Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses

Autores
Chatterjee, Shampa; Fujiwara, Keigi; Pérez, Néstor Gustavo; Ushio-Fukai, Masuko; Fisher, Aron B.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
reseña artículo
Estado
versión publicada
Descripción
Cells are constantly exposed to mechanical forces that play a role in modulating cellular structure and function. The cardiovascular system experiences physical forces in the form of shear stress and stretch associated with blood flow and contraction, respectively. These forces are sensed by endothelial cells and cardiomyocytes and lead to responses that control vascular and cardiac homeostasis. This was highlighted at the Pan American Physiological Society meeting at Iguassu Falls, Brazil, in a symposium titled “Mechanosignaling in the Vasculature.” This symposium presented recent research that showed the existence of a vital link between mechanosensing and downstream redox sensitive signaling cascades. This link helps to transduce and transmit the physical force into an observable physiological response. The speakers showcased how mechanosensors such as ion channels, membrane receptor kinases, adhesion molecules, and other cellular components transduce the force via redox signals (such as reactive oxygen species and nitric oxide) to receptors (transcription factors, growth factors, etc.). Receptor activated pathways then lead to cellular responses including cellular proliferation, contraction, and remodeling. These responses have major relevance to the physiology and pathophysiology of various cardiovascular diseases. Thus an understanding of the complex series of events, from the initial sensing through the final response, is essential for progress in this field. Overall, this symposium addressed some important emerging concepts in the field of mechanosignaling and the eventual pathophysiological responses.
Centro de Investigaciones Cardiovasculares
Materia
Ciencias Médicas
Anrep effect
Mechanotransduction
NADPH oxidase
Revascularization
Vasculature
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/107012

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spelling Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responsesChatterjee, ShampaFujiwara, KeigiPérez, Néstor GustavoUshio-Fukai, MasukoFisher, Aron B.Ciencias MédicasAnrep effectMechanotransductionNADPH oxidaseRevascularizationVasculatureCells are constantly exposed to mechanical forces that play a role in modulating cellular structure and function. The cardiovascular system experiences physical forces in the form of shear stress and stretch associated with blood flow and contraction, respectively. These forces are sensed by endothelial cells and cardiomyocytes and lead to responses that control vascular and cardiac homeostasis. This was highlighted at the Pan American Physiological Society meeting at Iguassu Falls, Brazil, in a symposium titled “Mechanosignaling in the Vasculature.” This symposium presented recent research that showed the existence of a vital link between mechanosensing and downstream redox sensitive signaling cascades. This link helps to transduce and transmit the physical force into an observable physiological response. The speakers showcased how mechanosensors such as ion channels, membrane receptor kinases, adhesion molecules, and other cellular components transduce the force via redox signals (such as reactive oxygen species and nitric oxide) to receptors (transcription factors, growth factors, etc.). Receptor activated pathways then lead to cellular responses including cellular proliferation, contraction, and remodeling. These responses have major relevance to the physiology and pathophysiology of various cardiovascular diseases. Thus an understanding of the complex series of events, from the initial sensing through the final response, is essential for progress in this field. Overall, this symposium addressed some important emerging concepts in the field of mechanosignaling and the eventual pathophysiological responses.Centro de Investigaciones Cardiovasculares2015info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/107012enginfo:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajpheart.00105.2015info:eu-repo/semantics/altIdentifier/issn/1522-1539info:eu-repo/semantics/altIdentifier/pmid/25862828info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpheart.00105.2015info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:23:56Zoai:sedici.unlp.edu.ar:10915/107012Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:23:56.875SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses
title Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses
spellingShingle Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses
Chatterjee, Shampa
Ciencias Médicas
Anrep effect
Mechanotransduction
NADPH oxidase
Revascularization
Vasculature
title_short Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses
title_full Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses
title_fullStr Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses
title_full_unstemmed Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses
title_sort Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses
dc.creator.none.fl_str_mv Chatterjee, Shampa
Fujiwara, Keigi
Pérez, Néstor Gustavo
Ushio-Fukai, Masuko
Fisher, Aron B.
author Chatterjee, Shampa
author_facet Chatterjee, Shampa
Fujiwara, Keigi
Pérez, Néstor Gustavo
Ushio-Fukai, Masuko
Fisher, Aron B.
author_role author
author2 Fujiwara, Keigi
Pérez, Néstor Gustavo
Ushio-Fukai, Masuko
Fisher, Aron B.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Anrep effect
Mechanotransduction
NADPH oxidase
Revascularization
Vasculature
topic Ciencias Médicas
Anrep effect
Mechanotransduction
NADPH oxidase
Revascularization
Vasculature
dc.description.none.fl_txt_mv Cells are constantly exposed to mechanical forces that play a role in modulating cellular structure and function. The cardiovascular system experiences physical forces in the form of shear stress and stretch associated with blood flow and contraction, respectively. These forces are sensed by endothelial cells and cardiomyocytes and lead to responses that control vascular and cardiac homeostasis. This was highlighted at the Pan American Physiological Society meeting at Iguassu Falls, Brazil, in a symposium titled “Mechanosignaling in the Vasculature.” This symposium presented recent research that showed the existence of a vital link between mechanosensing and downstream redox sensitive signaling cascades. This link helps to transduce and transmit the physical force into an observable physiological response. The speakers showcased how mechanosensors such as ion channels, membrane receptor kinases, adhesion molecules, and other cellular components transduce the force via redox signals (such as reactive oxygen species and nitric oxide) to receptors (transcription factors, growth factors, etc.). Receptor activated pathways then lead to cellular responses including cellular proliferation, contraction, and remodeling. These responses have major relevance to the physiology and pathophysiology of various cardiovascular diseases. Thus an understanding of the complex series of events, from the initial sensing through the final response, is essential for progress in this field. Overall, this symposium addressed some important emerging concepts in the field of mechanosignaling and the eventual pathophysiological responses.
Centro de Investigaciones Cardiovasculares
description Cells are constantly exposed to mechanical forces that play a role in modulating cellular structure and function. The cardiovascular system experiences physical forces in the form of shear stress and stretch associated with blood flow and contraction, respectively. These forces are sensed by endothelial cells and cardiomyocytes and lead to responses that control vascular and cardiac homeostasis. This was highlighted at the Pan American Physiological Society meeting at Iguassu Falls, Brazil, in a symposium titled “Mechanosignaling in the Vasculature.” This symposium presented recent research that showed the existence of a vital link between mechanosensing and downstream redox sensitive signaling cascades. This link helps to transduce and transmit the physical force into an observable physiological response. The speakers showcased how mechanosensors such as ion channels, membrane receptor kinases, adhesion molecules, and other cellular components transduce the force via redox signals (such as reactive oxygen species and nitric oxide) to receptors (transcription factors, growth factors, etc.). Receptor activated pathways then lead to cellular responses including cellular proliferation, contraction, and remodeling. These responses have major relevance to the physiology and pathophysiology of various cardiovascular diseases. Thus an understanding of the complex series of events, from the initial sensing through the final response, is essential for progress in this field. Overall, this symposium addressed some important emerging concepts in the field of mechanosignaling and the eventual pathophysiological responses.
publishDate 2015
dc.date.none.fl_str_mv 2015
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info:eu-repo/semantics/altIdentifier/issn/1522-1539
info:eu-repo/semantics/altIdentifier/pmid/25862828
info:eu-repo/semantics/altIdentifier/doi/10.1152/ajpheart.00105.2015
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
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rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
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