The characteristics and antigenic properties of recently emerged subclade 3C.3a and 3C.2a human influenza A(H3N2) viruses passaged in MDCK cells

• Autores: Lin, Yipu; Wharton, Stephen A; Whittaker, Lynne; Dai, Mian; Ermetal, Burcu; Lo, Janice; Pontoriero, Andrea; Baumeister, Elsa; Daniels, Rodney S; McCauley, John W
• Año de publicación: 2017
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Influenza and Other Respiratory Viruses 2017; 11(3):263-274.
• Materia: Virus de la Influenza A; Inmunogenicidad Vacunal
• Institución: Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"

Fil: Lin, Yipu. The Francis Crick Institute, London; Reino Unido.
Fil: Wharton, Stephen A. The Francis Crick Institute, London; Reino Unido.
Fil: Whittaker, Lynne. The Francis Crick Institute, London; Reino Unido.
Fil: Dai, Mian. The Francis Crick Institute, London; Reino Unido.
Fil: Ermetal, Burcu. The Francis Crick Institute, London; Reino Unido.
Fil: Lo, Janice. Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region; China.
Fil: Pontoriero, Andrea. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Baumeister, Elsa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Daniels, Rodney S. The Francis Crick Institute, London; Reino Unido.
Fil: McCauley, John W. The Francis Crick Institute, London; Reino Unido.
Two new subclades of influenza A(H3N2) viruses became prominent during the 2014-2015 Northern Hemisphere influenza season. The HA glycoproteins of these viruses showed sequence changes previously associated with alterations in receptor-binding properties. To address how these changes influence virus propagation, viruses were isolated and propagated in conventional MDCK cells and MDCK-SIAT1 cells, cells with enhanced expression of the human receptor for the virus, and analysed at each passage.