The role of primary cilia in cancer

Autores
Peixoto, Estanislao; Mansini, Adrian P.; Thelen, Kristen M.; Gaspari, Cesar I.; Jin, Sujeong; Gradilone, Sergio A.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
reseña artículo
Estado
versión publicada
Descripción
Primary cilia are microtubule based organelles that sense and transduce multiple extracellular signals to the interior of the cell through several signaling pathways. Ciliary defects lead to different pathologies. Interestingly, decreased ciliary expression has been associated with different types of cancer. In this review, we discuss the function and dynamics of primary cilia, their relation to different diseases and in particular their role in cancer, and how they can be explored as potential therapeutic targets.
Sociedad Argentina de Fisiología
Materia
Biología
Ciencias Médicas
Primary cilia
Cholangiocarcinoma
Cancer
HDAC6
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/125649
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/125649
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling The role of primary cilia in cancerPeixoto, EstanislaoMansini, Adrian P.Thelen, Kristen M.Gaspari, Cesar I.Jin, SujeongGradilone, Sergio A.BiologíaCiencias MédicasPrimary ciliaCholangiocarcinomaCancerHDAC6Primary cilia are microtubule based organelles that sense and transduce multiple extracellular signals to the interior of the cell through several signaling pathways. Ciliary defects lead to different pathologies. Interestingly, decreased ciliary expression has been associated with different types of cancer. In this review, we discuss the function and dynamics of primary cilia, their relation to different diseases and in particular their role in cancer, and how they can be explored as potential therapeutic targets.Sociedad Argentina de Fisiología2017-02info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf1-11http://sedici.unlp.edu.ar/handle/10915/125649enginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/archive/id/93info:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:11:09Zoai:sedici.unlp.edu.ar:10915/125649Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:11:09.739SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The role of primary cilia in cancer
title The role of primary cilia in cancer
spellingShingle The role of primary cilia in cancer
Peixoto, Estanislao
Biología
Ciencias Médicas
Primary cilia
Cholangiocarcinoma
Cancer
HDAC6
title_short The role of primary cilia in cancer
title_full The role of primary cilia in cancer
title_fullStr The role of primary cilia in cancer
title_full_unstemmed The role of primary cilia in cancer
title_sort The role of primary cilia in cancer
dc.creator.none.fl_str_mv Peixoto, Estanislao
Mansini, Adrian P.
Thelen, Kristen M.
Gaspari, Cesar I.
Jin, Sujeong
Gradilone, Sergio A.
author Peixoto, Estanislao
author_facet Peixoto, Estanislao
Mansini, Adrian P.
Thelen, Kristen M.
Gaspari, Cesar I.
Jin, Sujeong
Gradilone, Sergio A.
author_role author
author2 Mansini, Adrian P.
Thelen, Kristen M.
Gaspari, Cesar I.
Jin, Sujeong
Gradilone, Sergio A.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Biología
Ciencias Médicas
Primary cilia
Cholangiocarcinoma
Cancer
HDAC6
topic Biología
Ciencias Médicas
Primary cilia
Cholangiocarcinoma
Cancer
HDAC6
dc.description.none.fl_txt_mv Primary cilia are microtubule based organelles that sense and transduce multiple extracellular signals to the interior of the cell through several signaling pathways. Ciliary defects lead to different pathologies. Interestingly, decreased ciliary expression has been associated with different types of cancer. In this review, we discuss the function and dynamics of primary cilia, their relation to different diseases and in particular their role in cancer, and how they can be explored as potential therapeutic targets.
Sociedad Argentina de Fisiología
description Primary cilia are microtubule based organelles that sense and transduce multiple extracellular signals to the interior of the cell through several signaling pathways. Ciliary defects lead to different pathologies. Interestingly, decreased ciliary expression has been associated with different types of cancer. In this review, we discuss the function and dynamics of primary cilia, their relation to different diseases and in particular their role in cancer, and how they can be explored as potential therapeutic targets.
publishDate 2017
dc.date.none.fl_str_mv 2017-02
dc.type.none.fl_str_mv info:eu-repo/semantics/review
info:eu-repo/semantics/publishedVersion
Revision
http://purl.org/coar/resource_type/c_dcae04bc
info:ar-repo/semantics/resenaArticulo
format review
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/125649
url http://sedici.unlp.edu.ar/handle/10915/125649
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/archive/id/93
info:eu-repo/semantics/altIdentifier/issn/1669-5410
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
1-11
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 12.982451

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