Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children

Autores
García, Miriam Martin; De Rissio, Ana María; Villalonga, Ximena; Mengoni, Eleonora; Cardoni, Rita L.
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: García, Miriam Martin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: De Rissio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Villalonga, Ximena. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Mengoni, Eleonora. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Cardoni, Rita L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Most congenital transmissions of Trypanosoma cruzi are not detected. As the levels of mediators regulating the immune response might be different in the absence or in the presence of transmission, we explored the levels of tumor necrosis factor (TNF) and soluble TNF receptors TNF-R1 and -R2 in T. cruzi–infected pregnant women and the neonates. We previously found that the circulating levels of TNF were higher in non-transmitting than in transmitting pregnant women. This observation has now been extended to the spontaneous release of TNF by peripheral blood leukocytes (PBLs) that was also higher in non-transmitting than in transmitting pregnant women. As their mothers, non-infected neonates had higher circulating levels of TNF than congenitally infected children. The circulating levels of sTNF-R1 increased in non-transmitting and transmitting mothers and in infected and non-infected neonates. The circulating levels of sTNF-R2 were ∼60% higher in infected than in non-infected neonates (1,635 ± 101 and 1,027 ± 100 pg/mL, respectively) and remained higher at 1 year of age. This important increase, only observed in infected neonates, could be useful to orientate to the presence of vertical transmission of T. cruzi infection.
Fuente
The American Journal of Tropical Medicine and Hygiene 2008; 78(3): 499–503.
Materia
Enfermedad de Chagas
Transmisión Vertical de Enfermedad Infecciosa
Interleucina-10
Complicaciones Parasitarias del Embarazo
Receptores Tipo I de Factores de Necrosis Tumoral
Receptores Tipo II del Factor de Necrosis Tumoral
Trypanosoma cruzi
Factor de Necrosis Tumoral alfa
Leucocitos
Recién Nacido
Lactante
Envejecimiento
Enfermedad Crónica
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:Publications/123456789/244

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network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their childrenGarcía, Miriam MartinDe Rissio, Ana MaríaVillalonga, XimenaMengoni, EleonoraCardoni, Rita L.Enfermedad de ChagasTransmisión Vertical de Enfermedad InfecciosaInterleucina-10Complicaciones Parasitarias del EmbarazoReceptores Tipo I de Factores de Necrosis TumoralReceptores Tipo II del Factor de Necrosis TumoralTrypanosoma cruziFactor de Necrosis Tumoral alfaLeucocitosRecién NacidoLactanteEnvejecimientoEnfermedad CrónicaFil: García, Miriam Martin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: De Rissio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Villalonga, Ximena. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Mengoni, Eleonora. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Cardoni, Rita L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Most congenital transmissions of Trypanosoma cruzi are not detected. As the levels of mediators regulating the immune response might be different in the absence or in the presence of transmission, we explored the levels of tumor necrosis factor (TNF) and soluble TNF receptors TNF-R1 and -R2 in T. cruzi–infected pregnant women and the neonates. We previously found that the circulating levels of TNF were higher in non-transmitting than in transmitting pregnant women. This observation has now been extended to the spontaneous release of TNF by peripheral blood leukocytes (PBLs) that was also higher in non-transmitting than in transmitting pregnant women. As their mothers, non-infected neonates had higher circulating levels of TNF than congenitally infected children. The circulating levels of sTNF-R1 increased in non-transmitting and transmitting mothers and in infected and non-infected neonates. The circulating levels of sTNF-R2 were ∼60% higher in infected than in non-infected neonates (1,635 ± 101 and 1,027 ± 100 pg/mL, respectively) and remained higher at 1 year of age. This important increase, only observed in infected neonates, could be useful to orientate to the presence of vertical transmission of T. cruzi infection.American Society of Tropical Medicine and Hygiene2008info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1476-1645http://www.ajtmh.org/content/78/3/499.full.pdf+htmlhttp://sgc.anlis.gob.ar/handle/123456789/244The American Journal of Tropical Medicine and Hygiene 2008; 78(3): 499–503.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISThe American journal of tropical medicine and hygieneenginfo:eu-repo/semantics/openAccess2025-09-29T14:29:54Zoai:sgc.anlis.gob.ar:Publications/123456789/244Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:29:55.207Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children
title Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children
spellingShingle Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children
García, Miriam Martin
Enfermedad de Chagas
Transmisión Vertical de Enfermedad Infecciosa
Interleucina-10
Complicaciones Parasitarias del Embarazo
Receptores Tipo I de Factores de Necrosis Tumoral
Receptores Tipo II del Factor de Necrosis Tumoral
Trypanosoma cruzi
Factor de Necrosis Tumoral alfa
Leucocitos
Recién Nacido
Lactante
Envejecimiento
Enfermedad Crónica
title_short Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children
title_full Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children
title_fullStr Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children
title_full_unstemmed Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children
title_sort Soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and -R2) in pregnant women chronically infected with Trypanosoma cruzi and their children
dc.creator.none.fl_str_mv García, Miriam Martin
De Rissio, Ana María
Villalonga, Ximena
Mengoni, Eleonora
Cardoni, Rita L.
