Effect of the Incorporation of Amaranth (<i>Amaranthus Mantegazzianus</i>) into Fat- and Cholesterol-Rich Diets for Wistar Rats

Autores
Sisti, Martín Sebastián; Scilingo, Adriana Alicia; Añón, María Cristina
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The hypocholesterolemic effect of amaranth was studied in male Wistar rats fed a high-fat diet that was supplemented with amaranth flour, AF, or isolated protein, AI. Likewise, an in vitro test was carried out, in which the capacity of the AI, AF, the digested isolate, DAI, and the digested amaranth flour, DAF, to displace the cholesterol of the model micelles was evaluated. The in vivo results showed an increase in the excretion of cholesterol through feces (77% for AF7; 23% and 108% for AI30 and AF30, respect control) and a decrease in the content of hepatic cholesterol (98% for AF7; 96% and 53% for AI30 and AF30 respect control); whereas in vitro it was shown that both AF and DAF have greater power to displace cholesterol than the AI and DAI (IC50 0.1, 0.71, 0.2, and 2.1 for AF, DAF, AI, and DAI, respectively). These evidences show that the proteins and fibers of amaranth have an effect on cholesterol metabolism.
Centro de Investigación y Desarrollo en Criotecnología de Alimentos
Materia
Química
amaranth
cholesterol
hypocholesterolemia
fiber
peptides
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/105690
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/105690
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Effect of the Incorporation of Amaranth (<i>Amaranthus Mantegazzianus</i>) into Fat- and Cholesterol-Rich Diets for Wistar RatsSisti, Martín SebastiánScilingo, Adriana AliciaAñón, María CristinaQuímicaamaranthcholesterolhypocholesterolemiafiberpeptidesThe hypocholesterolemic effect of amaranth was studied in male Wistar rats fed a high-fat diet that was supplemented with amaranth flour, AF, or isolated protein, AI. Likewise, an in vitro test was carried out, in which the capacity of the AI, AF, the digested isolate, DAI, and the digested amaranth flour, DAF, to displace the cholesterol of the model micelles was evaluated. The in vivo results showed an increase in the excretion of cholesterol through feces (77% for AF7; 23% and 108% for AI30 and AF30, respect control) and a decrease in the content of hepatic cholesterol (98% for AF7; 96% and 53% for AI30 and AF30 respect control); whereas in vitro it was shown that both AF and DAF have greater power to displace cholesterol than the AI and DAI (IC50 0.1, 0.71, 0.2, and 2.1 for AF, DAF, AI, and DAI, respectively). These evidences show that the proteins and fibers of amaranth have an effect on cholesterol metabolism.Centro de Investigación y Desarrollo en Criotecnología de Alimentos2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf3075-3082http://sedici.unlp.edu.ar/handle/10915/105690enginfo:eu-repo/semantics/altIdentifier/issn/1750-3841info:eu-repo/semantics/altIdentifier/doi/10.1111/1750-3841.14810info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-10T12:26:12Zoai:sedici.unlp.edu.ar:10915/105690Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-10 12:26:12.529SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Effect of the Incorporation of Amaranth (<i>Amaranthus Mantegazzianus</i>) into Fat- and Cholesterol-Rich Diets for Wistar Rats
title Effect of the Incorporation of Amaranth (<i>Amaranthus Mantegazzianus</i>) into Fat- and Cholesterol-Rich Diets for Wistar Rats
spellingShingle Effect of the Incorporation of Amaranth (<i>Amaranthus Mantegazzianus</i>) into Fat- and Cholesterol-Rich Diets for Wistar Rats
Sisti, Martín Sebastián
Química
amaranth
cholesterol
hypocholesterolemia
fiber
peptides
title_short Effect of the Incorporation of Amaranth (<i>Amaranthus Mantegazzianus</i>) into Fat- and Cholesterol-Rich Diets for Wistar Rats
title_full Effect of the Incorporation of Amaranth (<i>Amaranthus Mantegazzianus</i>) into Fat- and Cholesterol-Rich Diets for Wistar Rats
title_fullStr Effect of the Incorporation of Amaranth (<i>Amaranthus Mantegazzianus</i>) into Fat- and Cholesterol-Rich Diets for Wistar Rats
title_full_unstemmed Effect of the Incorporation of Amaranth (<i>Amaranthus Mantegazzianus</i>) into Fat- and Cholesterol-Rich Diets for Wistar Rats
title_sort Effect of the Incorporation of Amaranth (<i>Amaranthus Mantegazzianus</i>) into Fat- and Cholesterol-Rich Diets for Wistar Rats
dc.creator.none.fl_str_mv Sisti, Martín Sebastián
Scilingo, Adriana Alicia
Añón, María Cristina
author Sisti, Martín Sebastián
author_facet Sisti, Martín Sebastián
Scilingo, Adriana Alicia
Añón, María Cristina
author_role author
author2 Scilingo, Adriana Alicia
Añón, María Cristina
author2_role author
author
dc.subject.none.fl_str_mv Química
amaranth
cholesterol
hypocholesterolemia
fiber
peptides
topic Química
amaranth
cholesterol
hypocholesterolemia
fiber
peptides
dc.description.none.fl_txt_mv The hypocholesterolemic effect of amaranth was studied in male Wistar rats fed a high-fat diet that was supplemented with amaranth flour, AF, or isolated protein, AI. Likewise, an in vitro test was carried out, in which the capacity of the AI, AF, the digested isolate, DAI, and the digested amaranth flour, DAF, to displace the cholesterol of the model micelles was evaluated. The in vivo results showed an increase in the excretion of cholesterol through feces (77% for AF7; 23% and 108% for AI30 and AF30, respect control) and a decrease in the content of hepatic cholesterol (98% for AF7; 96% and 53% for AI30 and AF30 respect control); whereas in vitro it was shown that both AF and DAF have greater power to displace cholesterol than the AI and DAI (IC50 0.1, 0.71, 0.2, and 2.1 for AF, DAF, AI, and DAI, respectively). These evidences show that the proteins and fibers of amaranth have an effect on cholesterol metabolism.
Centro de Investigación y Desarrollo en Criotecnología de Alimentos
description The hypocholesterolemic effect of amaranth was studied in male Wistar rats fed a high-fat diet that was supplemented with amaranth flour, AF, or isolated protein, AI. Likewise, an in vitro test was carried out, in which the capacity of the AI, AF, the digested isolate, DAI, and the digested amaranth flour, DAF, to displace the cholesterol of the model micelles was evaluated. The in vivo results showed an increase in the excretion of cholesterol through feces (77% for AF7; 23% and 108% for AI30 and AF30, respect control) and a decrease in the content of hepatic cholesterol (98% for AF7; 96% and 53% for AI30 and AF30 respect control); whereas in vitro it was shown that both AF and DAF have greater power to displace cholesterol than the AI and DAI (IC50 0.1, 0.71, 0.2, and 2.1 for AF, DAF, AI, and DAI, respectively). These evidences show that the proteins and fibers of amaranth have an effect on cholesterol metabolism.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/105690
url http://sedici.unlp.edu.ar/handle/10915/105690
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1750-3841
info:eu-repo/semantics/altIdentifier/doi/10.1111/1750-3841.14810
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
3075-3082
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 12.993085

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