Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage

Autores
Federico, Marilén; Valverde, Carlos Alfredo; Mattiazzi, Alicia Ramona; Palomeque, Julieta
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The present review focusses on the regulation and interplay of cardiac SR Ca2+ handling proteins involved in SR Ca2+ uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or different partners’ proteins. These control mechanisms guarantee a precise equilibrium between SR Ca2+ reuptake and release. The review then discusses how disruption of this balance alters SR Ca2+ handling and may constitute a first step toward cardiac damage and malignant arrhythmias. In the last part of the review, this concept is exemplified in different cardiac diseases, like prediabetic and diabetic cardiomyopathy, digitalis intoxication and ischemia-reperfusion injury.
Facultad de Ciencias Médicas
Centro de Investigaciones Cardiovasculares
Materia
Medicina
sarcoplasmic reticulum Ca2+-ATPase
ryanodine receptor 2
arrhythimas
phospholamban
Apoptosis
diabetic myocardiopathy
isquemia-reperfusión
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/107960
Acceder
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network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac DamageFederico, MarilénValverde, Carlos AlfredoMattiazzi, Alicia RamonaPalomeque, JulietaMedicinasarcoplasmic reticulum Ca2+-ATPaseryanodine receptor 2arrhythimasphospholambanApoptosisdiabetic myocardiopathyisquemia-reperfusiónThe present review focusses on the regulation and interplay of cardiac SR Ca<sup>2+</sup> handling proteins involved in SR Ca<sup>2+</sup> uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or different partners’ proteins. These control mechanisms guarantee a precise equilibrium between SR Ca<sup>2+</sup> reuptake and release. The review then discusses how disruption of this balance alters SR Ca<sup>2+</sup> handling and may constitute a first step toward cardiac damage and malignant arrhythmias. In the last part of the review, this concept is exemplified in different cardiac diseases, like prediabetic and diabetic cardiomyopathy, digitalis intoxication and ischemia-reperfusion injury.Facultad de Ciencias MédicasCentro de Investigaciones Cardiovasculares2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/107960enginfo:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6989610&blobtype=pdfinfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphys.2019.01630/fullinfo:eu-repo/semantics/altIdentifier/issn/1664-042Xinfo:eu-repo/semantics/altIdentifier/pmid/32038301info:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2019.01630info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-10T12:26:32Zoai:sedici.unlp.edu.ar:10915/107960Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-10 12:26:32.946SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
title Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
spellingShingle Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
Federico, Marilén
Medicina
sarcoplasmic reticulum Ca2+-ATPase
ryanodine receptor 2
arrhythimas
phospholamban
Apoptosis
diabetic myocardiopathy
isquemia-reperfusión
title_short Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
title_full Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
title_fullStr Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
title_full_unstemmed Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
title_sort Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
dc.creator.none.fl_str_mv Federico, Marilén
Valverde, Carlos Alfredo
Mattiazzi, Alicia Ramona
Palomeque, Julieta
author Federico, Marilén
author_facet Federico, Marilén
Valverde, Carlos Alfredo
Mattiazzi, Alicia Ramona
Palomeque, Julieta
author_role author
author2 Valverde, Carlos Alfredo
Mattiazzi, Alicia Ramona
Palomeque, Julieta
author2_role author
author
author
dc.subject.none.fl_str_mv Medicina
sarcoplasmic reticulum Ca2+-ATPase
ryanodine receptor 2
arrhythimas
phospholamban
Apoptosis
diabetic myocardiopathy
isquemia-reperfusión
topic Medicina
sarcoplasmic reticulum Ca2+-ATPase
ryanodine receptor 2
arrhythimas
phospholamban
Apoptosis
diabetic myocardiopathy
isquemia-reperfusión
dc.description.none.fl_txt_mv The present review focusses on the regulation and interplay of cardiac SR Ca<sup>2+</sup> handling proteins involved in SR Ca<sup>2+</sup> uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or different partners’ proteins. These control mechanisms guarantee a precise equilibrium between SR Ca<sup>2+</sup> reuptake and release. The review then discusses how disruption of this balance alters SR Ca<sup>2+</sup> handling and may constitute a first step toward cardiac damage and malignant arrhythmias. In the last part of the review, this concept is exemplified in different cardiac diseases, like prediabetic and diabetic cardiomyopathy, digitalis intoxication and ischemia-reperfusion injury.
Facultad de Ciencias Médicas
Centro de Investigaciones Cardiovasculares
description The present review focusses on the regulation and interplay of cardiac SR Ca<sup>2+</sup> handling proteins involved in SR Ca<sup>2+</sup> uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or different partners’ proteins. These control mechanisms guarantee a precise equilibrium between SR Ca<sup>2+</sup> reuptake and release. The review then discusses how disruption of this balance alters SR Ca<sup>2+</sup> handling and may constitute a first step toward cardiac damage and malignant arrhythmias. In the last part of the review, this concept is exemplified in different cardiac diseases, like prediabetic and diabetic cardiomyopathy, digitalis intoxication and ischemia-reperfusion injury.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/107960
url http://sedici.unlp.edu.ar/handle/10915/107960
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6989610&blobtype=pdf
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphys.2019.01630/full
info:eu-repo/semantics/altIdentifier/issn/1664-042X
info:eu-repo/semantics/altIdentifier/pmid/32038301
info:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2019.01630
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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