Emergence and spread of Neisseria gonorrhoeae isolates with decreased susceptibility to extended-spectrum Cephalosporins in Argentina, 2009 to 2013

Autores
Gianecini, Ricardo A; Romero, María Mercedes; Oviedo, Claudia; Vacchino, Martin; Galarza, Patricia G.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Gianecini, Ricardo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Romero, Maria de Las Mercedes. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Oviedo, Claudia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Vacchino, Martin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Galarza, Patricia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Background: The emergence of Neisseria gonorrhoeae strains with decreased susceptibility to cephalosporins represents a major concern globally. The aim of this study was to examine the phenotypic and molecular characteristics of N. gonorrhoeae isolates with decreased susceptibility to ceftriaxone and cefixime in Argentina. Methods: A total of 1987 isolates were collected during 2009 and 2013. The susceptibility to penicillin G, tetracycline, ciprofloxacin, cefixime, ceftriaxone, and azithromycin was determined using the agar dilution method. The major extended-spectrum cephalosporin resistance determinants (penA, mtrR, and porB1b) were sequenced in 42 N. gonorrhoeae isolates that showed decreased susceptibility to ceftriaxone (minimum inhibitory concentration [MIC], 0.06-0.125 mg/L) and cefixime (MIC, 0.125-0.25 mg/L). Genotyping by N. gonorrhoeae multiantigen sequence typing (NG-MAST) was performed. Results: Between 2009 and 2013, there was a shift in the modal MICs for ceftriaxone. Among the 42 isolates exhibiting decreased susceptibility to ceftriaxone and cefixime, 95.2% were resistant to penicillin G, 95.2% to tetracycline, 97.6% to ciprofloxacin, and 33.3% to azithromycin. Thirty-five (83.3%) of the 42 isolates had a mosaic penA allele XXXIV, which has been previously associated with resistance to ceftriaxone and cefixime as well as treatment failures. The isolates that contained the mosaic penicillin-binding protein 2 (PBP2) XXXIV were associated with NG-MAST ST1407 or closely related genotypes. Conclusions: In Argentina, N. gonorrhoeae isolates with decreased susceptibility to cefixime and ceftriaxone have now emerged, mostly due to the introduction of the internationally spread multidrug-resistant NG-MAST ST1407.
Fuente
Sexually Transmitted Diseases 2017; 44(6):351-355
Materia
Antibacterianos
Argentina
Cefixima
Ceftriaxona
Resistencia a las Cefalosporinas
Gonorrea
Humanos
Pruebas de Sensibilidad Microbiana
Tipificación Molecular
Neisseria gonorrhoeae
Filogenia
Vigilancia de Guardia
Análisis de Secuencia de ADN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/1813

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oai_identifier_str oai:sgc.anlis.gob.ar:Publications/123456789/1813
network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Emergence and spread of Neisseria gonorrhoeae isolates with decreased susceptibility to extended-spectrum Cephalosporins in Argentina, 2009 to 2013Gianecini, Ricardo ARomero, María MercedesOviedo, ClaudiaVacchino, MartinGalarza, Patricia G.AntibacterianosArgentinaCefiximaCeftriaxonaResistencia a las CefalosporinasGonorreaHumanosPruebas de Sensibilidad MicrobianaTipificación MolecularNeisseria gonorrhoeaeFilogeniaVigilancia de GuardiaAnálisis de Secuencia de ADNFil: Gianecini, Ricardo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Romero, Maria de Las Mercedes. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Oviedo, Claudia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Vacchino, Martin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Fil: Galarza, Patricia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.Background: The emergence of Neisseria gonorrhoeae strains with decreased susceptibility to cephalosporins represents a major concern globally. The aim of this study was to examine the phenotypic and molecular characteristics of N. gonorrhoeae isolates with decreased susceptibility to ceftriaxone and cefixime in Argentina. Methods: A total of 1987 isolates were collected during 2009 and 2013. The susceptibility to penicillin G, tetracycline, ciprofloxacin, cefixime, ceftriaxone, and azithromycin was determined using the agar dilution method. The major extended-spectrum cephalosporin resistance determinants (penA, mtrR, and porB1b) were sequenced in 42 N. gonorrhoeae isolates that showed decreased susceptibility to ceftriaxone (minimum inhibitory concentration [MIC], 0.06-0.125 mg/L) and cefixime (MIC, 0.125-0.25 mg/L). Genotyping by N. gonorrhoeae multiantigen sequence typing (NG-MAST) was performed. Results: Between 2009 and 2013, there was a shift in the modal MICs for ceftriaxone. Among the 42 isolates exhibiting decreased susceptibility to ceftriaxone and cefixime, 95.2% were resistant to penicillin G, 95.2% to tetracycline, 97.6% to ciprofloxacin, and 33.3% to azithromycin. Thirty-five (83.3%) of the 42 isolates had a mosaic penA allele XXXIV, which has been previously associated with resistance to ceftriaxone and cefixime as well as treatment failures. The isolates that contained the mosaic penicillin-binding protein 2 (PBP2) XXXIV were associated with NG-MAST ST1407 or closely related genotypes. Conclusions: In Argentina, N. gonorrhoeae isolates with decreased susceptibility to cefixime and ceftriaxone have now emerged, mostly due to the introduction of the internationally spread multidrug-resistant NG-MAST ST1407.Lippincott, Williams & Wilkins2017-06info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://sgc.anlis.gob.ar/handle/123456789/181310.1097/OLQ.0000000000000603Sexually Transmitted Diseases 2017; 44(6):351-355reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLIS#PLACEHOLDER_PARENT_METADATA_VALUE#datasetsSexually transmitted diseasesenginfo:eu-repo/semantics/openAccess2025-09-29T14:30:28Zoai:sgc.anlis.gob.ar:Publications/123456789/1813Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:28.491Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Emergence and spread of Neisseria gonorrhoeae isolates with decreased susceptibility to extended-spectrum Cephalosporins in Argentina, 2009 to 2013
