The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase

Autores
Apella, María Cristina; González, Silvia Nelina; Baran, Enrique José
Año de publicación
1988
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The inhibitory effect of vanadate species on the enzymatic activity of bovine copper-zinc superoxide dismutase has been investigated at different pH values and vanadium concentrations. A definite inhibitory effect, clearly related to the main negative charge of each of the vanadate solutions, has been found. The results suggest that the origin of the inhibitory effect may be similar to that found for the phosphate ion, i.e., a diminution of the effectiveness of the substrate electronic guidance mechanism by partial neutralization of the charges close to the active site. Under physiological conditions, the inhibitory effect of vanadate is somewhat smaller than the phosphate.
Facultad de Ciencias Exactas
Materia
Ciencias Exactas
Copper-zinc superoxide dismutase
vanadium oxoanions
inhibitory effect
effect of main negative charge
comparison with phosphate action
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/140438
Acceder
id SEDICI_a9173f0d84f622dc48a7543cbaa9304c
oai_identifier_str oai:sedici.unlp.edu.ar:10915/140438
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutaseApella, María CristinaGonzález, Silvia NelinaBaran, Enrique JoséCiencias ExactasCopper-zinc superoxide dismutasevanadium oxoanionsinhibitory effecteffect of main negative chargecomparison with phosphate actionThe inhibitory effect of vanadate species on the enzymatic activity of bovine copper-zinc superoxide dismutase has been investigated at different pH values and vanadium concentrations. A definite inhibitory effect, clearly related to the main negative charge of each of the vanadate solutions, has been found. The results suggest that the origin of the inhibitory effect may be similar to that found for the phosphate ion, i.e., a diminution of the effectiveness of the substrate electronic guidance mechanism by partial neutralization of the charges close to the active site. Under physiological conditions, the inhibitory effect of vanadate is somewhat smaller than the phosphate.Facultad de Ciencias Exactas1988info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf123-130http://sedici.unlp.edu.ar/handle/10915/140438enginfo:eu-repo/semantics/altIdentifier/issn/0163-4984info:eu-repo/semantics/altIdentifier/issn/1559-0720info:eu-repo/semantics/altIdentifier/doi/10.1007/bf02917496info:eu-repo/semantics/altIdentifier/pmid/2484557info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:07Zoai:sedici.unlp.edu.ar:10915/140438Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:07.418SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
title The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
spellingShingle The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
Apella, María Cristina
Ciencias Exactas
Copper-zinc superoxide dismutase
vanadium oxoanions
inhibitory effect
effect of main negative charge
comparison with phosphate action
title_short The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
title_full The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
title_fullStr The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
title_full_unstemmed The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
title_sort The inhibitory effect of vanadium oxoanions on the activity of copper-zinc superoxide dismutase
dc.creator.none.fl_str_mv Apella, María Cristina
González, Silvia Nelina
Baran, Enrique José
author Apella, María Cristina
author_facet Apella, María Cristina
González, Silvia Nelina
Baran, Enrique José
author_role author
author2 González, Silvia Nelina
Baran, Enrique José
author2_role author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Copper-zinc superoxide dismutase
vanadium oxoanions
inhibitory effect
effect of main negative charge
comparison with phosphate action
topic Ciencias Exactas
Copper-zinc superoxide dismutase
vanadium oxoanions
inhibitory effect
effect of main negative charge
comparison with phosphate action
dc.description.none.fl_txt_mv The inhibitory effect of vanadate species on the enzymatic activity of bovine copper-zinc superoxide dismutase has been investigated at different pH values and vanadium concentrations. A definite inhibitory effect, clearly related to the main negative charge of each of the vanadate solutions, has been found. The results suggest that the origin of the inhibitory effect may be similar to that found for the phosphate ion, i.e., a diminution of the effectiveness of the substrate electronic guidance mechanism by partial neutralization of the charges close to the active site. Under physiological conditions, the inhibitory effect of vanadate is somewhat smaller than the phosphate.
Facultad de Ciencias Exactas
description The inhibitory effect of vanadate species on the enzymatic activity of bovine copper-zinc superoxide dismutase has been investigated at different pH values and vanadium concentrations. A definite inhibitory effect, clearly related to the main negative charge of each of the vanadate solutions, has been found. The results suggest that the origin of the inhibitory effect may be similar to that found for the phosphate ion, i.e., a diminution of the effectiveness of the substrate electronic guidance mechanism by partial neutralization of the charges close to the active site. Under physiological conditions, the inhibitory effect of vanadate is somewhat smaller than the phosphate.
publishDate 1988
dc.date.none.fl_str_mv 1988
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/140438
url http://sedici.unlp.edu.ar/handle/10915/140438
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0163-4984
info:eu-repo/semantics/altIdentifier/issn/1559-0720
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf02917496
info:eu-repo/semantics/altIdentifier/pmid/2484557
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
123-130
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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