Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
- Autores
- Curciarello, Renata; Canziani, Karina Eva; Docena, Guillermo Horacio; Muglia, Cecilia Isabel
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The mucosal immune system constitutes a physical and dynamic barrier against foreign antigens and pathogens and exerts control mechanisms to maintain intestinal tolerance to the microbiota and food antigens. Chronic alterations of the intestinal homeostasis predispose to inflammatory diseases of the gastrointestinal tract, such as Inflammatory Bowel Diseases (IBD). There is growing evidence that the frequency and severity of these diseases are increasing worldwide, which may be probably due to changes in environmental factors. Several stromal and immune cells are involved in this delicate equilibrium that dictates homeostasis. In this review we aimed to summarize the role of epithelial cells and fibroblasts in the induction of mucosal inflammation in the context of IBD. It has been extensively described that environmental factors are key players in this process, and the microbiome of the gastrointestinal tract is currently being intensively investigated due to its profound impact the immune response. Recent findings have demonstrated the interplay between dietary and environmental components, the gut microbiome, and immune cells. “Western” dietary patterns, such as high caloric diets, and pollution can induce alterations in the gut microbiome that in turn affect the intestinal and systemic homeostasis. Here we summarize current knowledge on the influence of dietary components and air particulate matters on gut microbiome composition, and the impact on stromal and immune cells, with a particular focus on promoting local inflammation.
Facultad de Ciencias Exactas
Instituto de Estudios Inmunológicos y Fisiopatológicos
Departamento de Ciencias Biológicas - Materia
-
Ciencias Exactas
Biología
gut inflammation
inflammatory bowel disease
intestinal epithelial cells
intestinal fibroblasts
immune cell activation/modulation
intestinal microbiota - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/107685
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Contribution of Non-immune Cells to Activation and Modulation of the Intestinal InflammationCurciarello, RenataCanziani, Karina EvaDocena, Guillermo HoracioMuglia, Cecilia IsabelCiencias ExactasBiologíagut inflammationinflammatory bowel diseaseintestinal epithelial cellsintestinal fibroblastsimmune cell activation/modulationintestinal microbiotaThe mucosal immune system constitutes a physical and dynamic barrier against foreign antigens and pathogens and exerts control mechanisms to maintain intestinal tolerance to the microbiota and food antigens. Chronic alterations of the intestinal homeostasis predispose to inflammatory diseases of the gastrointestinal tract, such as Inflammatory Bowel Diseases (IBD). There is growing evidence that the frequency and severity of these diseases are increasing worldwide, which may be probably due to changes in environmental factors. Several stromal and immune cells are involved in this delicate equilibrium that dictates homeostasis. In this review we aimed to summarize the role of epithelial cells and fibroblasts in the induction of mucosal inflammation in the context of IBD. It has been extensively described that environmental factors are key players in this process, and the microbiome of the gastrointestinal tract is currently being intensively investigated due to its profound impact the immune response. Recent findings have demonstrated the interplay between dietary and environmental components, the gut microbiome, and immune cells. “Western” dietary patterns, such as high caloric diets, and pollution can induce alterations in the gut microbiome that in turn affect the intestinal and systemic homeostasis. Here we summarize current knowledge on the influence of dietary components and air particulate matters on gut microbiome composition, and the impact on stromal and immune cells, with a particular focus on promoting local inflammation.Facultad de Ciencias ExactasInstituto de Estudios Inmunológicos y FisiopatológicosDepartamento de Ciencias Biológicas2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/107685enginfo:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6467945&blobtype=pdfinfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2019.00647/fullinfo:eu-repo/semantics/altIdentifier/issn/1664-3224info:eu-repo/semantics/altIdentifier/pmid/31024529info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2019.00647info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:15:42Zoai:sedici.unlp.edu.ar:10915/107685Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:15:42.807SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation |
title |
Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation |
spellingShingle |
Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation Curciarello, Renata Ciencias Exactas Biología gut inflammation inflammatory bowel disease intestinal epithelial cells intestinal fibroblasts immune cell activation/modulation intestinal microbiota |
title_short |
Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation |
title_full |
Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation |
title_fullStr |
Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation |
title_full_unstemmed |
Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation |
title_sort |
Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation |
dc.creator.none.fl_str_mv |
Curciarello, Renata Canziani, Karina Eva Docena, Guillermo Horacio Muglia, Cecilia Isabel |
author |
Curciarello, Renata |
author_facet |
Curciarello, Renata Canziani, Karina Eva Docena, Guillermo Horacio Muglia, Cecilia Isabel |
author_role |
author |
author2 |
Canziani, Karina Eva Docena, Guillermo Horacio Muglia, Cecilia Isabel |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Ciencias Exactas Biología gut inflammation inflammatory bowel disease intestinal epithelial cells intestinal fibroblasts immune cell activation/modulation intestinal microbiota |
topic |
Ciencias Exactas Biología gut inflammation inflammatory bowel disease intestinal epithelial cells intestinal fibroblasts immune cell activation/modulation intestinal microbiota |
dc.description.none.fl_txt_mv |
The mucosal immune system constitutes a physical and dynamic barrier against foreign antigens and pathogens and exerts control mechanisms to maintain intestinal tolerance to the microbiota and food antigens. Chronic alterations of the intestinal homeostasis predispose to inflammatory diseases of the gastrointestinal tract, such as Inflammatory Bowel Diseases (IBD). There is growing evidence that the frequency and severity of these diseases are increasing worldwide, which may be probably due to changes in environmental factors. Several stromal and immune cells are involved in this delicate equilibrium that dictates homeostasis. In this review we aimed to summarize the role of epithelial cells and fibroblasts in the induction of mucosal inflammation in the context of IBD. It has been extensively described that environmental factors are key players in this process, and the microbiome of the gastrointestinal tract is currently being intensively investigated due to its profound impact the immune response. Recent findings have demonstrated the interplay between dietary and environmental components, the gut microbiome, and immune cells. “Western” dietary patterns, such as high caloric diets, and pollution can induce alterations in the gut microbiome that in turn affect the intestinal and systemic homeostasis. Here we summarize current knowledge on the influence of dietary components and air particulate matters on gut microbiome composition, and the impact on stromal and immune cells, with a particular focus on promoting local inflammation. Facultad de Ciencias Exactas Instituto de Estudios Inmunológicos y Fisiopatológicos Departamento de Ciencias Biológicas |
description |
The mucosal immune system constitutes a physical and dynamic barrier against foreign antigens and pathogens and exerts control mechanisms to maintain intestinal tolerance to the microbiota and food antigens. Chronic alterations of the intestinal homeostasis predispose to inflammatory diseases of the gastrointestinal tract, such as Inflammatory Bowel Diseases (IBD). There is growing evidence that the frequency and severity of these diseases are increasing worldwide, which may be probably due to changes in environmental factors. Several stromal and immune cells are involved in this delicate equilibrium that dictates homeostasis. In this review we aimed to summarize the role of epithelial cells and fibroblasts in the induction of mucosal inflammation in the context of IBD. It has been extensively described that environmental factors are key players in this process, and the microbiome of the gastrointestinal tract is currently being intensively investigated due to its profound impact the immune response. Recent findings have demonstrated the interplay between dietary and environmental components, the gut microbiome, and immune cells. “Western” dietary patterns, such as high caloric diets, and pollution can induce alterations in the gut microbiome that in turn affect the intestinal and systemic homeostasis. Here we summarize current knowledge on the influence of dietary components and air particulate matters on gut microbiome composition, and the impact on stromal and immune cells, with a particular focus on promoting local inflammation. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 |
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http://sedici.unlp.edu.ar/handle/10915/107685 |
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eng |
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eng |
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