Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery

Autores
Chain, Cecilia Yamil; Daza Millone, María Antonieta; Cisneros, José Sebastián; Ramírez, Eduardo Alejandro; Vela, María Elena
Año de publicación
2021
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The development of drug carriers based in lipid nanoparticles (LNPs) aims toward the synthesis of non-toxic multifunctional nanovehicles that can bypass the immune system and allow specific site targeting, controlled release and complete degradation of the carrier components. Among label free techniques, Surface Plasmon Resonance (SPR) biosensing is a versatile tool to study LNPs in the field of nanotherapeutics research. SPR, widely used for the analysis of molecular interactions, is based on the immobilization of one of the interacting partners to the sensor surface, which can be easily achieved in the case of LNPs by hydrophobic attachment onto commercial lipid- capture sensor chips. In the last years SPR technology has emerged as an interesting strategy for studying molecular aspects of drug delivery that determines the efficacy of the nanotherapeutical such as LNPs' interactions with biological targets, with serum proteins and with tumor extracelullar matrix. Moreover, SPR has contributed to the obtention and characterization of LNPs, gathering information about the interplay between components of the formulations, their response to organic molecules and, more recently, the quantification and molecular characterization of exosomes. By the combination of available sensor platforms, assay quickness and straight forward platform adaptation for new carrier systems, SPR is becoming a high throughput technique for LNPs' characterization and analysis.
Facultad de Ciencias Exactas
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Materia
Ciencias Exactas
Física
Química
lipid nanoparticles
drug carriers
Surface Plasmon Resonance
molecular target
protein corona
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/124237
Acceder
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network_name_str SEDICI (UNLP)
spelling Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug DeliveryChain, Cecilia YamilDaza Millone, María AntonietaCisneros, José SebastiánRamírez, Eduardo AlejandroVela, María ElenaCiencias ExactasFísicaQuímicalipid nanoparticlesdrug carriersSurface Plasmon Resonancemolecular targetprotein coronaThe development of drug carriers based in lipid nanoparticles (LNPs) aims toward the synthesis of non-toxic multifunctional nanovehicles that can bypass the immune system and allow specific site targeting, controlled release and complete degradation of the carrier components. Among label free techniques, Surface Plasmon Resonance (SPR) biosensing is a versatile tool to study LNPs in the field of nanotherapeutics research. SPR, widely used for the analysis of molecular interactions, is based on the immobilization of one of the interacting partners to the sensor surface, which can be easily achieved in the case of LNPs by hydrophobic attachment onto commercial lipid- capture sensor chips. In the last years SPR technology has emerged as an interesting strategy for studying molecular aspects of drug delivery that determines the efficacy of the nanotherapeutical such as LNPs' interactions with biological targets, with serum proteins and with tumor extracelullar matrix. Moreover, SPR has contributed to the obtention and characterization of LNPs, gathering information about the interplay between components of the formulations, their response to organic molecules and, more recently, the quantification and molecular characterization of exosomes. By the combination of available sensor platforms, assay quickness and straight forward platform adaptation for new carrier systems, SPR is becoming a high throughput technique for LNPs' characterization and analysis.Facultad de Ciencias ExactasInstituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas2021-01-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/124237spainfo:eu-repo/semantics/altIdentifier/issn/2296-2646info:eu-repo/semantics/altIdentifier/pmid/33490037info:eu-repo/semantics/altIdentifier/doi/10.3389/fchem.2020.605307info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:10:45Zoai:sedici.unlp.edu.ar:10915/124237Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:10:45.494SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
title Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
spellingShingle Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
Chain, Cecilia Yamil
Ciencias Exactas
Física
Química
lipid nanoparticles
drug carriers
Surface Plasmon Resonance
molecular target
protein corona
title_short Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
title_full Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
title_fullStr Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
title_full_unstemmed Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
title_sort Surface Plasmon Resonance as a Characterization Tool for Lipid Nanoparticles Used in Drug Delivery
dc.creator.none.fl_str_mv Chain, Cecilia Yamil
Daza Millone, María Antonieta
Cisneros, José Sebastián
Ramírez, Eduardo Alejandro
Vela, María Elena
author Chain, Cecilia Yamil
author_facet Chain, Cecilia Yamil
Daza Millone, María Antonieta
Cisneros, José Sebastián
Ramírez, Eduardo Alejandro
Vela, María Elena
author_role author
author2 Daza Millone, María Antonieta
Cisneros, José Sebastián
Ramírez, Eduardo Alejandro
Vela, María Elena
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Física
Química
lipid nanoparticles
drug carriers
Surface Plasmon Resonance
molecular target
protein corona
topic Ciencias Exactas
Física
Química
lipid nanoparticles
drug carriers
Surface Plasmon Resonance
molecular target
protein corona
dc.description.none.fl_txt_mv The development of drug carriers based in lipid nanoparticles (LNPs) aims toward the synthesis of non-toxic multifunctional nanovehicles that can bypass the immune system and allow specific site targeting, controlled release and complete degradation of the carrier components. Among label free techniques, Surface Plasmon Resonance (SPR) biosensing is a versatile tool to study LNPs in the field of nanotherapeutics research. SPR, widely used for the analysis of molecular interactions, is based on the immobilization of one of the interacting partners to the sensor surface, which can be easily achieved in the case of LNPs by hydrophobic attachment onto commercial lipid- capture sensor chips. In the last years SPR technology has emerged as an interesting strategy for studying molecular aspects of drug delivery that determines the efficacy of the nanotherapeutical such as LNPs' interactions with biological targets, with serum proteins and with tumor extracelullar matrix. Moreover, SPR has contributed to the obtention and characterization of LNPs, gathering information about the interplay between components of the formulations, their response to organic molecules and, more recently, the quantification and molecular characterization of exosomes. By the combination of available sensor platforms, assay quickness and straight forward platform adaptation for new carrier systems, SPR is becoming a high throughput technique for LNPs' characterization and analysis.
Facultad de Ciencias Exactas
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
description The development of drug carriers based in lipid nanoparticles (LNPs) aims toward the synthesis of non-toxic multifunctional nanovehicles that can bypass the immune system and allow specific site targeting, controlled release and complete degradation of the carrier components. Among label free techniques, Surface Plasmon Resonance (SPR) biosensing is a versatile tool to study LNPs in the field of nanotherapeutics research. SPR, widely used for the analysis of molecular interactions, is based on the immobilization of one of the interacting partners to the sensor surface, which can be easily achieved in the case of LNPs by hydrophobic attachment onto commercial lipid- capture sensor chips. In the last years SPR technology has emerged as an interesting strategy for studying molecular aspects of drug delivery that determines the efficacy of the nanotherapeutical such as LNPs' interactions with biological targets, with serum proteins and with tumor extracelullar matrix. Moreover, SPR has contributed to the obtention and characterization of LNPs, gathering information about the interplay between components of the formulations, their response to organic molecules and, more recently, the quantification and molecular characterization of exosomes. By the combination of available sensor platforms, assay quickness and straight forward platform adaptation for new carrier systems, SPR is becoming a high throughput technique for LNPs' characterization and analysis.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/124237
url http://sedici.unlp.edu.ar/handle/10915/124237
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2296-2646
info:eu-repo/semantics/altIdentifier/pmid/33490037
info:eu-repo/semantics/altIdentifier/doi/10.3389/fchem.2020.605307
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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