Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children
- Autores
- García, Miriam Martin; De Rissio, Ana María; Villalonga, Ximena; Mengoni, Eleonora; Cardoni, Rita L.
- Año de publicación
- 2008
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: García, Miriam Martin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: De Rissio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Villalonga, Ximena. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Mengoni, Eleonora. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Cardoni, Rita L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Most congenital transmissions of Trypanosoma cruzi are not detected. As the levels of mediators regulating the immune response might be different in the absence or in the presence of transmission, we explored the levels of tumor necrosis factor (TNF) and soluble TNF receptors TNF-R1 and -R2 in T. cruzi–infected pregnant women and the neonates. We previously found that the circulating levels of TNF were higher in non-transmitting than in transmitting pregnant women. This observation has now been extended to the spontaneous release of TNF by peripheral blood leukocytes (PBLs) that was also higher in non-transmitting than in transmitting pregnant women. As their mothers, non-infected neonates had higher circulating levels of TNF than congenitally infected children. The circulating levels of sTNF-R1 increased in non-transmitting and transmitting mothers and in infected and non-infected neonates. The circulating levels of sTNF-R2 were ∼60% higher in infected than in non-infected neonates (1,635 ± 101 and 1,027 ± 100 pg/mL, respectively) and remained higher at 1 year of age. This important increase, only observed in infected neonates, could be useful to orientate to the presence of vertical transmission of T. cruzi infection. - Fuente
- The American Journal of Tropical Medicine and Hygiene 2008; 78(3): 499–503.
- Materia
-
Enfermedad de Chagas
Transmisión Vertical de Enfermedad Infecciosa
Interleucina-10
Complicaciones Parasitarias del Embarazo
Receptores Tipo I de Factores de Necrosis Tumoral
Receptores Tipo II del Factor de Necrosis Tumoral
Trypanosoma cruzi
Factor de Necrosis Tumoral alfa
Leucocitos
Recién Nacido
Lactante
Envejecimiento
Enfermedad Crónica - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
- Institución
- Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
- OAI Identificador
- oai:sgc.anlis.gob.ar:Publications/123456789/244
Ver los metadatos del registro completo
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Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their childrenGarcía, Miriam MartinDe Rissio, Ana MaríaVillalonga, XimenaMengoni, EleonoraCardoni, Rita L.Enfermedad de ChagasTransmisión Vertical de Enfermedad InfecciosaInterleucina-10Complicaciones Parasitarias del EmbarazoReceptores Tipo I de Factores de Necrosis TumoralReceptores Tipo II del Factor de Necrosis TumoralTrypanosoma cruziFactor de Necrosis Tumoral alfaLeucocitosRecién NacidoLactanteEnvejecimientoEnfermedad CrónicaFil: García, Miriam Martin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: De Rissio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Villalonga, Ximena. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Mengoni, Eleonora. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Cardoni, Rita L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Most congenital transmissions of Trypanosoma cruzi are not detected. As the levels of mediators regulating the immune response might be different in the absence or in the presence of transmission, we explored the levels of tumor necrosis factor (TNF) and soluble TNF receptors TNF-R1 and -R2 in T. cruzi–infected pregnant women and the neonates. We previously found that the circulating levels of TNF were higher in non-transmitting than in transmitting pregnant women. This observation has now been extended to the spontaneous release of TNF by peripheral blood leukocytes (PBLs) that was also higher in non-transmitting than in transmitting pregnant women. As their mothers, non-infected neonates had higher circulating levels of TNF than congenitally infected children. The circulating levels of sTNF-R1 increased in non-transmitting and transmitting mothers and in infected and non-infected neonates. The circulating levels of sTNF-R2 were ∼60% higher in infected than in non-infected neonates (1,635 ± 101 and 1,027 ± 100 pg/mL, respectively) and remained higher at 1 year of age. This important increase, only observed in infected neonates, could be useful to orientate to the presence of vertical transmission of T. cruzi infection.American Society of Tropical Medicine and Hygiene2008info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1476-1645http://www.ajtmh.org/content/78/3/499.full.pdf+htmlhttp://sgc.anlis.gob.ar/handle/123456789/244The American Journal of Tropical Medicine and Hygiene 2008; 78(3): 499–503.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISThe American journal of tropical medicine and hygieneenginfo:eu-repo/semantics/openAccess2025-09-29T14:29:54Zoai:sgc.anlis.gob.ar:Publications/123456789/244Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:29:55.207Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false |
