A model to understand type I oxidations of biomolecules photosensitized by pterins

Autores
Lorente, Carolina; Serrano, Mariana Paula; Vignoni, Mariana; Dántola, María Laura; Thomas, Andrés Héctor
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Photosensitized oxidations, in part responsible for the harmful effect of UV and visible radiation on biological systems, can take place through type I (generation of radicals) and type II (singlet oxygen) mechanisms. Pterins are heterocyclic compounds, widespread in living systems and involved in relevant biological functions. Pterins present a profuse and amazing photochemistry and are endogenous photosensitizers that act mainly via type I mechanism. This survey is aimed to contribute to a better understanding on the complex set of competitive pathways involved in type I photosensitization. Based on studies performed in model systems with pterins as photosensitizers, this review explores the mechanisms involved in the type I photooxidations of proteins, DNA and lipids sensitized by pterins. The generation of radicals and their subsequent reactions are described together with the analysis of the role of O 2 and reactive oxygen species. The chemical modification of pterins seeking for better properties and the effect of the photochemical processes at a cellular level are also analyzed.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Materia
Química
Biología
pterins
photosensitization
singlet oxygen
radicals
photooxidation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-nd/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/160474
Acceder
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network_name_str SEDICI (UNLP)
spelling A model to understand type I oxidations of biomolecules photosensitized by pterinsLorente, CarolinaSerrano, Mariana PaulaVignoni, MarianaDántola, María LauraThomas, Andrés HéctorQuímicaBiologíapterinsphotosensitizationsinglet oxygenradicalsphotooxidationPhotosensitized oxidations, in part responsible for the harmful effect of UV and visible radiation on biological systems, can take place through type I (generation of radicals) and type II (singlet oxygen) mechanisms. Pterins are heterocyclic compounds, widespread in living systems and involved in relevant biological functions. Pterins present a profuse and amazing photochemistry and are endogenous photosensitizers that act mainly via type I mechanism. This survey is aimed to contribute to a better understanding on the complex set of competitive pathways involved in type I photosensitization. Based on studies performed in model systems with pterins as photosensitizers, this review explores the mechanisms involved in the type I photooxidations of proteins, DNA and lipids sensitized by pterins. The generation of radicals and their subsequent reactions are described together with the analysis of the role of O 2 and reactive oxygen species. The chemical modification of pterins seeking for better properties and the effect of the photochemical processes at a cellular level are also analyzed.Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/160474enginfo:eu-repo/semantics/altIdentifier/issn/2666-4690info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpap.2021.100045info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:14:00Zoai:sedici.unlp.edu.ar:10915/160474Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:14:00.523SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv A model to understand type I oxidations of biomolecules photosensitized by pterins
title A model to understand type I oxidations of biomolecules photosensitized by pterins
spellingShingle A model to understand type I oxidations of biomolecules photosensitized by pterins
Lorente, Carolina
Química
Biología
pterins
photosensitization
singlet oxygen
radicals
photooxidation
title_short A model to understand type I oxidations of biomolecules photosensitized by pterins
title_full A model to understand type I oxidations of biomolecules photosensitized by pterins
title_fullStr A model to understand type I oxidations of biomolecules photosensitized by pterins
title_full_unstemmed A model to understand type I oxidations of biomolecules photosensitized by pterins
title_sort A model to understand type I oxidations of biomolecules photosensitized by pterins
dc.creator.none.fl_str_mv Lorente, Carolina
Serrano, Mariana Paula
Vignoni, Mariana
Dántola, María Laura
Thomas, Andrés Héctor
author Lorente, Carolina
author_facet Lorente, Carolina
Serrano, Mariana Paula
Vignoni, Mariana
Dántola, María Laura
Thomas, Andrés Héctor
author_role author
author2 Serrano, Mariana Paula
Vignoni, Mariana
Dántola, María Laura
Thomas, Andrés Héctor
author2_role author
author
author
author
dc.subject.none.fl_str_mv Química
Biología
pterins
photosensitization
singlet oxygen
radicals
photooxidation
topic Química
Biología
pterins
photosensitization
singlet oxygen
radicals
photooxidation
dc.description.none.fl_txt_mv Photosensitized oxidations, in part responsible for the harmful effect of UV and visible radiation on biological systems, can take place through type I (generation of radicals) and type II (singlet oxygen) mechanisms. Pterins are heterocyclic compounds, widespread in living systems and involved in relevant biological functions. Pterins present a profuse and amazing photochemistry and are endogenous photosensitizers that act mainly via type I mechanism. This survey is aimed to contribute to a better understanding on the complex set of competitive pathways involved in type I photosensitization. Based on studies performed in model systems with pterins as photosensitizers, this review explores the mechanisms involved in the type I photooxidations of proteins, DNA and lipids sensitized by pterins. The generation of radicals and their subsequent reactions are described together with the analysis of the role of O 2 and reactive oxygen species. The chemical modification of pterins seeking for better properties and the effect of the photochemical processes at a cellular level are also analyzed.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
description Photosensitized oxidations, in part responsible for the harmful effect of UV and visible radiation on biological systems, can take place through type I (generation of radicals) and type II (singlet oxygen) mechanisms. Pterins are heterocyclic compounds, widespread in living systems and involved in relevant biological functions. Pterins present a profuse and amazing photochemistry and are endogenous photosensitizers that act mainly via type I mechanism. This survey is aimed to contribute to a better understanding on the complex set of competitive pathways involved in type I photosensitization. Based on studies performed in model systems with pterins as photosensitizers, this review explores the mechanisms involved in the type I photooxidations of proteins, DNA and lipids sensitized by pterins. The generation of radicals and their subsequent reactions are described together with the analysis of the role of O 2 and reactive oxygen species. The chemical modification of pterins seeking for better properties and the effect of the photochemical processes at a cellular level are also analyzed.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/160474
url http://sedici.unlp.edu.ar/handle/10915/160474
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2666-4690
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpap.2021.100045
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.13397

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