title Emergence and spread of Neisseria gonorrhoeae isolates with decreased susceptibility to extended-spectrum Cephalosporins in Argentina, 2009 to 2013
spellingShingle Emergence and spread of Neisseria gonorrhoeae isolates with decreased susceptibility to extended-spectrum Cephalosporins in Argentina, 2009 to 2013
Gianecini, Ricardo A
Antibacterianos
Argentina
Cefixima
Ceftriaxona
Resistencia a las Cefalosporinas
Gonorrea
Humanos
Pruebas de Sensibilidad Microbiana
Tipificación Molecular
Neisseria gonorrhoeae
Filogenia
Vigilancia de Guardia
Análisis de Secuencia de ADN
title_short Emergence and spread of Neisseria gonorrhoeae isolates with decreased susceptibility to extended-spectrum Cephalosporins in Argentina, 2009 to 2013
title_full Emergence and spread of Neisseria gonorrhoeae isolates with decreased susceptibility to extended-spectrum Cephalosporins in Argentina, 2009 to 2013
title_fullStr Emergence and spread of Neisseria gonorrhoeae isolates with decreased susceptibility to extended-spectrum Cephalosporins in Argentina, 2009 to 2013
title_full_unstemmed Emergence and spread of Neisseria gonorrhoeae isolates with decreased susceptibility to extended-spectrum Cephalosporins in Argentina, 2009 to 2013
title_sort Emergence and spread of Neisseria gonorrhoeae isolates with decreased susceptibility to extended-spectrum Cephalosporins in Argentina, 2009 to 2013
dc.creator.none.fl_str_mv Gianecini, Ricardo A
Romero, María Mercedes
Oviedo, Claudia
Vacchino, Martin
Galarza, Patricia G.
author Gianecini, Ricardo A
author_facet Gianecini, Ricardo A
Romero, María Mercedes
Oviedo, Claudia
Vacchino, Martin
Galarza, Patricia G.
author_role author
author2 Romero, María Mercedes
Oviedo, Claudia
Vacchino, Martin
Galarza, Patricia G.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Antibacterianos
Argentina
Cefixima
Ceftriaxona
Resistencia a las Cefalosporinas
Gonorrea
Humanos
Pruebas de Sensibilidad Microbiana
Tipificación Molecular
Neisseria gonorrhoeae
Filogenia
Vigilancia de Guardia
Análisis de Secuencia de ADN
topic Antibacterianos
Argentina
Cefixima
Ceftriaxona
Resistencia a las Cefalosporinas
Gonorrea
Humanos
Pruebas de Sensibilidad Microbiana
Tipificación Molecular
Neisseria gonorrhoeae
Filogenia
Vigilancia de Guardia
Análisis de Secuencia de ADN
dc.description.none.fl_txt_mv Fil: Gianecini, Ricardo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Romero, Maria de Las Mercedes. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Oviedo, Claudia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Vacchino, Martin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Galarza, Patricia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Background: The emergence of Neisseria gonorrhoeae strains with decreased susceptibility to cephalosporins represents a major concern globally. The aim of this study was to examine the phenotypic and molecular characteristics of N. gonorrhoeae isolates with decreased susceptibility to ceftriaxone and cefixime in Argentina. Methods: A total of 1987 isolates were collected during 2009 and 2013. The susceptibility to penicillin G, tetracycline, ciprofloxacin, cefixime, ceftriaxone, and azithromycin was determined using the agar dilution method. The major extended-spectrum cephalosporin resistance determinants (penA, mtrR, and porB1b) were sequenced in 42 N. gonorrhoeae isolates that showed decreased susceptibility to ceftriaxone (minimum inhibitory concentration [MIC], 0.06-0.125 mg/L) and cefixime (MIC, 0.125-0.25 mg/L). Genotyping by N. gonorrhoeae multiantigen sequence typing (NG-MAST) was performed. Results: Between 2009 and 2013, there was a shift in the modal MICs for ceftriaxone. Among the 42 isolates exhibiting decreased susceptibility to ceftriaxone and cefixime, 95.2% were resistant to penicillin G, 95.2% to tetracycline, 97.6% to ciprofloxacin, and 33.3% to azithromycin. Thirty-five (83.3%) of the 42 isolates had a mosaic penA allele XXXIV, which has been previously associated with resistance to ceftriaxone and cefixime as well as treatment failures. The isolates that contained the mosaic penicillin-binding protein 2 (PBP2) XXXIV were associated with NG-MAST ST1407 or closely related genotypes. Conclusions: In Argentina, N. gonorrhoeae isolates with decreased susceptibility to cefixime and ceftriaxone have now emerged, mostly due to the introduction of the internationally spread multidrug-resistant NG-MAST ST1407.
description Fil: Gianecini, Ricardo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
publishDate 2017
dc.date.none.fl_str_mv 2017-06
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sgc.anlis.gob.ar/handle/123456789/1813
10.1097/OLQ.0000000000000603
url http://sgc.anlis.gob.ar/handle/123456789/1813
identifier_str_mv 10.1097/OLQ.0000000000000603
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
datasets
Sexually transmitted diseases
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins
publisher.none.fl_str_mv Lippincott, Williams & Wilkins
dc.source.none.fl_str_mv Sexually Transmitted Diseases 2017; 44(6):351-355
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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