dc.title.none.fl_str_mv |
Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children |
title |
Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children |
spellingShingle |
Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children García, Miriam Martin Enfermedad de Chagas Transmisión Vertical de Enfermedad Infecciosa Interleucina-10 Complicaciones Parasitarias del Embarazo Receptores Tipo I de Factores de Necrosis Tumoral Receptores Tipo II del Factor de Necrosis Tumoral Trypanosoma cruzi Factor de Necrosis Tumoral alfa Leucocitos Recién Nacido Lactante Envejecimiento Enfermedad Crónica |
title_short |
Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children |
title_full |
Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children |
title_fullStr |
Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children |
title_full_unstemmed |
Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children |
title_sort |
Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children |
dc.creator.none.fl_str_mv |
García, Miriam Martin De Rissio, Ana María Villalonga, Ximena Mengoni, Eleonora Cardoni, Rita L. |
author |
García, Miriam Martin |
author_facet |
García, Miriam Martin De Rissio, Ana María Villalonga, Ximena Mengoni, Eleonora Cardoni, Rita L. |
author_role |
author |
author2 |
De Rissio, Ana María Villalonga, Ximena Mengoni, Eleonora Cardoni, Rita L. |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Enfermedad de Chagas Transmisión Vertical de Enfermedad Infecciosa Interleucina-10 Complicaciones Parasitarias del Embarazo Receptores Tipo I de Factores de Necrosis Tumoral Receptores Tipo II del Factor de Necrosis Tumoral Trypanosoma cruzi Factor de Necrosis Tumoral alfa Leucocitos Recién Nacido Lactante Envejecimiento Enfermedad Crónica |
topic |
Enfermedad de Chagas Transmisión Vertical de Enfermedad Infecciosa Interleucina-10 Complicaciones Parasitarias del Embarazo Receptores Tipo I de Factores de Necrosis Tumoral Receptores Tipo II del Factor de Necrosis Tumoral Trypanosoma cruzi Factor de Necrosis Tumoral alfa Leucocitos Recién Nacido Lactante Envejecimiento Enfermedad Crónica |
dc.description.none.fl_txt_mv |
Fil: García, Miriam Martin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: De Rissio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Villalonga, Ximena. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Mengoni, Eleonora. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Fil: Cardoni, Rita L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. Most congenital transmissions of Trypanosoma cruzi are not detected. As the levels of mediators regulating the immune response might be different in the absence or in the presence of transmission, we explored the levels of tumor necrosis factor (TNF) and soluble TNF receptors TNF-R1 and -R2 in T. cruzi–infected pregnant women and the neonates. We previously found that the circulating levels of TNF were higher in non-transmitting than in transmitting pregnant women. This observation has now been extended to the spontaneous release of TNF by peripheral blood leukocytes (PBLs) that was also higher in non-transmitting than in transmitting pregnant women. As their mothers, non-infected neonates had higher circulating levels of TNF than congenitally infected children. The circulating levels of sTNF-R1 increased in non-transmitting and transmitting mothers and in infected and non-infected neonates. The circulating levels of sTNF-R2 were ∼60% higher in infected than in non-infected neonates (1,635 ± 101 and 1,027 ± 100 pg/mL, respectively) and remained higher at 1 year of age. This important increase, only observed in infected neonates, could be useful to orientate to the presence of vertical transmission of T. cruzi infection. |
description |
Fil: García, Miriam Martin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008 |
dc.type.none.fl_str_mv |
info:ar-repo/semantics/articulo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
1476-1645 http://www.ajtmh.org/content/78/3/499.full.pdf+html http://sgc.anlis.gob.ar/handle/123456789/244 |
identifier_str_mv |
1476-1645 |
url |
http://www.ajtmh.org/content/78/3/499.full.pdf+html http://sgc.anlis.gob.ar/handle/123456789/244 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
The American journal of tropical medicine and hygiene |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
publisher.none.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
dc.source.none.fl_str_mv |
The American Journal of Tropical Medicine and Hygiene 2008; 78(3): 499–503. reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" instacron:ANLIS |
reponame_str |
Sistema de Gestión del Conocimiento ANLIS MALBRÁN |
collection |
Sistema de Gestión del Conocimiento ANLIS MALBRÁN |
instname_str |
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
instacron_str |
ANLIS |
institution |
ANLIS |
repository.name.fl_str_mv |
Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
repository.mail.fl_str_mv |
biblioteca@anlis.gov.ar |
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1844621851256422400 |
score |
12.559606 |