New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)

Autores
Lobo Maza, Flavia Emilia; Méndez De Leo, Lucila; Rubert, Aldo Alberto; Carro, Pilar; Salvarezza, Roberto Carlos; Vericat, Carolina
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this paper we have studied glutathione (GSH) self-assembled monolayers (SAMs) on Au(111) prepared by incubation from solutions in phosphate buffer (pH = 7). These SAMs degrade with increasing immersion time to yield adsorbed S and polysulfide species on the gold surface, as revealed by cyclic voltammetry and Xray photoelectron spectroscopy. Results from polarization modulation infrared reflection−absorption spectroscopy (PM-IRRAS) show that even if GSH decomposes on the surface the vibrational bands characteristic of the molecule are still present. This has direct relevance for the study of gold nanoparticles (AuNPs) protected by hydrophilic thiols and also for biomedical applications of GSH-capped AuNPs. Thiol exchange experiments of the drug 6- mercaptopurine (6MP) SAMs on Au(111) in contact with GSH solutions were also performed to better understand the possible role of the latter in the triggered release of 6MP from the surface of AuNPs for drug delivery applications. Our results show that 6MP is completely released only when a S adlayer, produced by desulfurization of GSH, is formed on the Au(111) surface.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Materia
Química
gold
Metal nanoparticles
Molecules
Solution chemistry
Thiols
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/170143
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/170143
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)Lobo Maza, Flavia EmiliaMéndez De Leo, LucilaRubert, Aldo AlbertoCarro, PilarSalvarezza, Roberto CarlosVericat, CarolinaQuímicagoldMetal nanoparticlesMoleculesSolution chemistryThiolsIn this paper we have studied glutathione (GSH) self-assembled monolayers (SAMs) on Au(111) prepared by incubation from solutions in phosphate buffer (pH = 7). These SAMs degrade with increasing immersion time to yield adsorbed S and polysulfide species on the gold surface, as revealed by cyclic voltammetry and Xray photoelectron spectroscopy. Results from polarization modulation infrared reflection−absorption spectroscopy (PM-IRRAS) show that even if GSH decomposes on the surface the vibrational bands characteristic of the molecule are still present. This has direct relevance for the study of gold nanoparticles (AuNPs) protected by hydrophilic thiols and also for biomedical applications of GSH-capped AuNPs. Thiol exchange experiments of the drug 6- mercaptopurine (6MP) SAMs on Au(111) in contact with GSH solutions were also performed to better understand the possible role of the latter in the triggered release of 6MP from the surface of AuNPs for drug delivery applications. Our results show that 6MP is completely released only when a S adlayer, produced by desulfurization of GSH, is formed on the Au(111) surface.Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf14597-14607http://sedici.unlp.edu.ar/handle/10915/170143enginfo:eu-repo/semantics/altIdentifier/issn/1932-7455info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.jpcc.5b12643info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:45:37Zoai:sedici.unlp.edu.ar:10915/170143Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:45:37.302SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)
title New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)
spellingShingle New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)
Lobo Maza, Flavia Emilia
Química
gold
Metal nanoparticles
Molecules
Solution chemistry
Thiols
title_short New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)
title_full New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)
title_fullStr New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)
title_full_unstemmed New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)
title_sort New Insight into the Interface Chemistry and Stability of Glutathione Self-Assembled Monolayers on Au(111)
dc.creator.none.fl_str_mv Lobo Maza, Flavia Emilia
Méndez De Leo, Lucila
Rubert, Aldo Alberto
Carro, Pilar
Salvarezza, Roberto Carlos
Vericat, Carolina
author Lobo Maza, Flavia Emilia
author_facet Lobo Maza, Flavia Emilia
Méndez De Leo, Lucila
Rubert, Aldo Alberto
Carro, Pilar
Salvarezza, Roberto Carlos
Vericat, Carolina
author_role author
author2 Méndez De Leo, Lucila
Rubert, Aldo Alberto
Carro, Pilar
Salvarezza, Roberto Carlos
Vericat, Carolina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Química
gold
Metal nanoparticles
Molecules
Solution chemistry
Thiols
topic Química
gold
Metal nanoparticles
Molecules
Solution chemistry
Thiols
dc.description.none.fl_txt_mv In this paper we have studied glutathione (GSH) self-assembled monolayers (SAMs) on Au(111) prepared by incubation from solutions in phosphate buffer (pH = 7). These SAMs degrade with increasing immersion time to yield adsorbed S and polysulfide species on the gold surface, as revealed by cyclic voltammetry and Xray photoelectron spectroscopy. Results from polarization modulation infrared reflection−absorption spectroscopy (PM-IRRAS) show that even if GSH decomposes on the surface the vibrational bands characteristic of the molecule are still present. This has direct relevance for the study of gold nanoparticles (AuNPs) protected by hydrophilic thiols and also for biomedical applications of GSH-capped AuNPs. Thiol exchange experiments of the drug 6- mercaptopurine (6MP) SAMs on Au(111) in contact with GSH solutions were also performed to better understand the possible role of the latter in the triggered release of 6MP from the surface of AuNPs for drug delivery applications. Our results show that 6MP is completely released only when a S adlayer, produced by desulfurization of GSH, is formed on the Au(111) surface.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
description In this paper we have studied glutathione (GSH) self-assembled monolayers (SAMs) on Au(111) prepared by incubation from solutions in phosphate buffer (pH = 7). These SAMs degrade with increasing immersion time to yield adsorbed S and polysulfide species on the gold surface, as revealed by cyclic voltammetry and Xray photoelectron spectroscopy. Results from polarization modulation infrared reflection−absorption spectroscopy (PM-IRRAS) show that even if GSH decomposes on the surface the vibrational bands characteristic of the molecule are still present. This has direct relevance for the study of gold nanoparticles (AuNPs) protected by hydrophilic thiols and also for biomedical applications of GSH-capped AuNPs. Thiol exchange experiments of the drug 6- mercaptopurine (6MP) SAMs on Au(111) in contact with GSH solutions were also performed to better understand the possible role of the latter in the triggered release of 6MP from the surface of AuNPs for drug delivery applications. Our results show that 6MP is completely released only when a S adlayer, produced by desulfurization of GSH, is formed on the Au(111) surface.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/170143
url http://sedici.unlp.edu.ar/handle/10915/170143
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1932-7455
info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.jpcc.5b12643
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
14597-14607
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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