Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells
- Autores
- Sanchez, Viviana; Villalba, Nerina; Fiore, Luciano; Luzzani, Carlos; Miriuka, Santiago Gabriel; Boveris, Alberto; Gelpi, Ricardo Jorge; Brusco, Alicia; Poderoso, Juan José
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Intercellular communication is one of the most important events in cell population behavior. In the last decade, tunneling nanotubes (TNTs) have been recognized as a new form of long distance intercellular connection. TNT function is to allow molecular and subcellular structure exchange between neighboring cells via the transfer of molecules and organelles such as calcium ions, prions, viral and bacterial pathogens, small lysosomes and mitochondria. New findings support the concept that mesenchymal stem cells (MSCs) can affect cell microenvironment by the release of soluble factors or the transfer of cellular components to neighboring cells, in a way which significantly contributes to cell regulation and tissue repair, although the underlying mechanisms remain poorly understood. MSCs have many advantages for their implementation in regenerative medicine. The TNTs in these cell types are heterogeneous in both structure and function, probably due to their highly dynamic behavior. In this work we report an extensive and detailed description of types, structure, components, dynamics and functionality of the TNTs bridging neighboring human umbilical cord MSCs obtained from Wharton"s jelly. Characterization studies were carried out through phase contrast, fluorescence, electron microscopy and time lapse images with the aim of describing cells suitable for an eventual regenerative medicine.
Facultad de Ciencias Médicas - Materia
-
Medicina
Tunneling nanotubes
Mesenchymal stem cells
Mitochondrial transfer
Intercellular communication
Intercellular bridges - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/131988
Ver los metadatos del registro completo
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Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring CellsSanchez, VivianaVillalba, NerinaFiore, LucianoLuzzani, CarlosMiriuka, Santiago GabrielBoveris, AlbertoGelpi, Ricardo JorgeBrusco, AliciaPoderoso, Juan JoséMedicinaTunneling nanotubesMesenchymal stem cellsMitochondrial transferIntercellular communicationIntercellular bridgesIntercellular communication is one of the most important events in cell population behavior. In the last decade, tunneling nanotubes (TNTs) have been recognized as a new form of long distance intercellular connection. TNT function is to allow molecular and subcellular structure exchange between neighboring cells via the transfer of molecules and organelles such as calcium ions, prions, viral and bacterial pathogens, small lysosomes and mitochondria. New findings support the concept that mesenchymal stem cells (MSCs) can affect cell microenvironment by the release of soluble factors or the transfer of cellular components to neighboring cells, in a way which significantly contributes to cell regulation and tissue repair, although the underlying mechanisms remain poorly understood. MSCs have many advantages for their implementation in regenerative medicine. The TNTs in these cell types are heterogeneous in both structure and function, probably due to their highly dynamic behavior. In this work we report an extensive and detailed description of types, structure, components, dynamics and functionality of the TNTs bridging neighboring human umbilical cord MSCs obtained from Wharton"s jelly. Characterization studies were carried out through phase contrast, fluorescence, electron microscopy and time lapse images with the aim of describing cells suitable for an eventual regenerative medicine.Facultad de Ciencias Médicas2017-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf491-498http://sedici.unlp.edu.ar/handle/10915/131988enginfo:eu-repo/semantics/altIdentifier/issn/2629-3277info:eu-repo/semantics/altIdentifier/issn/1550-8943info:eu-repo/semantics/altIdentifier/issn/1558-6804info:eu-repo/semantics/altIdentifier/doi/10.1007/s12015-017-9730-8info:eu-repo/semantics/altIdentifier/pmid/28214945info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:32:26Zoai:sedici.unlp.edu.ar:10915/131988Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:32:27.006SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells |
title |
Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells |
spellingShingle |
Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells Sanchez, Viviana Medicina Tunneling nanotubes Mesenchymal stem cells Mitochondrial transfer Intercellular communication Intercellular bridges |
title_short |
Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells |
title_full |
Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells |
title_fullStr |
Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells |
title_full_unstemmed |
Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells |
title_sort |
Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells : An Intercellular Exchange of Components between Neighboring Cells |
dc.creator.none.fl_str_mv |
Sanchez, Viviana Villalba, Nerina Fiore, Luciano Luzzani, Carlos Miriuka, Santiago Gabriel Boveris, Alberto Gelpi, Ricardo Jorge Brusco, Alicia Poderoso, Juan José |
author |
Sanchez, Viviana |
author_facet |
Sanchez, Viviana Villalba, Nerina Fiore, Luciano Luzzani, Carlos Miriuka, Santiago Gabriel Boveris, Alberto Gelpi, Ricardo Jorge Brusco, Alicia Poderoso, Juan José |
author_role |
author |
author2 |
Villalba, Nerina Fiore, Luciano Luzzani, Carlos Miriuka, Santiago Gabriel Boveris, Alberto Gelpi, Ricardo Jorge Brusco, Alicia Poderoso, Juan José |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Medicina Tunneling nanotubes Mesenchymal stem cells Mitochondrial transfer Intercellular communication Intercellular bridges |
topic |
Medicina Tunneling nanotubes Mesenchymal stem cells Mitochondrial transfer Intercellular communication Intercellular bridges |
dc.description.none.fl_txt_mv |
Intercellular communication is one of the most important events in cell population behavior. In the last decade, tunneling nanotubes (TNTs) have been recognized as a new form of long distance intercellular connection. TNT function is to allow molecular and subcellular structure exchange between neighboring cells via the transfer of molecules and organelles such as calcium ions, prions, viral and bacterial pathogens, small lysosomes and mitochondria. New findings support the concept that mesenchymal stem cells (MSCs) can affect cell microenvironment by the release of soluble factors or the transfer of cellular components to neighboring cells, in a way which significantly contributes to cell regulation and tissue repair, although the underlying mechanisms remain poorly understood. MSCs have many advantages for their implementation in regenerative medicine. The TNTs in these cell types are heterogeneous in both structure and function, probably due to their highly dynamic behavior. In this work we report an extensive and detailed description of types, structure, components, dynamics and functionality of the TNTs bridging neighboring human umbilical cord MSCs obtained from Wharton"s jelly. Characterization studies were carried out through phase contrast, fluorescence, electron microscopy and time lapse images with the aim of describing cells suitable for an eventual regenerative medicine. Facultad de Ciencias Médicas |
description |
Intercellular communication is one of the most important events in cell population behavior. In the last decade, tunneling nanotubes (TNTs) have been recognized as a new form of long distance intercellular connection. TNT function is to allow molecular and subcellular structure exchange between neighboring cells via the transfer of molecules and organelles such as calcium ions, prions, viral and bacterial pathogens, small lysosomes and mitochondria. New findings support the concept that mesenchymal stem cells (MSCs) can affect cell microenvironment by the release of soluble factors or the transfer of cellular components to neighboring cells, in a way which significantly contributes to cell regulation and tissue repair, although the underlying mechanisms remain poorly understood. MSCs have many advantages for their implementation in regenerative medicine. The TNTs in these cell types are heterogeneous in both structure and function, probably due to their highly dynamic behavior. In this work we report an extensive and detailed description of types, structure, components, dynamics and functionality of the TNTs bridging neighboring human umbilical cord MSCs obtained from Wharton"s jelly. Characterization studies were carried out through phase contrast, fluorescence, electron microscopy and time lapse images with the aim of describing cells suitable for an eventual regenerative medicine. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/131988 |
url |
http://sedici.unlp.edu.ar/handle/10915/131988 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
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info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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application/pdf 491-498 |
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