Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition

Autores
Cingolani, Horacio Eugenio; Rebolledo, Oscar Remigio; Portiansky, Enrique Leo; Pérez, Néstor Gustavo; Camilión de Hurtado, María Cristina
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We have recently reported that the inhibition of the Na+/H+ exchanger (NHE) during 1 month in spontaneously hypertensive rats (SHR) is followed by regression of cardiomyocyte hypertrophy but not of myocardial fibrosis. The aim of this study was to evaluate whether a treatment of longer duration could reduce myocardial fibrosis and stiffness. SHR received 3.0 mg/kg per day of the specific NHE-1 inhibitor cariporide; the effect on cardiomyocyte cross-sectional area, myocardial collagen volume fraction, collagen synthesis, and myocardial stiffness (length-tension relation in left papillary muscles) was evaluated at several time points (after 1, 2, or 3 months). A slight decrease of ≈5 mm Hg in systolic blood pressure was observed after 1 month of treatment with no further changes. After 2 and 3 months of treatment, the size of cardiomyocytes remained within normal values and myocardial fibrosis progressively decreased to normal level. Accordingly, myocardial stiffness and the serum levels of the carboxyterminal propeptide of procollagen type I, a marker of collagen type I synthesis, were normalized after 3 months. Left ventricular weight decreased from 910±43 (in untreated SHR) to 781±21 mg (treated SHR) after 3 months of treatment. No difference in body weight between treated and untreated SHR was observed after this period of treatment. The present data allow us to conclude that in the SHR the administration of an NHE-1 inhibitor for 2 or 3 months leads to the normalization of collagen type I synthesis, myocardial collagen volume fraction, and stiffness.
Facultad de Ciencias Médicas
Facultad de Ciencias Veterinarias
Materia
Ciencias Médicas
Extracellular matrix
Fibrosis
Myocardium
Signal transduction
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/83467

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network_name_str SEDICI (UNLP)
spelling Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibitionCingolani, Horacio EugenioRebolledo, Oscar RemigioPortiansky, Enrique LeoPérez, Néstor GustavoCamilión de Hurtado, María CristinaCiencias MédicasExtracellular matrixFibrosisMyocardiumSignal transductionWe have recently reported that the inhibition of the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger (NHE) during 1 month in spontaneously hypertensive rats (SHR) is followed by regression of cardiomyocyte hypertrophy but not of myocardial fibrosis. The aim of this study was to evaluate whether a treatment of longer duration could reduce myocardial fibrosis and stiffness. SHR received 3.0 mg/kg per day of the specific NHE-1 inhibitor cariporide; the effect on cardiomyocyte cross-sectional area, myocardial collagen volume fraction, collagen synthesis, and myocardial stiffness (length-tension relation in left papillary muscles) was evaluated at several time points (after 1, 2, or 3 months). A slight decrease of ≈5 mm Hg in systolic blood pressure was observed after 1 month of treatment with no further changes. After 2 and 3 months of treatment, the size of cardiomyocytes remained within normal values and myocardial fibrosis progressively decreased to normal level. Accordingly, myocardial stiffness and the serum levels of the carboxyterminal propeptide of procollagen type I, a marker of collagen type I synthesis, were normalized after 3 months. Left ventricular weight decreased from 910±43 (in untreated SHR) to 781±21 mg (treated SHR) after 3 months of treatment. No difference in body weight between treated and untreated SHR was observed after this period of treatment. The present data allow us to conclude that in the SHR the administration of an NHE-1 inhibitor for 2 or 3 months leads to the normalization of collagen type I synthesis, myocardial collagen volume fraction, and stiffness.Facultad de Ciencias MédicasFacultad de Ciencias Veterinarias2003info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf373-377http://sedici.unlp.edu.ar/handle/10915/83467enginfo:eu-repo/semantics/altIdentifier/issn/0194-911Xinfo:eu-repo/semantics/altIdentifier/doi/10.1161/01.HYP.0000051502.93374.1Cinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:15:50Zoai:sedici.unlp.edu.ar:10915/83467Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:15:50.839SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
title Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
spellingShingle Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
Cingolani, Horacio Eugenio
Ciencias Médicas
Extracellular matrix
Fibrosis
Myocardium
Signal transduction
title_short Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
title_full Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
