Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats

Autores
Sabbione, Ana Clara; Rinaldi, Gustavo; Añón, María Cristina; Scilingo, Adriana Alicia
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cardiovascular disease (CVD) is a major cause of disability and premature death throughout the world. Diets with antithrombotic components offer a convenient and effective way of preventing and reducing CVD incidence. The aim of the present work was to assess in vivo and ex vivo effects of Amaranthus hypochondriacus proteins on platelet plug formation and coagulation cascade. Amaranth proteins were orally administrated to rats (AG, 8 animals) and bleeding time was determined showing no significant difference compared with control rats (CG, 7 animals). However, results show a strong tendency, suggesting that amaranth proteins are involved in the inhibition of thrombus formation. Non-anticoagulated blood extracted from animals was analyzed with the hemostatometer, where AG parameters obtained were twice the values showed by CG. The clotting tests, thrombin time (TT) and activated partial thromboplastin time (APTT), presented a 17 and 14% clotting formation increase respectively when comparing AG with CG. The ex-vivo assays confirm the hypothesis inferring that amaranth proteins are a potential antithrombotic agent.
Centro de Investigación y Desarrollo en Criotecnología de Alimentos
Centro de Investigaciones Cardiovasculares
Materia
Ciencias Exactas
Ciencias Médicas
Functional food
Amaranth proteins
Antithrombotic activity
Animals assays
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/145015
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/145015
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in RatsSabbione, Ana ClaraRinaldi, GustavoAñón, María CristinaScilingo, Adriana AliciaCiencias ExactasCiencias MédicasFunctional foodAmaranth proteinsAntithrombotic activityAnimals assaysCardiovascular disease (CVD) is a major cause of disability and premature death throughout the world. Diets with antithrombotic components offer a convenient and effective way of preventing and reducing CVD incidence. The aim of the present work was to assess <i>in vivo</i> and <i>ex vivo</i> effects of <i>Amaranthus hypochondriacus</i> proteins on platelet plug formation and coagulation cascade. Amaranth proteins were orally administrated to rats (AG, 8 animals) and bleeding time was determined showing no significant difference compared with control rats (CG, 7 animals). However, results show a strong tendency, suggesting that amaranth proteins are involved in the inhibition of thrombus formation. Non-anticoagulated blood extracted from animals was analyzed with the hemostatometer, where AG parameters obtained were twice the values showed by CG. The clotting tests, thrombin time (TT) and activated partial thromboplastin time (APTT), presented a 17 and 14% clotting formation increase respectively when comparing AG with CG. The <i>ex-vivo</i> assays confirm the hypothesis inferring that amaranth proteins are a potential antithrombotic agent.Centro de Investigación y Desarrollo en Criotecnología de AlimentosCentro de Investigaciones Cardiovasculares2016-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf19-27http://sedici.unlp.edu.ar/handle/10915/145015enginfo:eu-repo/semantics/altIdentifier/issn/1573-9104info:eu-repo/semantics/altIdentifier/issn/0921-9668info:eu-repo/semantics/altIdentifier/doi/10.1007/s11130-015-0517-2info:eu-repo/semantics/altIdentifier/pmid/26627100info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:13:22Zoai:sedici.unlp.edu.ar:10915/145015Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:13:22.41SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats
title Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats
spellingShingle Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats
Sabbione, Ana Clara
Ciencias Exactas
Ciencias Médicas
Functional food
Amaranth proteins
Antithrombotic activity
Animals assays
title_short Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats
title_full Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats
title_fullStr Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats
title_full_unstemmed Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats
title_sort Antithrombotic Effects of <i>Amaranthus hypochondriacus</i> Proteins in Rats
dc.creator.none.fl_str_mv Sabbione, Ana Clara
Rinaldi, Gustavo
Añón, María Cristina
Scilingo, Adriana Alicia
author Sabbione, Ana Clara
author_facet Sabbione, Ana Clara
Rinaldi, Gustavo
Añón, María Cristina
Scilingo, Adriana Alicia
author_role author
author2 Rinaldi, Gustavo
Añón, María Cristina
Scilingo, Adriana Alicia
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Ciencias Médicas
Functional food
Amaranth proteins
Antithrombotic activity
Animals assays
topic Ciencias Exactas
Ciencias Médicas
Functional food
Amaranth proteins
Antithrombotic activity
Animals assays
dc.description.none.fl_txt_mv Cardiovascular disease (CVD) is a major cause of disability and premature death throughout the world. Diets with antithrombotic components offer a convenient and effective way of preventing and reducing CVD incidence. The aim of the present work was to assess <i>in vivo</i> and <i>ex vivo</i> effects of <i>Amaranthus hypochondriacus</i> proteins on platelet plug formation and coagulation cascade. Amaranth proteins were orally administrated to rats (AG, 8 animals) and bleeding time was determined showing no significant difference compared with control rats (CG, 7 animals). However, results show a strong tendency, suggesting that amaranth proteins are involved in the inhibition of thrombus formation. Non-anticoagulated blood extracted from animals was analyzed with the hemostatometer, where AG parameters obtained were twice the values showed by CG. The clotting tests, thrombin time (TT) and activated partial thromboplastin time (APTT), presented a 17 and 14% clotting formation increase respectively when comparing AG with CG. The <i>ex-vivo</i> assays confirm the hypothesis inferring that amaranth proteins are a potential antithrombotic agent.
Centro de Investigación y Desarrollo en Criotecnología de Alimentos
Centro de Investigaciones Cardiovasculares
description Cardiovascular disease (CVD) is a major cause of disability and premature death throughout the world. Diets with antithrombotic components offer a convenient and effective way of preventing and reducing CVD incidence. The aim of the present work was to assess <i>in vivo</i> and <i>ex vivo</i> effects of <i>Amaranthus hypochondriacus</i> proteins on platelet plug formation and coagulation cascade. Amaranth proteins were orally administrated to rats (AG, 8 animals) and bleeding time was determined showing no significant difference compared with control rats (CG, 7 animals). However, results show a strong tendency, suggesting that amaranth proteins are involved in the inhibition of thrombus formation. Non-anticoagulated blood extracted from animals was analyzed with the hemostatometer, where AG parameters obtained were twice the values showed by CG. The clotting tests, thrombin time (TT) and activated partial thromboplastin time (APTT), presented a 17 and 14% clotting formation increase respectively when comparing AG with CG. The <i>ex-vivo</i> assays confirm the hypothesis inferring that amaranth proteins are a potential antithrombotic agent.
publishDate 2016
dc.date.none.fl_str_mv 2016-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/145015
url http://sedici.unlp.edu.ar/handle/10915/145015
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1573-9104
info:eu-repo/semantics/altIdentifier/issn/0921-9668
info:eu-repo/semantics/altIdentifier/doi/10.1007/s11130-015-0517-2
info:eu-repo/semantics/altIdentifier/pmid/26627100
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
19-27
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 12.982451

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