Benznidazole levels in blood vary with age in rats

Autores
Bulffer, Romina Fernanda; Castro, José Alberto; Fanelli, Silvia Laura
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the present study, we determined Bz blood levels in rats of different ages that received Bz intragastrically (100 mg/kg). We developed and validated a high-pressure liquid chromatography with UV detector method for determination of Bz levels in whole blood. Bz levels were significantly higher and persisted for longer periods of time in the blood of young rats when compared to that of adult animals.
Instituto de Limnología "Dr. Raúl A. Ringuelet"
Materia
Zoología
Benznidazole
Rat blood
Chagas disease
HPLC
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/98702
Acceder
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network_name_str SEDICI (UNLP)
spelling Benznidazole levels in blood vary with age in ratsBulffer, Romina FernandaCastro, José AlbertoFanelli, Silvia LauraZoologíaBenznidazoleRat bloodChagas diseaseHPLCBenznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the present study, we determined Bz blood levels in rats of different ages that received Bz intragastrically (100 mg/kg). We developed and validated a high-pressure liquid chromatography with UV detector method for determination of Bz levels in whole blood. Bz levels were significantly higher and persisted for longer periods of time in the blood of young rats when compared to that of adult animals.Instituto de Limnología "Dr. Raúl A. Ringuelet"2011-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf374-377http://sedici.unlp.edu.ar/handle/10915/98702enginfo:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/24892info:eu-repo/semantics/altIdentifier/url/https://memorias.ioc.fiocruz.br/article/144/benznidazole-levels-in-blood-vary-with-age-in-ratsinfo:eu-repo/semantics/altIdentifier/issn/1678-8060info:eu-repo/semantics/altIdentifier/doi/10.1590/S0074-02762011000300021info:eu-repo/semantics/altIdentifier/hdl/11336/24892info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:20:00Zoai:sedici.unlp.edu.ar:10915/98702Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:20:01.081SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Benznidazole levels in blood vary with age in rats
title Benznidazole levels in blood vary with age in rats
spellingShingle Benznidazole levels in blood vary with age in rats
Bulffer, Romina Fernanda
Zoología
Benznidazole
Rat blood
Chagas disease
HPLC
title_short Benznidazole levels in blood vary with age in rats
title_full Benznidazole levels in blood vary with age in rats
title_fullStr Benznidazole levels in blood vary with age in rats
title_full_unstemmed Benznidazole levels in blood vary with age in rats
title_sort Benznidazole levels in blood vary with age in rats
dc.creator.none.fl_str_mv Bulffer, Romina Fernanda
Castro, José Alberto
Fanelli, Silvia Laura
author Bulffer, Romina Fernanda
author_facet Bulffer, Romina Fernanda
Castro, José Alberto
Fanelli, Silvia Laura
author_role author
author2 Castro, José Alberto
Fanelli, Silvia Laura
author2_role author
author
dc.subject.none.fl_str_mv Zoología
Benznidazole
Rat blood
Chagas disease
HPLC
topic Zoología
Benznidazole
Rat blood
Chagas disease
HPLC
dc.description.none.fl_txt_mv Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the present study, we determined Bz blood levels in rats of different ages that received Bz intragastrically (100 mg/kg). We developed and validated a high-pressure liquid chromatography with UV detector method for determination of Bz levels in whole blood. Bz levels were significantly higher and persisted for longer periods of time in the blood of young rats when compared to that of adult animals.
Instituto de Limnología "Dr. Raúl A. Ringuelet"
description Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the present study, we determined Bz blood levels in rats of different ages that received Bz intragastrically (100 mg/kg). We developed and validated a high-pressure liquid chromatography with UV detector method for determination of Bz levels in whole blood. Bz levels were significantly higher and persisted for longer periods of time in the blood of young rats when compared to that of adult animals.
publishDate 2011
dc.date.none.fl_str_mv 2011-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/98702
url http://sedici.unlp.edu.ar/handle/10915/98702
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/24892
info:eu-repo/semantics/altIdentifier/url/https://memorias.ioc.fiocruz.br/article/144/benznidazole-levels-in-blood-vary-with-age-in-rats
info:eu-repo/semantics/altIdentifier/issn/1678-8060
info:eu-repo/semantics/altIdentifier/doi/10.1590/S0074-02762011000300021
info:eu-repo/semantics/altIdentifier/hdl/11336/24892
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
374-377
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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