Whole-cell Bordetella pertussis vaccine component modulates the mouse immune response to an unrelated soluble antigen

Autores
Lavigne, María Victoria; Castro, Marisa; Mateo, Nancy A; Deluchi, Silvana; Atzori, Carlos; Piudo, Luciana; Calcagno, María; Brero, María Luisa; Manghi, Marcela
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Lavigne, María Victoria. Instituto de Estudios de la Inmunidad Humoral, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires; Argentina.
Fil: Castro, Marisa. Instituto de Estudios de la Inmunidad Humoral, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires; Argentina.
Fil: Mateo, Nancy A. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.
Fil: Deluchi, Silvana. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.
Fil: Atzori, Carlos. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.
Fil: Piudo, Luciana. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.
Fil: Calcagno, María. Departamento de Físico-Matemática, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires; Argentina.
Fil: Brero, María Luisa. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.
Fil: Manghi, Marcela. Instituto de Estudios de la Inmunidad Humoral, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires; Argentina.
Several factors are involved in the selective activation of Th1 or Th2 cells, such as different physical characteristics of antigens and the type of antigen-presenting cells involved in the immune response, among others. To study the influence of a particulate antigen on Th1/Th2 cell differentiation during the immune response to another antigen, we analysed the immune response to tetanus toxoid (soluble antigen) in BALB/c mice immunized with one of the three following vaccines: tetanus and diphtheria toxoids (DT), or DT associated with whole-cell Bordetella pertussis or its soluble antigens (DTPw and DTPa, respectively). Similar total antibody levels were observed for all vaccines. DT vaccine showed a higher IgG1/IgG2a ratio than the similar values observed for DTPw and DTPa vaccines. DT- and DTPa-primed spleen cells showed a Th2 (IL-5) profile while a Th1/Th2 (IFN gamma, IL-5) profile was observed for DTPw. IL-6 was only produced by DTPw-primed cells. Besides, IL-12 levels induced by DTPw were three times higher than the ones induced by both DT and DTPa. Our findings indicate that whole-cell B. pertussis priming modifies the tetanus immune response from Th2 to Th1/Th2 type probably via inflammatory mechanisms. In addition, in the light of conflicting reports regarding the mechanisms of protection induced by DTP vaccines, we studied the pertussis immune response. Only DTPw immunization generated memory T cells capable of proliferating with B. pertussis as an in vitro stimulus. Results might indicate that these cells may not play a key role in protecting against B. pertussis when the host is vaccinated with DTPa.
Fuente
Microbes and infection 2002; 4(8):815-20.
Materia
Bordetella pertussis
Toxoide Tetánico
Vacunas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
none
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/1652

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oai_identifier_str oai:sgc.anlis.gob.ar:123456789/1652
network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Whole-cell Bordetella pertussis vaccine component modulates the mouse immune response to an unrelated soluble antigenLavigne, María VictoriaCastro, MarisaMateo, Nancy ADeluchi, SilvanaAtzori, CarlosPiudo, LucianaCalcagno, MaríaBrero, María LuisaManghi, MarcelaBordetella pertussisToxoide TetánicoVacunasFil: Lavigne, María Victoria. Instituto de Estudios de la Inmunidad Humoral, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires; Argentina.Fil: Castro, Marisa. Instituto de Estudios de la Inmunidad Humoral, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires; Argentina.Fil: Mateo, Nancy A. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.Fil: Deluchi, Silvana. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.Fil: Atzori, Carlos. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.Fil: Piudo, Luciana. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.Fil: Calcagno, María. Departamento de Físico-Matemática, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires; Argentina.Fil: Brero, María Luisa. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.Fil: Manghi, Marcela. Instituto de Estudios de la Inmunidad Humoral, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires; Argentina.Several factors are involved in the selective activation of Th1 or Th2 cells, such as different physical characteristics of antigens and the type of antigen-presenting cells involved in the immune response, among others. To study the influence of a particulate antigen on Th1/Th2 cell differentiation during the immune response to another antigen, we analysed the immune response to tetanus toxoid (soluble antigen) in BALB/c mice immunized with one of the three following vaccines: tetanus and diphtheria toxoids (DT), or DT associated with whole-cell Bordetella pertussis or its soluble antigens (DTPw and DTPa, respectively). Similar total antibody levels were observed for all vaccines. DT vaccine showed a higher IgG1/IgG2a ratio than the similar values observed for DTPw and DTPa vaccines. DT- and DTPa-primed spleen cells showed a Th2 (IL-5) profile while a Th1/Th2 (IFN gamma, IL-5) profile was observed for DTPw. IL-6 was only produced by DTPw-primed cells. Besides, IL-12 levels induced by DTPw were three times higher than the ones induced by both DT and DTPa. Our findings indicate that whole-cell B. pertussis priming modifies the tetanus immune response from Th2 to Th1/Th2 type probably via inflammatory mechanisms. In addition, in the light of conflicting reports regarding the mechanisms of protection induced by DTP vaccines, we studied the pertussis immune response. Only DTPw immunization generated memory T cells capable of proliferating with B. pertussis as an in vitro stimulus. Results might indicate that these cells may not play a key role in protecting against B. pertussis when the host is vaccinated with DTPa.Elsevier2002-07info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1286-4579http://sgc.anlis.gob.ar/handle/123456789/165210.1016/s1286-4579(02)01601-5Microbes and infection 2002; 4(8):815-20.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISMicrobes and infectionnoneinfo:eu-repo/semantics/openAccesseng2025-09-29T14:30:22Zoai:sgc.anlis.gob.ar:123456789/1652Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:22.848Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Whole-cell Bordetella pertussis vaccine component modulates the mouse immune response to an unrelated soluble antigen
