Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis

Autores
Karavana, Sinem Y.; Senyi'it, Zeynep A.; Hilmioglu Polat, Süleyha; Metin, Dilek Y.; Zekioglu, Osman; Baloglu, Esra
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study focused on developing in situ gel formulations of miconazole nitrate with poloxamer 188 and 407 for treatment of mucosal candidiasis. In situ gel formulations were prepared and gelation temperature, rheological, mechanical and mucoadhesive properties, syringeability and release profiles were evaluated. Based on their suitable gelation temperature properties, formulations containing the poloxamer (Plx) 407 and 188 in ratios of 15:15 (F1), 15:20 (F2) and 20:10 (F3) were chosen for further studies. F3 exhibited typical gel-type mechanical spectra at 37 °C whereas F1 and F2 behaved like weakly cross-linked gels. Texture profile analysis demonstrated that F3 showed the highest cohesiveness, adhesiveness, hardness and compressibility. According to the these results, F3 was chosen for in vivo studies and it was shown that it is effective for the treatment of the vaginal candidiasis. Histopathologic evaluation also supported the effectiveness of the formulation. As a result, in situ gel formulations prepared with Plx 407 and 188 mixture of miconazole nitrate proved to be a promising alternative dosage form for treatment of mucosal candidiasis
Colegio de Farmacéuticos de la Provincia de Buenos Aires
Materia
Farmacia
Candidiasis
Miconazol
Poloxámero
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Licencia de distribución no exclusiva SEDICI
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/25644
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/25644
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasisKaravana, Sinem Y.Senyi'it, Zeynep A.Hilmioglu Polat, SüleyhaMetin, Dilek Y.Zekioglu, OsmanBaloglu, EsraFarmaciaCandidiasisMiconazolPoloxámeroThis study focused on developing in situ gel formulations of miconazole nitrate with poloxamer 188 and 407 for treatment of mucosal candidiasis. In situ gel formulations were prepared and gelation temperature, rheological, mechanical and mucoadhesive properties, syringeability and release profiles were evaluated. Based on their suitable gelation temperature properties, formulations containing the poloxamer (Plx) 407 and 188 in ratios of 15:15 (F1), 15:20 (F2) and 20:10 (F3) were chosen for further studies. F3 exhibited typical gel-type mechanical spectra at 37 °C whereas F1 and F2 behaved like weakly cross-linked gels. Texture profile analysis demonstrated that F3 showed the highest cohesiveness, adhesiveness, hardness and compressibility. According to the these results, F3 was chosen for in vivo studies and it was shown that it is effective for the treatment of the vaginal candidiasis. Histopathologic evaluation also supported the effectiveness of the formulation. As a result, in situ gel formulations prepared with Plx 407 and 188 mixture of miconazole nitrate proved to be a promising alternative dosage form for treatment of mucosal candidiasisColegio de Farmacéuticos de la Provincia de Buenos Aires2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf821-829http://sedici.unlp.edu.ar/handle/10915/25644enginfo:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_5.pdfinfo:eu-repo/semantics/altIdentifier/issn/0326-2383info:eu-repo/semantics/openAccessLicencia de distribución no exclusiva SEDICIreponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:29:04Zoai:sedici.unlp.edu.ar:10915/25644Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:29:04.531SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
title Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
spellingShingle Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
Karavana, Sinem Y.
Farmacia
Candidiasis
Miconazol
Poloxámero
title_short Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
title_full Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
title_fullStr Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
title_full_unstemmed Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
title_sort Mucoadhesive in situ gel formulations of miconazole nitrate for the treatment of mucosal candidiasis
dc.creator.none.fl_str_mv Karavana, Sinem Y.
Senyi'it, Zeynep A.
Hilmioglu Polat, Süleyha
Metin, Dilek Y.
Zekioglu, Osman
Baloglu, Esra
author Karavana, Sinem Y.
author_facet Karavana, Sinem Y.
Senyi'it, Zeynep A.
Hilmioglu Polat, Süleyha
Metin, Dilek Y.
Zekioglu, Osman
Baloglu, Esra
author_role author
author2 Senyi'it, Zeynep A.
Hilmioglu Polat, Süleyha
Metin, Dilek Y.
Zekioglu, Osman
Baloglu, Esra
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Farmacia
Candidiasis
Miconazol
Poloxámero
topic Farmacia
Candidiasis
Miconazol
Poloxámero
dc.description.none.fl_txt_mv This study focused on developing in situ gel formulations of miconazole nitrate with poloxamer 188 and 407 for treatment of mucosal candidiasis. In situ gel formulations were prepared and gelation temperature, rheological, mechanical and mucoadhesive properties, syringeability and release profiles were evaluated. Based on their suitable gelation temperature properties, formulations containing the poloxamer (Plx) 407 and 188 in ratios of 15:15 (F1), 15:20 (F2) and 20:10 (F3) were chosen for further studies. F3 exhibited typical gel-type mechanical spectra at 37 °C whereas F1 and F2 behaved like weakly cross-linked gels. Texture profile analysis demonstrated that F3 showed the highest cohesiveness, adhesiveness, hardness and compressibility. According to the these results, F3 was chosen for in vivo studies and it was shown that it is effective for the treatment of the vaginal candidiasis. Histopathologic evaluation also supported the effectiveness of the formulation. As a result, in situ gel formulations prepared with Plx 407 and 188 mixture of miconazole nitrate proved to be a promising alternative dosage form for treatment of mucosal candidiasis
Colegio de Farmacéuticos de la Provincia de Buenos Aires
description This study focused on developing in situ gel formulations of miconazole nitrate with poloxamer 188 and 407 for treatment of mucosal candidiasis. In situ gel formulations were prepared and gelation temperature, rheological, mechanical and mucoadhesive properties, syringeability and release profiles were evaluated. Based on their suitable gelation temperature properties, formulations containing the poloxamer (Plx) 407 and 188 in ratios of 15:15 (F1), 15:20 (F2) and 20:10 (F3) were chosen for further studies. F3 exhibited typical gel-type mechanical spectra at 37 °C whereas F1 and F2 behaved like weakly cross-linked gels. Texture profile analysis demonstrated that F3 showed the highest cohesiveness, adhesiveness, hardness and compressibility. According to the these results, F3 was chosen for in vivo studies and it was shown that it is effective for the treatment of the vaginal candidiasis. Histopathologic evaluation also supported the effectiveness of the formulation. As a result, in situ gel formulations prepared with Plx 407 and 188 mixture of miconazole nitrate proved to be a promising alternative dosage form for treatment of mucosal candidiasis
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/25644
url http://sedici.unlp.edu.ar/handle/10915/25644
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_5.pdf
info:eu-repo/semantics/altIdentifier/issn/0326-2383
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Licencia de distribución no exclusiva SEDICI
eu_rights_str_mv openAccess
rights_invalid_str_mv Licencia de distribución no exclusiva SEDICI
dc.format.none.fl_str_mv application/pdf
821-829
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.13397

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