Aging and rejuvenation - a modular epigenome model

Autores
Chiavellini, Priscila; Canatelli Mallat, Martina; Lehmann, Marianne; Gallardo, María Emilia; Hereñú, Claudia B.; Cordeiro, José L.; Clement, James P.; Goya, Rodolfo Gustavo
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like animal cloning and cell reprogramming have deeply changed our understanding of postnatal development, giving rise to the emerging view that the epigenome is the driver of aging. The idea was significantly strengthened by the converging discovery that DNA methylation (DNAm) at specific CpG sites could be used as a highly accurate biomarker of age defined by an algorithm known as the Horvath clock. It was at this point where epigenetic rejuvenation came into play as a strategy to reveal to what extent biological age can be set back by making the clock tick backwards. Initial evidence suggests that when the clock is forced to tick backwards in vivo, it is only able to drag the phenotype to a partially rejuvenated condition. In order to explain the results, a bimodular epigenome is proposed, where module A represents the DNAm clock component and module B the remainder of the epigenome. Epigenetic rejuvenation seems to hold the key to arresting or even reversing organismal aging.
Instituto de Investigaciones Bioquímicas de La Plata
Materia
Bioquímica
Aging
DNA methylation
Epigenetic clock
Rejuvenation
Cell reprogramming
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/3.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/128713
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/128713
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Aging and rejuvenation - a modular epigenome modelChiavellini, PriscilaCanatelli Mallat, MartinaLehmann, MarianneGallardo, María EmiliaHereñú, Claudia B.Cordeiro, José L.Clement, James P.Goya, Rodolfo GustavoBioquímicaAgingDNA methylationEpigenetic clockRejuvenationCell reprogrammingThe view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like animal cloning and cell reprogramming have deeply changed our understanding of postnatal development, giving rise to the emerging view that the epigenome is the driver of aging. The idea was significantly strengthened by the converging discovery that DNA methylation (DNAm) at specific CpG sites could be used as a highly accurate biomarker of age defined by an algorithm known as the Horvath clock. It was at this point where epigenetic rejuvenation came into play as a strategy to reveal to what extent biological age can be set back by making the clock tick backwards. Initial evidence suggests that when the clock is forced to tick backwards in vivo, it is only able to drag the phenotype to a partially rejuvenated condition. In order to explain the results, a bimodular epigenome is proposed, where module A represents the DNAm clock component and module B the remainder of the epigenome. Epigenetic rejuvenation seems to hold the key to arresting or even reversing organismal aging.Instituto de Investigaciones Bioquímicas de La Plata2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf4734-4746http://sedici.unlp.edu.ar/handle/10915/128713enginfo:eu-repo/semantics/altIdentifier/issn/1945-4589info:eu-repo/semantics/altIdentifier/pmid/33627519info:eu-repo/semantics/altIdentifier/doi/10.18632/aging.202712info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/Creative Commons Attribution 3.0 Unported (CC BY 3.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-17T10:13:42Zoai:sedici.unlp.edu.ar:10915/128713Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-17 10:13:42.704SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Aging and rejuvenation - a modular epigenome model
title Aging and rejuvenation - a modular epigenome model
spellingShingle Aging and rejuvenation - a modular epigenome model
Chiavellini, Priscila
Bioquímica
Aging
DNA methylation
Epigenetic clock
Rejuvenation
Cell reprogramming
title_short Aging and rejuvenation - a modular epigenome model
title_full Aging and rejuvenation - a modular epigenome model
title_fullStr Aging and rejuvenation - a modular epigenome model
title_full_unstemmed Aging and rejuvenation - a modular epigenome model
title_sort Aging and rejuvenation - a modular epigenome model
dc.creator.none.fl_str_mv Chiavellini, Priscila
Canatelli Mallat, Martina
Lehmann, Marianne
Gallardo, María Emilia
Hereñú, Claudia B.
Cordeiro, José L.
Clement, James P.
Goya, Rodolfo Gustavo
author Chiavellini, Priscila
author_facet Chiavellini, Priscila
Canatelli Mallat, Martina
Lehmann, Marianne
Gallardo, María Emilia
Hereñú, Claudia B.
Cordeiro, José L.
Clement, James P.
Goya, Rodolfo Gustavo
author_role author
author2 Canatelli Mallat, Martina
Lehmann, Marianne
Gallardo, María Emilia
Hereñú, Claudia B.
Cordeiro, José L.
Clement, James P.
Goya, Rodolfo Gustavo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bioquímica
Aging
DNA methylation
Epigenetic clock
Rejuvenation
Cell reprogramming
topic Bioquímica
Aging
DNA methylation
Epigenetic clock
Rejuvenation
Cell reprogramming
dc.description.none.fl_txt_mv The view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like animal cloning and cell reprogramming have deeply changed our understanding of postnatal development, giving rise to the emerging view that the epigenome is the driver of aging. The idea was significantly strengthened by the converging discovery that DNA methylation (DNAm) at specific CpG sites could be used as a highly accurate biomarker of age defined by an algorithm known as the Horvath clock. It was at this point where epigenetic rejuvenation came into play as a strategy to reveal to what extent biological age can be set back by making the clock tick backwards. Initial evidence suggests that when the clock is forced to tick backwards in vivo, it is only able to drag the phenotype to a partially rejuvenated condition. In order to explain the results, a bimodular epigenome is proposed, where module A represents the DNAm clock component and module B the remainder of the epigenome. Epigenetic rejuvenation seems to hold the key to arresting or even reversing organismal aging.
Instituto de Investigaciones Bioquímicas de La Plata
description The view of aging has evolved in parallel with the advances in biomedical sciences. Long considered as an irreversible process where interventions were only aimed at slowing down its progression, breakthrough discoveries like animal cloning and cell reprogramming have deeply changed our understanding of postnatal development, giving rise to the emerging view that the epigenome is the driver of aging. The idea was significantly strengthened by the converging discovery that DNA methylation (DNAm) at specific CpG sites could be used as a highly accurate biomarker of age defined by an algorithm known as the Horvath clock. It was at this point where epigenetic rejuvenation came into play as a strategy to reveal to what extent biological age can be set back by making the clock tick backwards. Initial evidence suggests that when the clock is forced to tick backwards in vivo, it is only able to drag the phenotype to a partially rejuvenated condition. In order to explain the results, a bimodular epigenome is proposed, where module A represents the DNAm clock component and module B the remainder of the epigenome. Epigenetic rejuvenation seems to hold the key to arresting or even reversing organismal aging.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/128713
url http://sedici.unlp.edu.ar/handle/10915/128713
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1945-4589
info:eu-repo/semantics/altIdentifier/pmid/33627519
info:eu-repo/semantics/altIdentifier/doi/10.18632/aging.202712
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/
Creative Commons Attribution 3.0 Unported (CC BY 3.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/
Creative Commons Attribution 3.0 Unported (CC BY 3.0)
dc.format.none.fl_str_mv application/pdf
4734-4746
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.001348

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