Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation

Autores
Curciarello, Renata; Canziani, Karina Eva; Docena, Guillermo Horacio; Muglia, Cecilia Isabel
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The mucosal immune system constitutes a physical and dynamic barrier against foreign antigens and pathogens and exerts control mechanisms to maintain intestinal tolerance to the microbiota and food antigens. Chronic alterations of the intestinal homeostasis predispose to inflammatory diseases of the gastrointestinal tract, such as Inflammatory Bowel Diseases (IBD). There is growing evidence that the frequency and severity of these diseases are increasing worldwide, which may be probably due to changes in environmental factors. Several stromal and immune cells are involved in this delicate equilibrium that dictates homeostasis. In this review we aimed to summarize the role of epithelial cells and fibroblasts in the induction of mucosal inflammation in the context of IBD. It has been extensively described that environmental factors are key players in this process, and the microbiome of the gastrointestinal tract is currently being intensively investigated due to its profound impact the immune response. Recent findings have demonstrated the interplay between dietary and environmental components, the gut microbiome, and immune cells. “Western” dietary patterns, such as high caloric diets, and pollution can induce alterations in the gut microbiome that in turn affect the intestinal and systemic homeostasis. Here we summarize current knowledge on the influence of dietary components and air particulate matters on gut microbiome composition, and the impact on stromal and immune cells, with a particular focus on promoting local inflammation.
Facultad de Ciencias Exactas
Instituto de Estudios Inmunológicos y Fisiopatológicos
Departamento de Ciencias Biológicas
Materia
Ciencias Exactas
Biología
gut inflammation
inflammatory bowel disease
intestinal epithelial cells
intestinal fibroblasts
immune cell activation/modulation
intestinal microbiota
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/107685

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spelling Contribution of Non-immune Cells to Activation and Modulation of the Intestinal InflammationCurciarello, RenataCanziani, Karina EvaDocena, Guillermo HoracioMuglia, Cecilia IsabelCiencias ExactasBiologíagut inflammationinflammatory bowel diseaseintestinal epithelial cellsintestinal fibroblastsimmune cell activation/modulationintestinal microbiotaThe mucosal immune system constitutes a physical and dynamic barrier against foreign antigens and pathogens and exerts control mechanisms to maintain intestinal tolerance to the microbiota and food antigens. Chronic alterations of the intestinal homeostasis predispose to inflammatory diseases of the gastrointestinal tract, such as Inflammatory Bowel Diseases (IBD). There is growing evidence that the frequency and severity of these diseases are increasing worldwide, which may be probably due to changes in environmental factors. Several stromal and immune cells are involved in this delicate equilibrium that dictates homeostasis. In this review we aimed to summarize the role of epithelial cells and fibroblasts in the induction of mucosal inflammation in the context of IBD. It has been extensively described that environmental factors are key players in this process, and the microbiome of the gastrointestinal tract is currently being intensively investigated due to its profound impact the immune response. Recent findings have demonstrated the interplay between dietary and environmental components, the gut microbiome, and immune cells. “Western” dietary patterns, such as high caloric diets, and pollution can induce alterations in the gut microbiome that in turn affect the intestinal and systemic homeostasis. Here we summarize current knowledge on the influence of dietary components and air particulate matters on gut microbiome composition, and the impact on stromal and immune cells, with a particular focus on promoting local inflammation.Facultad de Ciencias ExactasInstituto de Estudios Inmunológicos y FisiopatológicosDepartamento de Ciencias Biológicas2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/107685enginfo:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6467945&blobtype=pdfinfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2019.00647/fullinfo:eu-repo/semantics/altIdentifier/issn/1664-3224info:eu-repo/semantics/altIdentifier/pmid/31024529info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2019.00647info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:15:42Zoai:sedici.unlp.edu.ar:10915/107685Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:15:42.807SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
title Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
spellingShingle Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
Curciarello, Renata
Ciencias Exactas
Biología
gut inflammation
