Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans

Autores
Ennis, Irene Lucía; Pérez, Néstor Gustavo
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Current evidence reveals that cardiac mineralocorticoid receptor (MR) activation following myocardial stretch plays an important physiological role in adapting developed force to sudden changes in hemodynamic conditions. Its underlying mechanism involves a previously unknown nongenomic effect of the MR that triggers redox-mediated Na⁺/H⁺ exchanger (NHE1) activation, intracellular Na⁺ accumulation, and a consequent increase in Ca²⁺ transient amplitude through reverse Na⁺/Ca²⁺ exchange. However, clinical evidence assigns a detrimental role to MR activation in the pathogenesis of severe cardiac diseases such as congestive heart failure. This mini review is meant to present and briefly discuss some recent discoveries about locally triggered cardiac MR signals with the objective of shedding some light on its physiological but potentially pathological consequences in the heart.
Facultad de Ciencias Médicas
Centro de Investigaciones Cardiovasculares
Materia
Medicina
aldosterone
mineralocorticoid receptor (MR)
myocardial stretch
heart failure
NHE1
oxidative stress
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/124900
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/124900
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the BeansEnnis, Irene LucíaPérez, Néstor GustavoMedicinaaldosteronemineralocorticoid receptor (MR)myocardial stretchheart failureNHE1oxidative stressCurrent evidence reveals that cardiac mineralocorticoid receptor (MR) activation following myocardial stretch plays an important physiological role in adapting developed force to sudden changes in hemodynamic conditions. Its underlying mechanism involves a previously unknown nongenomic effect of the MR that triggers redox-mediated Na⁺/H⁺ exchanger (NHE1) activation, intracellular Na⁺ accumulation, and a consequent increase in Ca²⁺ transient amplitude through reverse Na⁺/Ca²⁺ exchange. However, clinical evidence assigns a detrimental role to MR activation in the pathogenesis of severe cardiac diseases such as congestive heart failure. This mini review is meant to present and briefly discuss some recent discoveries about locally triggered cardiac MR signals with the objective of shedding some light on its physiological but potentially pathological consequences in the heart.Facultad de Ciencias MédicasCentro de Investigaciones Cardiovasculares2021-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/124900enginfo:eu-repo/semantics/altIdentifier/issn/2297-055Xinfo:eu-repo/semantics/altIdentifier/pmid/33553262info:eu-repo/semantics/altIdentifier/doi/10.3389/fcvm.2020.614279info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:29:48Zoai:sedici.unlp.edu.ar:10915/124900Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:29:48.397SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans
title Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans
spellingShingle Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans
Ennis, Irene Lucía
Medicina
aldosterone
mineralocorticoid receptor (MR)
myocardial stretch
heart failure
NHE1
oxidative stress
title_short Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans
title_full Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans
title_fullStr Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans
title_full_unstemmed Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans
title_sort Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans
dc.creator.none.fl_str_mv Ennis, Irene Lucía
Pérez, Néstor Gustavo
author Ennis, Irene Lucía
author_facet Ennis, Irene Lucía
Pérez, Néstor Gustavo
author_role author
author2 Pérez, Néstor Gustavo
author2_role author
dc.subject.none.fl_str_mv Medicina
aldosterone
mineralocorticoid receptor (MR)
myocardial stretch
heart failure
NHE1
oxidative stress
topic Medicina
aldosterone
mineralocorticoid receptor (MR)
myocardial stretch
heart failure
NHE1
oxidative stress
dc.description.none.fl_txt_mv Current evidence reveals that cardiac mineralocorticoid receptor (MR) activation following myocardial stretch plays an important physiological role in adapting developed force to sudden changes in hemodynamic conditions. Its underlying mechanism involves a previously unknown nongenomic effect of the MR that triggers redox-mediated Na⁺/H⁺ exchanger (NHE1) activation, intracellular Na⁺ accumulation, and a consequent increase in Ca²⁺ transient amplitude through reverse Na⁺/Ca²⁺ exchange. However, clinical evidence assigns a detrimental role to MR activation in the pathogenesis of severe cardiac diseases such as congestive heart failure. This mini review is meant to present and briefly discuss some recent discoveries about locally triggered cardiac MR signals with the objective of shedding some light on its physiological but potentially pathological consequences in the heart.
Facultad de Ciencias Médicas
Centro de Investigaciones Cardiovasculares
description Current evidence reveals that cardiac mineralocorticoid receptor (MR) activation following myocardial stretch plays an important physiological role in adapting developed force to sudden changes in hemodynamic conditions. Its underlying mechanism involves a previously unknown nongenomic effect of the MR that triggers redox-mediated Na⁺/H⁺ exchanger (NHE1) activation, intracellular Na⁺ accumulation, and a consequent increase in Ca²⁺ transient amplitude through reverse Na⁺/Ca²⁺ exchange. However, clinical evidence assigns a detrimental role to MR activation in the pathogenesis of severe cardiac diseases such as congestive heart failure. This mini review is meant to present and briefly discuss some recent discoveries about locally triggered cardiac MR signals with the objective of shedding some light on its physiological but potentially pathological consequences in the heart.
publishDate 2021
dc.date.none.fl_str_mv 2021-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/124900
url http://sedici.unlp.edu.ar/handle/10915/124900
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2297-055X
info:eu-repo/semantics/altIdentifier/pmid/33553262
info:eu-repo/semantics/altIdentifier/doi/10.3389/fcvm.2020.614279
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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