author García, Miriam Martin
author_facet García, Miriam Martin
De Rissio, Ana María
Villalonga, Ximena
Mengoni, Eleonora
Cardoni, Rita L.
author_role author
author2 De Rissio, Ana María
Villalonga, Ximena
Mengoni, Eleonora
Cardoni, Rita L.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Enfermedad de Chagas
Transmisión Vertical de Enfermedad Infecciosa
Interleucina-10
Complicaciones Parasitarias del Embarazo
Receptores Tipo I de Factores de Necrosis Tumoral
Receptores Tipo II del Factor de Necrosis Tumoral
Trypanosoma cruzi
Factor de Necrosis Tumoral alfa
Leucocitos
Recién Nacido
Lactante
Envejecimiento
Enfermedad Crónica
topic Enfermedad de Chagas
Transmisión Vertical de Enfermedad Infecciosa
Interleucina-10
Complicaciones Parasitarias del Embarazo
Receptores Tipo I de Factores de Necrosis Tumoral
Receptores Tipo II del Factor de Necrosis Tumoral
Trypanosoma cruzi
Factor de Necrosis Tumoral alfa
Leucocitos
Recién Nacido
Lactante
Envejecimiento
Enfermedad Crónica
dc.description.none.fl_txt_mv Fil: García, Miriam Martin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: De Rissio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Villalonga, Ximena. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Mengoni, Eleonora. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Fil: Cardoni, Rita L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
Most congenital transmissions of Trypanosoma cruzi are not detected. As the levels of mediators regulating the immune response might be different in the absence or in the presence of transmission, we explored the levels of tumor necrosis factor (TNF) and soluble TNF receptors TNF-R1 and -R2 in T. cruzi–infected pregnant women and the neonates. We previously found that the circulating levels of TNF were higher in non-transmitting than in transmitting pregnant women. This observation has now been extended to the spontaneous release of TNF by peripheral blood leukocytes (PBLs) that was also higher in non-transmitting than in transmitting pregnant women. As their mothers, non-infected neonates had higher circulating levels of TNF than congenitally infected children. The circulating levels of sTNF-R1 increased in non-transmitting and transmitting mothers and in infected and non-infected neonates. The circulating levels of sTNF-R2 were ∼60% higher in infected than in non-infected neonates (1,635 ± 101 and 1,027 ± 100 pg/mL, respectively) and remained higher at 1 year of age. This important increase, only observed in infected neonates, could be useful to orientate to the presence of vertical transmission of T. cruzi infection.
description Fil: García, Miriam Martin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1476-1645
http://www.ajtmh.org/content/78/3/499.full.pdf+html
http://sgc.anlis.gob.ar/handle/123456789/244
identifier_str_mv 1476-1645
url http://www.ajtmh.org/content/78/3/499.full.pdf+html
http://sgc.anlis.gob.ar/handle/123456789/244
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv The American journal of tropical medicine and hygiene
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv The American Journal of Tropical Medicine and Hygiene 2008; 78(3): 499–503.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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