Predicting the partitioning of biological compounds between room-temperature ionic liquids and water by means of the solvation-parameter model

• Autores: Padró, Juan Manuel; Ponzinibbio, Agustín; Agudelo Mesa, Leidy Bibiana; Reta, Mario Roberto
• Año de publicación: 2011
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Ciencias Exactas; Química; Ionic liquids; Partition coefficients; Liquid–liquid extraction; Solvation-parameter model; RTIL synthesis
• Institución: Universidad Nacional de La Plata

The partition coefficients, P_IL/w, for different probe molecules as well as for compounds of biological interest between the room-temperature ionic liquids (RTILs) 1-butyl-3-methylimidazolium hexafluorophosphate, [BMIM][PF₆], 1-hexyl-3-methylimidazolium hexafluorophosphate, [HMIM][PF₆], 1-octyl-3-methylimidazolium tetrafluoroborate, [OMIM][BF₄] and water were accurately measured. [BMIM][PF₆] and [OMIM][BF₄] were synthesized by adapting a procedure from the literature to a simpler, single-vessel and faster methodology, with a much lesser consumption of organic solvent. We employed the solvation-parameter model to elucidate the general chemical interactions involved in RTIL/water partitioning. With this purpose, we have selected different solute descriptor parameters that measure polarity, polarizability, hydrogen-bond-donor and hydrogen-bond-acceptor interactions, and cavity formation for a set of specifically selected probe molecules (the training set). The obtained multiparametric equations were used to predict the partition coefficients for compounds not present in the training set (the test set), most being of biological interest. Partial solubility of the ionic liquid in water (and water into the ionic liquid) was taken into account to explain the obtained results. This fact has not been deeply considered up to date. Solute descriptors were obtained from the literature, when available, or else calculated through commercial software. An excellent agreement between calculated and experimental log P_IL/w values was obtained, which demonstrated that the resulting multiparametric equations are robust and allow predicting partitioning for any organic molecule in the biphasic systems studied.
Facultad de Ciencias Exactas
Laboratorio de Separaciones Analíticas
Laboratorio de Estudio de Compuestos Orgánicos