Positive chronotropic effect of Bay K 8644: participation of endogenous norepinephrine

Autores
Camilión, María Cecilia; Gende, Oscar Alfredo; Cingolani, Horacio Eugenio
Año de publicación
1989
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The chronotropic effect of Bay K 8644, a dihydropyridine known to increase the slow inward current, was studied in spontaneously beating rat atria. Increases in atrial rate were concentration-dependent and the maximal increase (106 ± 10 beats/min) was obtained at 3 × 10⁻⁶ mol/l. Reserpine pretreatment, or propranolol 3 × 10⁻⁷ mol/l, or propranolol plus prazosin 10⁻⁶ mol/l decreased the maximum chronotropic effect of Bay K 8644 by about 60%. Blockade of the removal mechanisms of catecholamines (hydrocortisone 3 × 10⁻⁵ mol/l plus cocaine 10⁻⁵ mol/1) did not prevent the chronotropic effect of the compound. Exposure to Bay K 8644 increased the spontaneous outflow of tritium from atria preloaded with [3H]-norepinephrine by 30%. The results indicate that Bay K 8644 produces positive chronotropic effects through two mechanisms: a direct one and an indirect mechanism that involves the participation of norepinephrine released from sympathetic nerve endings.
Centro de Investigaciones Cardiovasculares
Materia
Bioquímica
Ciencias Médicas
Bay K 8644
Norepinephrine release
Chronotropic response
Rat atria
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/144179
Acceder
id SEDICI_e2c8ed8b29ded6fc005588752bc9b2ae
oai_identifier_str oai:sedici.unlp.edu.ar:10915/144179
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Positive chronotropic effect of Bay K 8644: participation of endogenous norepinephrineCamilión, María CeciliaGende, Oscar AlfredoCingolani, Horacio EugenioBioquímicaCiencias MédicasBay K 8644Norepinephrine releaseChronotropic responseRat atriaThe chronotropic effect of Bay K 8644, a dihydropyridine known to increase the slow inward current, was studied in spontaneously beating rat atria. Increases in atrial rate were concentration-dependent and the maximal increase (106 ± 10 beats/min) was obtained at 3 × 10⁻⁶ mol/l. Reserpine pretreatment, or propranolol 3 × 10⁻⁷ mol/l, or propranolol plus prazosin 10⁻⁶ mol/l decreased the maximum chronotropic effect of Bay K 8644 by about 60%. Blockade of the removal mechanisms of catecholamines (hydrocortisone 3 × 10⁻⁵ mol/l plus cocaine 10⁻⁵ mol/1) did not prevent the chronotropic effect of the compound. Exposure to Bay K 8644 increased the spontaneous outflow of tritium from atria preloaded with [3H]-norepinephrine by 30%. The results indicate that Bay K 8644 produces positive chronotropic effects through two mechanisms: a direct one and an indirect mechanism that involves the participation of norepinephrine released from sympathetic nerve endings.Centro de Investigaciones Cardiovasculares1989info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf452-455http://sedici.unlp.edu.ar/handle/10915/144179enginfo:eu-repo/semantics/altIdentifier/issn/0028-1298info:eu-repo/semantics/altIdentifier/issn/1432-1912info:eu-repo/semantics/altIdentifier/doi/10.1007/bf00167048info:eu-repo/semantics/altIdentifier/pmid/2479845info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:26Zoai:sedici.unlp.edu.ar:10915/144179Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:27.194SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Positive chronotropic effect of Bay K 8644: participation of endogenous norepinephrine
title Positive chronotropic effect of Bay K 8644: participation of endogenous norepinephrine
spellingShingle Positive chronotropic effect of Bay K 8644: participation of endogenous norepinephrine
Camilión, María Cecilia
Bioquímica
Ciencias Médicas
Bay K 8644
Norepinephrine release
Chronotropic response
Rat atria
title_short Positive chronotropic effect of Bay K 8644: participation of endogenous norepinephrine
title_full Positive chronotropic effect of Bay K 8644: participation of endogenous norepinephrine
title_fullStr Positive chronotropic effect of Bay K 8644: participation of endogenous norepinephrine
title_full_unstemmed Positive chronotropic effect of Bay K 8644: participation of endogenous norepinephrine
title_sort Positive chronotropic effect of Bay K 8644: participation of endogenous norepinephrine
dc.creator.none.fl_str_mv Camilión, María Cecilia
Gende, Oscar Alfredo
Cingolani, Horacio Eugenio
author Camilión, María Cecilia
author_facet Camilión, María Cecilia
Gende, Oscar Alfredo
Cingolani, Horacio Eugenio
author_role author
author2 Gende, Oscar Alfredo
Cingolani, Horacio Eugenio
author2_role author
author
dc.subject.none.fl_str_mv Bioquímica
Ciencias Médicas
Bay K 8644
Norepinephrine release
Chronotropic response
Rat atria
topic Bioquímica
Ciencias Médicas
Bay K 8644
Norepinephrine release
Chronotropic response
Rat atria
dc.description.none.fl_txt_mv The chronotropic effect of Bay K 8644, a dihydropyridine known to increase the slow inward current, was studied in spontaneously beating rat atria. Increases in atrial rate were concentration-dependent and the maximal increase (106 ± 10 beats/min) was obtained at 3 × 10⁻⁶ mol/l. Reserpine pretreatment, or propranolol 3 × 10⁻⁷ mol/l, or propranolol plus prazosin 10⁻⁶ mol/l decreased the maximum chronotropic effect of Bay K 8644 by about 60%. Blockade of the removal mechanisms of catecholamines (hydrocortisone 3 × 10⁻⁵ mol/l plus cocaine 10⁻⁵ mol/1) did not prevent the chronotropic effect of the compound. Exposure to Bay K 8644 increased the spontaneous outflow of tritium from atria preloaded with [3H]-norepinephrine by 30%. The results indicate that Bay K 8644 produces positive chronotropic effects through two mechanisms: a direct one and an indirect mechanism that involves the participation of norepinephrine released from sympathetic nerve endings.
Centro de Investigaciones Cardiovasculares
description The chronotropic effect of Bay K 8644, a dihydropyridine known to increase the slow inward current, was studied in spontaneously beating rat atria. Increases in atrial rate were concentration-dependent and the maximal increase (106 ± 10 beats/min) was obtained at 3 × 10⁻⁶ mol/l. Reserpine pretreatment, or propranolol 3 × 10⁻⁷ mol/l, or propranolol plus prazosin 10⁻⁶ mol/l decreased the maximum chronotropic effect of Bay K 8644 by about 60%. Blockade of the removal mechanisms of catecholamines (hydrocortisone 3 × 10⁻⁵ mol/l plus cocaine 10⁻⁵ mol/1) did not prevent the chronotropic effect of the compound. Exposure to Bay K 8644 increased the spontaneous outflow of tritium from atria preloaded with [3H]-norepinephrine by 30%. The results indicate that Bay K 8644 produces positive chronotropic effects through two mechanisms: a direct one and an indirect mechanism that involves the participation of norepinephrine released from sympathetic nerve endings.
publishDate 1989
dc.date.none.fl_str_mv 1989
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/144179
url http://sedici.unlp.edu.ar/handle/10915/144179
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0028-1298
info:eu-repo/semantics/altIdentifier/issn/1432-1912
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf00167048
info:eu-repo/semantics/altIdentifier/pmid/2479845
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
452-455
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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