inflammatory bowel disease
intestinal epithelial cells
intestinal fibroblasts
immune cell activation/modulation
intestinal microbiota
title_short Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
title_full Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
title_fullStr Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
title_full_unstemmed Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
title_sort Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
dc.creator.none.fl_str_mv Curciarello, Renata
Canziani, Karina Eva
Docena, Guillermo Horacio
Muglia, Cecilia Isabel
author Curciarello, Renata
author_facet Curciarello, Renata
Canziani, Karina Eva
Docena, Guillermo Horacio
Muglia, Cecilia Isabel
author_role author
author2 Canziani, Karina Eva
Docena, Guillermo Horacio
Muglia, Cecilia Isabel
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Biología
gut inflammation
inflammatory bowel disease
intestinal epithelial cells
intestinal fibroblasts
immune cell activation/modulation
intestinal microbiota
topic Ciencias Exactas
Biología
gut inflammation
inflammatory bowel disease
intestinal epithelial cells
intestinal fibroblasts
immune cell activation/modulation
intestinal microbiota
dc.description.none.fl_txt_mv The mucosal immune system constitutes a physical and dynamic barrier against foreign antigens and pathogens and exerts control mechanisms to maintain intestinal tolerance to the microbiota and food antigens. Chronic alterations of the intestinal homeostasis predispose to inflammatory diseases of the gastrointestinal tract, such as Inflammatory Bowel Diseases (IBD). There is growing evidence that the frequency and severity of these diseases are increasing worldwide, which may be probably due to changes in environmental factors. Several stromal and immune cells are involved in this delicate equilibrium that dictates homeostasis. In this review we aimed to summarize the role of epithelial cells and fibroblasts in the induction of mucosal inflammation in the context of IBD. It has been extensively described that environmental factors are key players in this process, and the microbiome of the gastrointestinal tract is currently being intensively investigated due to its profound impact the immune response. Recent findings have demonstrated the interplay between dietary and environmental components, the gut microbiome, and immune cells. “Western” dietary patterns, such as high caloric diets, and pollution can induce alterations in the gut microbiome that in turn affect the intestinal and systemic homeostasis. Here we summarize current knowledge on the influence of dietary components and air particulate matters on gut microbiome composition, and the impact on stromal and immune cells, with a particular focus on promoting local inflammation.
Facultad de Ciencias Exactas
Instituto de Estudios Inmunológicos y Fisiopatológicos
Departamento de Ciencias Biológicas
description The mucosal immune system constitutes a physical and dynamic barrier against foreign antigens and pathogens and exerts control mechanisms to maintain intestinal tolerance to the microbiota and food antigens. Chronic alterations of the intestinal homeostasis predispose to inflammatory diseases of the gastrointestinal tract, such as Inflammatory Bowel Diseases (IBD). There is growing evidence that the frequency and severity of these diseases are increasing worldwide, which may be probably due to changes in environmental factors. Several stromal and immune cells are involved in this delicate equilibrium that dictates homeostasis. In this review we aimed to summarize the role of epithelial cells and fibroblasts in the induction of mucosal inflammation in the context of IBD. It has been extensively described that environmental factors are key players in this process, and the microbiome of the gastrointestinal tract is currently being intensively investigated due to its profound impact the immune response. Recent findings have demonstrated the interplay between dietary and environmental components, the gut microbiome, and immune cells. “Western” dietary patterns, such as high caloric diets, and pollution can induce alterations in the gut microbiome that in turn affect the intestinal and systemic homeostasis. Here we summarize current knowledge on the influence of dietary components and air particulate matters on gut microbiome composition, and the impact on stromal and immune cells, with a particular focus on promoting local inflammation.
publishDate 2019
dc.date.none.fl_str_mv 2019
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info:eu-repo/semantics/publishedVersion
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info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2019.00647/full
info:eu-repo/semantics/altIdentifier/issn/1664-3224
info:eu-repo/semantics/altIdentifier/pmid/31024529
info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2019.00647
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
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