Several strains of Echinococcus granulosus infect livestock and humans in Argentina

• Autores: Kamenetzky, Laura; Gutierrez, Ariana M.; Canova, S G; Haag, Karen L; Guarnera, Eduardo; Parra, Alberto; Garcia, Gustavo E; Rosenzvit, Mara C.
• Año de publicación: 2002
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: Infection, Genetics and Evolution 2002; 2(2):129-36.
• Materia: Echinococcus granulosus; Variación Genética; Equinococosis
• Institución: Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"

Fil: Kamenetzky, Laura. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Gutierrez, Ariana M. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Canova, S G. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Haag, Karen L. Departamento de Genética, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, CP 15053 Porto Alegre, RS, Brasil.
Fil: Guarnera, Eduardo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Fil: Parra, Alberto. Hospital “Elı́as Médici”(SI.PRO.SA.), CP 4137 Tafı́ del Valle, Tucumán; Argentina
Fil: Garcia, Gustavo E. Servicio de Cirugı́a del Hospital Provincial Neuquén, Buenos Aires 450, CP 8300 Neuquén; Argentina.
Fil: Rosenzvit, Mara C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina.
Mitochondrial cytochrome oxidase subunit 1 (CO1) sequencing, Southern blot of a repetitive DNA element and single strand conformation polymorphism of the 5' non-transcribed region of the cytosolic malate dehydrogenase (MDH) gene were used to determine the extent and distribution of Echinococcus granulosus genetic variation in Argentina. Five distinct strains of E. granulosus were shown to exist in the country. The common sheep, Tasmanian sheep, cattle and camel strains were identified in humans. Unlike the situation found in other countries, where the common sheep strain is the major source of human contamination, the Tasmanian sheep and camel strains produced a significant number of human infections in some regions of Argentina. This is the first report of cattle strain in humans in South America. Goats could be the natural intermediate host of the camel strain, which was not identified in humans from other regions so far. More than one genotype was identified in the same geographic area. These findings may have important consequences for human health and the control of hydatid disease. Within-strain differences were also observed, showing the potential of variation of E. granulosus.