Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin

Autores
Pardo, Joaquín; Schwerdt, José Ignacio; Reggiani, Paula Cecilia; Zappa, María Eugenia; Pereyra, Andrea Soledad; Brown, Oscar Alfredo; Goya, Juan Francisco
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Thymulin is a thymic hormone exclusively produced by the thymic epithelial cells. After its discovery and initial characterization in the ‘70s, it was demonstrated that thymulin production and secretion is strongly influenced by the neuroendocrine system. Conversely, a growing core of information, to be reviewed here, points to thymulin as a hypophysiotropic peptide. Additionally, the substantial body of evidence pointing to thymulin and some synthetic analogs as anti-inflammatory and analgesic molecules in the brain and other organs will be also reviewed. In recent years, a synthetic DNA sequence coding for a biologically active analog of thymulin, metFTS, was constructed and cloned in different adenoviral vectors. A number of recent studies suggest that thymulin gene therapy may be a suitable therapeutic strategy to prevent some of the endocrine and reproductive alterations that typically appear in congenitally athymic (nude) mice, used as a suitable model of neuroendocrine and reproductive aging. Summing up, the present article briefly reviews the literature on the physiology of the thymulin-neuroendocrine axis and the anti-inflammatory properties of the molecule and its analogs. The availability of novel biotechnological tools should boost basic studies on the molecular biology of thymulin and should also allow an assessment of the potential of gene therapy to restore circulating thymulin levels in thymodeficient animal models and eventually, in humans.
Sociedad Argentina de Fisiología
Materia
Ciencias Médicas
thymulin
neuroendocrine control
hypophysiotropic activity
artificial gene
gene therapy
anti-inflammatory
ovarian dysgenesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/131279

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network_name_str SEDICI (UNLP)
spelling Physiology, molecular biology and therapeutic potential of the thymic peptide thymulinPardo, JoaquínSchwerdt, José IgnacioReggiani, Paula CeciliaZappa, María EugeniaPereyra, Andrea SoledadBrown, Oscar AlfredoGoya, Juan FranciscoCiencias Médicasthymulinneuroendocrine controlhypophysiotropic activityartificial genegene therapyanti-inflammatoryovarian dysgenesisThymulin is a thymic hormone exclusively produced by the thymic epithelial cells. After its discovery and initial characterization in the ‘70s, it was demonstrated that thymulin production and secretion is strongly influenced by the neuroendocrine system. Conversely, a growing core of information, to be reviewed here, points to thymulin as a hypophysiotropic peptide. Additionally, the substantial body of evidence pointing to thymulin and some synthetic analogs as anti-inflammatory and analgesic molecules in the brain and other organs will be also reviewed. In recent years, a synthetic DNA sequence coding for a biologically active analog of thymulin, metFTS, was constructed and cloned in different adenoviral vectors. A number of recent studies suggest that thymulin gene therapy may be a suitable therapeutic strategy to prevent some of the endocrine and reproductive alterations that typically appear in congenitally athymic (nude) mice, used as a suitable model of neuroendocrine and reproductive aging. Summing up, the present article briefly reviews the literature on the physiology of the thymulin-neuroendocrine axis and the anti-inflammatory properties of the molecule and its analogs. The availability of novel biotechnological tools should boost basic studies on the molecular biology of thymulin and should also allow an assessment of the potential of gene therapy to restore circulating thymulin levels in thymodeficient animal models and eventually, in humans.Sociedad Argentina de Fisiología2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/131279enginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/uploadsarchivos/vol_6__1__physiology_w3.pdfinfo:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:33:02Zoai:sedici.unlp.edu.ar:10915/131279Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:33:02.608SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
title Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
spellingShingle Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
Pardo, Joaquín
Ciencias Médicas
thymulin
neuroendocrine control
hypophysiotropic activity
artificial gene
gene therapy
anti-inflammatory
ovarian dysgenesis
