Do DNA copy number changes differentiate uterine from non-uterine leiomyosarcomas and predict metastasis?

Autores
Svarvar, Catarina; Larramendy, Marcelo Luis; Blomqvist, Carl; Gentile, Massimiliano; Koivisto-Korander, Riitta; Leminen, Arto; Bützow, Ralf; Böhling, Tom; Knuutila, Sakari
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
DNA copy number changes were investigated in 51 (19 uterine and 32 nonuterine) primary leiomyosarcomas by comparative genomic hybridization. The aim was to evaluate whether true biological differences exist between uterine and nonuterine leiomyosarcoma and whether changes revealed by comparative genomic hybridization have prognostic value. Genomic imbalances were found in 48 (94%) cases. The most frequent DNA copy number changes were losses in 10q (35%), 13q (57%), and 16q (41%), gains in 1q (41%), and gains and high-level amplifications in 17p (39%). Gains were nearly as frequent as losses in both uterine and nonuterine leiomyosarcoma. Correlation-based tree modeling revealed two clusters that segregated significantly a group of uterine (gains at 1q11-q24) and a group of nonuterine (losses at 13q14-q34, 16q11.1-q24, and 10q21-q26) cases. The nonuterine cluster was associated with subcutaneous origin and a trend toward increased metastasis-free survival. Further explorative analyses identified aberrations associated with shorter metastasis-free survival time, including losses at 2q32.1-q37 and gains at 8q24.1-q24.3, whereas the cases with losses at 6cen-p25 showed longer metastasis-free survival time.
Facultad de Ciencias Naturales y Museo
Materia
Ciencias Médicas
Comparative genomic hybridization
DNA copy number changes
Leiomyosarcoma
Metastasis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/83259
Acceder
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network_name_str SEDICI (UNLP)
spelling Do DNA copy number changes differentiate uterine from non-uterine leiomyosarcomas and predict metastasis?Svarvar, CatarinaLarramendy, Marcelo LuisBlomqvist, CarlGentile, MassimilianoKoivisto-Korander, RiittaLeminen, ArtoBützow, RalfBöhling, TomKnuutila, SakariCiencias MédicasComparative genomic hybridizationDNA copy number changesLeiomyosarcomaMetastasisDNA copy number changes were investigated in 51 (19 uterine and 32 nonuterine) primary leiomyosarcomas by comparative genomic hybridization. The aim was to evaluate whether true biological differences exist between uterine and nonuterine leiomyosarcoma and whether changes revealed by comparative genomic hybridization have prognostic value. Genomic imbalances were found in 48 (94%) cases. The most frequent DNA copy number changes were losses in 10q (35%), 13q (57%), and 16q (41%), gains in 1q (41%), and gains and high-level amplifications in 17p (39%). Gains were nearly as frequent as losses in both uterine and nonuterine leiomyosarcoma. Correlation-based tree modeling revealed two clusters that segregated significantly a group of uterine (gains at 1q11-q24) and a group of nonuterine (losses at 13q14-q34, 16q11.1-q24, and 10q21-q26) cases. The nonuterine cluster was associated with subcutaneous origin and a trend toward increased metastasis-free survival. Further explorative analyses identified aberrations associated with shorter metastasis-free survival time, including losses at 2q32.1-q37 and gains at 8q24.1-q24.3, whereas the cases with losses at 6cen-p25 showed longer metastasis-free survival time.Facultad de Ciencias Naturales y Museo2006-04-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1068-1082http://sedici.unlp.edu.ar/handle/10915/83259enginfo:eu-repo/semantics/altIdentifier/issn/0893-3952info:eu-repo/semantics/altIdentifier/doi/10.1038/modpathol.3800617info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-10T12:18:27Zoai:sedici.unlp.edu.ar:10915/83259Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-10 12:18:27.693SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Do DNA copy number changes differentiate uterine from non-uterine leiomyosarcomas and predict metastasis?
title Do DNA copy number changes differentiate uterine from non-uterine leiomyosarcomas and predict metastasis?
spellingShingle Do DNA copy number changes differentiate uterine from non-uterine leiomyosarcomas and predict metastasis?
