The role of primary cilia in cancer
- Autores
- Peixoto, Estanislao; Mansini, Adrian P.; Thelen, Kristen M.; Gaspari, Cesar I.; Jin, Sujeong; Gradilone, Sergio A.
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- reseña artículo
- Estado
- versión publicada
- Descripción
- Primary cilia are microtubule based organelles that sense and transduce multiple extracellular signals to the interior of the cell through several signaling pathways. Ciliary defects lead to different pathologies. Interestingly, decreased ciliary expression has been associated with different types of cancer. In this review, we discuss the function and dynamics of primary cilia, their relation to different diseases and in particular their role in cancer, and how they can be explored as potential therapeutic targets.
Sociedad Argentina de Fisiología - Materia
-
Biología
Ciencias Médicas
Primary cilia
Cholangiocarcinoma
Cancer
HDAC6 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/125649
Ver los metadatos del registro completo
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The role of primary cilia in cancerPeixoto, EstanislaoMansini, Adrian P.Thelen, Kristen M.Gaspari, Cesar I.Jin, SujeongGradilone, Sergio A.BiologíaCiencias MédicasPrimary ciliaCholangiocarcinomaCancerHDAC6Primary cilia are microtubule based organelles that sense and transduce multiple extracellular signals to the interior of the cell through several signaling pathways. Ciliary defects lead to different pathologies. Interestingly, decreased ciliary expression has been associated with different types of cancer. In this review, we discuss the function and dynamics of primary cilia, their relation to different diseases and in particular their role in cancer, and how they can be explored as potential therapeutic targets.Sociedad Argentina de Fisiología2017-02info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf1-11http://sedici.unlp.edu.ar/handle/10915/125649enginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/archive/id/93info:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:30:13Zoai:sedici.unlp.edu.ar:10915/125649Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:30:13.369SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
The role of primary cilia in cancer |
title |
The role of primary cilia in cancer |
spellingShingle |
The role of primary cilia in cancer Peixoto, Estanislao Biología Ciencias Médicas Primary cilia Cholangiocarcinoma Cancer HDAC6 |
title_short |
The role of primary cilia in cancer |
title_full |
The role of primary cilia in cancer |
title_fullStr |
The role of primary cilia in cancer |
title_full_unstemmed |
The role of primary cilia in cancer |
title_sort |
The role of primary cilia in cancer |
dc.creator.none.fl_str_mv |
Peixoto, Estanislao Mansini, Adrian P. Thelen, Kristen M. Gaspari, Cesar I. Jin, Sujeong Gradilone, Sergio A. |
author |
Peixoto, Estanislao |
author_facet |
Peixoto, Estanislao Mansini, Adrian P. Thelen, Kristen M. Gaspari, Cesar I. Jin, Sujeong Gradilone, Sergio A. |
author_role |
author |
author2 |
Mansini, Adrian P. Thelen, Kristen M. Gaspari, Cesar I. Jin, Sujeong Gradilone, Sergio A. |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Biología Ciencias Médicas Primary cilia Cholangiocarcinoma Cancer HDAC6 |
topic |
Biología Ciencias Médicas Primary cilia Cholangiocarcinoma Cancer HDAC6 |
dc.description.none.fl_txt_mv |
Primary cilia are microtubule based organelles that sense and transduce multiple extracellular signals to the interior of the cell through several signaling pathways. Ciliary defects lead to different pathologies. Interestingly, decreased ciliary expression has been associated with different types of cancer. In this review, we discuss the function and dynamics of primary cilia, their relation to different diseases and in particular their role in cancer, and how they can be explored as potential therapeutic targets. Sociedad Argentina de Fisiología |
description |
Primary cilia are microtubule based organelles that sense and transduce multiple extracellular signals to the interior of the cell through several signaling pathways. Ciliary defects lead to different pathologies. Interestingly, decreased ciliary expression has been associated with different types of cancer. In this review, we discuss the function and dynamics of primary cilia, their relation to different diseases and in particular their role in cancer, and how they can be explored as potential therapeutic targets. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Revision http://purl.org/coar/resource_type/c_dcae04bc info:ar-repo/semantics/resenaArticulo |
format |
review |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/125649 |
url |
http://sedici.unlp.edu.ar/handle/10915/125649 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/archive/id/93 info:eu-repo/semantics/altIdentifier/issn/1669-5410 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
eu_rights_str_mv |
openAccess |
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http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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application/pdf 1-11 |
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SEDICI (UNLP) - Universidad Nacional de La Plata |
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