Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes
- Autores
- Cafferata, Lázaro F. R.; Rimada, Rubén S.
- Año de publicación
- 2003
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The kinetics and mechanism of the thermal decomposition reaction of cis-6-(4-fluoropheny1)-5,6-[2-(4-fluorophenyl)-propylidene]-3, 3-tetramethylene-1,2,4-trioxacyclo-hexane (I) were investigated separately in n-hexane and in methanol solutions over the temperature and concentration ranges of 393.2-443.2 K and 2.7-54 × 10-5 M, respectively. The values of the activation parameters for both reactions were compared with the corresponding ones for the thermolysis of cis-6-(4-fluorophenyl-5,6-[2-(4- fluorophenyl)-3-hydroxypropylidene]-3,3-tetramethylene-1,2,4-trioxacyclohexane (II), investigated in the same solvents and temperature range. Substituent and solvent effects on the initial homolytic rupture of the O-O peroxydic bonds of those molecules were evaluated.
Facultad de Ciencias Exactas - Materia
-
Ciencias Exactas
Química
alcohol oxidation
antimalarial compounds
chemical bond
fluorophenyl substituted 1,2,4-trioxanes
decomposition
peroxides
high temperature
solvent and substituents effects
temperature dependence
thermal decomposition reactions
thermal stimulation
thermolysis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/3.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/35017
Ver los metadatos del registro completo
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Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanesCafferata, Lázaro F. R.Rimada, Rubén S.Ciencias ExactasQuímicaalcohol oxidationantimalarial compoundschemical bondfluorophenyl substituted 1,2,4-trioxanesdecompositionperoxideshigh temperaturesolvent and substituents effectstemperature dependencethermal decomposition reactionsthermal stimulationthermolysisThe kinetics and mechanism of the thermal decomposition reaction of <i>cis</i>-6-(4-fluoropheny1)-5,6-[2-(4-fluorophenyl)-propylidene]-3, 3-tetramethylene-1,2,4-trioxacyclo-hexane (I) were investigated separately in <i>n</i>-hexane and in methanol solutions over the temperature and concentration ranges of 393.2-443.2 K and 2.7-54 × 10<SUP>-5</SUP> M, respectively. The values of the activation parameters for both reactions were compared with the corresponding ones for the thermolysis of <i>cis</i>-6-(4-fluorophenyl-5,6-[2-(4- fluorophenyl)-3-hydroxypropylidene]-3,3-tetramethylene-1,2,4-trioxacyclohexane (II), investigated in the same solvents and temperature range. Substituent and solvent effects on the initial homolytic rupture of the O-O peroxydic bonds of those molecules were evaluated.Facultad de Ciencias Exactas2003info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf655-662http://sedici.unlp.edu.ar/handle/10915/35017enginfo:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/1420-3049/8/9/655info:eu-repo/semantics/altIdentifier/issn/1420-3049info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/Creative Commons Attribution 3.0 Unported (CC BY 3.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T10:57:08Zoai:sedici.unlp.edu.ar:10915/35017Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 10:57:09.122SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes |
| title |
Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes |
| spellingShingle |
Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes Cafferata, Lázaro F. R. Ciencias Exactas Química alcohol oxidation antimalarial compounds chemical bond fluorophenyl substituted 1,2,4-trioxanes decomposition peroxides high temperature solvent and substituents effects temperature dependence thermal decomposition reactions thermal stimulation thermolysis |
| title_short |
Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes |
| title_full |
Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes |
| title_fullStr |
Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes |
| title_full_unstemmed |
Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes |
| title_sort |
Solvent and substituent effects on the thermolysis of antimalarial fluorophenyl substituted 1,2.4-trioxanes |
| dc.creator.none.fl_str_mv |
Cafferata, Lázaro F. R. Rimada, Rubén S. |
| author |
Cafferata, Lázaro F. R. |
| author_facet |
Cafferata, Lázaro F. R. Rimada, Rubén S. |
| author_role |
author |
| author2 |
Rimada, Rubén S. |
| author2_role |
author |
| dc.subject.none.fl_str_mv |
Ciencias Exactas Química alcohol oxidation antimalarial compounds chemical bond fluorophenyl substituted 1,2,4-trioxanes decomposition peroxides high temperature solvent and substituents effects temperature dependence thermal decomposition reactions thermal stimulation thermolysis |
| topic |
Ciencias Exactas Química alcohol oxidation antimalarial compounds chemical bond fluorophenyl substituted 1,2,4-trioxanes decomposition peroxides high temperature solvent and substituents effects temperature dependence thermal decomposition reactions thermal stimulation thermolysis |
| dc.description.none.fl_txt_mv |
The kinetics and mechanism of the thermal decomposition reaction of <i>cis</i>-6-(4-fluoropheny1)-5,6-[2-(4-fluorophenyl)-propylidene]-3, 3-tetramethylene-1,2,4-trioxacyclo-hexane (I) were investigated separately in <i>n</i>-hexane and in methanol solutions over the temperature and concentration ranges of 393.2-443.2 K and 2.7-54 × 10<SUP>-5</SUP> M, respectively. The values of the activation parameters for both reactions were compared with the corresponding ones for the thermolysis of <i>cis</i>-6-(4-fluorophenyl-5,6-[2-(4- fluorophenyl)-3-hydroxypropylidene]-3,3-tetramethylene-1,2,4-trioxacyclohexane (II), investigated in the same solvents and temperature range. Substituent and solvent effects on the initial homolytic rupture of the O-O peroxydic bonds of those molecules were evaluated. Facultad de Ciencias Exactas |
| description |
The kinetics and mechanism of the thermal decomposition reaction of <i>cis</i>-6-(4-fluoropheny1)-5,6-[2-(4-fluorophenyl)-propylidene]-3, 3-tetramethylene-1,2,4-trioxacyclo-hexane (I) were investigated separately in <i>n</i>-hexane and in methanol solutions over the temperature and concentration ranges of 393.2-443.2 K and 2.7-54 × 10<SUP>-5</SUP> M, respectively. The values of the activation parameters for both reactions were compared with the corresponding ones for the thermolysis of <i>cis</i>-6-(4-fluorophenyl-5,6-[2-(4- fluorophenyl)-3-hydroxypropylidene]-3,3-tetramethylene-1,2,4-trioxacyclohexane (II), investigated in the same solvents and temperature range. Substituent and solvent effects on the initial homolytic rupture of the O-O peroxydic bonds of those molecules were evaluated. |
| publishDate |
2003 |
| dc.date.none.fl_str_mv |
2003 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://sedici.unlp.edu.ar/handle/10915/35017 |
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eng |
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eng |
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openAccess |
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