title Whole-cell Bordetella pertussis vaccine component modulates the mouse immune response to an unrelated soluble antigen
spellingShingle Whole-cell Bordetella pertussis vaccine component modulates the mouse immune response to an unrelated soluble antigen
Lavigne, María Victoria
Bordetella pertussis
Toxoide Tetánico
Vacunas
title_short Whole-cell Bordetella pertussis vaccine component modulates the mouse immune response to an unrelated soluble antigen
title_full Whole-cell Bordetella pertussis vaccine component modulates the mouse immune response to an unrelated soluble antigen
title_fullStr Whole-cell Bordetella pertussis vaccine component modulates the mouse immune response to an unrelated soluble antigen
title_full_unstemmed Whole-cell Bordetella pertussis vaccine component modulates the mouse immune response to an unrelated soluble antigen
title_sort Whole-cell Bordetella pertussis vaccine component modulates the mouse immune response to an unrelated soluble antigen
dc.creator.none.fl_str_mv Lavigne, María Victoria
Castro, Marisa
Mateo, Nancy A
Deluchi, Silvana
Atzori, Carlos
Piudo, Luciana
Calcagno, María
Brero, María Luisa
Manghi, Marcela
author Lavigne, María Victoria
author_facet Lavigne, María Victoria
Castro, Marisa
Mateo, Nancy A
Deluchi, Silvana
Atzori, Carlos
Piudo, Luciana
Calcagno, María
Brero, María Luisa
Manghi, Marcela
author_role author
author2 Castro, Marisa
Mateo, Nancy A
Deluchi, Silvana
Atzori, Carlos
Piudo, Luciana
Calcagno, María
Brero, María Luisa
Manghi, Marcela
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bordetella pertussis
Toxoide Tetánico
Vacunas
topic Bordetella pertussis
Toxoide Tetánico
Vacunas
dc.description.none.fl_txt_mv Fil: Lavigne, María Victoria. Instituto de Estudios de la Inmunidad Humoral, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires; Argentina.
Fil: Castro, Marisa. Instituto de Estudios de la Inmunidad Humoral, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires; Argentina.
Fil: Mateo, Nancy A. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.
Fil: Deluchi, Silvana. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.
Fil: Atzori, Carlos. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.
Fil: Piudo, Luciana. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.
Fil: Calcagno, María. Departamento de Físico-Matemática, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires; Argentina.
Fil: Brero, María Luisa. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.
Fil: Manghi, Marcela. Instituto de Estudios de la Inmunidad Humoral, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires; Argentina.
Several factors are involved in the selective activation of Th1 or Th2 cells, such as different physical characteristics of antigens and the type of antigen-presenting cells involved in the immune response, among others. To study the influence of a particulate antigen on Th1/Th2 cell differentiation during the immune response to another antigen, we analysed the immune response to tetanus toxoid (soluble antigen) in BALB/c mice immunized with one of the three following vaccines: tetanus and diphtheria toxoids (DT), or DT associated with whole-cell Bordetella pertussis or its soluble antigens (DTPw and DTPa, respectively). Similar total antibody levels were observed for all vaccines. DT vaccine showed a higher IgG1/IgG2a ratio than the similar values observed for DTPw and DTPa vaccines. DT- and DTPa-primed spleen cells showed a Th2 (IL-5) profile while a Th1/Th2 (IFN gamma, IL-5) profile was observed for DTPw. IL-6 was only produced by DTPw-primed cells. Besides, IL-12 levels induced by DTPw were three times higher than the ones induced by both DT and DTPa. Our findings indicate that whole-cell B. pertussis priming modifies the tetanus immune response from Th2 to Th1/Th2 type probably via inflammatory mechanisms. In addition, in the light of conflicting reports regarding the mechanisms of protection induced by DTP vaccines, we studied the pertussis immune response. Only DTPw immunization generated memory T cells capable of proliferating with B. pertussis as an in vitro stimulus. Results might indicate that these cells may not play a key role in protecting against B. pertussis when the host is vaccinated with DTPa.
description Fil: Lavigne, María Victoria. Instituto de Estudios de la Inmunidad Humoral, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires; Argentina.
publishDate 2002
dc.date.none.fl_str_mv 2002-07
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1286-4579
http://sgc.anlis.gob.ar/handle/123456789/1652
10.1016/s1286-4579(02)01601-5
identifier_str_mv 1286-4579
10.1016/s1286-4579(02)01601-5
url http://sgc.anlis.gob.ar/handle/123456789/1652
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Microbes and infection
dc.rights.none.fl_str_mv none
info:eu-repo/semantics/openAccess
rights_invalid_str_mv none
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Microbes and infection 2002; 4(8):815-20.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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