Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic

Autores
Bunikis, Jonas; Tsao, Jean; Luke, Catherine J.; Luna, María Gabriela; Fish, Durland; Barbour, Alan G.
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Blood samples from Peromyscus leucopus mice captured at an enzootic site in Connecticut were examined for antibodies to and DNA of Borrelia burgdorferi, to characterize the dynamics of infection in this reservoir population. From trappings conducted over the course of 2 transmission seasons, 598 (75%) of 801 serum samples from 514 mice were found to be positive by enzyme immunoassay. Seropositivity correlated with date of capture and mouse age, was similar among locations within the site, increased from 57% to 93% over the course of the transmission season, and was associated with antibodies to outer surface protein (Osp) C, but not to OspA. Longitudinal samples from 184 mice revealed an incidence of 0.2 cases/mouse/week. Nineteen (10%) of 187 samples were found by polymerase chain reaction to be positive for B. burgdorferi, and, of those, 14 (74%) were found to be seropositive. Nearly the entire population of P. leucopus mice became infected with B. burgdorferi by late August, coinciding with the peak activity period of host-seeking larvae uninfected with the spirochete Ixodes scapularis, thereby perpetuating the agent through succeeding generations of ticks.
Centro de Estudios Parasitológicos y de Vectores
Facultad de Ciencias Naturales y Museo
Materia
Ciencias Naturales
Peromyscus leucopus mice
Borrelia burgdorferi
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/84414

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network_name_str SEDICI (UNLP)
spelling Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemicBunikis, JonasTsao, JeanLuke, Catherine J.Luna, María GabrielaFish, DurlandBarbour, Alan G.Ciencias NaturalesPeromyscus leucopus miceBorrelia burgdorferiBlood samples from <i>Peromyscus leucopus</i> mice captured at an enzootic site in Connecticut were examined for antibodies to and DNA of <i>Borrelia burgdorferi</i>, to characterize the dynamics of infection in this reservoir population. From trappings conducted over the course of 2 transmission seasons, 598 (75%) of 801 serum samples from 514 mice were found to be positive by enzyme immunoassay. Seropositivity correlated with date of capture and mouse age, was similar among locations within the site, increased from 57% to 93% over the course of the transmission season, and was associated with antibodies to outer surface protein (Osp) C, but not to OspA. Longitudinal samples from 184 mice revealed an incidence of 0.2 cases/mouse/week. Nineteen (10%) of 187 samples were found by polymerase chain reaction to be positive for <i>B. burgdorferi</i>, and, of those, 14 (74%) were found to be seropositive. Nearly the entire population of <i>P. leucopus</i> mice became infected with <i>B. burgdorferi</i> by late August, coinciding with the peak activity period of host-seeking larvae uninfected with the spirochete <i>Ixodes scapularis</i>, thereby perpetuating the agent through succeeding generations of ticks.Centro de Estudios Parasitológicos y de VectoresFacultad de Ciencias Naturales y Museo2004info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1515-1523http://sedici.unlp.edu.ar/handle/10915/84414enginfo:eu-repo/semantics/altIdentifier/issn/0022-1899info:eu-repo/semantics/altIdentifier/doi/10.1086/382594info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:16:15Zoai:sedici.unlp.edu.ar:10915/84414Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:16:15.385SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
title Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
spellingShingle Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
Bunikis, Jonas
Ciencias Naturales
Peromyscus leucopus mice
Borrelia burgdorferi
title_short Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
title_full Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
title_fullStr Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
title_full_unstemmed Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
title_sort Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
dc.creator.none.fl_str_mv Bunikis, Jonas
Tsao, Jean
Luke, Catherine J.
Luna, María Gabriela
Fish, Durland
Barbour, Alan G.
author Bunikis, Jonas
author_facet Bunikis, Jonas
Tsao, Jean
Luke, Catherine J.
Luna, María Gabriela
Fish, Durland
Barbour, Alan G.
author_role author
author2 Tsao, Jean
Luke, Catherine J.
Luna, María Gabriela
Fish, Durland
Barbour, Alan G.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Naturales
Peromyscus leucopus mice
Borrelia burgdorferi
topic Ciencias Naturales
Peromyscus leucopus mice
Borrelia burgdorferi
dc.description.none.fl_txt_mv Blood samples from <i>Peromyscus leucopus</i> mice captured at an enzootic site in Connecticut were examined for antibodies to and DNA of <i>Borrelia burgdorferi</i>, to characterize the dynamics of infection in this reservoir population. From trappings conducted over the course of 2 transmission seasons, 598 (75%) of 801 serum samples from 514 mice were found to be positive by enzyme immunoassay. Seropositivity correlated with date of capture and mouse age, was similar among locations within the site, increased from 57% to 93% over the course of the transmission season, and was associated with antibodies to outer surface protein (Osp) C, but not to OspA. Longitudinal samples from 184 mice revealed an incidence of 0.2 cases/mouse/week. Nineteen (10%) of 187 samples were found by polymerase chain reaction to be positive for <i>B. burgdorferi</i>, and, of those, 14 (74%) were found to be seropositive. Nearly the entire population of <i>P. leucopus</i> mice became infected with <i>B. burgdorferi</i> by late August, coinciding with the peak activity period of host-seeking larvae uninfected with the spirochete <i>Ixodes scapularis</i>, thereby perpetuating the agent through succeeding generations of ticks.
Centro de Estudios Parasitológicos y de Vectores
Facultad de Ciencias Naturales y Museo
description Blood samples from <i>Peromyscus leucopus</i> mice captured at an enzootic site in Connecticut were examined for antibodies to and DNA of <i>Borrelia burgdorferi</i>, to characterize the dynamics of infection in this reservoir population. From trappings conducted over the course of 2 transmission seasons, 598 (75%) of 801 serum samples from 514 mice were found to be positive by enzyme immunoassay. Seropositivity correlated with date of capture and mouse age, was similar among locations within the site, increased from 57% to 93% over the course of the transmission season, and was associated with antibodies to outer surface protein (Osp) C, but not to OspA. Longitudinal samples from 184 mice revealed an incidence of 0.2 cases/mouse/week. Nineteen (10%) of 187 samples were found by polymerase chain reaction to be positive for <i>B. burgdorferi</i>, and, of those, 14 (74%) were found to be seropositive. Nearly the entire population of <i>P. leucopus</i> mice became infected with <i>B. burgdorferi</i> by late August, coinciding with the peak activity period of host-seeking larvae uninfected with the spirochete <i>Ixodes scapularis</i>, thereby perpetuating the agent through succeeding generations of ticks.
publishDate 2004
dc.date.none.fl_str_mv 2004
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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url http://sedici.unlp.edu.ar/handle/10915/84414
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0022-1899
info:eu-repo/semantics/altIdentifier/doi/10.1086/382594
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
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