Svarvar, Catarina
Ciencias Médicas
Comparative genomic hybridization
DNA copy number changes
Leiomyosarcoma
Metastasis
title_short Do DNA copy number changes differentiate uterine from non-uterine leiomyosarcomas and predict metastasis?
title_full Do DNA copy number changes differentiate uterine from non-uterine leiomyosarcomas and predict metastasis?
title_fullStr Do DNA copy number changes differentiate uterine from non-uterine leiomyosarcomas and predict metastasis?
title_full_unstemmed Do DNA copy number changes differentiate uterine from non-uterine leiomyosarcomas and predict metastasis?
title_sort Do DNA copy number changes differentiate uterine from non-uterine leiomyosarcomas and predict metastasis?
dc.creator.none.fl_str_mv Svarvar, Catarina
Larramendy, Marcelo Luis
Blomqvist, Carl
Gentile, Massimiliano
Koivisto-Korander, Riitta
Leminen, Arto
Bützow, Ralf
Böhling, Tom
Knuutila, Sakari
author Svarvar, Catarina
author_facet Svarvar, Catarina
Larramendy, Marcelo Luis
Blomqvist, Carl
Gentile, Massimiliano
Koivisto-Korander, Riitta
Leminen, Arto
Bützow, Ralf
Böhling, Tom
Knuutila, Sakari
author_role author
author2 Larramendy, Marcelo Luis
Blomqvist, Carl
Gentile, Massimiliano
Koivisto-Korander, Riitta
Leminen, Arto
Bützow, Ralf
Böhling, Tom
Knuutila, Sakari
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Comparative genomic hybridization
DNA copy number changes
Leiomyosarcoma
Metastasis
topic Ciencias Médicas
Comparative genomic hybridization
DNA copy number changes
Leiomyosarcoma
Metastasis
dc.description.none.fl_txt_mv DNA copy number changes were investigated in 51 (19 uterine and 32 nonuterine) primary leiomyosarcomas by comparative genomic hybridization. The aim was to evaluate whether true biological differences exist between uterine and nonuterine leiomyosarcoma and whether changes revealed by comparative genomic hybridization have prognostic value. Genomic imbalances were found in 48 (94%) cases. The most frequent DNA copy number changes were losses in 10q (35%), 13q (57%), and 16q (41%), gains in 1q (41%), and gains and high-level amplifications in 17p (39%). Gains were nearly as frequent as losses in both uterine and nonuterine leiomyosarcoma. Correlation-based tree modeling revealed two clusters that segregated significantly a group of uterine (gains at 1q11-q24) and a group of nonuterine (losses at 13q14-q34, 16q11.1-q24, and 10q21-q26) cases. The nonuterine cluster was associated with subcutaneous origin and a trend toward increased metastasis-free survival. Further explorative analyses identified aberrations associated with shorter metastasis-free survival time, including losses at 2q32.1-q37 and gains at 8q24.1-q24.3, whereas the cases with losses at 6cen-p25 showed longer metastasis-free survival time.
Facultad de Ciencias Naturales y Museo
description DNA copy number changes were investigated in 51 (19 uterine and 32 nonuterine) primary leiomyosarcomas by comparative genomic hybridization. The aim was to evaluate whether true biological differences exist between uterine and nonuterine leiomyosarcoma and whether changes revealed by comparative genomic hybridization have prognostic value. Genomic imbalances were found in 48 (94%) cases. The most frequent DNA copy number changes were losses in 10q (35%), 13q (57%), and 16q (41%), gains in 1q (41%), and gains and high-level amplifications in 17p (39%). Gains were nearly as frequent as losses in both uterine and nonuterine leiomyosarcoma. Correlation-based tree modeling revealed two clusters that segregated significantly a group of uterine (gains at 1q11-q24) and a group of nonuterine (losses at 13q14-q34, 16q11.1-q24, and 10q21-q26) cases. The nonuterine cluster was associated with subcutaneous origin and a trend toward increased metastasis-free survival. Further explorative analyses identified aberrations associated with shorter metastasis-free survival time, including losses at 2q32.1-q37 and gains at 8q24.1-q24.3, whereas the cases with losses at 6cen-p25 showed longer metastasis-free survival time.
publishDate 2006
dc.date.none.fl_str_mv 2006-04-28
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/83259
url http://sedici.unlp.edu.ar/handle/10915/83259
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0893-3952
info:eu-repo/semantics/altIdentifier/doi/10.1038/modpathol.3800617
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
1068-1082
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
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reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
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repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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