Speckle interferometry applied to pharmacodynamic studies: evaluation of parasite motility

Autores
Pomarico, J. A.; Di Rocco, Héctor Oscar; Alvarez, L.; Lanusse, Carlos E.; Mottier, L.; Saumell, C.; Arizaga, Ricardo Augusto; Rabal, Héctor Jorge; Trivi, Marcelo Ricardo
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The work reported here describes the application of the optical technique known as dynamic speckle interferometry to evaluate the motility of nematode parasites exposed to different anthelmintic drugs. This technique, a well proven tool for assessing the time evolution of different phenomena, is here successfully used to quantify parasite motility in pharmacodynamic assays. The characterization of the pharmacological properties of anthelmintic drugs is critical to optimize their use in parasite control. Besides, the evaluation of nematode motility is a relevant indicator of the pharmacodynamic effect of anthelmintic drugs. The application of this approach to study the motility of Haemonchus contortus (used as a model of nematode parasites) larvae exposed to different drugs is presented, showing its usefulness.
Facultad de Ingeniería
Centro de Investigaciones Ópticas
Materia
Ingeniería
Ciencias Exactas
Parasites
Pharmacodynamics
Speckle
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/131639
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/131639
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Speckle interferometry applied to pharmacodynamic studies: evaluation of parasite motilityPomarico, J. A.Di Rocco, Héctor OscarAlvarez, L.Lanusse, Carlos E.Mottier, L.Saumell, C.Arizaga, Ricardo AugustoRabal, Héctor JorgeTrivi, Marcelo RicardoIngenieríaCiencias ExactasParasitesPharmacodynamicsSpeckleThe work reported here describes the application of the optical technique known as dynamic speckle interferometry to evaluate the motility of nematode parasites exposed to different anthelmintic drugs. This technique, a well proven tool for assessing the time evolution of different phenomena, is here successfully used to quantify parasite motility in pharmacodynamic assays. The characterization of the pharmacological properties of anthelmintic drugs is critical to optimize their use in parasite control. Besides, the evaluation of nematode motility is a relevant indicator of the pharmacodynamic effect of anthelmintic drugs. The application of this approach to study the motility of <i>Haemonchus contortus</i> (used as a model of nematode parasites) larvae exposed to different drugs is presented, showing its usefulness.Facultad de IngenieríaCentro de Investigaciones Ópticas2004-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf694-699http://sedici.unlp.edu.ar/handle/10915/131639enginfo:eu-repo/semantics/altIdentifier/issn/0175-7571info:eu-repo/semantics/altIdentifier/issn/1432-1017info:eu-repo/semantics/altIdentifier/doi/10.1007/s00249-004-0413-4info:eu-repo/semantics/altIdentifier/pmid/15133648info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:31:48Zoai:sedici.unlp.edu.ar:10915/131639Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:31:48.21SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Speckle interferometry applied to pharmacodynamic studies: evaluation of parasite motility
title Speckle interferometry applied to pharmacodynamic studies: evaluation of parasite motility
spellingShingle Speckle interferometry applied to pharmacodynamic studies: evaluation of parasite motility
Pomarico, J. A.
Ingeniería
Ciencias Exactas
Parasites
Pharmacodynamics
Speckle
title_short Speckle interferometry applied to pharmacodynamic studies: evaluation of parasite motility
title_full Speckle interferometry applied to pharmacodynamic studies: evaluation of parasite motility
title_fullStr Speckle interferometry applied to pharmacodynamic studies: evaluation of parasite motility
title_full_unstemmed Speckle interferometry applied to pharmacodynamic studies: evaluation of parasite motility
title_sort Speckle interferometry applied to pharmacodynamic studies: evaluation of parasite motility
dc.creator.none.fl_str_mv Pomarico, J. A.
Di Rocco, Héctor Oscar
Alvarez, L.
Lanusse, Carlos E.
Mottier, L.
Saumell, C.
Arizaga, Ricardo Augusto
Rabal, Héctor Jorge
Trivi, Marcelo Ricardo
author Pomarico, J. A.
author_facet Pomarico, J. A.
Di Rocco, Héctor Oscar
Alvarez, L.
Lanusse, Carlos E.
Mottier, L.
Saumell, C.
Arizaga, Ricardo Augusto
Rabal, Héctor Jorge
Trivi, Marcelo Ricardo
author_role author
author2 Di Rocco, Héctor Oscar
Alvarez, L.
Lanusse, Carlos E.
Mottier, L.
Saumell, C.
Arizaga, Ricardo Augusto
Rabal, Héctor Jorge
Trivi, Marcelo Ricardo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ingeniería
Ciencias Exactas
Parasites
Pharmacodynamics
Speckle
topic Ingeniería
Ciencias Exactas
Parasites
Pharmacodynamics
Speckle
dc.description.none.fl_txt_mv The work reported here describes the application of the optical technique known as dynamic speckle interferometry to evaluate the motility of nematode parasites exposed to different anthelmintic drugs. This technique, a well proven tool for assessing the time evolution of different phenomena, is here successfully used to quantify parasite motility in pharmacodynamic assays. The characterization of the pharmacological properties of anthelmintic drugs is critical to optimize their use in parasite control. Besides, the evaluation of nematode motility is a relevant indicator of the pharmacodynamic effect of anthelmintic drugs. The application of this approach to study the motility of <i>Haemonchus contortus</i> (used as a model of nematode parasites) larvae exposed to different drugs is presented, showing its usefulness.
Facultad de Ingeniería
Centro de Investigaciones Ópticas
description The work reported here describes the application of the optical technique known as dynamic speckle interferometry to evaluate the motility of nematode parasites exposed to different anthelmintic drugs. This technique, a well proven tool for assessing the time evolution of different phenomena, is here successfully used to quantify parasite motility in pharmacodynamic assays. The characterization of the pharmacological properties of anthelmintic drugs is critical to optimize their use in parasite control. Besides, the evaluation of nematode motility is a relevant indicator of the pharmacodynamic effect of anthelmintic drugs. The application of this approach to study the motility of <i>Haemonchus contortus</i> (used as a model of nematode parasites) larvae exposed to different drugs is presented, showing its usefulness.
publishDate 2004
dc.date.none.fl_str_mv 2004-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/131639
url http://sedici.unlp.edu.ar/handle/10915/131639
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0175-7571
info:eu-repo/semantics/altIdentifier/issn/1432-1017
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00249-004-0413-4
info:eu-repo/semantics/altIdentifier/pmid/15133648
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
694-699
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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