title_short Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
title_full Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
title_fullStr Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
title_full_unstemmed Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
title_sort Physiology, molecular biology and therapeutic potential of the thymic peptide thymulin
dc.creator.none.fl_str_mv Pardo, Joaquín
Schwerdt, José Ignacio
Reggiani, Paula Cecilia
Zappa, María Eugenia
Pereyra, Andrea Soledad
Brown, Oscar Alfredo
Goya, Juan Francisco
author Pardo, Joaquín
author_facet Pardo, Joaquín
Schwerdt, José Ignacio
Reggiani, Paula Cecilia
Zappa, María Eugenia
Pereyra, Andrea Soledad
Brown, Oscar Alfredo
Goya, Juan Francisco
author_role author
author2 Schwerdt, José Ignacio
Reggiani, Paula Cecilia
Zappa, María Eugenia
Pereyra, Andrea Soledad
Brown, Oscar Alfredo
Goya, Juan Francisco
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
thymulin
neuroendocrine control
hypophysiotropic activity
artificial gene
gene therapy
anti-inflammatory
ovarian dysgenesis
topic Ciencias Médicas
thymulin
neuroendocrine control
hypophysiotropic activity
artificial gene
gene therapy
anti-inflammatory
ovarian dysgenesis
dc.description.none.fl_txt_mv Thymulin is a thymic hormone exclusively produced by the thymic epithelial cells. After its discovery and initial characterization in the ‘70s, it was demonstrated that thymulin production and secretion is strongly influenced by the neuroendocrine system. Conversely, a growing core of information, to be reviewed here, points to thymulin as a hypophysiotropic peptide. Additionally, the substantial body of evidence pointing to thymulin and some synthetic analogs as anti-inflammatory and analgesic molecules in the brain and other organs will be also reviewed. In recent years, a synthetic DNA sequence coding for a biologically active analog of thymulin, metFTS, was constructed and cloned in different adenoviral vectors. A number of recent studies suggest that thymulin gene therapy may be a suitable therapeutic strategy to prevent some of the endocrine and reproductive alterations that typically appear in congenitally athymic (nude) mice, used as a suitable model of neuroendocrine and reproductive aging. Summing up, the present article briefly reviews the literature on the physiology of the thymulin-neuroendocrine axis and the anti-inflammatory properties of the molecule and its analogs. The availability of novel biotechnological tools should boost basic studies on the molecular biology of thymulin and should also allow an assessment of the potential of gene therapy to restore circulating thymulin levels in thymodeficient animal models and eventually, in humans.
Sociedad Argentina de Fisiología
description Thymulin is a thymic hormone exclusively produced by the thymic epithelial cells. After its discovery and initial characterization in the ‘70s, it was demonstrated that thymulin production and secretion is strongly influenced by the neuroendocrine system. Conversely, a growing core of information, to be reviewed here, points to thymulin as a hypophysiotropic peptide. Additionally, the substantial body of evidence pointing to thymulin and some synthetic analogs as anti-inflammatory and analgesic molecules in the brain and other organs will be also reviewed. In recent years, a synthetic DNA sequence coding for a biologically active analog of thymulin, metFTS, was constructed and cloned in different adenoviral vectors. A number of recent studies suggest that thymulin gene therapy may be a suitable therapeutic strategy to prevent some of the endocrine and reproductive alterations that typically appear in congenitally athymic (nude) mice, used as a suitable model of neuroendocrine and reproductive aging. Summing up, the present article briefly reviews the literature on the physiology of the thymulin-neuroendocrine axis and the anti-inflammatory properties of the molecule and its analogs. The availability of novel biotechnological tools should boost basic studies on the molecular biology of thymulin and should also allow an assessment of the potential of gene therapy to restore circulating thymulin levels in thymodeficient animal models and eventually, in humans.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/131279
url http://sedici.unlp.edu.ar/handle/10915/131279
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/issn/1669-5410
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
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reponame_str SEDICI (UNLP)
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