Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells

Autores
Sanchez, Viviana; Villalba, Nerina; Fiore, Luciano; Luzzani, Carlos; Miriuka, Santiago Gabriel; Boveris, Alberto; Gelpi, Ricardo Jorge; Brusco, Alicia; Poderoso, Juan José
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Intercellular communication is one of the most important events in cell population behavior. In the last decade, tunneling nanotubes (TNTs) have been recognized as a new form of long distance intercellular connection. TNT function is to allow molecular and subcellular structure exchange between neighboring cells via the transfer of molecules and organelles such as calcium ions, prions, viral and bacterial pathogens, small lysosomes and mitochondria. New findings support the concept that mesenchymal stem cells (MSCs) can affect cell microenvironment by the release of soluble factors or the transfer of cellular components to neighboring cells, in a way which significantly contributes to cell regulation and tissue repair, although the underlying mechanisms remain poorly understood. MSCs have many advantages for their implementation in regenerative medicine. The TNTs in these cell types are heterogeneous in both structure and function, probably due to their highly dynamic behavior. In this work we report an extensive and detailed description of types, structure, components, dynamics and functionality of the TNTs bridging neighboring human umbilical cord MSCs obtained from Wharton"s jelly. Characterization studies were carried out through phase contrast, fluorescence, electron microscopy and time lapse images with the aim of describing cells suitable for an eventual regenerative medicine.
Facultad de Ciencias Médicas
Materia
Medicina
Tunneling nanotubes
Mesenchymal stem cells
Mitochondrial transfer
Intercellular communication
Intercellular bridges
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/131988

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network_name_str SEDICI (UNLP)
spelling Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring CellsSanchez, VivianaVillalba, NerinaFiore, LucianoLuzzani, CarlosMiriuka, Santiago GabrielBoveris, AlbertoGelpi, Ricardo JorgeBrusco, AliciaPoderoso, Juan JoséMedicinaTunneling nanotubesMesenchymal stem cellsMitochondrial transferIntercellular communicationIntercellular bridgesIntercellular communication is one of the most important events in cell population behavior. In the last decade, tunneling nanotubes (TNTs) have been recognized as a new form of long distance intercellular connection. TNT function is to allow molecular and subcellular structure exchange between neighboring cells via the transfer of molecules and organelles such as calcium ions, prions, viral and bacterial pathogens, small lysosomes and mitochondria. New findings support the concept that mesenchymal stem cells (MSCs) can affect cell microenvironment by the release of soluble factors or the transfer of cellular components to neighboring cells, in a way which significantly contributes to cell regulation and tissue repair, although the underlying mechanisms remain poorly understood. MSCs have many advantages for their implementation in regenerative medicine. The TNTs in these cell types are heterogeneous in both structure and function, probably due to their highly dynamic behavior. In this work we report an extensive and detailed description of types, structure, components, dynamics and functionality of the TNTs bridging neighboring human umbilical cord MSCs obtained from Wharton"s jelly. Characterization studies were carried out through phase contrast, fluorescence, electron microscopy and time lapse images with the aim of describing cells suitable for an eventual regenerative medicine.Facultad de Ciencias Médicas2017-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf491-498http://sedici.unlp.edu.ar/handle/10915/131988enginfo:eu-repo/semantics/altIdentifier/issn/2629-3277info:eu-repo/semantics/altIdentifier/issn/1550-8943info:eu-repo/semantics/altIdentifier/issn/1558-6804info:eu-repo/semantics/altIdentifier/doi/10.1007/s12015-017-9730-8info:eu-repo/semantics/altIdentifier/pmid/28214945info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:26Zoai:sedici.unlp.edu.ar:10915/131988Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:27.006SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells
title Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells
spellingShingle Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells
Sanchez, Viviana
Medicina
Tunneling nanotubes
Mesenchymal stem cells
Mitochondrial transfer
Intercellular communication
Intercellular bridges
