Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic
- Autores
- Bunikis, Jonas; Tsao, Jean; Luke, Catherine J.; Luna, María Gabriela; Fish, Durland; Barbour, Alan G.
- Año de publicación
- 2004
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Blood samples from Peromyscus leucopus mice captured at an enzootic site in Connecticut were examined for antibodies to and DNA of Borrelia burgdorferi, to characterize the dynamics of infection in this reservoir population. From trappings conducted over the course of 2 transmission seasons, 598 (75%) of 801 serum samples from 514 mice were found to be positive by enzyme immunoassay. Seropositivity correlated with date of capture and mouse age, was similar among locations within the site, increased from 57% to 93% over the course of the transmission season, and was associated with antibodies to outer surface protein (Osp) C, but not to OspA. Longitudinal samples from 184 mice revealed an incidence of 0.2 cases/mouse/week. Nineteen (10%) of 187 samples were found by polymerase chain reaction to be positive for B. burgdorferi, and, of those, 14 (74%) were found to be seropositive. Nearly the entire population of P. leucopus mice became infected with B. burgdorferi by late August, coinciding with the peak activity period of host-seeking larvae uninfected with the spirochete Ixodes scapularis, thereby perpetuating the agent through succeeding generations of ticks.
Centro de Estudios Parasitológicos y de Vectores
Facultad de Ciencias Naturales y Museo - Materia
-
Ciencias Naturales
Peromyscus leucopus mice
Borrelia burgdorferi - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/84414
Ver los metadatos del registro completo
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Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemicBunikis, JonasTsao, JeanLuke, Catherine J.Luna, María GabrielaFish, DurlandBarbour, Alan G.Ciencias NaturalesPeromyscus leucopus miceBorrelia burgdorferiBlood samples from <i>Peromyscus leucopus</i> mice captured at an enzootic site in Connecticut were examined for antibodies to and DNA of <i>Borrelia burgdorferi</i>, to characterize the dynamics of infection in this reservoir population. From trappings conducted over the course of 2 transmission seasons, 598 (75%) of 801 serum samples from 514 mice were found to be positive by enzyme immunoassay. Seropositivity correlated with date of capture and mouse age, was similar among locations within the site, increased from 57% to 93% over the course of the transmission season, and was associated with antibodies to outer surface protein (Osp) C, but not to OspA. Longitudinal samples from 184 mice revealed an incidence of 0.2 cases/mouse/week. Nineteen (10%) of 187 samples were found by polymerase chain reaction to be positive for <i>B. burgdorferi</i>, and, of those, 14 (74%) were found to be seropositive. Nearly the entire population of <i>P. leucopus</i> mice became infected with <i>B. burgdorferi</i> by late August, coinciding with the peak activity period of host-seeking larvae uninfected with the spirochete <i>Ixodes scapularis</i>, thereby perpetuating the agent through succeeding generations of ticks.Centro de Estudios Parasitológicos y de VectoresFacultad de Ciencias Naturales y Museo2004info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1515-1523http://sedici.unlp.edu.ar/handle/10915/84414enginfo:eu-repo/semantics/altIdentifier/issn/0022-1899info:eu-repo/semantics/altIdentifier/doi/10.1086/382594info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:16:15Zoai:sedici.unlp.edu.ar:10915/84414Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:16:15.385SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic |
title |
Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic |
spellingShingle |
Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic Bunikis, Jonas Ciencias Naturales Peromyscus leucopus mice Borrelia burgdorferi |
title_short |
Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic |
title_full |
Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic |
title_fullStr |
Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic |
title_full_unstemmed |
Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic |
title_sort |
Borrelia burgdorferi infection in a natural population of Peromyscus leucopus mice: A longitudinal study in an area where lyme borreliosis is highly endemic |
dc.creator.none.fl_str_mv |
Bunikis, Jonas Tsao, Jean Luke, Catherine J. Luna, María Gabriela Fish, Durland Barbour, Alan G. |
author |
Bunikis, Jonas |
author_facet |
Bunikis, Jonas Tsao, Jean Luke, Catherine J. Luna, María Gabriela Fish, Durland Barbour, Alan G. |
author_role |
author |
author2 |
Tsao, Jean Luke, Catherine J. Luna, María Gabriela Fish, Durland Barbour, Alan G. |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Ciencias Naturales Peromyscus leucopus mice Borrelia burgdorferi |
topic |
Ciencias Naturales Peromyscus leucopus mice Borrelia burgdorferi |
dc.description.none.fl_txt_mv |
Blood samples from <i>Peromyscus leucopus</i> mice captured at an enzootic site in Connecticut were examined for antibodies to and DNA of <i>Borrelia burgdorferi</i>, to characterize the dynamics of infection in this reservoir population. From trappings conducted over the course of 2 transmission seasons, 598 (75%) of 801 serum samples from 514 mice were found to be positive by enzyme immunoassay. Seropositivity correlated with date of capture and mouse age, was similar among locations within the site, increased from 57% to 93% over the course of the transmission season, and was associated with antibodies to outer surface protein (Osp) C, but not to OspA. Longitudinal samples from 184 mice revealed an incidence of 0.2 cases/mouse/week. Nineteen (10%) of 187 samples were found by polymerase chain reaction to be positive for <i>B. burgdorferi</i>, and, of those, 14 (74%) were found to be seropositive. Nearly the entire population of <i>P. leucopus</i> mice became infected with <i>B. burgdorferi</i> by late August, coinciding with the peak activity period of host-seeking larvae uninfected with the spirochete <i>Ixodes scapularis</i>, thereby perpetuating the agent through succeeding generations of ticks. Centro de Estudios Parasitológicos y de Vectores Facultad de Ciencias Naturales y Museo |
description |
Blood samples from <i>Peromyscus leucopus</i> mice captured at an enzootic site in Connecticut were examined for antibodies to and DNA of <i>Borrelia burgdorferi</i>, to characterize the dynamics of infection in this reservoir population. From trappings conducted over the course of 2 transmission seasons, 598 (75%) of 801 serum samples from 514 mice were found to be positive by enzyme immunoassay. Seropositivity correlated with date of capture and mouse age, was similar among locations within the site, increased from 57% to 93% over the course of the transmission season, and was associated with antibodies to outer surface protein (Osp) C, but not to OspA. Longitudinal samples from 184 mice revealed an incidence of 0.2 cases/mouse/week. Nineteen (10%) of 187 samples were found by polymerase chain reaction to be positive for <i>B. burgdorferi</i>, and, of those, 14 (74%) were found to be seropositive. Nearly the entire population of <i>P. leucopus</i> mice became infected with <i>B. burgdorferi</i> by late August, coinciding with the peak activity period of host-seeking larvae uninfected with the spirochete <i>Ixodes scapularis</i>, thereby perpetuating the agent through succeeding generations of ticks. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/84414 |
url |
http://sedici.unlp.edu.ar/handle/10915/84414 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/altIdentifier/issn/0022-1899 info:eu-repo/semantics/altIdentifier/doi/10.1086/382594 |
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openAccess |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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