaCooley, GretchenAlbareda, María CeciliaViotti, RodolfoPérez-Mazliah, Damián ELococo, BrunoCastro Eiro, Melisa DLaucella, Susana A.Tarleton, Rick LEnfermedad de ChagasTrypanosoma cruziAmérica LatinaFil: Alvarez, María G. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina.Fil: Bertocchi, Graciela Luciana. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina.Fil: Cooley, Gretchen. Center for Tropical and Emerging Global Diseases, Athens, Georgia; Estados Unidos.Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Viotti, Rodolfo. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina.Fil: Pérez-Mazliah, Damián E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Lococo, Bruno. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina.Fil: Castro Eiro, Melisa D. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Tarleton, Rick L. Center for Tropical and Emerging Global Diseases, Athens, Georgia; Estados Unidos.Chagas disease is the highest impact parasitic disease in Latin America. We have proposed that changes in Trypanosoma cruzi-specific immune responses might serve as surrogate indicators of treatment success. Herein, we addressed in a long-term follow-up study whether cure achieved after treatment can be predicted by changes in non-conventional indexes of anti-parasite serological and T cell activities.Yes2016-04-29info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1935-2735http://sgc.anlis.gob.ar/handle/123456789/142610.1371/journal.pntd.0004657PLoS neglected tropical diseases 2016; 10(4):e0004657.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISPLoS neglected tropical diseasesenginfo:eu-repo/semantics/openAccess2025-09-11T10:51:15Zoai:sgc.anlis.gob.ar:123456789/1426Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-11 10:51:16.238Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses
title Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses
spellingShingle Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses
Alvarez, María G
Enfermedad de Chagas
Trypanosoma cruzi
América Latina
title_short Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses
title_full Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses
title_fullStr Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses
title_full_unstemmed Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses
title_sort Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses
dc.creator.none.fl_str_mv Alvarez, María G
Bertocchi, Graciela Luciana
Cooley, Gretchen
Albareda, María Cecilia
Viotti, Rodolfo
Pérez-Mazliah, Damián E
Lococo, Bruno
Castro Eiro, Melisa D
Laucella, Susana A.
Tarleton, Rick L
author Alvarez, María G
author_facet Alvarez, María G
Bertocchi, Graciela Luciana
Cooley, Gretchen
Albareda, María Cecilia
Viotti, Rodolfo
Pérez-Mazliah, Damián E
Lococo, Bruno
Castro Eiro, Melisa D
Laucella, Susana A.
Tarleton, Rick L
author_role author
author2 Bertocchi, Graciela Luciana
Cooley, Gretchen
Albareda, María Cecilia
Viotti, Rodolfo
Pérez-Mazliah, Damián E
Lococo, Bruno
Castro Eiro, Melisa D
Laucella, Susana A.
Tarleton, Rick L
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Enfermedad de Chagas
Trypanosoma cruzi
América Latina
topic Enfermedad de Chagas
Trypanosoma cruzi
América Latina
dc.description.none.fl_txt_mv Fil: Alvarez, María G. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina.
Fil: Bertocchi, Graciela Luciana. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina.
Fil: Cooley, Gretchen. Center for Tropical and Emerging Global Diseases, Athens, Georgia; Estados Unidos.
Fil: Albareda, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Viotti, Rodolfo. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina.
Fil: Pérez-Mazliah, Damián E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Lococo, Bruno. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina.
Fil: Castro Eiro, Melisa D. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Tarleton, Rick L. Center for Tropical and Emerging Global Diseases, Athens, Georgia; Estados Unidos.
Chagas disease is the highest impact parasitic disease in Latin America. We have proposed that changes in Trypanosoma cruzi-specific immune responses might serve as surrogate indicators of treatment success. Herein, we addressed in a long-term follow-up study whether cure achieved after treatment can be predicted by changes in non-conventional indexes of anti-parasite serological and T cell activities.
description Fil: Alvarez, María G. Hospital Interzonal General de Agudos Eva Perón, Buenos Aires; Argentina.
publishDate 2016
dc.date.none.fl_str_mv 2016-04-29
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1935-2735
http://sgc.anlis.gob.ar/handle/123456789/1426
10.1371/journal.pntd.0004657
identifier_str_mv 1935-2735
10.1371/journal.pntd.0004657
url http://sgc.anlis.gob.ar/handle/123456789/1426
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS neglected tropical diseases
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Yes
publisher.none.fl_str_mv Yes
dc.source.none.fl_str_mv PLoS neglected tropical diseases 2016; 10(4):e0004657.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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score 12.993085

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