Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
- Autores
- Cingolani, Horacio Eugenio; Rebolledo, Oscar Remigio; Portiansky, Enrique Leo; Pérez, Néstor Gustavo; Camilión de Hurtado, María Cristina
- Año de publicación
- 2003
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We have recently reported that the inhibition of the Na+/H+ exchanger (NHE) during 1 month in spontaneously hypertensive rats (SHR) is followed by regression of cardiomyocyte hypertrophy but not of myocardial fibrosis. The aim of this study was to evaluate whether a treatment of longer duration could reduce myocardial fibrosis and stiffness. SHR received 3.0 mg/kg per day of the specific NHE-1 inhibitor cariporide; the effect on cardiomyocyte cross-sectional area, myocardial collagen volume fraction, collagen synthesis, and myocardial stiffness (length-tension relation in left papillary muscles) was evaluated at several time points (after 1, 2, or 3 months). A slight decrease of ≈5 mm Hg in systolic blood pressure was observed after 1 month of treatment with no further changes. After 2 and 3 months of treatment, the size of cardiomyocytes remained within normal values and myocardial fibrosis progressively decreased to normal level. Accordingly, myocardial stiffness and the serum levels of the carboxyterminal propeptide of procollagen type I, a marker of collagen type I synthesis, were normalized after 3 months. Left ventricular weight decreased from 910±43 (in untreated SHR) to 781±21 mg (treated SHR) after 3 months of treatment. No difference in body weight between treated and untreated SHR was observed after this period of treatment. The present data allow us to conclude that in the SHR the administration of an NHE-1 inhibitor for 2 or 3 months leads to the normalization of collagen type I synthesis, myocardial collagen volume fraction, and stiffness.
Facultad de Ciencias Médicas
Facultad de Ciencias Veterinarias - Materia
-
Ciencias Médicas
Extracellular matrix
Fibrosis
Myocardium
Signal transduction - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/83467
Ver los metadatos del registro completo
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Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibitionCingolani, Horacio EugenioRebolledo, Oscar RemigioPortiansky, Enrique LeoPérez, Néstor GustavoCamilión de Hurtado, María CristinaCiencias MédicasExtracellular matrixFibrosisMyocardiumSignal transductionWe have recently reported that the inhibition of the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger (NHE) during 1 month in spontaneously hypertensive rats (SHR) is followed by regression of cardiomyocyte hypertrophy but not of myocardial fibrosis. The aim of this study was to evaluate whether a treatment of longer duration could reduce myocardial fibrosis and stiffness. SHR received 3.0 mg/kg per day of the specific NHE-1 inhibitor cariporide; the effect on cardiomyocyte cross-sectional area, myocardial collagen volume fraction, collagen synthesis, and myocardial stiffness (length-tension relation in left papillary muscles) was evaluated at several time points (after 1, 2, or 3 months). A slight decrease of ≈5 mm Hg in systolic blood pressure was observed after 1 month of treatment with no further changes. After 2 and 3 months of treatment, the size of cardiomyocytes remained within normal values and myocardial fibrosis progressively decreased to normal level. Accordingly, myocardial stiffness and the serum levels of the carboxyterminal propeptide of procollagen type I, a marker of collagen type I synthesis, were normalized after 3 months. Left ventricular weight decreased from 910±43 (in untreated SHR) to 781±21 mg (treated SHR) after 3 months of treatment. No difference in body weight between treated and untreated SHR was observed after this period of treatment. The present data allow us to conclude that in the SHR the administration of an NHE-1 inhibitor for 2 or 3 months leads to the normalization of collagen type I synthesis, myocardial collagen volume fraction, and stiffness.Facultad de Ciencias MédicasFacultad de Ciencias Veterinarias2003info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf373-377http://sedici.unlp.edu.ar/handle/10915/83467enginfo:eu-repo/semantics/altIdentifier/issn/0194-911Xinfo:eu-repo/semantics/altIdentifier/doi/10.1161/01.HYP.0000051502.93374.1Cinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:15:50Zoai:sedici.unlp.edu.ar:10915/83467Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:15:50.839SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition |
title |
Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition |
spellingShingle |
Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition Cingolani, Horacio Eugenio Ciencias Médicas Extracellular matrix Fibrosis Myocardium Signal transduction |
title_short |
Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition |
title_full |
Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition |
title_fullStr |
Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition |
title_full_unstemmed |
Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition |
title_sort |
Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition |
dc.creator.none.fl_str_mv |
Cingolani, Horacio Eugenio Rebolledo, Oscar Remigio Portiansky, Enrique Leo Pérez, Néstor Gustavo Camilión de Hurtado, María Cristina |
author |
Cingolani, Horacio Eugenio |
author_facet |
Cingolani, Horacio Eugenio Rebolledo, Oscar Remigio Portiansky, Enrique Leo Pérez, Néstor Gustavo Camilión de Hurtado, María Cristina |
author_role |
author |
author2 |
Rebolledo, Oscar Remigio Portiansky, Enrique Leo Pérez, Néstor Gustavo Camilión de Hurtado, María Cristina |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Ciencias Médicas Extracellular matrix Fibrosis Myocardium Signal transduction |
topic |
Ciencias Médicas Extracellular matrix Fibrosis Myocardium Signal transduction |
dc.description.none.fl_txt_mv |
We have recently reported that the inhibition of the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger (NHE) during 1 month in spontaneously hypertensive rats (SHR) is followed by regression of cardiomyocyte hypertrophy but not of myocardial fibrosis. The aim of this study was to evaluate whether a treatment of longer duration could reduce myocardial fibrosis and stiffness. SHR received 3.0 mg/kg per day of the specific NHE-1 inhibitor cariporide; the effect on cardiomyocyte cross-sectional area, myocardial collagen volume fraction, collagen synthesis, and myocardial stiffness (length-tension relation in left papillary muscles) was evaluated at several time points (after 1, 2, or 3 months). A slight decrease of ≈5 mm Hg in systolic blood pressure was observed after 1 month of treatment with no further changes. After 2 and 3 months of treatment, the size of cardiomyocytes remained within normal values and myocardial fibrosis progressively decreased to normal level. Accordingly, myocardial stiffness and the serum levels of the carboxyterminal propeptide of procollagen type I, a marker of collagen type I synthesis, were normalized after 3 months. Left ventricular weight decreased from 910±43 (in untreated SHR) to 781±21 mg (treated SHR) after 3 months of treatment. No difference in body weight between treated and untreated SHR was observed after this period of treatment. The present data allow us to conclude that in the SHR the administration of an NHE-1 inhibitor for 2 or 3 months leads to the normalization of collagen type I synthesis, myocardial collagen volume fraction, and stiffness. Facultad de Ciencias Médicas Facultad de Ciencias Veterinarias |
description |
We have recently reported that the inhibition of the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger (NHE) during 1 month in spontaneously hypertensive rats (SHR) is followed by regression of cardiomyocyte hypertrophy but not of myocardial fibrosis. The aim of this study was to evaluate whether a treatment of longer duration could reduce myocardial fibrosis and stiffness. SHR received 3.0 mg/kg per day of the specific NHE-1 inhibitor cariporide; the effect on cardiomyocyte cross-sectional area, myocardial collagen volume fraction, collagen synthesis, and myocardial stiffness (length-tension relation in left papillary muscles) was evaluated at several time points (after 1, 2, or 3 months). A slight decrease of ≈5 mm Hg in systolic blood pressure was observed after 1 month of treatment with no further changes. After 2 and 3 months of treatment, the size of cardiomyocytes remained within normal values and myocardial fibrosis progressively decreased to normal level. Accordingly, myocardial stiffness and the serum levels of the carboxyterminal propeptide of procollagen type I, a marker of collagen type I synthesis, were normalized after 3 months. Left ventricular weight decreased from 910±43 (in untreated SHR) to 781±21 mg (treated SHR) after 3 months of treatment. No difference in body weight between treated and untreated SHR was observed after this period of treatment. The present data allow us to conclude that in the SHR the administration of an NHE-1 inhibitor for 2 or 3 months leads to the normalization of collagen type I synthesis, myocardial collagen volume fraction, and stiffness. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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http://sedici.unlp.edu.ar/handle/10915/83467 |
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http://sedici.unlp.edu.ar/handle/10915/83467 |
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eng |
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eng |
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