title_short Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells
title_full Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells
title_fullStr Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells
title_full_unstemmed Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells
title_sort Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells
dc.creator.none.fl_str_mv Sanchez, Viviana
Villalba, Nerina
Fiore, Luciano
Luzzani, Carlos
Miriuka, Santiago Gabriel
Boveris, Alberto
Gelpi, Ricardo Jorge
Brusco, Alicia
Poderoso, Juan José
author Sanchez, Viviana
author_facet Sanchez, Viviana
Villalba, Nerina
Fiore, Luciano
Luzzani, Carlos
Miriuka, Santiago Gabriel
Boveris, Alberto
Gelpi, Ricardo Jorge
Brusco, Alicia
Poderoso, Juan José
author_role author
author2 Villalba, Nerina
Fiore, Luciano
Luzzani, Carlos
Miriuka, Santiago Gabriel
Boveris, Alberto
Gelpi, Ricardo Jorge
Brusco, Alicia
Poderoso, Juan José
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Medicina
Tunneling nanotubes
Mesenchymal stem cells
Mitochondrial transfer
Intercellular communication
Intercellular bridges
topic Medicina
Tunneling nanotubes
Mesenchymal stem cells
Mitochondrial transfer
Intercellular communication
Intercellular bridges
dc.description.none.fl_txt_mv Intercellular communication is one of the most important events in cell population behavior. In the last decade, tunneling nanotubes (TNTs) have been recognized as a new form of long distance intercellular connection. TNT function is to allow molecular and subcellular structure exchange between neighboring cells via the transfer of molecules and organelles such as calcium ions, prions, viral and bacterial pathogens, small lysosomes and mitochondria. New findings support the concept that mesenchymal stem cells (MSCs) can affect cell microenvironment by the release of soluble factors or the transfer of cellular components to neighboring cells, in a way which significantly contributes to cell regulation and tissue repair, although the underlying mechanisms remain poorly understood. MSCs have many advantages for their implementation in regenerative medicine. The TNTs in these cell types are heterogeneous in both structure and function, probably due to their highly dynamic behavior. In this work we report an extensive and detailed description of types, structure, components, dynamics and functionality of the TNTs bridging neighboring human umbilical cord MSCs obtained from Wharton"s jelly. Characterization studies were carried out through phase contrast, fluorescence, electron microscopy and time lapse images with the aim of describing cells suitable for an eventual regenerative medicine.
Facultad de Ciencias Médicas
description Intercellular communication is one of the most important events in cell population behavior. In the last decade, tunneling nanotubes (TNTs) have been recognized as a new form of long distance intercellular connection. TNT function is to allow molecular and subcellular structure exchange between neighboring cells via the transfer of molecules and organelles such as calcium ions, prions, viral and bacterial pathogens, small lysosomes and mitochondria. New findings support the concept that mesenchymal stem cells (MSCs) can affect cell microenvironment by the release of soluble factors or the transfer of cellular components to neighboring cells, in a way which significantly contributes to cell regulation and tissue repair, although the underlying mechanisms remain poorly understood. MSCs have many advantages for their implementation in regenerative medicine. The TNTs in these cell types are heterogeneous in both structure and function, probably due to their highly dynamic behavior. In this work we report an extensive and detailed description of types, structure, components, dynamics and functionality of the TNTs bridging neighboring human umbilical cord MSCs obtained from Wharton"s jelly. Characterization studies were carried out through phase contrast, fluorescence, electron microscopy and time lapse images with the aim of describing cells suitable for an eventual regenerative medicine.
publishDate 2017
dc.date.none.fl_str_mv 2017-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/131988
url http://sedici.unlp.edu.ar/handle/10915/131988
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2629-3277
info:eu-repo/semantics/altIdentifier/issn/1550-8943
info:eu-repo/semantics/altIdentifier/issn/1558-6804
info:eu-repo/semantics/altIdentifier/doi/10.1007/s12015-017-9730-8
info:eu-repo/semantics/altIdentifier/pmid/28214945
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
491-498
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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