title_fullStr Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
title_full_unstemmed Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
title_sort Regression of hypertensive myocardial fibrosis by Na+/H+ exchange inhibition
dc.creator.none.fl_str_mv Cingolani, Horacio Eugenio
Rebolledo, Oscar Remigio
Portiansky, Enrique Leo
Pérez, Néstor Gustavo
Camilión de Hurtado, María Cristina
author Cingolani, Horacio Eugenio
author_facet Cingolani, Horacio Eugenio
Rebolledo, Oscar Remigio
Portiansky, Enrique Leo
Pérez, Néstor Gustavo
Camilión de Hurtado, María Cristina
author_role author
author2 Rebolledo, Oscar Remigio
Portiansky, Enrique Leo
Pérez, Néstor Gustavo
Camilión de Hurtado, María Cristina
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Extracellular matrix
Fibrosis
Myocardium
Signal transduction
topic Ciencias Médicas
Extracellular matrix
Fibrosis
Myocardium
Signal transduction
dc.description.none.fl_txt_mv We have recently reported that the inhibition of the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger (NHE) during 1 month in spontaneously hypertensive rats (SHR) is followed by regression of cardiomyocyte hypertrophy but not of myocardial fibrosis. The aim of this study was to evaluate whether a treatment of longer duration could reduce myocardial fibrosis and stiffness. SHR received 3.0 mg/kg per day of the specific NHE-1 inhibitor cariporide; the effect on cardiomyocyte cross-sectional area, myocardial collagen volume fraction, collagen synthesis, and myocardial stiffness (length-tension relation in left papillary muscles) was evaluated at several time points (after 1, 2, or 3 months). A slight decrease of ≈5 mm Hg in systolic blood pressure was observed after 1 month of treatment with no further changes. After 2 and 3 months of treatment, the size of cardiomyocytes remained within normal values and myocardial fibrosis progressively decreased to normal level. Accordingly, myocardial stiffness and the serum levels of the carboxyterminal propeptide of procollagen type I, a marker of collagen type I synthesis, were normalized after 3 months. Left ventricular weight decreased from 910±43 (in untreated SHR) to 781±21 mg (treated SHR) after 3 months of treatment. No difference in body weight between treated and untreated SHR was observed after this period of treatment. The present data allow us to conclude that in the SHR the administration of an NHE-1 inhibitor for 2 or 3 months leads to the normalization of collagen type I synthesis, myocardial collagen volume fraction, and stiffness.
Facultad de Ciencias Médicas
Facultad de Ciencias Veterinarias
description We have recently reported that the inhibition of the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger (NHE) during 1 month in spontaneously hypertensive rats (SHR) is followed by regression of cardiomyocyte hypertrophy but not of myocardial fibrosis. The aim of this study was to evaluate whether a treatment of longer duration could reduce myocardial fibrosis and stiffness. SHR received 3.0 mg/kg per day of the specific NHE-1 inhibitor cariporide; the effect on cardiomyocyte cross-sectional area, myocardial collagen volume fraction, collagen synthesis, and myocardial stiffness (length-tension relation in left papillary muscles) was evaluated at several time points (after 1, 2, or 3 months). A slight decrease of ≈5 mm Hg in systolic blood pressure was observed after 1 month of treatment with no further changes. After 2 and 3 months of treatment, the size of cardiomyocytes remained within normal values and myocardial fibrosis progressively decreased to normal level. Accordingly, myocardial stiffness and the serum levels of the carboxyterminal propeptide of procollagen type I, a marker of collagen type I synthesis, were normalized after 3 months. Left ventricular weight decreased from 910±43 (in untreated SHR) to 781±21 mg (treated SHR) after 3 months of treatment. No difference in body weight between treated and untreated SHR was observed after this period of treatment. The present data allow us to conclude that in the SHR the administration of an NHE-1 inhibitor for 2 or 3 months leads to the normalization of collagen type I synthesis, myocardial collagen volume fraction, and stiffness.
publishDate 2003
dc.date.none.fl_str_mv 2003
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/83467
url http://sedici.unlp.edu.ar/handle/10915/83467
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0194-911X
info:eu-repo/semantics/altIdentifier/doi/10.1161/01.HYP.0000051502.93374.1C
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
373-377
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
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instname_str Universidad Nacional de La Plata
instacron_str UNLP
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repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
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