Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome
- Autores
- Khaiboullina, Svetlana F; Levis, Silvana; Morzunov, Sergey P; Martynova, Ekaterina V; Anokhin, Vladimir A; Gusev, Oleg A; St. Jeor, Stephen; Lombardi, Vincent C; Rizvanov, Albert A
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Khaiboullina, Svetlana F. Nevada Center for Biomedical Research, Reno, NV; Estados Unidos.
Fil: Levis, Silvana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
Fil: Morzunov, Sergey P. Department of Pathology, University of Nevada School of Medicine, Reno, NV; Estados Unidos.
Fil: Martynova, Ekaterina V. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan; Rusia.
Fil: Anokhin, Vladimir A. Kazan State Medical University, Kazan; Rusia.
Fil: Gusev, Oleg A. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan; Rusia.
Fil: St. Jeor, Stephen. Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, NV; Estados Unidos.
Fil: Lombardi, Vincent C. Nevada Center for Biomedical Research, Reno, NV; Estados Unidos.
Fil: Rizvanov, Albert A. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan; Rusia.
Hantavirus infection is an acute zoonosis that clinically manifests in two primary forms, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). HFRS is endemic in Europe and Russia, where the mild form of the disease is prevalent in the Tatarstan region. HPS is endemic in Argentina, as well as other countries of North and South American. HFRS and HPS are usually acquired via the upper respiratory tract by inhalation of virus-contaminated aerosol. Although the pathogenesis of HFRS and HPS remains largely unknown, postmortem tissue studies have identified endothelial cells as the primary target of infection. Importantly, cell damage due to virus replication, or subsequent tissue repair, has not been documented. Since no single factor has been identified that explains the complexity of HFRS or HPS pathogenesis, it has been suggested that a cytokine storm may play a crucial role in the manifestation of both diseases. In order to identify potential serological markers that distinguish HFRS and HPS, serum samples collected during early and late phases of the disease were analyzed for 48 analytes using multiplex magnetic bead-based assays. Overall, serum cytokine profiles associated with HPS revealed a more pro-inflammatory milieu as compared to HFRS. Furthermore, HPS was strictly characterized by the upregulation of cytokine levels, in contrast to HFRS where cases were distinguished by a dichotomy in serum cytokine levels. The severe form of hantavirus zoonosis, HPS, was characterized by the upregulation of a higher number of cytokines than HFRS (40 vs 21). In general, our analysis indicates that, although HPS and HFRS share many characteristic features, there are distinct cytokine profiles for these diseases. These profiles suggest a strong activation of an innate immune and inflammatory responses are associated with HPS, relative to HFRS, as well as a robust activation of Th1-type immune responses. Finally, the results of our analysis suggest that serum cytokines profiles of HPS and HFRS cases are consistent with the presence of extracellular matrix degradation, increased mononuclear leukocyte proliferation, and transendothelial migration. - Fuente
- Frontiers in Immunology 2017; 8:567.
- Materia
-
Suero
Fiebre Hemorrágica con Síndrome Renal
Síndrome Pulmonar por Hantavirus
Hantavirus - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
- Institución
- Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
- OAI Identificador
- oai:sgc.anlis.gob.ar:123456789/2015
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Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary SyndromeKhaiboullina, Svetlana FLevis, SilvanaMorzunov, Sergey PMartynova, Ekaterina VAnokhin, Vladimir AGusev, Oleg ASt. Jeor, StephenLombardi, Vincent CRizvanov, Albert ASueroFiebre Hemorrágica con Síndrome RenalSíndrome Pulmonar por HantavirusHantavirusFil: Khaiboullina, Svetlana F. Nevada Center for Biomedical Research, Reno, NV; Estados Unidos.Fil: Levis, Silvana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.Fil: Morzunov, Sergey P. Department of Pathology, University of Nevada School of Medicine, Reno, NV; Estados Unidos.Fil: Martynova, Ekaterina V. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan; Rusia.Fil: Anokhin, Vladimir A. Kazan State Medical University, Kazan; Rusia.Fil: Gusev, Oleg A. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan; Rusia.Fil: St. Jeor, Stephen. Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, NV; Estados Unidos.Fil: Lombardi, Vincent C. Nevada Center for Biomedical Research, Reno, NV; Estados Unidos.Fil: Rizvanov, Albert A. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan; Rusia.Hantavirus infection is an acute zoonosis that clinically manifests in two primary forms, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). HFRS is endemic in Europe and Russia, where the mild form of the disease is prevalent in the Tatarstan region. HPS is endemic in Argentina, as well as other countries of North and South American. HFRS and HPS are usually acquired via the upper respiratory tract by inhalation of virus-contaminated aerosol. Although the pathogenesis of HFRS and HPS remains largely unknown, postmortem tissue studies have identified endothelial cells as the primary target of infection. Importantly, cell damage due to virus replication, or subsequent tissue repair, has not been documented. Since no single factor has been identified that explains the complexity of HFRS or HPS pathogenesis, it has been suggested that a cytokine storm may play a crucial role in the manifestation of both diseases. In order to identify potential serological markers that distinguish HFRS and HPS, serum samples collected during early and late phases of the disease were analyzed for 48 analytes using multiplex magnetic bead-based assays. Overall, serum cytokine profiles associated with HPS revealed a more pro-inflammatory milieu as compared to HFRS. Furthermore, HPS was strictly characterized by the upregulation of cytokine levels, in contrast to HFRS where cases were distinguished by a dichotomy in serum cytokine levels. The severe form of hantavirus zoonosis, HPS, was characterized by the upregulation of a higher number of cytokines than HFRS (40 vs 21). In general, our analysis indicates that, although HPS and HFRS share many characteristic features, there are distinct cytokine profiles for these diseases. These profiles suggest a strong activation of an innate immune and inflammatory responses are associated with HPS, relative to HFRS, as well as a robust activation of Th1-type immune responses. Finally, the results of our analysis suggest that serum cytokines profiles of HPS and HFRS cases are consistent with the presence of extracellular matrix degradation, increased mononuclear leukocyte proliferation, and transendothelial migration.Frontiers Media2017-05-18info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1664-3224https://www.frontiersin.org/articles/10.3389/fimmu.2017.00567/fullhttp://sgc.anlis.gob.ar/handle/123456789/201510.3389/fimmu.2017.00567Frontiers in Immunology 2017; 8:567.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISFrontiers in immunologyenginfo:eu-repo/semantics/openAccess2025-09-29T14:30:35Zoai:sgc.anlis.gob.ar:123456789/2015Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:30:35.679Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false |
