Seroincidence and phylogeny of human immunodeficiency virus infections in a cohort of commercial sex workers in Montevideo, Uruguay

• Autores: Viñoles, Jose; Serra, Margarita; Russi, J.; Ruchansky, Dora; Sosa-Estani, Sergio; Montano, Silvia M; Carrion, Gladys; Eyzaguirre, Lindsay; Carr, Jean K; Olson, James G; Bautista, Christian; Sánchez, José L; Weissenbacher, Mercedes C.
• Año de publicación: 2005
• Idioma: inglés
• Tipo de recurso: artículo
• Fuente: The American Journal of Tropical Medicine and Hygiene 2005; 72(4):495–500
• Materia: VIH; Uruguay
• Institución: Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"

Fil: Viñoles, Jose. HIV/AIDS National Control Program, and Department of Laboratories of Public Health, Ministry of Health, Montevideo; Uruguay.
Fil: Serra, Margarita. HIV/AIDS National Control Program, and Department of Laboratories of Public Health, Ministry of Health, Montevideo; Uruguay.
Fil: Russi, J. Ministerio de Salud Pública. Departamento de Laboratorios; Uruguay.
Fil: Ruchansky, Dora. Servicio de Virología Molecular, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina.
Fil: Montano, Silvia M. US Naval Medical Research Center Detachment-Lima; Peru.
Fil: Carrion, Gladys. US Naval Medical Research Center Detachment (NMRCD). Unit 3800, APO-AA 34031-3800, Lima; Peru.
Fil: Eyzaguirre, Lindsay. Department of Epidemiology, Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, Baltimore; Estados Unidos.
Fil: Carr, Jean K. US Military HIV Research Program and Henry M. Jackson Foundation, Rockville, MD; Estados Unidos.
Fil: Olson, James G. US Naval Medical Research Center Detachment-Lima; Peru.
Fil: Bautista, Christian T. US Military HIV Research Program at the Walter Reed Army Institute of Research, Division of Retrovirology, the Henry M Jackson Foundation for the Advancement Military Medicine, Inc, Rockville, MD; Estados Unidos.
Fil: Sanchez, Jose L. US Military HIV Research Program and Henry M. Jackson Foundation, Rockville, MD; Estados Unidos.
Fil: Weissenbacher, Mercedes. Centro Nacional de Referencia de SIDA, Universidad de Buenos Aires; Argentina.
A cohort study involving 60 human immunodeficiency virus (HIV)-negative male transvestite commercial sex workers (CSWs) was conducted in Montevideo, Uruguay in 1999-2001. Serum samples were tested for HIV by an enzyme-linked immunosorbent assay screening with immunoblot confirmation. Six participants seroconverted for an incidence-density rate of 6.03 (95% confidence interval = 2.21-13.12) per 100 person-years. Inconsistent condom use during client sex (adjusted hazard ratio [AHR] = 6.7), during oral sex (AHR = 5.6), and at the last sexual encounter (AHR = 7.8), and use of marihuana (AHR = 5.4) were marginally associated with HIV seroconversion. Five samples were genotyped in the protease and reverse transcriptase regions; three were subtypes B and two were BF recombinants. Full genome analysis of four samples confirmed all three subtype B samples and one of the two BF recombinants. Male transvestite CSWs sustained a high rate of HIV infection. Larger prospective studies are required to better define subtypes and associated sexual and drug-related risk factors.