dc.title.none.fl_str_mv |
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome |
title |
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome |
spellingShingle |
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome Khaiboullina, Svetlana F Suero Fiebre Hemorrágica con Síndrome Renal Síndrome Pulmonar por Hantavirus Hantavirus |
title_short |
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome |
title_full |
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome |
title_fullStr |
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome |
title_full_unstemmed |
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome |
title_sort |
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome |
dc.creator.none.fl_str_mv |
Khaiboullina, Svetlana F Levis, Silvana Morzunov, Sergey P Martynova, Ekaterina V Anokhin, Vladimir A Gusev, Oleg A St. Jeor, Stephen Lombardi, Vincent C Rizvanov, Albert A |
author |
Khaiboullina, Svetlana F |
author_facet |
Khaiboullina, Svetlana F Levis, Silvana Morzunov, Sergey P Martynova, Ekaterina V Anokhin, Vladimir A Gusev, Oleg A St. Jeor, Stephen Lombardi, Vincent C Rizvanov, Albert A |
author_role |
author |
author2 |
Levis, Silvana Morzunov, Sergey P Martynova, Ekaterina V Anokhin, Vladimir A Gusev, Oleg A St. Jeor, Stephen Lombardi, Vincent C Rizvanov, Albert A |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Suero Fiebre Hemorrágica con Síndrome Renal Síndrome Pulmonar por Hantavirus Hantavirus |
topic |
Suero Fiebre Hemorrágica con Síndrome Renal Síndrome Pulmonar por Hantavirus Hantavirus |
dc.description.none.fl_txt_mv |
Fil: Khaiboullina, Svetlana F. Nevada Center for Biomedical Research, Reno, NV; Estados Unidos. Fil: Levis, Silvana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina. Fil: Morzunov, Sergey P. Department of Pathology, University of Nevada School of Medicine, Reno, NV; Estados Unidos. Fil: Martynova, Ekaterina V. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan; Rusia. Fil: Anokhin, Vladimir A. Kazan State Medical University, Kazan; Rusia. Fil: Gusev, Oleg A. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan; Rusia. Fil: St. Jeor, Stephen. Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, NV; Estados Unidos. Fil: Lombardi, Vincent C. Nevada Center for Biomedical Research, Reno, NV; Estados Unidos. Fil: Rizvanov, Albert A. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan; Rusia. Hantavirus infection is an acute zoonosis that clinically manifests in two primary forms, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). HFRS is endemic in Europe and Russia, where the mild form of the disease is prevalent in the Tatarstan region. HPS is endemic in Argentina, as well as other countries of North and South American. HFRS and HPS are usually acquired via the upper respiratory tract by inhalation of virus-contaminated aerosol. Although the pathogenesis of HFRS and HPS remains largely unknown, postmortem tissue studies have identified endothelial cells as the primary target of infection. Importantly, cell damage due to virus replication, or subsequent tissue repair, has not been documented. Since no single factor has been identified that explains the complexity of HFRS or HPS pathogenesis, it has been suggested that a cytokine storm may play a crucial role in the manifestation of both diseases. In order to identify potential serological markers that distinguish HFRS and HPS, serum samples collected during early and late phases of the disease were analyzed for 48 analytes using multiplex magnetic bead-based assays. Overall, serum cytokine profiles associated with HPS revealed a more pro-inflammatory milieu as compared to HFRS. Furthermore, HPS was strictly characterized by the upregulation of cytokine levels, in contrast to HFRS where cases were distinguished by a dichotomy in serum cytokine levels. The severe form of hantavirus zoonosis, HPS, was characterized by the upregulation of a higher number of cytokines than HFRS (40 vs 21). In general, our analysis indicates that, although HPS and HFRS share many characteristic features, there are distinct cytokine profiles for these diseases. These profiles suggest a strong activation of an innate immune and inflammatory responses are associated with HPS, relative to HFRS, as well as a robust activation of Th1-type immune responses. Finally, the results of our analysis suggest that serum cytokines profiles of HPS and HFRS cases are consistent with the presence of extracellular matrix degradation, increased mononuclear leukocyte proliferation, and transendothelial migration. |
description |
Fil: Khaiboullina, Svetlana F. Nevada Center for Biomedical Research, Reno, NV; Estados Unidos. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-05-18 |
dc.type.none.fl_str_mv |
info:ar-repo/semantics/articulo info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
1664-3224 https://www.frontiersin.org/articles/10.3389/fimmu.2017.00567/full http://sgc.anlis.gob.ar/handle/123456789/2015 10.3389/fimmu.2017.00567 |
identifier_str_mv |
1664-3224 10.3389/fimmu.2017.00567 |
url |
https://www.frontiersin.org/articles/10.3389/fimmu.2017.00567/full http://sgc.anlis.gob.ar/handle/123456789/2015 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Frontiers in immunology |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
Frontiers in Immunology 2017; 8:567. reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" instacron:ANLIS |
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Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán" |
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